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Lansac E, Veen KM, Joseph A, Blancarte Jaber P, Sossi F, Das-Gupta Z, Aktaa S, Sádaba JR, Thourani VH, Dahle G, Szeto WY, Bakaeen F, Aikawa E, Schoen FJ, Girdauskas E, Almeida A, Zuckermann A, Meuris B, Stott J, Kluin J, Meel R, Woan W, Colgan D, Jneid H, Balkhy H, Szerlip M, Preventza O, Shah P, Rigolin VH, Medica S, Holmes P, Sitges M, Pibarot P, Donal E, Hahn RT, Takkenberg JJM
The First International Consortium for Health Outcomes Measurement (ICHOM) Standard Dataset for Reporting Outcomes in Heart Valve Disease: Moving From Device- to Patient-Centered Outcomes.
Innovations (Phila). 2025;:15569845241269309 - PMID: 39968696 - DOI: 10.1177/15569845241269309
Yagi H, Qiu C, Zeng Y, Boeck M, Nian S, Chen CT, Harman JC, Kasai T, Lee J, Hirst V, Neilsen K, Wang C, Bora K, Maurya M, Rodrick T, Grumbine M, Yang Y, Hua Z, Sweet IR, Singh SA, Aikawa M, Chen J, Fu Z
Serine supplementation suppresses hypoxia-induced pathological retinal angiogenesis.
Theranostics. 2025;15(11):5087-5105 - PMID: 40303351 - PMCID: PMC12036884 - DOI: 10.7150/thno.105299
Jung B, Yagi H, Kuo A, Dorweiler TF, Aikawa M, Kasai T, Singh SA, Dannenberg AJ, Fu Z, Niaudet C, Smith LEH, Hla T
ApoM-bound S1P acts via endothelial S1PR1 to suppress choroidal neovascularization and vascular leakage.
Angiogenesis. 2025;28(2):24 - PMID: 40266369 - PMCID: PMC12018641 - DOI: 10.1007/s10456-025-09975-7
Bortolin RH, de Souza Leite F, Luchessi AD, Esposito J, Barbosa IN, Costa de Freitas RC, Sonawane AR, Singh SA, Aikawa E, Silva KAT, Hirata TDC, Neta APR, Goulart E, Caires-Júnior LC, Mata Martins TMD, Semedo P, de Paula Moreira D, Naslavsky M, Faludi AA, Gonçalves RM, Araujo DB, Malaquias VB, Ferreira GM, DeOcesano-Pereira C, Chudzinski-Tavassi AM, Pu WT, Zatz M, Hirata RDC, Hirata MH
Translational insights into statin-induced myotoxicity: differential impact of lipophilic and hydrophilic statins on iPSC-derived skeletal muscle cells from patients with familial hypercholesterolemia.
Toxicology. 2025;515:154159 - PMID: 40254247 - DOI: 10.1016/j.tox.2025.154159
Jha PK, Nakano T, Itto LYU, Barbeiro MC, Lupieri A, Aikawa E, Aikawa M
Vascular inflammation in chronic kidney disease: the role of uremic toxins in macrophage activation.
Front Cardiovasc Med. 2025;12:1574489 - PMID: 40201789 - PMCID: PMC11975941 - DOI: 10.3389/fcvm.2025.1574489
Lupieri A, Jha PK, Nizet V, Dutra WO, Nunes MCP, Levine RA, Aikawa E
Rheumatic heart valve disease: navigating the challenges of an overlooked autoimmune disorder.
Front Cardiovasc Med. 2025;12:1537104 - PMID: 40182432 - PMCID: PMC11966398 - DOI: 10.3389/fcvm.2025.1537104
Song N, Ji E, Yu JE, Choi KH, Kim DH, Song JM, Kang DH, Song JK, Yu J, Kim K, Lee S, Aikawa E
Spermidine Enhances Mitochondrial Function and Mitigates Aortic Valve Calcification: Implications for DNA Methyltransferase-1 Activity.
JACC Basic Transl Sci. 2025;10(3):345-366 - PMID: 40139876 - PMCID: PMC12013848 - DOI: 10.1016/j.jacbts.2024.11.011
Lansac E, Veen KM, Joseph A, Jaber PB, Sossi F, Das-Gupta Z, Aktaa S, Sádaba JR, Thourani VH, Dahle G, Szeto WY, Bakaeen F, Aikawa E, Schoen FJ, Girdauskas E, Almeida A, Zuckermann A, Meuris B, Stott J, Kluin J, Meel R, Woan W, Colgan D, Jneid H, Balkhy H, Szerlip M, Preventza O, Shah P, Rigolin VH, Medica S, Holmes P, Sitges M, Pibarot P, Donal E, Hahn RT, Takkenberg JJM
The First International Consortium for Health Outcomes Measurement (ICHOM) Standard Dataset for Reporting Outcomes in Heart Valve Disease: Moving From Device- to Patient-Centered Outcomes: Developed by a multisociety taskforce coordinated by the Heart Valve Society (HVS) including the American Heart Association (AHA), the American College of Cardiology (ACC), the European Association for Cardio-Thoracic Surgery (EACTS), the European Society of Cardiology (ESC), The Society of Thoracic Surgeons (STS), the Australian & New Zealand Society of Cardiac & Thoracic Surgeons (ANZSCTS), the International Society for Applied Cardiovascular Biology (ISACB), the International Society for Minimally Invasive Cardiothoracic Surgery (ISMICS), the South African Heart Association (SHA), Heart Valve Voice, and Global Heart Hub.
Ann Thorac Surg Short Rep. 2025;3(1):71-85 - PMID: 40098847 - PMCID: PMC11910787 - DOI: 10.1016/j.atssr.2024.05.005
Boeck M, Yagi H, Chen CT, Zeng Y, Lee D, Nian S, Kasai T, Lee J, Hirst V, Wang C, Neilsen K, Rodrick TC, McCutcheon A, Yu M, Lodhi IJ, Singh SA, Aikawa M, Bazinet RP, Fu Z
Nutrient supplementation mitigates retinal dysfunction in Acox1 knockout mice with impaired peroxisomal fatty acid oxidation.
J Adv Res. 2025;:ePub - PMID: 40049514 - DOI: 10.1016/j.jare.2025.03.004
Kasai T, Nakamura Y, Aikawa M, Singh SA
In-Source Collision-Induced Dissociation (CID) Improves Higher-Energy Collisional Dissociation (HCD)-Dependent Fragmentation of ADP-Ribosyl Peptides.
Rapid Commun Mass Spectrom. 2025;39(4):e9961 - PMID: 39632390 - PMCID: PMC11617611 - DOI: 10.1002/rcm.9961
Lansac E, Veen KM, Joseph A, Blancarte Jaber P, Sossi F, Das-Gupta Z, Aktaa S, Sádaba JR, Thourani VH, Dahle G, Szeto WY, Bakaeen F, Aikawa E, Schoen FJ, Girdauskas E, Almeida A, Zuckermann A, Meuris B, Stott J, Kluin J, Meel R, Woan W, Colgan D, Jneid H, Balkhy H, Szerlip M, Preventza O, Shah P, Rigolin VH, Medica S, Holmes P, Sitges M, Pibarot P, Donal E, Hahn RT, Takkenberg JJM
The First International Consortium for Health Outcomes Measurement (ICHOM) Standard Dataset for Reporting Outcomes in Heart Valve Disease: Moving From Device- to Patient-Centered Outcomes: Developed by a multisociety taskforce coordinated by the Heart Valve Society (HVS) including the American Heart Association (AHA), the American College of Cardiology (ACC), the European Association for Cardio-Thoracic Surgery (EACTS), the European Society of Cardiology (ESC), The Society of Thoracic Surgeons (STS), the Australian & New Zealand Society of Cardiac & Thoracic Surgeons (ANZSCTS), the International Society for Applied Cardiovascular Biology (ISACB), the International Society for Minimally Invasive Cardiothoracic Surgery (ISMICS), the South African Heart Association (SHA), Heart Valve Voice, and Global Heart Hub.
JACC Adv. 2025;4(4):101059 - PMID: 39966045 - DOI: 10.1016/j.jacadv.2024.101059
Lansac E, Veen KM, Joseph A, Blancarte Jaber P, Sossi F, Das-Gupta Z, Aktaa S, Sádaba JR, Thourani VH, Dahle G, Szeto WY, Bakaeen F, Aikawa E, Schoen FJ, Girdauskas E, Almeida A, Zuckermann A, Meuris B, Stott J, Kluin J, Meel R, Woan W, Colgan D, Jneid H, Balkhy H, Szerlip M, Preventza O, Shah P, Rigolin VH, Medica S, Holmes P, Sitges M, Pibarot P, Donal E, Hahn RT, Takkenberg JJM
The First International Consortium for Health Outcomes Measurement (ICHOM) Standard Dataset for Reporting Outcomes in Heart Valve Disease: Moving From Device- to Patient-Centered Outcomes.
Circ Cardiovasc Qual Outcomes. 2025;18(3):e000128 - PMID: 39957624 - PMCID: PMC11917533 - DOI: 10.1161/HCQ.0000000000000128
Lansac E, Veen KM, Joseph A, Jaber PB, Sossi F, Das-Gupta Z, Aktaa S, Sádaba JR, Thourani VH, Dahle G, Szeto WY, Bakaeen F, Aikawa E, Schoen FJ, Girdauskas E, Almeida A, Zuckermann A, Meuris B, Stott J, Kluin J, Meel R, Woan W, Colgan D, Jneid H, Balkhy H, Szerlip M, Preventza O, Shah P, Rigolin VH, Medica S, Holmes P, Sitges M, Pibarot P, Donal E, Hahn RT, Takkenberg JJM
The first International Consortium for Health Outcomes Measurement (ICHOM) standard dataset for reporting outcomes in heart valve disease: moving from device- to patient- centered outcomes.
Eur Heart J Qual Care Clin Outcomes. 2025;:ePub - PMID: 39957667 - DOI: 10.1093/ehjqcco/qcae051
Lansac E, Veen KM, Joseph A, Jaber PB, Sossi F, Das-Gupta Z, Aktaa S, Rafael Sádaba J, Thourani VH, Dahle G, Szeto WY, Bakaeen F, Aikawa E, Schoen FJ, Girdauskas E, Almeida A, Zuckermann A, Meuris B, Stott J, Kluin J, Meel R, Woan W, Colgan D, Jneid H, Balkhy H, Szerlip M, Preventza O, Shah P, Rigolin VH, Medica S, Holmes P, Sitges M, Pibarot P, Donal E, Hahn RT, Takkenberg JJM
The First International Consortium for Health Outcomes Measurement (ICHOM) Standard Dataset for Reporting Outcomes in Heart Valve Disease: Moving From Device- to Patient-Centered Outcomes.
Eur J Cardiothorac Surg. 2025;67(2):ePub - PMID: 39957685 - PMCID: PMC11842054 - DOI: 10.1093/ejcts/ezae254
Boucher DM, Robichaud S, Lorant V, Leon JS, Suliman I, Rasheed A, Susser LI, Emerton C, Geoffrion M, De Jong E, Bowdish DME, Aikawa M, Aikawa E, Singh SA, Rayner KJ, Ouimet M
Age-Related Impairments in Immune Cell Efferocytosis and Autophagy Hinder Atherosclerosis Regression.
Arterioscler Thromb Vasc Biol. 2025;45(4):481-495 - PMID: 39945065 - PMCID: PMC11936474 - DOI: 10.1161/ATVBAHA.124.321662
Bhattacharjee S, Gao J, Lu YW, Eisa-Beygi S, Wu H, Li K, Birsner AE, Wong S, Song Y, Shyy JY, Cowan DB, Huang W, Wei W, Aikawa M, Shi J, Chen H
Endothelial FOXM1 and Dab2 promote diabetic wound healing.
JCI Insight. 2025;10(2):ePub - PMID: 39846251 - PMCID: PMC11790024 - DOI: 10.1172/jci.insight.186504
Halu A, Chelvanambi S, Decano JL, Matamalas JT, Whelan M, Asano T, Kalicharran N, Singh SA, Loscalzo J, Aikawa M
Integrating pharmacogenomics and cheminformatics with diverse disease phenotypes for cell type-guided drug discovery.
Genome Med. 2025;17(1):7 - PMID: 39833831 - PMCID: PMC11744892 - DOI: 10.1186/s13073-025-01431-x
Costa de Freitas RC, Bortolin RH, Kuraoka S, Rogers MA, Blaser MC, Chelvanambi S, Borges JB, de Oliveira VF, Dagli-Hernandez C, Bastos GM, da Silva Rodrigues Marçal E, Malaquias VB, Gonçalves RM, Faludi AA, Silbiger VN, Luchessi AD, Aikawa M, Crespo Hirata RD, Singh SA, Aikawa E, Hirata MH
Integrative analysis of miRNAs and proteins in plasma extracellular vesicles of patients with familial hypercholesterolemia.
Clin Chim Acta. 2025;568:120123 - PMID: 39778611 - DOI: 10.1016/j.cca.2025.120123
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