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Nakano T, Fukuda D, Koga JI, Aikawa M

Delta-Like Ligand 4-Notch Signaling in Macrophage Activation.
Arterioscler Thromb Vasc Biol. 2016;36(10):2038-47 - PMID: 27562914 - PMCID: PMC5033717 - DOI: 10.1161/ATVBAHA.116.306926

Sasaki Y, Ohta M, Desai D, Figueiredo JL, Whelan MC, Sugano T, Yamabi M, Yano W, Faits T, Yabusaki K, Zhang H, Mlynarchik AK, Inoue K, Mizuno K, Aikawa M

Angiopoietin Like Protein 2 (ANGPTL2) Promotes Adipose Tissue Macrophage and T lymphocyte Accumulation and Leads to Insulin Resistance.
PLOS One. 2015;10(7):e0131176 - PMID: 26132105 - PMCID: PMC4489192 - DOI: 10.1371/journal.pone.0131176

Rogers MA, Aikawa E

A Not-so-Little Role for Lp(a) in the Development of Calcific Aortic Valve Disease.
Circulation. 2015;132(8):621-3 - PMID: 26224809 - PMCID: PMC4550561 - DOI: 10.1161/CIRCULATIONAHA.115.018139

Hjortnaes J, Shapero K, Goettsch C, Hutcheson JD, Keegan J, Kluin J, Mayer JE, Bischoff J, Aikawa E

Valvular interstitial cells suppress calcification of valvular endothelial cells.
Atherosclerosis. 2015;242(1):251-260 - PMID: 26232165 - PMCID: PMC4546848 - DOI: 10.1016/j.atherosclerosis.2015.07.008

Ricchiuto P, Iwata H, Yabusaki K, Yamada I, Pieper B, Sharma A, Aikawa M, Singh SA

mIMT-visHTS: A novel method for multiplexing isobaric mass tagged datasets with an accompanying visualization high throughput screening tool for protein profiling.
J Proteomics. 2015;128:132-140 - PMID: 26232111 - DOI: 10.1016/j.jprot.2015.07.024

Singh SA, Miyosawa K, Aikawa M

Mass spectrometry meets the challenge of understanding the complexity of the lipoproteome: recent findings regarding proteins involved in dyslipidemia and cardiovascular disease.
Expert Rev Proteomics. 2015;12(5):519-32 - PMID: 26325144 - DOI: 10.1586/14789450.2015.1078731

Hutcheson JD, Goettsch C, Rogers MA, Aikawa E

Revisiting Cardiovascular Calcification: A Multifaceted Disease Requiring a Multidisciplinary Approach.
Semin Cell Dev Biol. 2015;46:68-77 - PMID: 26358815 - DOI: 10.1016/j.semcdb.2015.09.004

Shibasaki M, Wang JG, Figueiredo JL, New SE, Quillard T, Goettsch C, Koga JI, Sonoki H, Matsumoto J, Aikawa M, Aikawa E

Pitavastatin Reduces Inflammation in Atherosclerotic Plaques in Apolipoprotein E-Deficient Mice with Late Stage Renal Disease.
PLOS One. 2015;10(9):e0138047 - PMID: 26367531 - PMCID: PMC4569429 - DOI: 10.1371/journal.pone.0138047

Wang JG, Aikawa M

Toll-Like Receptors and Src-Family Kinases in Atherosclerosis　- Focus on Macrophages.
Circ J. 2015;79(11):2332-2334 - PMID: 26467082 - DOI: 10.1253/circj.CJ-15-1039

Levine RA, Hagége AA, Judge DP, Padala M, Dal-Bianco JP, Aikawa E, Beaudoin J, Bischoff J, Bouatia-Naji N, Bruneval P, Butcher JT, Carpentier A, Chaput M, Chester AH, Clusel C, Delling FN, Dietz HC, Dina C, Durst R, Fernandez-Friera L, Handschumacher MD, Jensen MO, Jeunemaitre XP, Marec HL, Tourneau TL, Markwald RR, Mérot J, Messas E, Milan DP, Neri T, Norris RA, Peal D, Perrocheau M, Probst V, Pucéat M, Rosenthal N, Solis J, Schott JJ, Schwammenthal E, Slaugenhaupt SA, Song JK, Yacoub MH,

Mitral valve disease-morphology and mechanisms.
Nat Rev Cardiol. 2015;12(12):689-710 - PMID: 26483167 - PMCID: PMC4804623 - DOI: 10.1038/nrcardio.2015.161

Sun X, Haas ME, Miao J, Mehta A, Graham MJ, Crooke RM, de Barros JP, Wang JG, Aikawa M, Masson D, Biddinger SB

Insulin dissociates the effects of Liver X Receptor on lipogenesis, endoplasmic reticulum stress and inflammation.
J Biol Chem. 2015;291(3):1115-1122 - PMID: 26511317 - PMCID: PMC4714195 - DOI: 10.1074/jbc.M115.668269

Hutcheson JD, Goettsch C, Bertazzo S, Maldonado N, Ruiz JL, Goh W, Yabusaki K, Faits T, Bouten C, Franck G, Quillard T, Libby P, Aikawa M, Weinbaum S, Aikawa E

Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques.
Nat Mater. 2016;15(3):335-43 - PMID: 26752654 - PMCID: PMC4767675 - DOI: 10.1038/nmat4519

Krohn JB, Hutcheson JD, Martínez-Martínez E, Irvin WS, Bouten CV, Bertazzo S, Bendeck MP, Aikawa E

Discoidin Domain Receptor-1 Regulates Calcific Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response via Transforming Growth Factor-β Signaling.
Arterioscler Thromb Vasc Biol. 2016;36(3):525-33 - PMID: 26800565 - PMCID: PMC4767541 - DOI: 10.1161/ATVBAHA.115.307009

Dal-Bianco JP, Aikawa E, Bischoff J, Guerrero JL, Hjortnaes J, Beaudoin J, Szymanski C, Bartko PE, Seybolt MM, Handschumacher MD, Sullivan S, Garcia ML, Mauskapf A, Titus JS, Wylie-Sears J, Irvin WS, Chaput M, Messas E, Hagège AA, Carpentier A, Levine RA,

Myocardial Infarction Alters Adaptation of the Tethered Mitral Valve.
J Am Coll Cardiol. 2016;67(3):275-87 - PMID: 26796392 - PMCID: PMC5099077 - DOI: 10.1016/j.jacc.2015.10.092

Krohn JB, Hutcheson JD, Martínez-Martínez E, Aikawa E

Extracellular vesicles in cardiovascular calcification: Expanding current paradigms.
J Physiol. 2016;594(11):2895-903 - PMID: 26824781 - PMCID: PMC4887674 - DOI: 10.1113/JP271338

Singh SA, Andraski AB, Pieper B, Goh W, Mendivil CO, Sacks FM, Aikawa M

Multiple apolipoprotein kinetics measured in human HDL by high resolution/accurate mass parallel reaction monitoring.
J Lipid Res. 2016;57(4):714-28 - PMID: 26862155 - PMCID: PMC4808760 - DOI: 10.1194/jlr.D061432

Goettsch C, Hutcheson JD, Aikawa M, Iwata H, Pham T, Nykjaer A, Kjolby M, Rogers M, Michel T, Shibasaki M, Hagita S, Kramann R, Rader DJ, Libby P, Singh SA, Aikawa E

Sortilin mediates vascular calcification via its recruitment into extracellular vesicles.
J Clin Invest. 2016;126(4):1323-1336 - PMID: 26950419 - PMCID: PMC4811143 - DOI: 10.1172/JCI80851

Dal-Bianco JP, Bartko PE, Beaudoin J, Aikawa E, Bischoff J, Levine RA

3D Ultrasound: seeing is understanding-from imaging to pathophysiology to developing therapies in secondary MR.
Eur Heart J Cardiovasc Imaging. 2016;17(5):510-1 - PMID: 26976355 - PMCID: PMC4829123 - DOI: 10.1093/ehjci/jew029

Hjortnaes J, Goettsch C, Hutcheson JD, Camci-Unal G, Lax L, Scherer K, Body S, Schoen FJ, Kluin J, Khademhosseini A, Aikawa E

Simulation of early calcific aortic valve disease in a 3D platform: A role for myofibroblast differentiation.
J Mol Cell Cardiol. 2016;94:13-20 - PMID: 26996755 - PMCID: PMC4906202 - DOI: 10.1016/j.yjmcc.2016.03.004

Ruiz JL, Weinbaum S, Aikawa E, Hutcheson JD

Zooming in on the genesis of atherosclerotic plaque microcalcifications.
J Physiol. 2016;594(11):2915-27 - PMID: 27040360 - PMCID: PMC4887667 - DOI: 10.1113/JP271339

Decano JL, Mattson PC, Aikawa M

Macrophages in Vascular Inflammation: Origins and Functions.
Curr Atheroscler Rep. 2016;18(6):34 - PMID: 27125207 - DOI: 10.1007/s11883-016-0585-2

Aikawa E

Extracellular vesicles in cardiovascular disease: focus on vascular calcification.
J Physiol. 2016;594(11):2877-80

O'Rourke C, Shelton G, Hutcheson JD, Burke MF, Martyn T, Thayer TE, Shakartzi HR, Buswell MD, Tainsh RE, Yu B, Bagchi A, Rhee DK, Wu C, Derwall M, Buys ES, Yu PB, Bloch KD, Aikawa E, Bloch DB, Malhotra R

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation.
J Vis Exp. 2016;(111):ePub - PMID: 27284788 - PMCID: PMC4927747 - DOI: 10.3791/54017

Ghiassian SD, Menche J, Chasman DI, Giulianini F, Wang R, Ricchiuto P, Aikawa M, Iwata H, Müller C, Zeller T, Sharma A, Wild P, Lackner K, Singh S, Ridker PM, Blankenberg S, Barabási AL, Loscalzo J

Endophenotype Network Models: Common Core of Complex Diseases.
Sci Rep. 2016;6:27414 - PMID: 27278246 - PMCID: PMC4899691 - DOI: 10.1038/srep27414

Aikawa E

Extracellular vesicles in cardiovascular disease: focus on vascular calcification.
J Physiol. 2016;594(11):2877-80 - PMID: 27246548 - PMCID: PMC4887668 - DOI: 10.1113/JP272112

Goettsch C, Hutcheson JD, Hagita S, Rogers MA, Creager MD, Pham T, Choi J, Mlynarchik AK, Pieper B, Kjolby M, Aikawa M, Aikawa E

A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification.
Atherosclerosis. 2016;251:109-118 - PMID: 27318830 - PMCID: PMC4983246 - DOI: 10.1016/j.atherosclerosis.2016.06.011

Mosch J, Gleissner CA, Body S, Aikawa E

Histopathological assessment of calcification and inflammation of calcific aortic valves from patients with and without diabetes mellitus.
Histol Histopathol. 2016;32(3):293-306 - PMID: 27353274 - PMCID: PMC5199639 - DOI: 10.14670/HH-11-797

Dweck MR, Aikawa E, Newby DE, Tarkin JM, Rudd JH, Narula J, Fayad ZA

Noninvasive Molecular Imaging of Disease Activity in Atherosclerosis.
Circ Res. 2016;119(2):330-40 - PMID: 27390335 - PMCID: PMC4939871 - DOI: 10.1161/CIRCRESAHA.116.307971

Schlotter F, Haussig S, Schuler G, Linke A

Valve-in-valve Medtronic CoreValve implantation into a degenerated transapical Ventor Embracer aortic valve bioprosthesis.
Clin Res Cardiol. 2015;104(10):908-10

Joshi D, Mazimba S, Neal Kay G, Nanda NC, Fan P, Schlotter F, Venkataraman R, Dumaswala B, Dumaswala K

Role of live/real time three-dimensional transesophageal echocardiography in the percutaneous epicardial closure of the left atrial appendage.
Echocardiography. 2012;29(10):1256-60

Schlotter F, Matsumoto Y, Mangner N, Schuler G, Linke A, Adams V

Regular exercise or changing diet does not influence aortic valve disease progression in LDLR deficient mice.
PLOS One. 2012;7(5):e37298 - PMCID: PMC3351435

Singh SA, Aikawa E, Aikawa M

Current Trends and Future Perspectives of State-of-the-Art Proteomics Technologies Applied to Cardiovascular Disease Research.
Circ J. 2016;80(8):1674-83 - PMID: 27430298 - DOI: 10.1253/circj.CJ-16-0499

Mangner N, Woitek F, Haussig S, Schlotter F, Stachel G, Höllriegel R, Wilde J, Lindner A, Holzhey D, Leontyev S, Mohr FW, Schuler G, Linke A

Incidence, Predictors, and Outcome of Patients Developing Infective Endocarditis Following Transfemoral Transcatheter Aortic Valve Replacement.
J Am Coll Cardiol. 2016;67(24):2907-8

Masoumi N, Copper D, Chen P, Cubberley A, Guo K, Lin RZ, Ahmed B, Martin D, Aikawa E, Melero-Martin J, Mayer J

Elastomeric Fibrous Hybrid Scaffold Supports In Vitro and In Vivo Tissue Formation.
Adv Funct Mater. 2017;27(27):ePub - PMID: 32863817 - PMCID: PMC7450820 - DOI: 10.1002/adfm.201606614

Atkins SK, Cao K, Rajamannan NM, Sucosky P

Bicuspid aortic valve hemodynamics induces abnormal medial remodeling in the convexity of porcine ascending aortas.
Biomech Model Mechanobiol. 2014;13(6):1209-25 - PMID: 24599392 - DOI: 10.1007/s10237-014-0567-7

Atkins SK, Sucosky P

Etiology of bicuspid aortic valve disease: Focus on hemodynamics.
World J Cardiol. 2014;6(12):1227-33 - PMID: 25548612 - PMCID: PMC4278157 - DOI: 10.4330/wjc.v6.i12.1227

Atkins SK, Moore AN, Sucosky P

Bicuspid aortic valve hemodynamics does not promote remodeling in porcine aortic wall concavity.
World J Cardiol. 2016;8(1):89-97 - PMID: 26839660 - PMCID: PMC4728110 - DOI: 10.4330/wjc.v8.i1.89

Atkins SK, McNally A, Sucosky P

Mechanobiology in Cardiovascular Disease Management: Potential Strategies and Current Needs.
Front Bioeng Biotechnol. 2016;4:79 - PMID: 27777927 - PMCID: PMC5056184 - DOI: 10.3389/fbioe.2016.00079

Cao K, Atkins SK, McNally A, Liu J, Sucosky P

Simulations of morphotype-dependent hemodynamics in non-dilated bicuspid aortic valve aortas.
J Biomech. 2016;50:63-70 - PMID: 27855987 - DOI: 10.1016/j.jbiomech.2016.11.024

Bakhshian Nik A, Hutcheson JD, Aikawa E

Extracellular Vesicles As Mediators of Cardiovascular Calcification.
Front Cardiovasc Med. 2017;4:78 - PMID: 29322046 - PMCID: PMC5732140 - DOI: 10.3389/fcvm.2017.00078

Kim DH, Heo R, Handschumacher MD, Lee S, Choi YS, Kim KR, Shin Y, Park HK, Bischoff J, Aikawa E, Song JM, Kang DH, Levine RA, Song JK

Mitral Valve Adaptation to Isolated Annular Dilation: Insights Into the Mechanism of Atrial Functional Mitral Regurgitation.
JACC Cardiovasc Imaging. 2017;12(4):665-677 - PMID: 29248661 - PMCID: PMC5993562 - DOI: 10.1016/j.jcmg.2017.09.013

Goettsch C, Kjolby M, Aikawa E

Sortilin and Its Multiple Roles in Cardiovascular and Metabolic Diseases.
Arterioscler Thromb Vasc Biol. 2017;38(1):19-25 - PMID: 29191923 - PMCID: PMC5746432 - DOI: 10.1161/ATVBAHA.117.310292

Peeters FECM, Meex SJR, Dweck MR, Aikawa E, Crijns HJGM, Schurgers LJ, Kietselaer BLJH

Calcific aortic valve stenosis: hard disease in the heart: A biomolecular approach towards diagnosis and treatment.
Eur Heart J. 2017;:ePub

Beaudoin J, Dal-Bianco JP, Aikawa E, Bischoff J, Guerrero JL, Sullivan S, Bartko PE, Handschumacher MD, Kim DH, Wylie-Sears J, Aaron J, Levine RA

Mitral Leaflet Changes Following Myocardial Infarction: Clinical Evidence for Maladaptive Valvular Remodeling.
Circ Cardiovasc Imaging. 2017;10(11):ePub - PMID: 29042413 - PMCID: PMC5683411 - DOI: 10.1161/CIRCIMAGING.117.006512

Le Tourneau T, Le Scouarnec S, Cueff C, Bernstein D, Aalberts JJJ, Lecointe S, Mérot J, Bernstein JA, Oomen T, Dina C, Karakachoff M, Desal H, Al Habash O, Delling FN, Capoulade R, Suurmeijer AJH, Milan D, Norris RA, Markwald R, Aikawa E, Slaugenhaupt SA, Jeunemaitre X, Hagège A, Roussel JC, Trochu JN, Levine RA, Kyndt F, Probst V, Le Marec H, Schott JJ

New insights into mitral valve dystrophy: a Filamin-A genotype-phenotype and outcome study.
Eur Heart J. 2017;39(15):1269-1277 - PMID: 29020406 - PMCID: PMC5905589 - DOI: 10.1093/eurheartj/ehx505

Bartko PE, Dal-Bianco JP, Guerrero JL, Beaudoin J, Szymanski C, Kim DH, Seybolt MM, Handschumacher MD, Sullivan S, Garcia ML, Titus JS, Wylie-Sears J, Irvin WS, Messas E, Hagège AA, Carpentier A, Aikawa E, Bischoff J, Levine RA, Leducq Transatlantic Mitral Network

Effect of Losartan on Mitral Valve Changes After Myocardial Infarction.
J Am Coll Cardiol. 2017;70(10):1232-1244 - PMID: 28859786 - PMCID: PMC5679094 - DOI: 10.1016/j.jacc.2017.07.734

Rogers MA, Aikawa M, Aikawa E

Macrophage Heterogeneity Complicates Reversal of Calcification in Cardiovascular Tissues.
Circ Res. 2017;121(1):5-7 - PMID: 28642321 - PMCID: PMC5507366 - DOI: 10.1161/CIRCRESAHA.117.311219

Schlotter F, de Waha S, Eitel I, Desch S, Fuernau G, Thiele H

Interventional post-myocardial infarction ventricular septal defect closure: a systematic review of current evidence.
EuroIntervention. 2016;12(1):94-102

Singh SA, Aikawa M

Unbiased and targeted mass spectrometry for the HDL proteome.
Curr Opin Lipidol. 2016;28(1):68-77 - PMID: 28002079 - PMCID: PMC6211176 - DOI: 10.1097/MOL.0000000000000374

Yabusaki K, Hutcheson JD, Vyas P, Bertazzo S, Body SC, Aikawa M, Aikawa E

Quantification of Calcified Particles in Human Valve Tissue Reveals Asymmetry of Calcific Aortic Valve Disease Development.
Front Cardiovasc Med. 2016;3:44 - PMID: 27867942 - PMCID: PMC5095138 - DOI: 10.3389/fcvm.2016.00044
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