Our History and Mission


The Center for Interdisciplinary Cardiovascular Sciences (CICS) was established in 2009 by a collaboration agreement between the Brigham and Women’s Hospital (Boston, MA) and Kowa Company, Ltd. (Tokyo, Japan).

The goals of CICS are to promote better understanding of the mechanisms of cardiovascular inflammation and cardiometabolic disorders and to enhance further advancement in cardiovascular prevention and therapy through a translational research program that consists of investigators from academia and industry with multidisciplinary backgrounds acting in concert in a shared space.

Featured Scientist

Dr. Sasha Singh

Dr. Sasha Singh

Dr. Sasha Singh joined CICS in January 2012 as the Director of the Proteomics Group. Sasha completed her MSc in plant developmental genetics and then moved onto protein crystallography for her PhD, both completed at the University of Toronto. She then joined the Steen and Steen Laboratories at Boston Children’s Hospital for a post-doctoral fellowship in the field of proteomics.

At CICS, Sasha and her team work with the groups of Drs. Masanori Aikawa, Elena Aikawa and Ken Mizuno, to implement proteomics into their exciting research programs. One of her favorite technologies is parallel reaction monitoring (PRM), a targeted mass spectrometric method that CICS has used to track the behaviors of key proteins implicated in cardiovascular disease in the circulatory systems of animal models and humans. Recently, in collaboration with Drs. Masanori Aikawa and Frank Sacks, PRM was instrumental in unveiling a new picture of HDL metabolism, an exciting development for the field of lipid research.

Sasha is a member of the American Society for Mass Spectrometry and the American Heart Association, and enjoys presenting at both annual conferences. She has had the pleasure of presenting her CICS research locally and world-wide including in Japan, Brazil, Germany and Canada. She loves meeting new people and talking science at every opportunity. Sasha is thrilled to participate with CICS in finding new therapies for cardiovascular diseases, and enjoys reading and learning from what other groups have done for the same cause.



Masanori Aikawa,MD, Ph.D became Chief Editor of Frontiers in Cardiovascular Medicine.


Celebrating Women in Women in Medicine and Science (WMSS)’s fifth year, the symposium was co-sponsored by the BWH Center for Faculty Development and Diversity (CFDD), the Brigham Research Institute, the Center for Clinical Investigation and the Connors Center for Women’s Health and Gender Biology. Elena Aikawa,MD, Ph.D the event founder and co-chair, noted the symposium provides an opportunity for clinicians and researchers from various disciplines—whose paths may not ordinarily cross—to learn about their colleagues’ work. Sited from the Elena Aikawa,MD, Ph.D became the first women president of the International Society for Applied Cardiovascular Biology .


Our recent HDL metabolism study is featured in the Atlas of Science.


Masanori Aikawa,MD, Ph.D became Specialty Chief Editor of the section Atherosclerosis and Vascular Medicine of Frontiers in Cardiovascular Medicine.

(Past News)