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Figueiredo JL, Santa-Cruz F, Lima-Filho JL, Hilgendorf I, Aikawa M, Pittet MJ, Nahrendorf M, Weissleder R, Swirski FK, Robbins CS
A durable murine model of spleen transplantation with arterial and venous anastomoses.
Sci Rep. 2020;10(1):3979 - PMID: 32132617 - PMCID: PMC7055260 - DOI: 10.1038/s41598-020-60983-7
Hutcheson JD, Schlotter F, Creager MD, Li X, Pham T, Vyas P, Higashi H, Body SC, Aikawa M, Singh SA, Kos L, Aikawa E
Elastogenesis Correlates With Pigment Production in Murine Aortic Valve Leaflets.
Front Cardiovasc Med. 2021;8:678401 - PMID: 34239903 - PMCID: PMC8257952 - DOI: 10.3389/fcvm.2021.678401
Rogers MA, Aikawa E
Unbiased omics identifies mechanistic regulators of calcific aortic valve disease.
Eur Heart J. 2021;42(30):2948-2950 - PMID: 34179985 - PMCID: PMC8347449 - DOI: 10.1093/eurheartj/ehab381
Bartoli-Leonard F, Aikawa E
Old Drugs for an Old Pathology? Drug Repurposing for Calcific Aortic Valve Disease.
Circ Res. 2021;128(9):1317-1319 - PMID: 33914606 - PMCID: PMC8095786 - DOI: 10.1161/CIRCRESAHA.121.319149
Blaser MC, Kraler S, Lüscher TF, Aikawa E
Multi-Omics Approaches to Define Calcific Aortic Valve Disease Pathogenesis.
Circ Res. 2021;128(9):1371-1397 - PMID: 33914608 - PMCID: PMC8095729 - DOI: 10.1161/CIRCRESAHA.120.317979
Jha PK, Vijay A, Halu A, Uchida S, Aikawa M
Gene Expression Profiling Reveals the Shared and Distinct Transcriptional Signatures in Human Lung Epithelial Cells Infected With SARS-CoV-2, MERS-CoV, or SARS-CoV: Potential Implications in Cardiovascular Complications of COVID-19.
Front Cardiovasc Med. 2021;7:623012 - PMID: 33521069 - PMCID: PMC7844200 - DOI: 10.3389/fcvm.2020.623012
Ruiz JL, Hutcheson JD, Cardoso L, Bakhshian Nik A, Condado de Abreu A, Pham T, Buffolo F, Busatto S, Federici S, Ridolfi A, Aikawa M, Bertazzo S, Bergese P, Weinbaum S, Aikawa E
Nanoanalytical analysis of bisphosphonate-driven alterations of microcalcifications using a 3D hydrogel system and in vivo mouse model.
Proc Natl Acad Sci U S A. 2021;118(14):ePub - PMID: 33795519 - PMCID: PMC8040669 - DOI: 10.1073/pnas.1811725118
de Freitas RCC, Hirata RDC, Hirata MH, Aikawa E
Circulating Extracellular Vesicles As Biomarkers and Drug Delivery Vehicles in Cardiovascular Diseases.
Biomolecules. 2021;11(3):ePub - PMID: 33808038 - PMCID: PMC8001426 - DOI: 10.3390/biom11030388
Decano JL, Singh SA, Bueno CG, Lee LH, Halu A, Chelvanambi S, Matamalas JT, Zhang H, Mlynarchik AK, Qiao J, Sharma A, Mukai S, Wang J, Anderson DG, Ozaki CK, Libby P, Aikawa E, Aikawa M
Systems Approach to Discovery of Therapeutic Targets for Vein Graft Disease PPARα Pivotally Regulates Metabolism, Activation, and Heterogeneity of Macrophages and Lesion Development.
Circulation. 2021;143(25):2454-2470 - PMID: 33821665 - PMCID: PMC8212880 - DOI: 10.1161/CIRCULATIONAHA.119.043724
Kraler S, Wenzl FA, Akhmedov A, Blaser MC, Aikawa E, Lüscher TF
ApoA-I mimetics improve aortic stenosis-associated left-ventricular diastolic dysfunction but fail to benefit rabbit models with normal aortic valves.
Int J Cardiol. 2021;332:159-161 - PMID: 33626387 - DOI: 10.1016/j.ijcard.2021.02.044
Silva VR, Neves EGA, Passos LSA, Cristina de Melo F, Teixeira-Carvalho A, Nassif MCL, Junqueira LL, Aikawa E, Dutra WO, Nunes MCP
Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis.
Front Cardiovasc Med. 2021;7:604826 - PMID: 33614739 - PMCID: PMC7888299 - DOI: 10.3389/fcvm.2020.604826
Majumdar U, Manivannan S, Basu M, Ueyama Y, Blaser MC, Cameron E, McDermott MR, Lincoln J, Cole SE, Wood S, Aikawa E, Lilly B, Garg V
Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling.
Sci Adv. 2021;7(6):ePub - PMID: 33547080 - PMCID: PMC7864581 - DOI: 10.1126/sciadv.abe3706
Passos LSA, Nunes MCP, Aikawa E
Rheumatic Heart Valve Disease Pathophysiology and Underlying Mechanisms.
Front Cardiovasc Med. 2021;7:612716 - PMID: 33537348 - PMCID: PMC7848031 - DOI: 10.3389/fcvm.2020.612716
Rogers MA, Hutcheson JD, Okui T, Goettsch C, Singh SA, Halu A, Schlotter F, Higashi H, Wang L, Whelan MC, Mlynarchik AK, Daugherty A, Nomura M, Aikawa M, Aikawa E
Dynamin-related protein 1 inhibition reduces hepatic PCSK9 secretion.
Cardiovasc Res. 2021;117(11):2340-2353 - PMID: 33523181 - PMCID: PMC8479802 - DOI: 10.1093/cvr/cvab034
Passos LSA, Nunes MCP, Zilla P, Yacoub MH, Aikawa E
Raising awareness for rheumatic mitral valve disease.
Glob Cardiol Sci Pract. 2020;2020(2):e202026 - PMID: 33426043 - PMCID: PMC7768627 - DOI: 10.21542/gcsp.2020.26
Uiterwijk M, Smits AIPM, van Geemen D, van Klarenbosch B, Dekker S, Cramer MJ, van Rijswijk JW, Lurier EB, Di Luca A, Brugmans MCP, Mes T, Bosman AW, Aikawa E, Gründeman PF, Bouten CVC, Kluin J
In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Elastomeric Tissue-Engineered Heart Valves.
JACC Basic Transl Sci. 2020;5(12):1187-1206 - PMID: 33426376 - PMCID: PMC7775962 - DOI: 10.1016/j.jacbts.2020.09.011
Atkins SK, Singh SA, Aikawa E
Calcific Aortic Valve Disease "Omics"; Is Timely, But Are We Looking Too Late?
JACC Basic Transl Sci. 2020;5(12):1178-1180 - PMID: 33427821 - PMCID: PMC7775952 - DOI: 10.1016/j.jacbts.2020.11.001
Okui T, Iwashita M, Rogers MA, Halu A, Atkins SK, Kuraoka S, Abdelhamid I, Higashi H, Ramsaroop A, Aikawa M, Singh SA, Aikawa E
CROT (Carnitine O-Octanoyltransferase) Is a Novel Contributing Factor in Vascular Calcification via Promoting Fatty Acid Metabolism and Mitochondrial Dysfunction.
Arterioscler Thromb Vasc Biol. 2020;41(2):755-768 - PMID: 33356393 - PMCID: PMC8105275 - DOI: 10.1161/ATVBAHA.120.315007
Singh SA, Andraski AB, Higashi H, Lee LH, Ramsaroop A, Sacks FM, Aikawa M
Metabolism of PLTP, CETP, and LCAT on multiple HDL sizes using the Orbitrap Fusion Lumos.
JCI Insight. 2020;6(3):ePub - PMID: 33351780 - PMCID: PMC7934878 - DOI: 10.1172/jci.insight.143526
Schlotter F, de Freitas RCC, Rogers MA, Blaser MC, Wu PJ, Higashi H, Halu A, Iqbal F, Andraski AB, Rodia CN, Kuraoka S, Wen JR, Creager M, Pham T, Hutcheson JD, Body SC, Kohan AB, Sacks FM, Aikawa M, Singh SA, Aikawa E
ApoC-III is a novel inducer of calcification in human aortic valves.
J Biol Chem. 2020;296:100193 - PMID: 33334888 - PMCID: PMC7948477 - DOI: 10.1074/jbc.RA120.015700
Iqbal F, Lupieri A, Aikawa M, Aikawa E
Harnessing Single-Cell RNA Sequencing to Better Understand How Diseased Cells Behave the Way They Do in Cardiovascular Disease.
Arterioscler Thromb Vasc Biol. 2020;41(2):585-600 - PMID: 33327741 - PMCID: PMC8105278 - DOI: 10.1161/ATVBAHA.120.314776
Bartoli-Leonard F, Aikawa E
Heart Valve Disease: Challenges and New Opportunities.
Front Cardiovasc Med. 2020;7:602271 - PMID: 33195488 - PMCID: PMC7642276 - DOI: 10.3389/fcvm.2020.602271
Aikawa E, Blaser MC
2020 Jeffrey M. Hoeg Award Lecture: Calcifying Extracellular Vesicles as Building Blocks of Microcalcifications in Cardiovascular Disorders.
Arterioscler Thromb Vasc Biol. 2020;41(1):117-127 - PMID: 33115271 - PMCID: PMC7832175 - DOI: 10.1161/ATVBAHA.120.314704
Rogers MA, Aikawa E
An (Auto)Taxing Effort to Mechanistically Link Obesity and Calcific Aortic Valve Disease.
JACC Basic Transl Sci. 2020;5(9):898-900 - PMID: 33016951 - PMCID: PMC7524779 - DOI: 10.1016/j.jacbts.2020.04.016
Brandão SCS, Ramos JOX, Dompieri LT, Godoi ETAM, Figueiredo JL, Sarinho ESC, Chelvanambi S, Aikawa M
Is Toll-like receptor 4 involved in the severity of COVID-19 pathology in patients with cardiometabolic comorbidities?
Cytokine Growth Factor Rev. 2020;58:102-110 - PMID: 32988728 - PMCID: PMC7505161 - DOI: 10.1016/j.cytogfr.2020.09.002
Nunes MCP, Levine RA, Braulio R, Pascoal-Xavier MA, Elmariah S, Gomes NFA, Soares JR, Esteves WAM, Zeng X, Dal-Bianco JP, Passos LSA, Passaglia LG, Ribeiro VT, Gelape CL, Costa PHN, Lodi-Junqueira L, Dutra W, Tan TC, Aikawa E, Hung J
Mitral Regurgitation After Percutaneous Mitral Valvuloplasty: Insights Into Mechanisms and Impact on Clinical Outcomes.
JACC Cardiovasc Imaging. 2020;13(12):2513-2526 - PMID: 32950446 - PMCID: PMC7861508 - DOI: 10.1016/j.jcmg.2020.07.020
Rogers MA, Buffolo F, Schlotter F, Atkins SK, Lee LH, Halu A, Blaser MC, Tsolaki E, Higashi H, Luther K, Daaboul G, Bouten CVC, Body SC, Singh SA, Bertazzo S, Libby P, Aikawa M, Aikawa E
Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis.
Sci Adv. 2020;6(38):ePub - PMID: 32938681 - PMCID: PMC7494353 - DOI: 10.1126/sciadv.abb1244
Masoumi N, Copper D, Chen P, Cubberley A, Guo K, Lin RZ, Ahmed B, Martin D, Aikawa E, Melero-Martin J, Mayer J
Elastomeric Fibrous Hybrid Scaffold Supports In Vitro and In Vivo Tissue Formation.
Adv Funct Mater. 2017;27(27):ePub - PMID: 32863817 - PMCID: PMC7450820 - DOI: 10.1002/adfm.201606614
Christensen JL, Tan S, Chung HE, Ghosalkar DS, Qureshi R, Chu A, Yu W, Berus J, Shah NR, Wu WC, Chun H, Aikawa E, Choudhary G, Morrison AR
Aortic valve calcification predicts all-cause mortality independent of coronary calcification and severe stenosis.
Atherosclerosis. 2020;307:16-20 - PMID: 32702536 - PMCID: PMC7583087 - DOI: 10.1016/j.atherosclerosis.2020.06.019
Toyohara T, Roudnicky F, Florido MHC, Nakano T, Yu H, Katsuki S, Lee M, Meissner T, Friesen M, Davidow LS, Ptaszek L, Abe T, Rubin LL, Pereira AC, Aikawa M, Cowan CA
Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis.
Cell Stem Cell. 2020;27(1):178-180 - PMID: 32619513 - DOI: 10.1016/j.stem.2020.05.013
Kawakami R, Katsuki S, Travers R, Romero DC, Becker-Greene D, Araujo Passos LS, Higashi H, Blaser MC, Sukhova GK, Buttigieg J, Kopriva D, Schmidt AM, Anderson DG, Singh SA, Cardoso L, Weinbaum S, Libby P, Aikawa M, Croce K, Aikawa E
S100A9-RAGE Axis Accelerates Formation of Macrophage-Mediated Extracellular Vesicle Microcalcification in Diabetes Mellitus.
Arterioscler Thromb Vasc Biol. 2020;40(8):1838-1853 - PMID: 32460581 - PMCID: PMC7377960 - DOI: 10.1161/ATVBAHA.118.314087
Watanabe Y, Takase K, Okada K, Aikawa M, Okamoto K, Koyama I
Portal vein aneurysm with complete spontaneous regression after 10 years using conservative treatment.
Clin J Gastroenterol. 2020;13(5):940-945 - PMID: 32449089 - DOI: 10.1007/s12328-020-01131-6
Toyohara T, Roudnicky F, Florido MHC, Nakano T, Yu H, Katsuki S, Lee M, Meissner T, Friesen M, Davidow LS, Ptaszek L, Abe T, Rubin LL, Pereira AC, Aikawa M, Cowan CA
Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis.
Cell Stem Cell. 2020;27(1):147-157.e7 - PMID: 32413331 - PMCID: PMC8530449 - DOI: 10.1016/j.stem.2020.04.018
Passos LSA, Lupieri A, Becker-Greene D, Aikawa E
Innate and adaptive immunity in cardiovascular calcification.
Atherosclerosis. 2020;306:59-67 - PMID: 32222287 - PMCID: PMC7483874 - DOI: 10.1016/j.atherosclerosis.2020.02.016
Lee LH, Halu A, Morgan S, Iwata H, Aikawa M, Singh SA
XINA: A Workflow for the Integration of Multiplexed Proteomics Kinetics Data with Network Analysis.
J Proteome Res. 2018;18(2):775-781 - PMID: 30370770 - DOI: 10.1021/acs.jproteome.8b00615
Phillippi JA, Aikawa E, Hutcheson J
Editorial: Exploring the Frontiers of Regenerative Cardiovascular Medicine.
Front Cardiovasc Med. 2019;6:13 - PMID: 30873414 - PMCID: PMC6401650 - DOI: 10.3389/fcvm.2019.00013
Hutcheson JD, Goergen CJ, Schoen FJ, Aikawa M, Zilla P, Aikawa E, Gaudette GR
After 50 Years of Heart Transplants: What Does the Next 50 Years Hold for Cardiovascular Medicine? A Perspective From the International Society for Applied Cardiovascular Biology.
Front Cardiovasc Med. 2019;6:8 - PMID: 30838213 - PMCID: PMC6382669 - DOI: 10.3389/fcvm.2019.00008
Blaser MC, Aikawa E
Differential miRNA Loading Underpins Dual Harmful and Protective Roles for Extracellular Vesicles in Atherogenesis.
Circ Res. 2019;124(4):467-469 - PMID: 30763209 - PMCID: PMC6383776 - DOI: 10.1161/CIRCRESAHA.119.314596
Kovacic JC, Dimmeler S, Harvey RP, Finkel T, Aikawa E, Krenning G, Baker AH
Endothelial to Mesenchymal Transition in Cardiovascular Disease: JACC State-of-the-Art Review.
J Am Coll Cardiol. 2019;73(2):190-209 - PMID: 30654892 - PMCID: PMC6865825 - DOI: 10.1016/j.jacc.2018.09.089
Creager MD, Hohl T, Hutcheson JD, Moss AJ, Schlotter F, Blaser MC, Park MA, Lee LH, Singh SA, Alcaide-Corral CJ, Tavares AAS, Newby DE, Kijewski MF, Aikawa M, Di Carli M, Dweck MR, Aikawa E
18F-Fluoride Signal Amplification Identifies Microcalcifications Associated With Atherosclerotic Plaque Instability in Positron Emission Tomography/Computed Tomography Images.
Circ Cardiovasc Imaging. 2019;12(1):e007835 - PMID: 30642216 - PMCID: PMC6338081 - DOI: 10.1161/CIRCIMAGING.118.007835
Théry C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, Antoniou A, Arab T, Archer F, Atkin-Smith GK, Ayre DC, Bach JM, Bachurski D, Baharvand H, Balaj L, Baldacchino S, Bauer NN, Baxter AA, Bebawy M, Beckham C, Bedina Zavec A, Benmoussa A, Berardi AC, Bergese P, Bielska E, Blenkiron C, Bobis-Wozowicz S, Boilard E, Boireau W, Bongiovanni A, Borràs FE, Bosch S, Boulanger CM, Breakefield X, Breglio AM, Brennan MÁ, Brigstock DR, Brisson A, Broekman ML, Bromberg JF, Bryl-Górecka P, Buch S, Buck AH, Burger D, Busatto S, Buschmann D, Bussolati B, Buzás EI, Byrd JB, Camussi G, Carter DR, Caruso S, Chamley LW, Chang YT, Chen C, Chen S, Cheng L, Chin AR, Clayton A, Clerici SP, Cocks A, Cocucci E, Coffey RJ, Cordeiro-da-Silva A, Couch Y, Coumans FA, Coyle B, Crescitelli R, Criado MF, D'Souza-Schorey C, Das S, Datta Chaudhuri A, de Candia P, De Santana EF, De Wever O, Del Portillo HA, Demaret T, Deville S, Devitt A, Dhondt B, Di Vizio D, Dieterich LC, Dolo V, Dominguez Rubio AP, Dominici M, Dourado MR, Driedonks TA, Duarte FV, Duncan HM, Eichenberger RM, Ekström K, El Andaloussi S, Elie-Caille C, Erdbrügger U, Falcón-Pérez JM, Fatima F, Fish JE, Flores-Bellver M, Försönits A, Frelet-Barrand A, Fricke F, Fuhrmann G, Gabrielsson S, Gámez-Valero A, Gardiner C, Gärtner K, Gaudin R, Gho YS, Giebel B, Gilbert C, Gimona M, Giusti I, Goberdhan DC, Görgens A, Gorski SM, Greening DW, Gross JC, Gualerzi A, Gupta GN, Gustafson D, Handberg A, Haraszti RA, Harrison P, Hegyesi H, Hendrix A, Hill AF, Hochberg FH, Hoffmann KF, Holder B, Holthofer H, Hosseinkhani B, Hu G, Huang Y, Huber V, Hunt S, Ibrahim AG, Ikezu T, Inal JM, Isin M, Ivanova A, Jackson HK, Jacobsen S, Jay SM, Jayachandran M, Jenster G, Jiang L, Johnson SM, Jones JC, Jong A, Jovanovic-Talisman T, Jung S, Kalluri R, Kano SI, Kaur S, Kawamura Y, Keller ET, Khamari D, Khomyakova E, Khvorova A, Kierulf P, Kim KP, Kislinger T, Klingeborn M, Klinke DJ, Kornek M, Kosanović MM, Kovács ÁF, Krämer-Albers EM, Krasemann S, Krause M, Kurochkin IV, Kusuma GD, Kuypers S, Laitinen S, Langevin SM, Languino LR, Lannigan J, Lässer C, Laurent LC, Lavieu G, Lázaro-Ibáñez E, Le Lay S, Lee MS, Lee YXF, Lemos DS, Lenassi M, Leszczynska A, Li IT, Liao K, Libregts SF, Ligeti E, Lim R, Lim SK, Linē A, Linnemannstöns K, Llorente A, Lombard CA, Lorenowicz MJ, Lörincz ÁM, Lötvall J, Lovett J, Lowry MC, Loyer X, Lu Q, Lukomska B, Lunavat TR, Maas SL, Malhi H, Marcilla A, Mariani J, Mariscal J, Martens-Uzunova ES, Martin-Jaular L, Martinez MC, Martins VR, Mathieu M, Mathivanan S, Maugeri M, McGinnis LK, McVey MJ, Meckes DG, Meehan KL, Mertens I, Minciacchi VR, Möller A, Møller Jørgensen M, Morales-Kastresana A, Morhayim J, Mullier F, Muraca M, Musante L, Mussack V, Muth DC, Myburgh KH, Najrana T, Nawaz M, Nazarenko I, Nejsum P, Neri C, Neri T, Nieuwland R, Nimrichter L, Nolan JP, Nolte-'t Hoen EN, Noren Hooten N, O'Driscoll L, O'Grady T, O'Loghlen A, Ochiya T, Olivier M, Ortiz A, Ortiz LA, Osteikoetxea X, Østergaard O, Ostrowski M, Park J, Pegtel DM, Peinado H, Perut F, Pfaffl MW, Phinney DG, Pieters BC, Pink RC, Pisetsky DS, Pogge von Strandmann E, Polakovicova I, Poon IK, Powell BH, Prada I, Pulliam L, Quesenberry P, Radeghieri A, Raffai RL, Raimondo S, Rak J, Ramirez MI, Raposo G, Rayyan MS, Regev-Rudzki N, Ricklefs FL, Robbins PD, Roberts DD, Rodrigues SC, Rohde E, Rome S, Rouschop KM, Rughetti A, Russell AE, Saá P, Sahoo S, Salas-Huenuleo E, Sánchez C, Saugstad JA, Saul MJ, Schiffelers RM, Schneider R, Schøyen TH, Scott A, Shahaj E, Sharma S, Shatnyeva O, Shekari F, Shelke GV, Shetty AK, Shiba K, Siljander PR, Silva AM, Skowronek A, Snyder OL, Soares RP, Sódar BW, Soekmadji C, Sotillo J, Stahl PD, Stoorvogel W, Stott SL, Strasser EF, Swift S, Tahara H, Tewari M, Timms K, Tiwari S, Tixeira R, Tkach M, Toh WS, Tomasini R, Torrecilhas AC, Tosar JP, Toxavidis V, Urbanelli L, Vader P, van Balkom BW, van der Grein SG, Van Deun J, van Herwijnen MJ, Van Keuren-Jensen K, van Niel G, van Royen ME, van Wijnen AJ, Vasconcelos MH, Vechetti IJ, Veit TD, Vella LJ, Velot É, Verweij FJ, Vestad B, Viñas JL, Visnovitz T, Vukman KV, Wahlgren J, Watson DC, Wauben MH, Weaver A, Webber JP, Weber V, Wehman AM, Weiss DJ, Welsh JA, Wendt S, Wheelock AM, Wiener Z, Witte L, Wolfram J, Xagorari A, Xander P, Xu J, Yan X, Yáñez-Mó M, Yin H, Yuana Y, Zappulli V, Zarubova J, Žėkas V, Zhang JY, Zhao Z, Zheng L, Zheutlin AR, Zickler AM, Zimmermann P, Zivkovic AM, Zocco D, Zuba-Surma EK
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.
J Extracell Vesicles. 2018;7(1):1535750 - PMID: 30637094 - PMCID: PMC6322352 - DOI: 10.1080/20013078.2018.1535750
Blaser MC, Aikawa E
Roles and Regulation of Extracellular Vesicles in Cardiovascular Mineral Metabolism.
Front Cardiovasc Med. 2018;5:187 - PMID: 30622949 - PMCID: PMC6308298 - DOI: 10.3389/fcvm.2018.00187
Rogers MA, Aikawa E
Cardiovascular calcification: artificial intelligence and big data accelerate mechanistic discovery.
Nat Rev Cardiol. 2018;16(5):261-274 - PMID: 30531869 - DOI: 10.1038/s41569-018-0123-8
Decano JL, Aikawa M
Dynamic Macrophages: Understanding Mechanisms of Activation as Guide to Therapy for Atherosclerotic Vascular Disease.
Front Cardiovasc Med. 2018;5:97 - PMID: 30123798 - PMCID: PMC6086112 - DOI: 10.3389/fcvm.2018.00097
Atkins SK, Sucosky P
Etiology of bicuspid aortic valve disease: Focus on hemodynamics.
World J Cardiol. 2014;6(12):1227-33 - PMID: 25548612 - PMCID: PMC4278157 - DOI: 10.4330/wjc.v6.i12.1227
Atkins SK, Cao K, Rajamannan NM, Sucosky P
Bicuspid aortic valve hemodynamics induces abnormal medial remodeling in the convexity of porcine ascending aortas.
Biomech Model Mechanobiol. 2014;13(6):1209-25 - PMID: 24599392 - DOI: 10.1007/s10237-014-0567-7
Sen DG, Halu A, Razzaque M, Gorham JM, Hartnett J, Seidman JG, Aikawa E, Seidman CE
The Transcriptional Signature of Growth in Human Fetal Aortic Valve Development.
Ann Thorac Surg. 2018;106(6):1834-1840 - PMID: 30071238 - DOI: 10.1016/j.athoracsur.2018.06.034
Koenen RR, Aikawa E
Editorial: Extracellular Vesicle-Mediated Processes in Cardiovascular Diseases.
Front Cardiovasc Med. 2018;5:133 - PMID: 30283791 - PMCID: PMC6157324 - DOI: 10.3389/fcvm.2018.00133
Halu A, Wang JG, Iwata H, Mojcher A, Abib AL, Singh SA, Aikawa M, Sharma A
Context-enriched interactome powered by proteomics helps the identification of novel regulators of macrophage activation.
Elife. 2018;7:ePub - PMID: 30303482 - PMCID: PMC6179386 - DOI: 10.7554/eLife.37059
Higashi H, Maejima T, Lee LH, Yamazaki Y, Hottiger MO, Singh SA, Aikawa M
A study into the ADP-ribosylome of IFN-γ-stimulated THP-1 human macrophage-like cells identifies ARTD8/PARP14 and ARTD9/PARP9 ADP-ribosylation.
J Proteome Res. 2019;18(4):1607-1622 - PMID: 30848916 - PMCID: PMC6456868 - DOI: 10.1021/acs.jproteome.8b00895
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