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Sharma A, Halu A, Decano JL, Padi M, Liu YY, Prasad RB, Fadista J, Santolini M, Menche J, Weiss ST, Vidal M, Silverman EK, Aikawa M, Barabási AL, Groop L, Loscalzo J
Controllability in an islet specific regulatory network identifies the transcriptional factor NFATC4, which regulates Type 2 Diabetes associated genes.
NPJ Syst Biol Appl. 2018;4:25 - PMID: 29977601 - PMCID: PMC6028434 - DOI: 10.1038/s41540-018-0057-0
Théry C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, Antoniou A, Arab T, Archer F, Atkin-Smith GK, Ayre DC, Bach JM, Bachurski D, Baharvand H, Balaj L, Baldacchino S, Bauer NN, Baxter AA, Bebawy M, Beckham C, Bedina Zavec A, Benmoussa A, Berardi AC, Bergese P, Bielska E, Blenkiron C, Bobis-Wozowicz S, Boilard E, Boireau W, Bongiovanni A, Borràs FE, Bosch S, Boulanger CM, Breakefield X, Breglio AM, Brennan MÁ, Brigstock DR, Brisson A, Broekman ML, Bromberg JF, Bryl-Górecka P, Buch S, Buck AH, Burger D, Busatto S, Buschmann D, Bussolati B, Buzás EI, Byrd JB, Camussi G, Carter DR, Caruso S, Chamley LW, Chang YT, Chen C, Chen S, Cheng L, Chin AR, Clayton A, Clerici SP, Cocks A, Cocucci E, Coffey RJ, Cordeiro-da-Silva A, Couch Y, Coumans FA, Coyle B, Crescitelli R, Criado MF, D'Souza-Schorey C, Das S, Datta Chaudhuri A, de Candia P, De Santana EF, De Wever O, Del Portillo HA, Demaret T, Deville S, Devitt A, Dhondt B, Di Vizio D, Dieterich LC, Dolo V, Dominguez Rubio AP, Dominici M, Dourado MR, Driedonks TA, Duarte FV, Duncan HM, Eichenberger RM, Ekström K, El Andaloussi S, Elie-Caille C, Erdbrügger U, Falcón-Pérez JM, Fatima F, Fish JE, Flores-Bellver M, Försönits A, Frelet-Barrand A, Fricke F, Fuhrmann G, Gabrielsson S, Gámez-Valero A, Gardiner C, Gärtner K, Gaudin R, Gho YS, Giebel B, Gilbert C, Gimona M, Giusti I, Goberdhan DC, Görgens A, Gorski SM, Greening DW, Gross JC, Gualerzi A, Gupta GN, Gustafson D, Handberg A, Haraszti RA, Harrison P, Hegyesi H, Hendrix A, Hill AF, Hochberg FH, Hoffmann KF, Holder B, Holthofer H, Hosseinkhani B, Hu G, Huang Y, Huber V, Hunt S, Ibrahim AG, Ikezu T, Inal JM, Isin M, Ivanova A, Jackson HK, Jacobsen S, Jay SM, Jayachandran M, Jenster G, Jiang L, Johnson SM, Jones JC, Jong A, Jovanovic-Talisman T, Jung S, Kalluri R, Kano SI, Kaur S, Kawamura Y, Keller ET, Khamari D, Khomyakova E, Khvorova A, Kierulf P, Kim KP, Kislinger T, Klingeborn M, Klinke DJ, Kornek M, Kosanović MM, Kovács ÁF, Krämer-Albers EM, Krasemann S, Krause M, Kurochkin IV, Kusuma GD, Kuypers S, Laitinen S, Langevin SM, Languino LR, Lannigan J, Lässer C, Laurent LC, Lavieu G, Lázaro-Ibáñez E, Le Lay S, Lee MS, Lee YXF, Lemos DS, Lenassi M, Leszczynska A, Li IT, Liao K, Libregts SF, Ligeti E, Lim R, Lim SK, Linē A, Linnemannstöns K, Llorente A, Lombard CA, Lorenowicz MJ, Lörincz ÁM, Lötvall J, Lovett J, Lowry MC, Loyer X, Lu Q, Lukomska B, Lunavat TR, Maas SL, Malhi H, Marcilla A, Mariani J, Mariscal J, Martens-Uzunova ES, Martin-Jaular L, Martinez MC, Martins VR, Mathieu M, Mathivanan S, Maugeri M, McGinnis LK, McVey MJ, Meckes DG, Meehan KL, Mertens I, Minciacchi VR, Möller A, Møller Jørgensen M, Morales-Kastresana A, Morhayim J, Mullier F, Muraca M, Musante L, Mussack V, Muth DC, Myburgh KH, Najrana T, Nawaz M, Nazarenko I, Nejsum P, Neri C, Neri T, Nieuwland R, Nimrichter L, Nolan JP, Nolte-'t Hoen EN, Noren Hooten N, O'Driscoll L, O'Grady T, O'Loghlen A, Ochiya T, Olivier M, Ortiz A, Ortiz LA, Osteikoetxea X, Østergaard O, Ostrowski M, Park J, Pegtel DM, Peinado H, Perut F, Pfaffl MW, Phinney DG, Pieters BC, Pink RC, Pisetsky DS, Pogge von Strandmann E, Polakovicova I, Poon IK, Powell BH, Prada I, Pulliam L, Quesenberry P, Radeghieri A, Raffai RL, Raimondo S, Rak J, Ramirez MI, Raposo G, Rayyan MS, Regev-Rudzki N, Ricklefs FL, Robbins PD, Roberts DD, Rodrigues SC, Rohde E, Rome S, Rouschop KM, Rughetti A, Russell AE, Saá P, Sahoo S, Salas-Huenuleo E, Sánchez C, Saugstad JA, Saul MJ, Schiffelers RM, Schneider R, Schøyen TH, Scott A, Shahaj E, Sharma S, Shatnyeva O, Shekari F, Shelke GV, Shetty AK, Shiba K, Siljander PR, Silva AM, Skowronek A, Snyder OL, Soares RP, Sódar BW, Soekmadji C, Sotillo J, Stahl PD, Stoorvogel W, Stott SL, Strasser EF, Swift S, Tahara H, Tewari M, Timms K, Tiwari S, Tixeira R, Tkach M, Toh WS, Tomasini R, Torrecilhas AC, Tosar JP, Toxavidis V, Urbanelli L, Vader P, van Balkom BW, van der Grein SG, Van Deun J, van Herwijnen MJ, Van Keuren-Jensen K, van Niel G, van Royen ME, van Wijnen AJ, Vasconcelos MH, Vechetti IJ, Veit TD, Vella LJ, Velot É, Verweij FJ, Vestad B, Viñas JL, Visnovitz T, Vukman KV, Wahlgren J, Watson DC, Wauben MH, Weaver A, Webber JP, Weber V, Wehman AM, Weiss DJ, Welsh JA, Wendt S, Wheelock AM, Wiener Z, Witte L, Wolfram J, Xagorari A, Xander P, Xu J, Yan X, Yáñez-Mó M, Yin H, Yuana Y, Zappulli V, Zarubova J, Žėkas V, Zhang JY, Zhao Z, Zheng L, Zheutlin AR, Zickler AM, Zimmermann P, Zivkovic AM, Zocco D, Zuba-Surma EK
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.
J Extracell Vesicles. 2018;7(1):1535750 - PMID: 30637094 - PMCID: PMC6322352 - DOI: 10.1080/20013078.2018.1535750
Blaser MC, Aikawa E
Roles and Regulation of Extracellular Vesicles in Cardiovascular Mineral Metabolism.
Front Cardiovasc Med. 2018;5:187 - PMID: 30622949 - PMCID: PMC6308298 - DOI: 10.3389/fcvm.2018.00187
Rogers MA, Aikawa E
Cardiovascular calcification: artificial intelligence and big data accelerate mechanistic discovery.
Nat Rev Cardiol. 2018;16(5):261-274 - PMID: 30531869 - DOI: 10.1038/s41569-018-0123-8
Lee LH, Halu A, Morgan S, Iwata H, Aikawa M, Singh SA
XINA: A Workflow for the Integration of Multiplexed Proteomics Kinetics Data with Network Analysis.
J Proteome Res. 2018;18(2):775-781 - PMID: 30370770 - DOI: 10.1021/acs.jproteome.8b00615
Halu A, Wang JG, Iwata H, Mojcher A, Abib AL, Singh SA, Aikawa M, Sharma A
Context-enriched interactome powered by proteomics helps the identification of novel regulators of macrophage activation.
Elife. 2018;7:ePub - PMID: 30303482 - PMCID: PMC6179386 - DOI: 10.7554/eLife.37059
Koenen RR, Aikawa E
Editorial: Extracellular Vesicle-Mediated Processes in Cardiovascular Diseases.
Front Cardiovasc Med. 2018;5:133 - PMID: 30283791 - PMCID: PMC6157324 - DOI: 10.3389/fcvm.2018.00133
Dekker S, van Geemen D, van den Bogaerdt AJ, Driessen-Mol A, Aikawa E, Smits AIPM
Sheep-Specific Immunohistochemical Panel for the Evaluation of Regenerative and Inflammatory Processes in Tissue-Engineered Heart Valves.
Front Cardiovasc Med. 2018;5:105 - PMID: 30159315 - PMCID: PMC6104173 - DOI: 10.3389/fcvm.2018.00105
Decano JL, Aikawa M
Dynamic Macrophages: Understanding Mechanisms of Activation as Guide to Therapy for Atherosclerotic Vascular Disease.
Front Cardiovasc Med. 2018;5:97 - PMID: 30123798 - PMCID: PMC6086112 - DOI: 10.3389/fcvm.2018.00097
Sen DG, Halu A, Razzaque M, Gorham JM, Hartnett J, Seidman JG, Aikawa E, Seidman CE
The Transcriptional Signature of Growth in Human Fetal Aortic Valve Development.
Ann Thorac Surg. 2018;106(6):1834-1840 - PMID: 30071238 - DOI: 10.1016/j.athoracsur.2018.06.034
Sena BF, Figueiredo JL, Aikawa E
Cathepsin S As an Inhibitor of Cardiovascular Inflammation and Calcification in Chronic Kidney Disease.
Front Cardiovasc Med. 2018;4:88 - PMID: 29379789 - PMCID: PMC5770806 - DOI: 10.3389/fcvm.2017.00088
Hagita S, Rogers MA, Pham T, Wen JR, Mlynarchik AK, Aikawa M, Aikawa E
Transcriptional control of intestinal cholesterol absorption, adipose energy expenditure and lipid handling by Sortilin.
Sci Rep. 2018;8(1):9006 - PMID: 29899496 - PMCID: PMC5998044 - DOI: 10.1038/s41598-018-27416-y
van der Valk DC, van der Ven CFT, Blaser MC, Grolman JM, Wu PJ, Fenton OS, Lee LH, Tibbitt MW, Andresen JL, Wen JR, Ha AH, Buffolo F, van Mil A, Bouten CVC, Body SC, Mooney DJ, Sluijter JPG, Aikawa M, Hjortnaes J, Langer R, Aikawa E
Engineering a 3D-Bioprinted Model of Human Heart Valve Disease Using Nanoindentation-Based Biomechanics.
Nanomaterials (Basel). 2018;8(5):ePub - PMID: 29751516 - PMCID: PMC5977310 - DOI: 10.3390/nano8050296
Kim DH, Dal-Bianco JP, Aikawa E, Bischoff J, Levine RA
Mitral Valve Adaptation: Can We Win the Race?
Circ Cardiovasc Imaging. 2018;11(4):e007642 - PMID: 29626080 - PMCID: PMC5890943 - DOI: 10.1161/CIRCIMAGING.118.007642
Schlotter F, Halu A, Goto S, Blaser MC, Body SC, Lee LH, Higashi H, DeLaughter DM, Hutcheson JD, Vyas P, Pham T, Rogers MA, Sharma A, Seidman CE, Loscalzo J, Seidman JG, Aikawa M, Singh SA, Aikawa E
Spatiotemporal Multi-omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving Disease.
Circulation. 2018;138(4):377-393 - PMID: 29588317 - PMCID: PMC6160370 - DOI: 10.1161/CIRCULATIONAHA.117.032291
Hoganson DM, Cooper DA, Rich KN, Piekarski BL, Gui L, Gaut JP, Mayer JE, Aikawa E, Niklason LE, Emani SM
Flow Preservation of Umbilical Vein for Autologous Shunt and Cardiovascular Reconstruction.
Ann Thorac Surg. 2018;105(6):1809-1818 - PMID: 29510094 - PMCID: PMC6292668 - DOI: 10.1016/j.athoracsur.2018.01.076
Guix FX, Corbett GT, Cha DJ, Mustapic M, Liu W, Mengel D, Chen Z, Aikawa E, Young-Pearse T, Kapogiannis D, Selkoe DJ, Walsh DM
Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles.
Int J Mol Sci. 2018;19(3):ePub - PMID: 29495441 - PMCID: PMC5877524 - DOI: 10.3390/ijms19030663
Hutcheson JD, Aikawa E
Extracellular vesicles in cardiovascular homeostasis and disease.
Curr Opin Cardiol. 2018;33(3):290-297 - PMID: 29465447 - PMCID: PMC5895489 - DOI: 10.1097/HCO.0000000000000510
Itoh S, Mizuno K, Aikawa M, Aikawa E
Dimerization of sortilin regulates its trafficking to extracellular vesicles.
J Biol Chem. 2018;293(12):4532-4544 - PMID: 29382723 - PMCID: PMC5868269 - DOI: 10.1074/jbc.RA117.000732
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