Center for Interdisciplinary Cardiovascular Sciences

Paquin A, Marsit O, Deschênes V, Rouabhia D, Hadjadj S, Clisson M, Robitaille C, Aikawa E, Levine RA, Pibarot P, Clavel MA, Beaudoin J

Progression of aortic stenosis after an acute myocardial infarction.

Open Heart. 2022;9(1):ePub - PMID: 35728891 - PMCID: PMC9214429 - DOI: 10.1136/openhrt-2022-002046

Natarajan R, Moore K, Sahoo D, Nana-Sinkam P, Fowler AAB, Sime P, Sorci-Thomas M, Aikawa E, ATVB Council, friends, and colleagues

Shobha Ghosh (1958-2021).

Arterioscler Thromb Vasc Biol. 2022;42(3):239-240 - PMID: 36808997 - DOI: 10.1161/ATVBAHA.122.317419

Kum AST, De Moura DTH, Proença IM, Aikawa M, Sánchez-Luna SA, Ribeiro IB, Sasso JGRJ, Bestetti AM, Bernardo WM, Hourneaux de Moura EG

Gastroesophageal Reflux Waning Over Time in Endoscopic Versus Surgical Myotomy for the Treatment of Achalasia: A Systematic Review and Meta-Analysis.

Cureus. 2022;14(11):e31756 - PMID: 36569663 - PMCID: PMC9771598 - DOI: 10.7759/cureus.31756

Sutton NR, Malhotra R, Hilaire CS, Aikawa E, Blumenthal RS, Gackenbach G, Goyal P, Johnson A, Nigwekar SU, Shanahan CM, Towler DA, Wolford BN, Chen Y

Molecular Mechanisms of Vascular Health: Insights From Vascular Aging and Calcification.

Arterioscler Thromb Vasc Biol. 2022;43(1):15-29 - PMID: 36412195 - PMCID: PMC9793888 - DOI: 10.1161/ATVBAHA.122.317332

Krohn JB, Aikawa E, Aikawa M, Hutcheson JD, Sahoo S, Fish JE

Editorial: Extracellular vesicles in cardiovascular inflammation and calcification.

Front Cardiovasc Med. 2022;9:1077124 - PMID: 36426218 - PMCID: PMC9680153 - DOI: 10.3389/fcvm.2022.1077124

Corti A, De Paolis A, Grossman P, Dinh PA, Aikawa E, Weinbaum S, Cardoso L

The effect of plaque morphology, material composition and microcalcifications on the risk of cap rupture: A structural analysis of vulnerable atherosclerotic plaques.

Front Cardiovasc Med. 2022;9:1019917 - PMID: 36277774 - PMCID: PMC9583261 - DOI: 10.3389/fcvm.2022.1019917

Kuo A, Checa A, Niaudet C, Jung B, Fu Z, Wheelock CE, Singh SA, Aikawa M, Smith LEH, Proia RL, Hla T

Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasi.

Elife. 2022;11:ePub - PMID: 36197001 - PMCID: PMC9578713 - DOI: 10.7554/eLife.78861

Morgan S, Lee LH, Halu A, Nicolau JS, Higashi H, Ha AH, Wen JR, Daugherty A, Libby P, Cameron SJ, Mix D, Aikawa E, Owens AP, Singh SA, Aikawa M

Identifying novel mechanisms of abdominal aortic aneurysm via unbiased proteomics and systems biology.

Front Cardiovasc Med. 2022;9:889994 - PMID: 35990960 - PMCID: PMC9382335 - DOI: 10.3389/fcvm.2022.889994

Atkins SK, Sonawane AR, Brouwhuis R, Barrientos J, Ha A, Rogers M, Tanaka T, Okui T, Kuraoka S, Singh SA, Aikawa M, Aikawa E

Induced pluripotent stem cell-derived smooth muscle cells to study cardiovascular calcification.

Front Cardiovasc Med. 2022;9:925777 - PMID: 35958427 - PMCID: PMC9357895 - DOI: 10.3389/fcvm.2022.925777

Uchida S, Yu J, Goldman M, Asmis R, Yang X, Aikawa E, Bourantas C, Aikawa M, Tevaearai Stahel H

Editorial: Research reproducibility and preventing fraud.

Front Cardiovasc Med. 2022;9:979467 - PMID: 35979020 - PMCID: PMC9376614 - DOI: 10.3389/fcvm.2022.979467

Marsit O, Clavel MA, Paquin A, Deschênes V, Hadjadj S, Sénéchal-Dumais I, Couet J, Arsenault M, Handschumacher MD, Levine RA, Aikawa E, Pibarot P, Beaudoin J

Effects of Cyproheptadine on Mitral Valve Remodeling and Regurgitation After Myocardial Infarction.

J Am Coll Cardiol. 2022;80(5):500-510 - PMID: 35902173 - DOI: 10.1016/j.jacc.2022.05.025

Wang L, Xu GE, Pan L, Aikawa E, Aikawa M, Xiao J, Huang NF

Editorial: Frontiers in Cardiovascular Medicine: Rising Stars 2021.

Front Cardiovasc Med. 2022;9:928981 - PMID: 35757336 - PMCID: PMC9218798 - DOI: 10.3389/fcvm.2022.928981

Asano T, Chelvanambi S, Decano JL, Whelan MC, Aikawa E, Aikawa M

In silico Drug Screening Approach Using L1000-Based Connectivity Map and Its Application to COVID-19.

Front Cardiovasc Med. 2022;9:842641 - PMID: 35402570 - PMCID: PMC8989014 - DOI: 10.3389/fcvm.2022.842641

Decano JL, Iwamoto Y, Goto S, Lee JY, Matamalas JT, Halu A, Blaser M, Lee LH, Pieper B, Chelvanambi S, Silva-Nicolau J, Bartoli-Leonard F, Higashi H, Shibata H, Vyas P, Wang J, Gostjeva E, Body SC, Singh SA, Aikawa M, Aikawa E

A disease-driver population within interstitial cells of human calcific aortic valves identified via single-cell and proteomic profiling.

Cell Rep. 2022;39(2):110685 - PMID: 35417712 - DOI: 10.1016/j.celrep.2022.110685

Human P, Bezuidenhout D, Aikawa E, Zilla P

Residual Bioprosthetic Valve Immunogenicity: Forgotten, Not Lost.

Front Cardiovasc Med. 2022;8:760635 - PMID: 35059444 - PMCID: PMC8764456 - DOI: 10.3389/fcvm.2021.760635

Bartoli-Leonard F, Turner ME, Zimmer J, Chapurlat R, Pham T, Aikawa M, Pradhan AD, Szulc P, Aikawa E

Elevated lipoprotein(a) as a predictor for coronary events in older men.

J Lipid Res. 2022;63(8):100242 - PMID: 35724702 - PMCID: PMC9304778 - DOI: 10.1016/j.jlr.2022.100242

Sonawane AR, Aikawa E, Aikawa M

Connections for Matters of the Heart: Network Medicine in Cardiovascular Diseases.

Front Cardiovasc Med. 2022;9:873582 - PMID: 35665246 - PMCID: PMC9160390 - DOI: 10.3389/fcvm.2022.873582

Dacano JL, Aikawa M, Singh SA

Promise of a Novel Bedside-to-Bench Paradigm: Can Percutaneous Coronary Intervention Proteomics Balloon Into Clinical Practice?

Arterioscler Thromb Vasc Biol. 2022;42(7):865-867 - PMID: 35616034 - DOI: 10.1161/ATVBAHA.122.317802

Garelnabi M, Cowdin M, Fang Y, Shrestha B, Ushio-Fukai M, Aikawa E, Graham G, Molema G, Yanagisawa H, Aikawa M

Embracing Diversity, Equity, and Inclusion in the Scientific Community-Viewpoints of the Diversity, Equity, and Inclusion Committee of the North American Vascular Biology Organization.

Front Cardiovasc Med. 2022;9:863256 - PMID: 35463765 - PMCID: PMC9021758 - DOI: 10.3389/fcvm.2022.863256

Aikawa E, Hutcheson JD

The Developmental Origin of Calcific Aortic Stenosis.

N Engl J Med. 2022;386(14):1372-1374 - PMID: 35388675 - DOI: 10.1056/NEJMcibr2200439

Gomes NFA, Silva VR, Levine RA, Esteves WAM, de Castro ML, Passos LSA, Dal-Bianco JP, Pantaleão AN, da Silva JLP, Tan TC, Dutra WO, Aikawa E, Hung J, Nunes MCP

Progression of Mitral Regurgitation in Rheumatic Valve Disease: Role of Left Atrial Remodeling.

Front Cardiovasc Med. 2022;9:862382 - PMID: 35360029 - PMCID: PMC8962951 - DOI: 10.3389/fcvm.2022.862382

Alvandi Z, Nagata Y, Passos LSA, Hashemi Gheinani A, Guerrero JL, Wylie-Sears J, Romero DC, Morris BA, Sullivan SM, Yaghoubian KM, Alvandi A, Adam RM, Aikawa E, Levine RA, Bischoff J

Wnt Site Signaling Inhibitor Secreted Frizzled-Related Protein 3 Protects Mitral Valve Endothelium From Myocardial Infarction-Induced Endothelial-to-Mesenchymal Transition.

J Am Heart Assoc. 2022;11(7):e023695 - PMID: 35348006 - PMCID: PMC9075477 - DOI: 10.1161/JAHA.121.023695

Davidson SM, Boulanger CM, Aikawa E, Badimon L, Barile L, Binder CJ, Brisson A, Buzas E, Emanueli C, Jansen F, Katsur M, Lacroix R, Lim SK, Mackman N, Mayr M, Menasché P, Nieuwland R, Sahoo S, Takov K, Thum T, Vader P, Wauben MHM, Witwer K, Sluijter JPG

Methods for the identification and characterization of extracellular vesicles in cardiovascular studies - from exosomes to microvesicles.

Cardiovasc Res. 2022;119(1):45-63 - PMID: 35325061 - PMCID: PMC10233250 - DOI: 10.1093/cvr/cvac031

Passos LSA, Jha PK, Becker-Greene D, Blaser MC, Romero D, Lupieri A, Sukhova GK, Libby P, Singh SA, Dutra WO, Aikawa M, Levine RA, Nunes MCP, Aikawa E

Prothymosin Alpha: A Novel Contributor to Estradiol Receptor Alpha-Mediated CD8⁺ T-Cell Pathogenic Responses and Recognition of Type 1 Collagen in Rheumatic Heart Valve Disease.

Circulation. 2022;145(7):531-548 - PMID: 35157519 - PMCID: PMC8869797 - DOI: 10.1161/CIRCULATIONAHA.121.057301

Rogers MA, Atkins SK, Zheng KH, Singh SA, Chelvanambi S, Pham TH, Kuraoka S, Stroes ESG, Aikawa M, Aikawa E

Lipoprotein(a) Induces Vesicular Cardiovascular Calcification Revealed With Single-Extracellular Vesicle Analysis.

Front Cardiovasc Med. 2022;9:778919 - PMID: 35155626 - PMCID: PMC8831739 - DOI: 10.3389/fcvm.2022.778919

Sawada H, Katsumata Y, Higashi H, Zhang C, Li Y, Morgan S, Lee LH, Singh SA, Chen JZ, Franklin MK, Moorleghen JJ, Howatt DA, Rateri DL, Shen YH, LeMaire SA, Aikawa M, Majesky MW, Lu HS, Daugherty A

Second Heart Field-derived Cells Contribute to Angiotensin II-mediated Ascending Aortopathies.

Circulation. 2022;145(13):987-1001 - PMID: 35143327 - PMCID: PMC9008740 - DOI: 10.1161/CIRCULATIONAHA.121.058173

Buffolo F, Monticone S, Camussi G, Aikawa E

Role of Extracellular Vesicles in the Pathogenesis of Vascular Damage.

Hypertension. 2022;79(5):863-873 - PMID: 35144490 - PMCID: PMC9010370 - DOI: 10.1161/HYPERTENSIONAHA.121.17957

Tanaka T, Asano T, Okui T, Kuraoka S, Singh SA, Aikawa M, Aikawa E

Computational Screening Strategy for Drug Repurposing Identified Niclosamide as Inhibitor of Vascular Calcification.

Front Cardiovasc Med. 2022;8:826529 - PMID: 35127876 - PMCID: PMC8811128 - DOI: 10.3389/fcvm.2021.826529