Center for Interdisciplinary Cardiovascular Sciences

Raju S, Botts SR, Blaser M, Prajapati K, Ho TWW, Ching C, Galant NJ, Fiddes L, Wu R, Clift CL, Pham T, Lee WL, Singh SA, Aikawa E, Fish JE, Howe KL

Endothelial cells secrete small extracellular vesicles bidirectionally containing distinct cargo to uniquely reprogram vascular cells in the circulation and vessel wall.

bioRxiv. 2023;:ePub - PMID: 37162986 - PMCID: PMC10168399 - DOI: 10.1101/2023.04.28.538787

Kasai T, Kuraoka S, Higashi H, Delanghe B, Aikawa M, Singh SA

A Combined Gas-Phase Separation Strategy for ADP-ribosylated Peptides.

J Am Soc Mass Spectrom. 2023;:ePub - PMID: 37589412 - DOI: 10.1021/jasms.3c00129

Ho YC, Geng X, O'Donnell A, Ibarrola J, Fernandez-Celis A, Varshney R, Subramani K, Azartash-Namin ZJ, Kim J, Silasi R, Wylie-Sears J, Alvandi Z, Chen L, Cha B, Chen H, Xia L, Zhou B, Lupu F, Burkhart HM, Aikawa E, Olson LE, Ahamed J, López-Andrés N, Bischoff J, Yutzey KE, Srinivasan RS

PROX1 Inhibits PDGF-B Expression to Prevent Myxomatous Degeneration of Heart Valves.

Circ Res. 2023;133(6):463-480 - PMID: 37555328 - PMCID: PMC10487359 - DOI: 10.1161/CIRCRESAHA.123.323027

Perez KA, Deppe DW, Filas A, Singh SA, Aikawa E

Multimodal analytical tools to enhance mechanistic understanding of aortic valve calcification.

Am J Pathol. 2023;:ePub - PMID: 37517686 - DOI: 10.1016/j.ajpath.2023.06.017

Santinelli-Pestana DV, Aikawa E, Singh SA, Aikawa M

PARPs and ADP-Ribosylation in Chronic Inflammation: A Focus on Macrophages.

Pathogens. 2023;12(7):ePub - PMID: 37513811 - PMCID: PMC10386340 - DOI: 10.3390/pathogens12070964

Bartoli-Leonard F, Chelvanambi S, Pham T, Turner ME, Blaser MC, Caputo M, Aikawa M, Pang A, Muehlschlegel J, Aikawa E

Single-cell T cell receptor sequencing of paired tissue and blood samples reveals clonal expansion of CD8+ effector T cells in patients with calcific aortic valve disease.

bioRxiv. 2023;:ePub - PMID: 37461603 - PMCID: PMC10350049 - DOI: 10.1101/2023.07.08.548203

Blaser MC, Buffolo F, Halu A, Turner ME, Schlotter F, Higashi H, Pantano L, Clift CL, Saddic LA, Atkins SK, Rogers MA, Pham T, Vromman A, Shvartz E, Sukhova GK, Monticone S, Camussi G, Robson SC, Body SC, Muehlschlegel JD, Singh SA, Aikawa M, Aikawa E

Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis.

Circulation. 2023;148(8):661-678 - PMID: 37427430 - DOI: 10.1161/CIRCULATIONAHA.122.063402

Greco E, Vinciguerra M, Sampaio R, Aikawa E

Editorial: New insights in heart valve disease 2022.

Front Cardiovasc Med. 2023;10:1226113 - PMID: 37416925 - PMCID: PMC10321655 - DOI: 10.3389/fcvm.2023.1226113

Nehl D, Goody PR, Maus K, Pfeifer A, Aikawa E, Bakthiary F, Zimmer S, Nickenig G, Jansen F, Hosen MR

Human and porcine aortic valve endothelial and interstitial cell isolation and characterization.

Front Cardiovasc Med. 2023;10:1151028 - PMID: 37408661 - PMCID: PMC10318150 - DOI: 10.3389/fcvm.2023.1151028

Distefano R, Ilieva M, Madsen JH, Ishii H, Aikawa M, Rennie S, Uchida S

T2DB: A Web Database for Long Non-Coding RNA Genes in Type II Diabetes.

Noncoding RNA. 2023;9(3):ePub - PMID: 37218990 - PMCID: PMC10204529 - DOI: 10.3390/ncrna9030030

Sud K, Narula N, Aikawa E, Arbustini E, Pibarot P, Merlini G, Rosenson RS, Seshan SV, Argulian E, Ahmadi A, Zhou F, Moreira AL, Côté N, Tsimikas S, Fuster V, Gandy S, Bonow RO, Gursky O, Narula J

The contribution of amyloid deposition in the aortic valve to calcification and aortic stenosis.

Nat Rev Cardiol. 2023;20(6):418-428 - PMID: 36624274 - PMCID: PMC10199673 - DOI: 10.1038/s41569-022-00818-2

Andraski AB, Singh SA, Higashi H, Lee LH, Aikawa M, Sacks FM

The distinct metabolism between large and small HDL indicates unique origins of human apolipoprotein A4.

JCI Insight. 2023;8(8):ePub - PMID: 37092549 - PMCID: PMC10243815 - DOI: 10.1172/jci.insight.162481

Veulemans V, Billaud M, Nunes MCP, Goettsch C, Aikawa E

Editorial: Women in heart valve disease.

Front Cardiovasc Med. 2023;10:1150169 - PMID: 36994000 - PMCID: PMC10041336 - DOI: 10.3389/fcvm.2023.1150169

Cable J, Witwer KW, Coffey RJ, Milosavljevic A, von Lersner AK, Jimenez L, Pucci F, Barr MM, Dekker N, Barman B, Humphrys D, Williams J, de Palma M, Guo W, Bastos N, Hill AF, Levy E, Hantak MP, Crewe C, Aikawa E, Adamczyk AM, Zanotto TM, Ostrowski M, Arab T, Rabe DC, Sheikh A, da Silva DR, Jones JC, Okeoma C, Gaborski T, Zhang Q, Gololobova O

Exosomes, microvesicles, and other extracellular vesicles-a Keystone Symposia report.

Ann N Y Acad Sci. 2023;1523(1):24-37 - PMID: 36961472 - DOI: 10.1111/nyas.14974

Bartoli-Leonard F, Zimmer J, Sonawane AR, Perez K, Turner ME, Kuraoka S, Pham T, Li F, Aikawa M, Singh S, Brewster L, Aikawa E

NLRP3 Inflammasome Activation in Peripheral Arterial Disease.

J Am Heart Assoc. 2023;12(6):e026945 - PMID: 36892058 - PMCID: PMC10111545 - DOI: 10.1161/JAHA.122.026945

Sud K, Narula N, Aikawa E, Arbustini E, Pibarot P, Merlini G, Rosenson RS, Seshan SV, Argulian E, Ahmadi A, Zhou F, Moreira AL, Côté N, Tsimikas S, Fuster V, Gandy S, Bonow RO, Gursky O, Narula J

Author Correction: The contribution of amyloid deposition in the aortic valve to calcification and aortic stenosis.

Nat Rev Cardiol. 2023;20(6):429 - PMID: 36807395 - DOI: 10.1038/s41569-023-00848-4

Wang Z, Tang M, Luan X, Tevaearai Stahel H, Aikawa M, Xie M, Ge S, Zhang S

Editorial: What do we know about COVID-19 implications for cardiovascular disease?

Front Cardiovasc Med. 2023;10:1125655 - PMID: 36733303 - PMCID: PMC9887308 - DOI: 10.3389/fcvm.2023.1125655

Blaser MC, Kraler S, Lüscher TF, Aikawa E

Network-Guided Multiomic Mapping of Aortic Valve Calcification.

Arterioscler Thromb Vasc Biol. 2023;43(3):417-426 - PMID: 36727519 - PMCID: PMC9975082 - DOI: 10.1161/ATVBAHA.122.318334

Iqbal F, Schlotter F, Becker-Greene D, Lupieri A, Goettsch C, Hutcheson JD, Rogers MA, Itoh S, Halu A, Lee LH, Blaser MC, Mlynarchik AK, Hagita S, Kuraoka S, Chen HY, Engert JC, Passos LSA, Jha PK, Osborn EA, Jaffer FA, Body SC, Robson SC, Thanassoulis G, Aikawa M, Singh SA, Sonawane AR, Aikawa E

Sortilin enhances fibrosis and calcification in aortic valve disease by inducing interstitial cell heterogeneity.

Eur Heart J. 2023;44(10):885-898 - PMID: 36660854 - PMCID: PMC9991042 - DOI: 10.1093/eurheartj/ehac818