Center for Interdisciplinary Cardiovascular Sciences

Rogers MA, Aikawa E

Unbiased omics identifies mechanistic regulators of calcific aortic valve disease.

Eur Heart J. 2021;42(30):2948-2950 - PMID: 34179985 - PMCID: PMC8347449 - DOI: 10.1093/eurheartj/ehab381

Kraler S, Blaser MC, Aikawa E, Camici GG, Luscher TF

Calcific aortic valve disease: from molecular and cellular mechanisms to medical therapy.

Eur Heart J. 2021;43(7):683-697 - PMID: 34849696 - PMCID: PMC8843796 - DOI: 10.1093/eurheartj/ehab757

van der Ven CFT, Tibbitt MW, Conde J, van Mil A, Hjortnaes J, Doevendans PA, Sluijter JPG, Aikawa E, Langer RS

Controlled delivery of gold nanoparticle-coupled miRNA therapeutics via an injectable self-healing hydrogel.

Nanoscale. 2021;13(48):20451-20461 - PMID: 34817483 - PMCID: PMC8675028 - DOI: 10.1039/d1nr04973a

Iwata H, Osborn EA, Ughi GJ, Murakami K, Goettsch C, Hutcheson JD, Mauskapf A, Mattson PC, Libby P, Singh SA, Matamalas J, Aikawa E, Tearney GJ, Aikawa M, Jaffer FA

Highly Selective PPARα (Peroxisome Proliferator-Activated Receptor α) Agonist Pemafibrate Inhibits Stent Inflammation and Restenosis Assessed by Multimodality Molecular-Microstructural Imaging.

J Am Heart Assoc. 2021;10(20):e020834 - PMID: 34632804 - PMCID: PMC8751880 - DOI: 10.1161/JAHA.121.020834

Kuraoka S, Higashi H, Yanagihara Y, Sonawane AR, Mukai S, Mlynarchik AK, Whelan MC, Hottiger MO, Nasir W, Delanghe B, Aikawa M, Singh SA

A Novel Spectral Annotation Strategy Streamlines Reporting of mono-ADP-ribosylated Peptides Derived from Mouse Liver and Spleen in Response to IFN-γ.

Mol Cell Proteomics. 2021;21(4):100153 - PMID: 34592425 - PMCID: PMC9014395 - DOI: 10.1016/j.mcpro.2021.100153

Zhang H, Chen ZB, Fredman G, Gomez D, Grumbach IM, Huang NF, Nguyen P, Ouimet M, Sutton NR, Aikawa E

What Makes a Great Mentor: Interviews With Recipients of the ATVB Mentor of Women Award.

Arterioscler Thromb Vasc Biol. 2021;41(11):2641-2647 - PMID: 34547925 - PMCID: PMC8551033 - DOI: 10.1161/ATVBAHA.121.316558

Meerman M, Driessen R, van Engeland NCA, Bergsma I, Steenhuijsen JLG, Kozono D, Aikawa E, Hjortnaes J, Bouten CVC

Radiation Induces Valvular Interstitial Cell Calcific Response in an in vitro Model of Calcific Aortic Valve Disease.

Front Cardiovasc Med. 2021;8:687885 - PMID: 34527708 - PMCID: PMC8435633 - DOI: 10.3389/fcvm.2021.687885

Bartoli-Leonard F, Zimmer J, Aikawa E

Innate and adaptative immunity: The understudied driving force of heart valve disease.

Cardiovasc Res. 2021;117(13):2506-2524 - PMID: 34432007 - PMCID: PMC8783388 - DOI: 10.1093/cvr/cvab273

Lupieri A, Nagata Y, Passos LSA, Beker-Greene D, Kirkwood KA, Wylie-Sears J, Alvandi Z, Higashi H, Hung JW, Singh SA, Bischoff J, Levine RA, Aikawa E

Integration of Functional Imaging, Cytometry, and Unbiased Proteomics Reveals New Features of Endothelial-to-Mesenchymal Transition in Ischemic Mitral Valve Regurgitation in Human Patients.

Front Cardiovasc Med. 2021;8:688396 - PMID: 34458332 - PMCID: PMC8387660 - DOI: 10.3389/fcvm.2021.688396

Bartoli-Leonard F, Aikawa E

Recapitulating the Complex Pathology of Atherosclerosis: Which Model to Use?

Circ Res. 2021;129(4):491-493 - PMID: 34351800 - PMCID: PMC8352010 - DOI: 10.1161/CIRCRESAHA.121.319721

Hutcheson JD, Schlotter F, Creager MD, Li X, Pham T, Vyas P, Higashi H, Body SC, Aikawa M, Singh SA, Kos L, Aikawa E

Elastogenesis Correlates With Pigment Production in Murine Aortic Valve Leaflets.

Front Cardiovasc Med. 2021;8:678401 - PMID: 34239903 - PMCID: PMC8257952 - DOI: 10.3389/fcvm.2021.678401

Rogers MA, Hutcheson JD, Okui T, Goettsch C, Singh SA, Halu A, Schlotter F, Higashi H, Wang L, Whelan MC, Mlynarchik AK, Daugherty A, Nomura M, Aikawa M, Aikawa E

Dynamin-related protein 1 inhibition reduces hepatic PCSK9 secretion.

Cardiovasc Res. 2021;117(11):2340-2353 - PMID: 33523181 - PMCID: PMC8479802 - DOI: 10.1093/cvr/cvab034

Bartoli-Leonard F, Aikawa E

Old Drugs for an Old Pathology? Drug Repurposing for Calcific Aortic Valve Disease.

Circ Res. 2021;128(9):1317-1319 - PMID: 33914606 - PMCID: PMC8095786 - DOI: 10.1161/CIRCRESAHA.121.319149

Blaser MC, Kraler S, Lüscher TF, Aikawa E

Multi-Omics Approaches to Define Calcific Aortic Valve Disease Pathogenesis.

Circ Res. 2021;128(9):1371-1397 - PMID: 33914608 - PMCID: PMC8095729 - DOI: 10.1161/CIRCRESAHA.120.317979

Jha PK, Vijay A, Halu A, Uchida S, Aikawa M

Gene Expression Profiling Reveals the Shared and Distinct Transcriptional Signatures in Human Lung Epithelial Cells Infected With SARS-CoV-2, MERS-CoV, or SARS-CoV: Potential Implications in Cardiovascular Complications of COVID-19.

Front Cardiovasc Med. 2021;7:623012 - PMID: 33521069 - PMCID: PMC7844200 - DOI: 10.3389/fcvm.2020.623012

Ruiz JL, Hutcheson JD, Cardoso L, Bakhshian Nik A, Condado de Abreu A, Pham T, Buffolo F, Busatto S, Federici S, Ridolfi A, Aikawa M, Bertazzo S, Bergese P, Weinbaum S, Aikawa E

Nanoanalytical analysis of bisphosphonate-driven alterations of microcalcifications using a 3D hydrogel system and in vivo mouse model.

Proc Natl Acad Sci U S A. 2021;118(14):ePub - PMID: 33795519 - PMCID: PMC8040669 - DOI: 10.1073/pnas.1811725118

de Freitas RCC, Hirata RDC, Hirata MH, Aikawa E

Circulating Extracellular Vesicles As Biomarkers and Drug Delivery Vehicles in Cardiovascular Diseases.

Biomolecules. 2021;11(3):ePub - PMID: 33808038 - PMCID: PMC8001426 - DOI: 10.3390/biom11030388

Decano JL, Singh SA, Bueno CG, Lee LH, Halu A, Chelvanambi S, Matamalas JT, Zhang H, Mlynarchik AK, Qiao J, Sharma A, Mukai S, Wang J, Anderson DG, Ozaki CK, Libby P, Aikawa E, Aikawa M

Systems Approach to Discovery of Therapeutic Targets for Vein Graft Disease PPARα Pivotally Regulates Metabolism, Activation, and Heterogeneity of Macrophages and Lesion Development.

Circulation. 2021;143(25):2454-2470 - PMID: 33821665 - PMCID: PMC8212880 - DOI: 10.1161/CIRCULATIONAHA.119.043724

Kraler S, Wenzl FA, Akhmedov A, Blaser MC, Aikawa E, Lüscher TF

ApoA-I mimetics improve aortic stenosis-associated left-ventricular diastolic dysfunction but fail to benefit rabbit models with normal aortic valves.

Int J Cardiol. 2021;332:159-161 - PMID: 33626387 - DOI: 10.1016/j.ijcard.2021.02.044

Silva VR, Neves EGA, Passos LSA, Cristina de Melo F, Teixeira-Carvalho A, Nassif MCL, Junqueira LL, Aikawa E, Dutra WO, Nunes MCP

Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis.

Front Cardiovasc Med. 2021;7:604826 - PMID: 33614739 - PMCID: PMC7888299 - DOI: 10.3389/fcvm.2020.604826

Majumdar U, Manivannan S, Basu M, Ueyama Y, Blaser MC, Cameron E, McDermott MR, Lincoln J, Cole SE, Wood S, Aikawa E, Lilly B, Garg V

Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling.

Sci Adv. 2021;7(6):ePub - PMID: 33547080 - PMCID: PMC7864581 - DOI: 10.1126/sciadv.abe3706

Passos LSA, Nunes MCP, Aikawa E

Rheumatic Heart Valve Disease Pathophysiology and Underlying Mechanisms.

Front Cardiovasc Med. 2021;7:612716 - PMID: 33537348 - PMCID: PMC7848031 - DOI: 10.3389/fcvm.2020.612716