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Delta-Like Ligand 4-Notch Signaling in Macrophage Activation.
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Sasaki Y, Ohta M, Desai D, Figueiredo JL, Whelan MC, Sugano T, Yamabi M, Yano W, Faits T, Yabusaki K, Zhang H, Mlynarchik AK, Inoue K, Mizuno K, Aikawa M

Angiopoietin Like Protein 2 (ANGPTL2) Promotes Adipose Tissue Macrophage and T lymphocyte Accumulation and Leads to Insulin Resistance.
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A Not-so-Little Role for Lp(a) in the Development of Calcific Aortic Valve Disease.
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Hjortnaes J, Shapero K, Goettsch C, Hutcheson JD, Keegan J, Kluin J, Mayer JE, Bischoff J, Aikawa E

Valvular interstitial cells suppress calcification of valvular endothelial cells.
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Ricchiuto P, Iwata H, Yabusaki K, Yamada I, Pieper B, Sharma A, Aikawa M, Singh SA

mIMT-visHTS: A novel method for multiplexing isobaric mass tagged datasets with an accompanying visualization high throughput screening tool for protein profiling.
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Singh SA, Miyosawa K, Aikawa M

Mass spectrometry meets the challenge of understanding the complexity of the lipoproteome: recent findings regarding proteins involved in dyslipidemia and cardiovascular disease.
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Hutcheson JD, Goettsch C, Rogers MA, Aikawa E

Revisiting Cardiovascular Calcification: A Multifaceted Disease Requiring a Multidisciplinary Approach.
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Shibasaki M, Wang JG, Figueiredo JL, New SE, Quillard T, Goettsch C, Koga JI, Sonoki H, Matsumoto J, Aikawa M, Aikawa E

Pitavastatin Reduces Inflammation in Atherosclerotic Plaques in Apolipoprotein E-Deficient Mice with Late Stage Renal Disease.
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Toll-Like Receptors and Src-Family Kinases in Atherosclerosis - Focus on Macrophages.
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Levine RA, Hagége AA, Judge DP, Padala M, Dal-Bianco JP, Aikawa E, Beaudoin J, Bischoff J, Bouatia-Naji N, Bruneval P, Butcher JT, Carpentier A, Chaput M, Chester AH, Clusel C, Delling FN, Dietz HC, Dina C, Durst R, Fernandez-Friera L, Handschumacher MD, Jensen MO, Jeunemaitre XP, Marec HL, Tourneau TL, Markwald RR, Mérot J, Messas E, Milan DP, Neri T, Norris RA, Peal D, Perrocheau M, Probst V, Pucéat M, Rosenthal N, Solis J, Schott JJ, Schwammenthal E, Slaugenhaupt SA, Song JK, Yacoub MH,

Mitral valve disease-morphology and mechanisms.
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Sun X, Haas ME, Miao J, Mehta A, Graham MJ, Crooke RM, de Barros JP, Wang JG, Aikawa M, Masson D, Biddinger SB

Insulin dissociates the effects of Liver X Receptor on lipogenesis, endoplasmic reticulum stress and inflammation.
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Hutcheson JD, Goettsch C, Bertazzo S, Maldonado N, Ruiz JL, Goh W, Yabusaki K, Faits T, Bouten C, Franck G, Quillard T, Libby P, Aikawa M, Weinbaum S, Aikawa E

Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques.
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Krohn JB, Hutcheson JD, Martínez-Martínez E, Irvin WS, Bouten CV, Bertazzo S, Bendeck MP, Aikawa E

Discoidin Domain Receptor-1 Regulates Calcific Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response via Transforming Growth Factor-β Signaling.
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Dal-Bianco JP, Aikawa E, Bischoff J, Guerrero JL, Hjortnaes J, Beaudoin J, Szymanski C, Bartko PE, Seybolt MM, Handschumacher MD, Sullivan S, Garcia ML, Mauskapf A, Titus JS, Wylie-Sears J, Irvin WS, Chaput M, Messas E, Hagège AA, Carpentier A, Levine RA,

Myocardial Infarction Alters Adaptation of the Tethered Mitral Valve.
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Krohn JB, Hutcheson JD, Martínez-Martínez E, Aikawa E

Extracellular vesicles in cardiovascular calcification: Expanding current paradigms.
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Singh SA, Andraski AB, Pieper B, Goh W, Mendivil CO, Sacks FM, Aikawa M

Multiple apolipoprotein kinetics measured in human HDL by high resolution/accurate mass parallel reaction monitoring.
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Goettsch C, Hutcheson JD, Aikawa M, Iwata H, Pham T, Nykjaer A, Kjolby M, Rogers M, Michel T, Shibasaki M, Hagita S, Kramann R, Rader DJ, Libby P, Singh SA, Aikawa E

Sortilin mediates vascular calcification via its recruitment into extracellular vesicles.
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Dal-Bianco JP, Bartko PE, Beaudoin J, Aikawa E, Bischoff J, Levine RA

3D Ultrasound: seeing is understanding-from imaging to pathophysiology to developing therapies in secondary MR.
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Hjortnaes J, Goettsch C, Hutcheson JD, Camci-Unal G, Lax L, Scherer K, Body S, Schoen FJ, Kluin J, Khademhosseini A, Aikawa E

Simulation of early calcific aortic valve disease in a 3D platform: A role for myofibroblast differentiation.
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Zooming in on the genesis of atherosclerotic plaque microcalcifications.
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Decano JL, Mattson PC, Aikawa M

Macrophages in Vascular Inflammation: Origins and Functions.
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Extracellular vesicles in cardiovascular disease: focus on vascular calcification.
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O'Rourke C, Shelton G, Hutcheson JD, Burke MF, Martyn T, Thayer TE, Shakartzi HR, Buswell MD, Tainsh RE, Yu B, Bagchi A, Rhee DK, Wu C, Derwall M, Buys ES, Yu PB, Bloch KD, Aikawa E, Bloch DB, Malhotra R

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Endophenotype Network Models: Common Core of Complex Diseases.
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Extracellular vesicles in cardiovascular disease: focus on vascular calcification.
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Goettsch C, Hutcheson JD, Hagita S, Rogers MA, Creager MD, Pham T, Choi J, Mlynarchik AK, Pieper B, Kjolby M, Aikawa M, Aikawa E

A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification.
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Noninvasive Molecular Imaging of Disease Activity in Atherosclerosis.
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Joshi D, Mazimba S, Neal Kay G, Nanda NC, Fan P, Schlotter F, Venkataraman R, Dumaswala B, Dumaswala K

Role of live/real time three-dimensional transesophageal echocardiography in the percutaneous epicardial closure of the left atrial appendage.
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Schlotter F, Matsumoto Y, Mangner N, Schuler G, Linke A, Adams V

Regular exercise or changing diet does not influence aortic valve disease progression in LDLR deficient mice.
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Singh SA, Aikawa E, Aikawa M

Current Trends and Future Perspectives of State-of-the-Art Proteomics Technologies Applied to Cardiovascular Disease Research.
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Mangner N, Woitek F, Haussig S, Schlotter F, Stachel G, Höllriegel R, Wilde J, Lindner A, Holzhey D, Leontyev S, Mohr FW, Schuler G, Linke A

Incidence, Predictors, and Outcome of Patients Developing Infective Endocarditis Following Transfemoral Transcatheter Aortic Valve Replacement.
J Am Coll Cardiol. 2016;67(24):2907-8

Masoumi N, Copper D, Chen P, Cubberley A, Guo K, Lin RZ, Ahmed B, Martin D, Aikawa E, Melero-Martin J, Mayer J

Elastomeric Fibrous Hybrid Scaffold Supports In Vitro and In Vivo Tissue Formation.
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Bicuspid aortic valve hemodynamics induces abnormal medial remodeling in the convexity of porcine ascending aortas.
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Etiology of bicuspid aortic valve disease: Focus on hemodynamics.
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Bicuspid aortic valve hemodynamics does not promote remodeling in porcine aortic wall concavity.
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Atkins SK, McNally A, Sucosky P

Mechanobiology in Cardiovascular Disease Management: Potential Strategies and Current Needs.
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Cao K, Atkins SK, McNally A, Liu J, Sucosky P

Simulations of morphotype-dependent hemodynamics in non-dilated bicuspid aortic valve aortas.
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Bakhshian Nik A, Hutcheson JD, Aikawa E

Extracellular Vesicles As Mediators of Cardiovascular Calcification.
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Kim DH, Heo R, Handschumacher MD, Lee S, Choi YS, Kim KR, Shin Y, Park HK, Bischoff J, Aikawa E, Song JM, Kang DH, Levine RA, Song JK

Mitral Valve Adaptation to Isolated Annular Dilation: Insights Into the Mechanism of Atrial Functional Mitral Regurgitation.
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Goettsch C, Kjolby M, Aikawa E

Sortilin and Its Multiple Roles in Cardiovascular and Metabolic Diseases.
Arterioscler Thromb Vasc Biol. 2017;38(1):19-25 - PMID: 29191923 - PMCID: PMC5746432 - DOI: 10.1161/ATVBAHA.117.310292

Peeters FECM, Meex SJR, Dweck MR, Aikawa E, Crijns HJGM, Schurgers LJ, Kietselaer BLJH

Calcific aortic valve stenosis: hard disease in the heart: A biomolecular approach towards diagnosis and treatment.
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Beaudoin J, Dal-Bianco JP, Aikawa E, Bischoff J, Guerrero JL, Sullivan S, Bartko PE, Handschumacher MD, Kim DH, Wylie-Sears J, Aaron J, Levine RA

Mitral Leaflet Changes Following Myocardial Infarction: Clinical Evidence for Maladaptive Valvular Remodeling.
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Le Tourneau T, Le Scouarnec S, Cueff C, Bernstein D, Aalberts JJJ, Lecointe S, Mérot J, Bernstein JA, Oomen T, Dina C, Karakachoff M, Desal H, Al Habash O, Delling FN, Capoulade R, Suurmeijer AJH, Milan D, Norris RA, Markwald R, Aikawa E, Slaugenhaupt SA, Jeunemaitre X, Hagège A, Roussel JC, Trochu JN, Levine RA, Kyndt F, Probst V, Le Marec H, Schott JJ

New insights into mitral valve dystrophy: a Filamin-A genotype-phenotype and outcome study.
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Bartko PE, Dal-Bianco JP, Guerrero JL, Beaudoin J, Szymanski C, Kim DH, Seybolt MM, Handschumacher MD, Sullivan S, Garcia ML, Titus JS, Wylie-Sears J, Irvin WS, Messas E, Hagège AA, Carpentier A, Aikawa E, Bischoff J, Levine RA, Leducq Transatlantic Mitral Network

Effect of Losartan on Mitral Valve Changes After Myocardial Infarction.
J Am Coll Cardiol. 2017;70(10):1232-1244 - PMID: 28859786 - PMCID: PMC5679094 - DOI: 10.1016/j.jacc.2017.07.734

Rogers MA, Aikawa M, Aikawa E

Macrophage Heterogeneity Complicates Reversal of Calcification in Cardiovascular Tissues.
Circ Res. 2017;121(1):5-7 - PMID: 28642321 - PMCID: PMC5507366 - DOI: 10.1161/CIRCRESAHA.117.311219

Schlotter F, de Waha S, Eitel I, Desch S, Fuernau G, Thiele H

Interventional post-myocardial infarction ventricular septal defect closure: a systematic review of current evidence.
EuroIntervention. 2016;12(1):94-102

Singh SA, Aikawa M

Unbiased and targeted mass spectrometry for the HDL proteome.
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Yabusaki K, Hutcheson JD, Vyas P, Bertazzo S, Body SC, Aikawa M, Aikawa E

Quantification of Calcified Particles in Human Valve Tissue Reveals Asymmetry of Calcific Aortic Valve Disease Development.
Front Cardiovasc Med. 2016;3:44 - PMID: 27867942 - PMCID: PMC5095138 - DOI: 10.3389/fcvm.2016.00044
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