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Nunes MCP, Levine RA, Braulio R, Pascoal-Xavier MA, Elmariah S, Gomes NFA, Soares JR, Esteves WAM, Zeng X, Dal-Bianco JP, Passos LSA, Passaglia LG, Ribeiro VT, Gelape CL, Costa PHN, Lodi-Junqueira L, Dutra W, Tan TC, Aikawa E, Hung J
Mitral Regurgitation After Percutaneous Mitral Valvuloplasty: Insights Into Mechanisms and Impact on Clinical Outcomes.
JACC Cardiovasc Imaging. 2020;13(12):2513-2526 - PMID: 32950446 - PMCID: PMC7861508 - DOI: 10.1016/j.jcmg.2020.07.020
Passos LSA, Nunes MCP, Zilla P, Yacoub MH, Aikawa E
Raising awareness for rheumatic mitral valve disease.
Glob Cardiol Sci Pract. 2020;2020(2):e202026 - PMID: 33426043 - PMCID: PMC7768627 - DOI: 10.21542/gcsp.2020.26
Uiterwijk M, Smits AIPM, van Geemen D, van Klarenbosch B, Dekker S, Cramer MJ, van Rijswijk JW, Lurier EB, Di Luca A, Brugmans MCP, Mes T, Bosman AW, Aikawa E, Gründeman PF, Bouten CVC, Kluin J
In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Elastomeric Tissue-Engineered Heart Valves.
JACC Basic Transl Sci. 2020;5(12):1187-1206 - PMID: 33426376 - PMCID: PMC7775962 - DOI: 10.1016/j.jacbts.2020.09.011
Atkins SK, Singh SA, Aikawa E
Calcific Aortic Valve Disease "Omics"; Is Timely, But Are We Looking Too Late?
JACC Basic Transl Sci. 2020;5(12):1178-1180 - PMID: 33427821 - PMCID: PMC7775952 - DOI: 10.1016/j.jacbts.2020.11.001
Okui T, Iwashita M, Rogers MA, Halu A, Atkins SK, Kuraoka S, Abdelhamid I, Higashi H, Ramsaroop A, Aikawa M, Singh SA, Aikawa E
CROT (Carnitine O-Octanoyltransferase) Is a Novel Contributing Factor in Vascular Calcification via Promoting Fatty Acid Metabolism and Mitochondrial Dysfunction.
Arterioscler Thromb Vasc Biol. 2020;41(2):755-768 - PMID: 33356393 - PMCID: PMC8105275 - DOI: 10.1161/ATVBAHA.120.315007
Singh SA, Andraski AB, Higashi H, Lee LH, Ramsaroop A, Sacks FM, Aikawa M
Metabolism of PLTP, CETP, and LCAT on multiple HDL sizes using the Orbitrap Fusion Lumos.
JCI Insight. 2020;6(3):ePub - PMID: 33351780 - PMCID: PMC7934878 - DOI: 10.1172/jci.insight.143526
Schlotter F, de Freitas RCC, Rogers MA, Blaser MC, Wu PJ, Higashi H, Halu A, Iqbal F, Andraski AB, Rodia CN, Kuraoka S, Wen JR, Creager M, Pham T, Hutcheson JD, Body SC, Kohan AB, Sacks FM, Aikawa M, Singh SA, Aikawa E
ApoC-III is a novel inducer of calcification in human aortic valves.
J Biol Chem. 2020;296:100193 - PMID: 33334888 - PMCID: PMC7948477 - DOI: 10.1074/jbc.RA120.015700
Iqbal F, Lupieri A, Aikawa M, Aikawa E
Harnessing Single-Cell RNA Sequencing to Better Understand How Diseased Cells Behave the Way They Do in Cardiovascular Disease.
Arterioscler Thromb Vasc Biol. 2020;41(2):585-600 - PMID: 33327741 - PMCID: PMC8105278 - DOI: 10.1161/ATVBAHA.120.314776
Bartoli-Leonard F, Aikawa E
Heart Valve Disease: Challenges and New Opportunities.
Front Cardiovasc Med. 2020;7:602271 - PMID: 33195488 - PMCID: PMC7642276 - DOI: 10.3389/fcvm.2020.602271
Aikawa E, Blaser MC
2020 Jeffrey M. Hoeg Award Lecture: Calcifying Extracellular Vesicles as Building Blocks of Microcalcifications in Cardiovascular Disorders.
Arterioscler Thromb Vasc Biol. 2020;41(1):117-127 - PMID: 33115271 - PMCID: PMC7832175 - DOI: 10.1161/ATVBAHA.120.314704
Rogers MA, Aikawa E
An (Auto)Taxing Effort to Mechanistically Link Obesity and Calcific Aortic Valve Disease.
JACC Basic Transl Sci. 2020;5(9):898-900 - PMID: 33016951 - PMCID: PMC7524779 - DOI: 10.1016/j.jacbts.2020.04.016
Brandão SCS, Ramos JOX, Dompieri LT, Godoi ETAM, Figueiredo JL, Sarinho ESC, Chelvanambi S, Aikawa M
Is Toll-like receptor 4 involved in the severity of COVID-19 pathology in patients with cardiometabolic comorbidities?
Cytokine Growth Factor Rev. 2020;58:102-110 - PMID: 32988728 - PMCID: PMC7505161 - DOI: 10.1016/j.cytogfr.2020.09.002
Marsit O, Clavel MA, Côté-Laroche C, Hadjadj S, Bouchard MA, Handschumacher MD, Clisson M, Drolet MC, Boulanger MC, Kim DH, Guerrero JL, Bartko PE, Couet J, Arsenault M, Mathieu P, Pibarot P, Aïkawa E, Bischoff J, Levine RA, Beaudoin J
Attenuated Mitral Leaflet Enlargement Contributes to Functional Mitral Regurgitation After Myocardial Infarction.
J Am Coll Cardiol. 2020;75(4):395-405 - PMID: 32000951 - PMCID: PMC7946170 - DOI: 10.1016/j.jacc.2019.11.039
Rogers MA, Buffolo F, Schlotter F, Atkins SK, Lee LH, Halu A, Blaser MC, Tsolaki E, Higashi H, Luther K, Daaboul G, Bouten CVC, Body SC, Singh SA, Bertazzo S, Libby P, Aikawa M, Aikawa E
Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis.
Sci Adv. 2020;6(38):ePub - PMID: 32938681 - PMCID: PMC7494353 - DOI: 10.1126/sciadv.abb1244
Christensen JL, Tan S, Chung HE, Ghosalkar DS, Qureshi R, Chu A, Yu W, Berus J, Shah NR, Wu WC, Chun H, Aikawa E, Choudhary G, Morrison AR
Aortic valve calcification predicts all-cause mortality independent of coronary calcification and severe stenosis.
Atherosclerosis. 2020;307:16-20 - PMID: 32702536 - PMCID: PMC7583087 - DOI: 10.1016/j.atherosclerosis.2020.06.019
Toyohara T, Roudnicky F, Florido MHC, Nakano T, Yu H, Katsuki S, Lee M, Meissner T, Friesen M, Davidow LS, Ptaszek L, Abe T, Rubin LL, Pereira AC, Aikawa M, Cowan CA
Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis.
Cell Stem Cell. 2020;27(1):178-180 - PMID: 32619513 - DOI: 10.1016/j.stem.2020.05.013
Kawakami R, Katsuki S, Travers R, Romero DC, Becker-Greene D, Araujo Passos LS, Higashi H, Blaser MC, Sukhova GK, Buttigieg J, Kopriva D, Schmidt AM, Anderson DG, Singh SA, Cardoso L, Weinbaum S, Libby P, Aikawa M, Croce K, Aikawa E
S100A9-RAGE Axis Accelerates Formation of Macrophage-Mediated Extracellular Vesicle Microcalcification in Diabetes Mellitus.
Arterioscler Thromb Vasc Biol. 2020;40(8):1838-1853 - PMID: 32460581 - PMCID: PMC7377960 - DOI: 10.1161/ATVBAHA.118.314087
Watanabe Y, Takase K, Okada K, Aikawa M, Okamoto K, Koyama I
Portal vein aneurysm with complete spontaneous regression after 10 years using conservative treatment.
Clin J Gastroenterol. 2020;13(5):940-945 - PMID: 32449089 - DOI: 10.1007/s12328-020-01131-6
Toyohara T, Roudnicky F, Florido MHC, Nakano T, Yu H, Katsuki S, Lee M, Meissner T, Friesen M, Davidow LS, Ptaszek L, Abe T, Rubin LL, Pereira AC, Aikawa M, Cowan CA
Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis.
Cell Stem Cell. 2020;27(1):147-157.e7 - PMID: 32413331 - PMCID: PMC8530449 - DOI: 10.1016/j.stem.2020.04.018
Passos LSA, Lupieri A, Becker-Greene D, Aikawa E
Innate and adaptive immunity in cardiovascular calcification.
Atherosclerosis. 2020;306:59-67 - PMID: 32222287 - PMCID: PMC7483874 - DOI: 10.1016/j.atherosclerosis.2020.02.016
Figueiredo JL, Santa-Cruz F, Lima-Filho JL, Hilgendorf I, Aikawa M, Pittet MJ, Nahrendorf M, Weissleder R, Swirski FK, Robbins CS
A durable murine model of spleen transplantation with arterial and venous anastomoses.
Sci Rep. 2020;10(1):3979 - PMID: 32132617 - PMCID: PMC7055260 - DOI: 10.1038/s41598-020-60983-7
Engelbrecht E, Levesque MV, He L, Vanlandewijck M, Nitzsche A, Niazi H, Kuo A, Singh SA, Aikawa M, Holton K, Proia RL, Kono M, Pu WT, Camerer E, Betsholtz C, Hla T
Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta.
Elife. 2020;9:ePub - PMID: 32091396 - PMCID: PMC7054001 - DOI: 10.7554/eLife.52690
Rogers MA, Aikawa E
Complex association of lipoprotein(a) with aortic stenosis.
Heart. 2020;106(10):711-712 - PMID: 32086294 - DOI: 10.1136/heartjnl-2019-316498
Fehr AR, Singh SA, Kerr CM, Mukai S, Higashi H, Aikawa M
The impact of PARPs and ADP-ribosylation on inflammation and host-pathogen interactions.
Genes Dev. 2020;34(5-6):341-359 - PMID: 32029454 - PMCID: PMC7050484 - DOI: 10.1101/gad.334425.119
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