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Hutcheson JD, Aikawa E
Extracellular vesicles in cardiovascular homeostasis and disease.
Curr Opin Cardiol. 2018;:ePub - PMID: 29465447
Itoh S, Mizuno K, Aikawa M, Aikawa E
Dimerization of sortilin regulates its trafficking to extracellular vesicles.
J Biol Chem. 2018;:ePub - PMID: 29382723
Sena BF, Figueiredo JL, Aikawa E
Cathepsin S As an Inhibitor of Cardiovascular Inflammation and Calcification in Chronic Kidney Disease.
Front Cardiovasc Med. 2018;4:88 - PMID: 29379789 - PMCID: PMC5770806
Bakhshian Nik A, Hutcheson JD, Aikawa E
Extracellular Vesicles As Mediators of Cardiovascular Calcification.
Front Cardiovasc Med. 2017;4:78 - PMID: 29322046 - PMCID: PMC5732140
Kim DH, Heo R, Handschumacher MD, Lee S, Choi YS, Kim KR, Shin Y, Park HK, Bischoff J, Aikawa E, Song JM, Kang DH, Levine RA, Song JK
Mitral Valve Adaptation to Isolated Annular Dilation: Insights Into the Mechanism of Atrial Functional Mitral Regurgitation.
JACC Cardiovasc Imaging. 2017;:ePub - PMID: 29248661
Goettsch C, Kjolby M, Aikawa E
Sortilin and Its Multiple Roles in Cardiovascular and Metabolic Diseases.
Arterioscler Thromb Vasc Biol. 2017;38(1):19-25 - PMID: 29191923 - PMCID: PMC5746432
Peeters FECM, Meex SJR, Dweck MR, Aikawa E, Crijns HJGM, Schurgers LJ, Kietselaer BLJH
Calcific aortic valve stenosis: hard disease in the heart: A biomolecular approach towards diagnosis and treatment.
Eur Heart J. 2017;:ePub
Beaudoin J, Dal-Bianco JP, Aikawa E, Bischoff J, Guerrero JL, Sullivan S, Bartko PE, Handschumacher MD, Kim DH, Wylie-Sears J, Aaron J, Levine RA
Mitral Leaflet Changes Following Myocardial Infarction: Clinical Evidence for Maladaptive Valvular Remodeling.
Circ Cardiovasc Imaging. 2017;10(11):ePub - PMID: 29042413 - PMCID: PMC5683411
Le Tourneau T, Le Scouarnec S, Cueff C, Bernstein D, Aalberts JJJ, Lecointe S, Mérot J, Bernstein JA, Oomen T, Dina C, Karakachoff M, Desal H, Al Habash O, Delling FN, Capoulade R, Suurmeijer AJH, Milan D, Norris RA, Markwald R, Aikawa E, Slaugenhaupt SA, Jeunemaitre X, Hagège A, Roussel JC, Trochu JN, Levine RA, Kyndt F, Probst V, Le Marec H, Schott JJ
New insights into mitral valve dystrophy: a Filamin-A genotype-phenotype and outcome study.
Eur Heart J. 2017;:ePub - PMID: 29020406
Bartko PE, Dal-Bianco JP, Guerrero JL, Beaudoin J, Szymanski C, Kim DH, Seybolt MM, Handschumacher MD, Sullivan S, Garcia ML, Titus JS, Wylie-Sears J, Irvin WS, Messas E, Hagège AA, Carpentier A, Aikawa E, Bischoff J, Levine RA, Leducq Transatlantic Mitral Network
Effect of Losartan on Mitral Valve Changes After Myocardial Infarction.
J Am Coll Cardiol. 2017;70(10):1232-1244 - PMID: 28859786 - PMCID: PMC5679094
Rogers MA, Aikawa M, Aikawa E
Macrophage Heterogeneity Complicates Reversal of Calcification in Cardiovascular Tissues.
Circ Res. 2017;121(1):5-7 - PMID: 28642321 - PMCID: PMC5507366
Rogers M, Maldonado-Martinez N, Hutcheson JD, Goettsch C, Goto S, Yamada I, Faits T, Sesaki H, Aikawa M, Aikawa E
Dynamin-Related Protein 1 Inhibition Attenuates Cardiovascular Calcification in the Presence of Oxidative Stress.
Circ Res. 2017;121(3):220-233 - PMID: 28607103 - PMCID: PMC5546003
Aikawa E, Libby P
A Rock and a Hard Place: Chiseling Away at the Multiple Mechanisms of Aortic Stenosis.
Circulation. 2017;135(20):1951-1955 - PMID: 28507250 - PMCID: PMC5479353
Franck G, Mawson T, Sausen G, Salinas M, Santos Masson G, Cole AP, Beltrami Moreira M, Chatzizisis Y, Quillard T, Tesmenitsky Y, Shvartz E, Sukhova GK, Swirski FK, Nahrendorf M, Aikawa E, Croce K, Libby P
Flow Perturbation Mediates Neutrophil Recruitment and Potentiates Endothelial Injury via TLR2 in Mice - Implications for Superficial Erosion.
Circ Res. 2017;121(1):31-42 - PMID: 28428204 - PMCID: PMC5488735
Nagy E, Lei Y, Martínez-Martínez E, Body SC, Schlotter F, Creager M, Assmann A, Khabbaz K, Libby P, Hansson GK, Aikawa E
Interferon-γ Released by Activated CD8(+) T Lymphocytes Impairs the Calcium Resorption Potential of Osteoclasts in Calcified Human Aortic Valves.
Am J Pathol. 2017;187(6):1413-1425 - PMID: 28431214 - PMCID: PMC5455058
Goettsch C, Iwata H, Hutcheson JD, O'Donnell CJ, Chapurlat R, Cook NR, Aikawa M, Szulc P, Aikawa E
Serum Sortilin Associates With Aortic Calcification and Cardiovascular Risk in Men.
Arterioscler Thromb Vasc Biol. 2017;37(5):1005-1011 - PMID: 28279970 - PMCID: PMC5407935
Hutcheson JD, Blaser MC, Aikawa E
Giving Calcification Its Due: Recognition of a Diverse Disease: A First Attempt to Standardize the Field.
Circ Res. 2017;120(2):270-273 - PMID: 28104767 - PMCID: PMC5260841
van der Ven CF, Wu PJ, Tibbitt MW, van Mil A, Sluijter JP, Langer R, Aikawa E
In vitro 3D model and miRNA drug delivery to target calcific aortic valve disease.
Clin Sci (Lond). 2017;131(3):181-195 - PMID: 28057890 - PMCID: PMC5459552
Schlotter F, de Waha S, Eitel I, Desch S, Fuernau G, Thiele H
Interventional post-myocardial infarction ventricular septal defect closure: a systematic review of current evidence.
EuroIntervention. 2016;12(1):94-102
Mangner N, Woitek F, Haussig S, Schlotter F, Stachel G, Höllriegel R, Wilde J, Lindner A, Holzhey D, Leontyev S, Mohr FW, Schuler G, Linke A
Incidence, Predictors, and Outcome of Patients Developing Infective Endocarditis Following Transfemoral Transcatheter Aortic Valve Replacement.
J Am Coll Cardiol. 2016;67(24):2907-8
Hjortnaes J, Keegan J, Bruneval P, Schwartz E, Schoen FJ, Carpentier A, Levine RA, Hagège A, Aikawa E
Comparative Histopathological Analysis of Mitral Valves in Barlow Disease and Fibroelastic Deficiency.
Semin Thorac Cardiovasc Surg. 2016;28(4):757-767 - PMID: 28417861
Hjortnaes J, Keegan J, Bruneval P, Schwartz E, Schoen FJ, Carpentier A, Levine RA, Hagège A, Aikawa E
Comparative Histopathological Analysis of Mitral Valves in Barlow Disease and Fibroelastic Deficiency.
Semin Thorac Cardiovasc Surg. 2016;28(4):757-767
Singh SA, Aikawa M
Unbiased and targeted mass spectrometry for the HDL proteome.
Curr Opin Lipidol. 2016;28(1):68-77 - PMID: 28002079
Yabusaki K, Hutcheson JD, Vyas P, Bertazzo S, Body SC, Aikawa M, Aikawa E
Quantification of Calcified Particles in Human Valve Tissue Reveals Asymmetry of Calcific Aortic Valve Disease Development.
Front Cardiovasc Med. 2016;3:44 - PMID: 27867942 - PMCID: PMC5095138
Lee LH, Andraski AB, Pieper B, Higashi H, Sacks FM, Aikawa M, Singh SA
Automation of PRM-dependent D3-Leu tracer enrichment in HDL to study the metabolism of apoA-I, LCAT and other apolipoproteins.
Proteomics. 2016;:ePub - PMID: 27862954 - PMCID: PMC5572145
Singh SA, Aikawa E, Aikawa M
Current Trends and Future Perspectives of State-of-the-Art Proteomics Technologies Applied to Cardiovascular Disease Research.
Circ J. 2016;80(8):1674-83 - PMID: 27430298
Bischoff J, Casanovas G, Wylie-Sears J, Kim DH, Bartko P, Guerrero J, Dal-Bianco J, Beaudoin J, Garcia M, Sullivan , Seybolt M, Morris B, Keegan J, Irvin W, Aikawa E, Levine R
CD45 Expression in Mitral Valve Endothelial Cells After Myocardial Infarction.
Circ Res. 2016;119(11):1215-1225 - PMID: 27750208 - PMCID: PMC5215059
Iwata H, Goettsch C, Sharma A, Ricchiuto P, Goh WW, Halu A, Yamada I, Yoshida H, Hara T, Wei M, Inoue N, Fukuda D, Mojcher A, Mattson PC, Barabási AL, Boothby M, Aikawa E, Singh SA, Aikawa M
PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation.
Nat Commun. 2016;7:12849 - PMID: 27796300 - PMCID: PMC5095532
Kramann R, Goettsch C, Wongboonsin J, Iwata H, Schneider RK, Kuppe C, Kaesler N, Chang-Panesso M, Machado FG, Gratwohl S, Madhurima K, Hutcheson JD, Jain S, Aikawa E, Humphreys BD
Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease.
Cell Stem Cell. 2016;19(5):628-642 - PMID: 27618218 - PMCID: PMC5097006
Nakano T, Fukuda D, Koga JI, Aikawa M
Delta-Like Ligand 4-Notch Signaling in Macrophage Activation.
Arterioscler Thromb Vasc Biol. 2016;36(10):2038-47 - PMID: 27562914 - PMCID: PMC5033717
Dweck MR, Aikawa E, Newby DE, Tarkin JM, Rudd JH, Narula J, Fayad ZA
Noninvasive Molecular Imaging of Disease Activity in Atherosclerosis.
Circ Res. 2016;119(2):330-40 - PMID: 27390335 - PMCID: PMC4939871
Mosch J, Gleissner CA, Body S, Aikawa E
Histopathological assessment of calcification and inflammation of calcific aortic valves from patients with and without diabetes mellitus.
Histol Histopathol. 2016;:11797 - PMID: 27353274 - PMCID: PMC5199639
Goettsch C, Hutcheson JD, Hagita S, Rogers MA, Creager MD, Pham T, Choi J, Mlynarchik AK, Pieper B, Kjolby M, Aikawa M, Aikawa E
A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification.
Atherosclerosis. 2016;251:109-118 - PMID: 27318830 - PMCID: PMC4983246
Aikawa E
Extracellular vesicles in cardiovascular disease: focus on vascular calcification.
J Physiol. 2016;594(11):2877-80 - PMID: 27246548 - PMCID: PMC4887668
Ghiassian SD, Menche J, Chasman DI, Giulianini F, Wang R, Ricchiuto P, Aikawa M, Iwata H, Müller C, Zeller T, Sharma A, Wild P, Lackner K, Singh S, Ridker PM, Blankenberg S, Barabási AL, Loscalzo J
Endophenotype Network Models: Common Core of Complex Diseases.
Sci Rep. 2016;6:27414 - PMID: 27278246 - PMCID: PMC4899691
O'Rourke C, Shelton G, Hutcheson JD, Burke MF, Martyn T, Thayer TE, Shakartzi HR, Buswell MD, Tainsh RE, Yu B, Bagchi A, Rhee DK, Wu C, Derwall M, Buys ES, Yu PB, Bloch KD, Aikawa E, Bloch DB, Malhotra R
Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation.
J Vis Exp. 2016;(111):ePub - PMID: 27284788 - PMCID: PMC4927747
Aikawa E
Extracellular vesicles in cardiovascular disease: focus on vascular calcification.
J Physiol. 2016;594(11):2877-80
Decano JL, Mattson PC, Aikawa M
Macrophages in Vascular Inflammation: Origins and Functions.
Curr Atheroscler Rep. 2016;18(6):34 - PMID: 27125207
Ruiz JL, Weinbaum S, Aikawa E, Hutcheson JD
Zooming in on the genesis of atherosclerotic plaque microcalcifications.
J Physiol. 2016;594(11):2915-27 - PMID: 27040360 - PMCID: PMC4887667
Hjortnaes J, Goettsch C, Hutcheson JD, Camci-Unal G, Lax L, Scherer K, Body S, Schoen FJ, Kluin J, Khademhosseini A, Aikawa E
Simulation of early calcific aortic valve disease in a 3D platform: A role for myofibroblast differentiation.
J Mol Cell Cardiol. 2016;94:13-20 - PMID: 26996755 - PMCID: PMC4906202
Dal-Bianco JP, Bartko PE, Beaudoin J, Aikawa E, Bischoff J, Levine RA
3D Ultrasound: seeing is understanding-from imaging to pathophysiology to developing therapies in secondary MR.
Eur Heart J Cardiovasc Imaging. 2016;17(5):510-1 - PMID: 26976355 - PMCID: PMC4829123
Goettsch C, Hutcheson JD, Aikawa M, Iwata H, Pham T, Nykjaer A, Kjolby M, Rogers M, Michel T, Shibasaki M, Hagita S, Kramann R, Rader DJ, Libby P, Singh SA, Aikawa E
Sortilin mediates vascular calcification via its recruitment into extracellular vesicles.
J Clin Invest. 2016;126(4):1323-1336 - PMID: 26950419 - PMCID: PMC4811143
Singh SA, Andraski AB, Pieper B, Goh W, Mendivil CO, Sacks FM, Aikawa M
Multiple apolipoprotein kinetics measured in human HDL by high resolution/accurate mass parallel reaction monitoring.
J Lipid Res. 2016;57(4):714-28 - PMID: 26862155 - PMCID: PMC4808760
Krohn JB, Hutcheson JD, Martínez-Martínez E, Aikawa E
Extracellular vesicles in cardiovascular calcification: Expanding current paradigms.
J Physiol. 2016;594(11):2895-903 - PMID: 26824781 - PMCID: PMC4887674
Dal-Bianco JP, Aikawa E, Bischoff J, Guerrero JL, Hjortnaes J, Beaudoin J, Szymanski C, Bartko PE, Seybolt MM, Handschumacher MD, Sullivan S, Garcia ML, Mauskapf A, Titus JS, Wylie-Sears J, Irvin WS, Chaput M, Messas E, Hagège AA, Carpentier A, Levine RA,
Myocardial Infarction Alters Adaptation of the Tethered Mitral Valve.
J Am Coll Cardiol. 2016;67(3):275-87 - PMID: 26796392 - PMCID: PMC5099077
Krohn JB, Hutcheson JD, Martínez-Martínez E, Irvin WS, Bouten CV, Bertazzo S, Bendeck MP, Aikawa E
Discoidin Domain Receptor-1 Regulates Calcific Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response via Transforming Growth Factor-β Signaling.
Arterioscler Thromb Vasc Biol. 2016;36(3):525-33 - PMID: 26800565 - PMCID: PMC4767541
Hutcheson JD, Goettsch C, Bertazzo S, Maldonado N, Ruiz JL, Goh W, Yabusaki K, Faits T, Bouten C, Franck G, Quillard T, Libby P, Aikawa M, Weinbaum S, Aikawa E
Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques.
Nat Mater. 2016;15(3):335-43 - PMID: 26752654 - PMCID: PMC4767675
Kramann R, Goettsch C, Wongboonsin J, Iwata H, Schneider RK, Kuppe C, Kaesler N, Chang-Panesso M, Machado FG, Gratwohl S, Madhurima K, Hutcheson JD, Jain S, Aikawa E, Humphreys BD
Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease.
2016;19(5):628-642 - PMID: 27618218 - PMCID: PMC5097006
Schlotter F, Haussig S, Schuler G, Linke A
Valve-in-valve Medtronic CoreValve implantation into a degenerated transapical Ventor Embracer aortic valve bioprosthesis.
Clin Res Cardiol. 2015;104(10):908-10
Sun X, Haas ME, Miao J, Mehta A, Graham MJ, Crooke RM, de Barros JP, Wang JG, Aikawa M, Masson D, Biddinger SB
Insulin dissociates the effects of Liver X Receptor on lipogenesis, endoplasmic reticulum stress and inflammation.
J Biol Chem. 2015;291(3):1115-1122 - PMID: 26511317 - PMCID: PMC4714195
Levine RA, Hagége AA, Judge DP, Padala M, Dal-Bianco JP, Aikawa E, Beaudoin J, Bischoff J, Bouatia-Naji N, Bruneval P, Butcher JT, Carpentier A, Chaput M, Chester AH, Clusel C, Delling FN, Dietz HC, Dina C, Durst R, Fernandez-Friera L, Handschumacher MD, Jensen MO, Jeunemaitre XP, Marec HL, Tourneau TL, Markwald RR, Mérot J, Messas E, Milan DP, Neri T, Norris RA, Peal D, Perrocheau M, Probst V, Pucéat M, Rosenthal N, Solis J, Schott JJ, Schwammenthal E, Slaugenhaupt SA, Song JK, Yacoub MH,
Mitral valve disease-morphology and mechanisms.
Nat Rev Cardiol. 2015;12(12):689-710 - PMID: 26483167 - PMCID: PMC4804623
Wang JG, Aikawa M
Toll-Like Receptors and Src-Family Kinases in Atherosclerosis - Focus on Macrophages.
Circ J. 2015;79(11):2332-2334 - PMID: 26467082
Shibasaki M, Wang JG, Figueiredo JL, New SE, Quillard T, Goettsch C, Koga JI, Sonoki H, Matsumoto J, Aikawa M, Aikawa E
Pitavastatin Reduces Inflammation in Atherosclerotic Plaques in Apolipoprotein E-Deficient Mice with Late Stage Renal Disease.
PLOS One. 2015;10(9):e0138047 - PMID: 26367531 - PMCID: PMC4569429
Hutcheson JD, Goettsch C, Rogers MA, Aikawa E
Revisiting Cardiovascular Calcification: A Multifaceted Disease Requiring a Multidisciplinary Approach.
Semin Cell Dev Biol. 2015;46:68-77 - PMID: 26358815
Singh SA, Miyosawa K, Aikawa M
Mass spectrometry meets the challenge of understanding the complexity of the lipoproteome: recent findings regarding proteins involved in dyslipidemia and cardiovascular disease.
Expert Rev Proteomics. 2015;:1-14 - PMID: 26325144
Ricchiuto P, Iwata H, Yabusaki K, Yamada I, Pieper B, Sharma A, Aikawa M, Singh SA
mIMT-visHTS: A novel method for multiplexing isobaric mass tagged datasets with an accompanying visualization high throughput screening tool for protein profiling.
J Proteomics. 2015;128:132-140 - PMID: 26232111
Hjortnaes J, Shapero K, Goettsch C, Hutcheson JD, Keegan J, Kluin J, Mayer JE, Bischoff J, Aikawa E
Valvular interstitial cells suppress calcification of valvular endothelial cells.
Atherosclerosis. 2015;242(1):251-260 - PMID: 26232165 - PMCID: PMC4546848
Rogers MA, Aikawa E
A Not-so-Little Role for Lp(a) in the Development of Calcific Aortic Valve Disease.
Circulation. 2015;132(8):621-3 - PMID: 26224809 - PMCID: PMC4550561
Sasaki Y, Ohta M, Desai D, Figueiredo JL, Whelan MC, Sugano T, Yamabi M, Yano W, Faits T, Yabusaki K, Zhang H, Mlynarchik AK, Inoue K, Mizuno K, Aikawa M
Angiopoietin Like Protein 2 (ANGPTL2) Promotes Adipose Tissue Macrophage and T lymphocyte Accumulation and Leads to Insulin Resistance.
PLOS One. 2015;10(7):e0131176 - PMID: 26132105 - PMCID: PMC4489192
Miyosawa K, Watanabe Y, Murakami K, Murakami T, Shibata H, Iwashita M, Yamazaki H, Yamazaki K, Ohgiya T, Shibuya K, Mizuno K, Tanabe S, Singh SA, Aikawa M
New CETP Inhibitor K-312 Reduces PCSK9 Expression: A Potential Effect on LDL Cholesterol Metabolism.
Am J Physiol Endocrinol Metab. 2015;:ajpendo.00528.2014 - PMID: 26015437
Lei Y, Iwashita M, Choi J, Aikawa M, Aikawa E
N-acetylglucosamine-1-Phosphate Transferase Suppresses Lysosomal Hydrolases in Dysfunctional Osteoclasts: A Potential Mechanism for Vascular Calcification
J. Cardiovasc. Dev. Dis. 2015;2:31-47 - PMID: 29371511 - PMCID: PMC5753093
Ruiz JL, Hutcheson JD, Aikawa E
Cardiovascular calcification: current controversies and novel concepts.
Cardiovasc Pathol. 2015;24(4):207-212 - PMID: 25797772
Hutcheson JD, Maldonado N, Aikawa E
Small entities with large impact: microcalcifications and atherosclerotic plaque vulnerability.
Curr Opin Lipidol. 2014;25(5):327-332 - PMID: 25188916 - PMCID: PMC4166045
Goettsch C, Iwata H, Aikawa E
Parathyroid hormone: critical bridge between bone metabolism and cardiovascular disease.
Arterioscler Thromb Vasc Biol. 2014;34(7):1333-5 - PMID: 24951650 - PMCID: PMC4094346
Miyazaki T, Chiuve S, Sacks FM, Ridker PM, Libby P, Aikawa M
Plasma Pentraxin 3 Levels Do Not Predict Coronary Events but Reflect Metabolic Disorders in Patients with Coronary Artery Disease in the CARE Trial.
PLOS One. 2014;9(4):e94073 - PMID: 24705587 - PMCID: PMC3976379
Rogers MA, Aikawa E
Modifying Vascular Calcification in Diabetes Mellitus: Contribution of O-GlcNAcylation.
Circ Res. 2014;114(7):1074-6 - PMID: 24677232 - PMCID: PMC3989539
Yabusaki K, Faits T, McMullen E, Figueiredo JL, Aikawa M, Aikawa E
A novel quantitative approach for eliminating sample-to-sample variation using a hue saturation value analysis program.
PLOS One. 2014;9(3):e89627 - PMID: 24595280 - PMCID: PMC3940696
Itou T, Maldonado N, Yamada I, Goettsch C, Matsumoto J, Aikawa M, Singh S, Aikawa E
Cystathionine γ-lyase Accelerates Osteoclast Differentiation: Identification of a Novel Regulator of Osteoclastogenesis by Proteomic Analysis.
Arterioscler Thromb Vasc Biol. 2013;34(3):626-634 - PMID: 24357058 - PMCID: PMC3959796
Rogers M, Goettsch C, Aikawa E
Medial and intimal calcification in chronic kidney disease: stressing the contributions.
J Am Heart Assoc. 2013;2(5):e000481 - PMID: 24060959 - PMCID: PMC3835265
Fukuda D, Aikawa M
Expanding Role of Delta-Like 4 Mediated Notch Signaling in Cardiovascular and Metabolic Diseases.
Circ J. 2013;77(10):2462-8 - PMID: 24025398 - PMCID: PMC4545641
New SE, Aikawa E
Role of Extracellular Vesicles in De Novo Mineralization: An Additional Novel Mechanism of Cardiovascular Calcification.
Arterioscler Thromb Vasc Biol. 2013;33(8):1753-8 - PMID: 23766262 - PMCID: PMC3788633
Wang JG, Aikawa E, Aikawa M
Leukocyte-derived Microparticles as Pro-inflammatory Mediators in Atherosclerosis.
J Am Coll Cardiol. 2013;62(16):1442-1445 - PMID: 23707315
Zheng C, Morishige K, Aikawa M
Functional Molecular Imaging Linking Macrophages to Reverse Cholesterol Transport.
Circ J. 2013;77(6):1403-1406 - PMID: 23685734
New SE, Goettsch C, Aikawa M, Marchini JF, Shibasaki M, Yabusaki K, Libby P, Shanahan CM, Croce K, Aikawa E
Macrophage-Derived Matrix Vesicles: An Alternative Novel Mechanism for Microcalcification in Atherosclerotic Plaques.
Circ Res. 2013;113(1):72-77 - PMID: 23616621 - PMCID: PMC3703850
Goettsch C, Hutcheson JD, Aikawa E
MicroRNA in Cardiovascular Calcification: Focus on Targets and Extracellular Vesicle Delivery Mechanisms.
Circ Res. 2013;112(7):1073-84 - PMID: 23538277 - PMCID: PMC3668680
Iwata H, Aikawa M
Liver-Artery Interactions via the Plasminogen-CD36 Axis in Macrophage Foam Cell Formation: New Evidence for the Role of Remote Organ Crosstalk in Atherosclerosis.
Circulation. 2013;127(11):1173-6 - PMID: 23509031
Schlotter F, Matsumoto Y, Mangner N, Schuler G, Linke A, Adams V
Regular exercise or changing diet does not influence aortic valve disease progression in LDLR deficient mice.
PLOS One. 2012;7(5):e37298 - PMCID: PMC3351435
Joshi D, Mazimba S, Neal Kay G, Nanda NC, Fan P, Schlotter F, Venkataraman R, Dumaswala B, Dumaswala K
Role of live/real time three-dimensional transesophageal echocardiography in the percutaneous epicardial closure of the left atrial appendage.
Echocardiography. 2012;29(10):1256-60
Hutcheson JD, Chen J, Sewell-Loftin MK, Ryzhova LM, Fisher CI, Su YR, Merryman WD
Cadherin-11 regulates cell-cell tension necessary for calcific nodule formation by valvular myofibroblasts.
Arterioscler Thromb Vasc Biol. 2012;33(1):114-20 - PMID: 23162011 - PMCID: PMC3536033
Zheng C, Aikawa M
High-Density Lipoproteins: From Function to Therapy.
J Am Coll Cardiol. 2012;60(23):2380-3 - PMID: 23141492
Yoshida H, Ashikawa Y, Itoh S, Nakagawa T, Asanuma A, Tanabe S, Inoue Y, Hidaka H
K-134, a phosphodiesterase 3 inhibitor, prevents brain damage by inhibiting thrombus formation in a rat cerebral infarction model.
PLOS One. 2012;7(10):e46432 - PMID: 23110051 - PMCID: PMC3479105
Hutcheson JD, Ryzhova LM, Setola V, Merryman WD
5-HT(2B) antagonism arrests non-canonical TGF-β1-induced valvular myofibroblast differentiation.
J Mol Cell Cardiol. 2012;53(5):707-14 - PMID: 22940605 - PMCID: PMC3472096
Azcutia V, Stefanidakis M, Tsuboi N, Mayadas T, Croce KJ, Fukuda D, Aikawa M, Newton G, Luscinskas FW
Endothelial CD47 Promotes Vascular Endothelial-Cadherin Tyrosine Phosphorylation and Participates in T Cell Recruitment at Sites of Inflammation In Vivo.
J Immunol. 2012;189(5):2553-62 - PMID: 22815286 - PMCID: PMC3424398
Fukuda D, Aikawa E, Swirski FK, Novobrantseva TI, Kotelianski V, Gorgun CZ, Chudnovskiy A, Yamazaki H, Croce K, Weissleder R, Aster JC, Hotamisligil GS, Yagita H, Aikawa M
Notch ligand Delta-like 4 blockade attenuates atherosclerosis and metabolic disorders.
Proc Natl Acad Sci U S A. 2012;109(27):E1868-77 - PMID: 22699504 - PMCID: PMC3390871
Semba H, Kinugawa K, Takeda N, Shiga T, Nishimura G, Inajima T, Uchino Y, Iwata H, Hasumi E, Abe H, Terada Y, Yonenaga A, Hirata Y, Nagai R
Preliminary report of tolvaptan treatment in Japanese patients with heart failure.
Int Heart J. 2012;53(1):72-4 - PMID: 22398679
Kohro T, Iwata H, Fujiu K, Manabe I, Fujita H, Haraguchi G, Morino Y, Oguri A, Ikenouchi H, Kurabayashi M, Ikari Y, Isobe M, Ohe K, Nagai R
Development and implementation of an advanced coronary angiography and intervention database system.
Int Heart J. 2012;53(1):35-42 - PMID: 22398674
New SE, Aikawa E
Cardiovascular calcification: an inflammatory disease.
Circ J. 2011;75(6):1305-13 - PMID: 21566338
Hutcheson JD, Setola V, Roth BL, Merryman WD
Serotonin receptors and heart valve disease--it was meant 2B.
Pharmacol Ther. 2011;132(2):146-57 - PMID: 21440001 - PMCID: PMC3179857
Hutcheson JD, Venkataraman R, Baudenbacher FJ, Merryman WD
Intracellular Ca(2+) accumulation is strain-dependent and correlates with apoptosis in aortic valve fibroblasts.
J Biomech. 2011;45(5):888-94 - PMID: 22176709 - PMCID: PMC3293991
Hasumi E, Iwata H, Saito K, Fujiu K, Ando J, Imai Y, Fujita H, Hirata Y, Nagai R
Diagnostic efficacy of coronary CT angiography as a follow-up modality for procedure-related coronary dissection.
Int Heart J. 2011;52(4):240-2 - PMID: 21828951
Ikutomi M, Matsumura T, Iwata H, Nishimura G, Ishizaka N, Hirata Y, Ono M, Nagai R
Giant tumorous lesions (correction of legions) surrounding the right coronary artery associated with immunoglobulin-G4-related systemic disease.
Cardiology. 2011;120(1):22-6 - PMID: 22094884
Kimura K, Takenaka K, Ebihara A, Uno K, Iwata H, Sata M, Kohro T, Morita H, Yatomi Y, Nagai R
Reproducibility and diagnostic accuracy of three-layer speckle tracking echocardiography in a swine chronic ischemia model.
Echocardiography. 2011;28(10):1148-55 - PMID: 21967399
Matsubara TJ, Iwata H, Shiga T, Hatano M, Yao A, Ono M, Kinugawa K, Hirata Y, Nagai R
Progressive coronary artery-pulmonary artery fistula after size-mismatch cardiac transplantation.
ASAIO J. 2011;57(4):346-7 - PMID: 21508827
Higashikuni Y, Sainz J, Nakamura K, Takaoka M, Enomoto S, Iwata H, Tanaka K, Sahara M, Hirata Y, Nagai R, Sata M
The ATP-Binding Cassette Transporter ABCG2 Protects Against Pressure Overload-Induced Cardiac Hypertrophy and Heart Failure by Promoting Angiogenesis and Antioxidant Response.
Arterioscler Thromb Vasc Biol. 2011;32(3):654-61 - PMID: 22116099
Higashikuni Y, Takaoka M, Iwata H, Tanaka K, Hirata Y, Nagai R, Sata M
Aliskiren in combination with valsartan exerts synergistic protective effects against ventricular remodeling after myocardial infarction in mice.
Hypertens Res. 2011;35(1):62-9 - PMID: 21833001
Myojo M, Iwata H, Kohro T, Sato H, Kiyosue A, Ando J, Sawaki D, Takahashi M, Fujita H, Hirata Y, Nagai R
Prognostic implication of macrocytosis on adverse outcomes after coronary intervention.
Atherosclerosis. 2011;221(1):148-53 - PMID: 22222418
Hutcheson JD, Schlicher RK, Hicks HK, Prausnitz MR
Saving cells from ultrasound-induced apoptosis: quantification of cell death and uptake following sonication and effects of targeted calcium chelation.
Ultrasound Med Biol. 2010;36(6):1008-21 - PMID: 20447754 - PMCID: PMC2878894
Choi SO, Kim YC, Park JH, Hutcheson J, Gill HS, Yoon YK, Prausnitz MR, Allen MG
An electrically active microneedle array for electroporation.
Biomed Microdevices. 2010;12(2):263-73 - PMID: 20012696 - PMCID: PMC2905216
Schlicher RK, Hutcheson JD, Radhakrishna H, Apkarian RP, Prausnitz MR
Changes in cell morphology due to plasma membrane wounding by acoustic cavitation.
Ultrasound Med Biol. 2010;36(4):677-92 - PMID: 20350691 - PMCID: PMC2848178
Higashikuni Y, Sainz J, Nakamura K, Takaoka M, Enomoto S, Iwata H, Sahara M, Tanaka K, Koibuchi N, Ito S, Kusuhara H, Sugiyama Y, Hirata Y, Nagai R, Sata M
The ATP-binding cassette transporter BCRP1/ABCG2 plays a pivotal role in cardiac repair after myocardial infarction via modulation of microvascular endothelial cell survival and function.
Arterioscler Thromb Vasc Biol. 2010;30(11):2128-35 - PMID: 20829509
Iwata H, Manabe I, Fujiu K, Yamamoto T, Takeda N, Eguchi K, Furuya A, Kuro-o M, Sata M, Nagai R
Bone marrow-derived cells contribute to vascular inflammation but do not differentiate into smooth muscle cell lineages.
Circulation. 2010;122(20):2048-57 - PMID: 21041690
Iwata H, Sata M, Ando J, Fujita H, Morita T, Sawaki D, Takahashi M, Hirata Y, Takanashi S, Tabata M, Hirata Y, Nagai R
Impact of primitive cells in intracoronary thrombi on lesion prognosis: temporal analysis of cellular constituents of thrombotic material obtained from patients with acute coronary syndrome.
Heart. 2010;96(10):748-55 - PMID: 20448125
Kataoka K, Nannya Y, Iwata H, Seo S, Kumano K, Takahashi T, Nagai R, Kurokawa M
Plasma brain natriuretic peptide is associated with hepatic veno-occlusive disease and early mortality after allogeneic hematopoietic stem cell transplantation.
Bone Marrow Transplant. 2010;45(11):1631-7 - PMID: 20173786
Iwata H, Nakamura K, Sumi M, Ninomiya M, Sakai Y, Hirata Y, Akaike M, Igarashi T, Takamoto S, Nagai R, Sata M
Local delivery of synthetic prostacycline agonist augments collateral growth and improves cardiac function in a swine chronic cardiac ischemia model.
Life Sci. 2009;85(5-6):255-61 - PMID: 19527738
Iwata H, Ako J, Nagai R
Recurrence of late-acquired incomplete stent apposition following sirolimus-eluting stent implantation.
J Invasive Cardiol. 2008;20(9):E265-8 - PMID: 18762685
Iwata H, Sata M
Origin of cells that contribute to neointima growth.
Circulation. 2008;117(24):3060-1 - PMID: 18559712
Iwata H, Sata M
Potential contribution of bone marrow-derived precursors to vascular repair and lesion formation: lessons from animal models of vascular diseases.
Front Biosci. 2007;12:4157-67 - PMID: 17485364
Nakamura K, Sata M, Iwata H, Sakai Y, Hirata Y, Kugiyama K, Nagai R
A synthetic small molecule, ONO-1301, enhances endogenous growth factor expression and augments angiogenesis in the ischaemic heart.
Clin Sci (Lond). 2007;112(12):607-16 - PMID: 17263691
Takeda N, Manabe I, Shindo T, Iwata H, Iimuro S, Kagechika H, Shudo K, Nagai R
Synthetic retinoid Am80 reduces scavenger receptor expression and atherosclerosis in mice by inhibiting IL-6.
Arterioscler Thromb Vasc Biol. 2006;26(5):1177-83 - PMID: 16484594
Fujiu K, Manabe I, Ishihara A, Oishi Y, Iwata H, Nishimura G, Shindo T, Maemura K, Kagechika H, Shudo K, Nagai R
Synthetic retinoid Am80 suppresses smooth muscle phenotypic modulation and in-stent neointima formation by inhibiting KLF5.
Circ Res. 2005;97(11):1132-41 - PMID: 16224062
Iwata H, Sata M, Nagai R
Complete aspiration of thrombi from an occluded coronary artery.
Heart. 2005;91(4):530 - PMID: 15772221 - PMCID: PMC1768818
Murashige N, Kami M, Iwata H, Kishi Y, Matsuo K
No relationship between hepatitis C infection and risk of myeloid malignancy.
Haematologica. 2005;90(4):572-4 - PMID: 15820965
Kamaev PP, Hutcheson JD, Wilson ML, Prausnitz MR
Quantification of optison bubble size and lifetime during sonication dominant role of secondary cavitation bubbles causing acoustic bioeffects.
J Acoust Soc Am. 2004;115(4):1818-25 - PMID: 15101659
Hamaki T, Kami M, Kishi A, Kusumi E, Kishi Y, Iwata H, Miyakoshi S, Ueyama J, Morinaga S, Taniguchi S, Ohara K, Muto Y
Vesicles as initial skin manifestation of disseminated fusariosis after non-myeloablative stem cell transplantation.
Leuk Lymphoma. 2004;45(3):631-3 - PMID: 15160931
Iimuro S, Shindo T, Moriyama N, Amaki T, Niu P, Takeda N, Iwata H, Zhang Y, Ebihara A, Nagai R
Angiogenic effects of adrenomedullin in ischemia and tumor growth.
Circ Res. 2004;95(4):415-23 - PMID: 15242974
Iwata H, Matsuo K, Takeuchi K, Kishi Y, Murashige N, Kami M
High incidences of malignant lymphoma in patients infected with hepatitis B or hepatitis C virus.
Haematologica. 2004;89(3):368-70 - PMID: 15020283
Kami M, Hamaki T, Kusumi E, Iwata H, Ueyama J, Morinaga S, Miyakoshi S, Taniguchi S, Muto Y
Recurrent psychotic episodes in a patient who received rituximab for the treatment of non-Hodgkin's lymphoma.
Hematol J. 2004;5(1):90 - PMID: 14745437
Niu P, Shindo T, Iwata H, Iimuro S, Takeda N, Zhang Y, Ebihara A, Suematsu Y, Kangawa K, Hirata Y, Nagai R
Protective effects of endogenous adrenomedullin on cardiac hypertrophy, fibrosis, and renal damage.
Circulation. 2004;109(14):1789-94 - PMID: 14967720
Niu P, Shindo T, Iwata H, Ebihara A, Suematsu Y, Zhang Y, Takeda N, Iimuro S, Hirata Y, Nagai R
Accelerated cardiac hypertrophy and renal damage induced by angiotensin II in adrenomedullin knockout mice.
Hypertens Res. 2003;26(9):731-6 - PMID: 14620929
Iwata H, Aoyama T, Kami M
Effects of pravastatin in the elderly.
Ann Intern Med. 2002;136(11):W2 - PMID: 12044146
Iwata H, Aoyama T, Kusumi E, Hamaki T, Kami M
Limitations of a meta-analysis investigating the association between cancer and statin use.
Am J Med. 2002;112(2):157-8 - PMID: 11835959
Aikawa M, Libby P
Vascular inflammation and activation: new targets for lipid lowering.
Eur Heart J. 2001;3:A3-A11
Iwata H, Kami M, Hori A, Hamaki T, Takeuchi K, Mutou Y
An autopsy-based retrospective study of secondary thrombotic thrombocytopenic purpura.
Haematologica. 2001;86(6):669-70 - PMID: 11418383
Kami M, Kishi Y, Hamaki T, Maruta Y, Kusumi E, Iwata H, Ueyama JI, Miyakoshi S, Morinaga SI, Mutou Y
A prospective surveillance of nosocomial respiratory syncytial virus infection in a hematology ward: a single-center experience in Japan.
Int J Hematol. 2001;74(3):357-9 - PMID: 11721978
Shibata S, Kami M, Kanda Y, Machida U, Iwata H, Kishi Y, Takeshita A, Miyakoshi S, Ueyama J, Morinaga S, Mutou Y
Acute adrenal failure associated with fluconazole after administration of high-dose cyclophosphamide.
Am J Hematol. 2001;66(4):303-5 - PMID: 11279645
Iwata H, Kami M, Kishi Y, Oki Y, Tanaka Y, Takeuchi K, Yamazaki I, Suzuki R, Morinaga S, Mutou Y
Limitations of the diagnostic criteria for minimally differentiated acute myeloid leukemia (AML-MO)
Leukemia. 2000;14(11):2013-4 - PMID: 11069040