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Decano JL, Mattson PC, Aikawa M

Macrophages in Vascular Inflammation: Origins and Functions.
Curr Atheroscler Rep. 2016;18(6):34 - PMID: 27125207 - DOI: 10.1007/s11883-016-0585-2

Yabusaki K, Faits T, McMullen E, Figueiredo JL, Aikawa M, Aikawa E

A novel quantitative approach for eliminating sample-to-sample variation using a hue saturation value analysis program.
PLOS One. 2014;9(3):e89627 - PMID: 24595280 - PMCID: PMC3940696 - DOI: 10.1371/journal.pone.0089627

Rogers MA, Aikawa E

Modifying Vascular Calcification in Diabetes Mellitus: Contribution of O-GlcNAcylation.
Circ Res. 2014;114(7):1074-6 - PMID: 24677232 - PMCID: PMC3989539 - DOI: 10.1161/CIRCRESAHA.114.303684

Miyazaki T, Chiuve S, Sacks FM, Ridker PM, Libby P, Aikawa M

Plasma Pentraxin 3 Levels Do Not Predict Coronary Events but Reflect Metabolic Disorders in Patients with Coronary Artery Disease in the CARE Trial.
PLOS One. 2014;9(4):e94073 - PMID: 24705587 - PMCID: PMC3976379 - DOI: 10.1371/journal.pone.0094073

Goettsch C, Iwata H, Aikawa E

Parathyroid hormone: critical bridge between bone metabolism and cardiovascular disease.
Arterioscler Thromb Vasc Biol. 2014;34(7):1333-5 - PMID: 24951650 - PMCID: PMC4094346 - DOI: 10.1161/ATVBAHA.114.303637

Hutcheson JD, Maldonado N, Aikawa E

Small entities with large impact: microcalcifications and atherosclerotic plaque vulnerability.
Curr Opin Lipidol. 2014;25(5):327-332 - PMID: 25188916 - PMCID: PMC4166045 - DOI: 10.1097/MOL.0000000000000105

Ruiz JL, Hutcheson JD, Aikawa E

Cardiovascular calcification: current controversies and novel concepts.
Cardiovasc Pathol. 2015;24(4):207-212 - PMID: 25797772 - DOI: 10.1016/j.carpath.2015.03.002

Lei Y, Iwashita M, Choi J, Aikawa M, Aikawa E

N-acetylglucosamine-1-Phosphate Transferase Suppresses Lysosomal Hydrolases in Dysfunctional Osteoclasts: A Potential Mechanism for Vascular Calcification
J. Cardiovasc. Dev. Dis. 2015;2:31-47 - PMID: 29371511 - PMCID: PMC5753093 - DOI: 10.3390/jcdd2020031

Miyosawa K, Watanabe Y, Murakami K, Murakami T, Shibata H, Iwashita M, Yamazaki H, Yamazaki K, Ohgiya T, Shibuya K, Mizuno K, Tanabe S, Singh SA, Aikawa M

New CETP Inhibitor K-312 Reduces PCSK9 Expression: A Potential Effect on LDL Cholesterol Metabolism.
Am J Physiol Endocrinol Metab. 2015;309(2):E177-90 - PMID: 26015437 - DOI: 10.1152/ajpendo.00528.2014

Sasaki Y, Ohta M, Desai D, Figueiredo JL, Whelan MC, Sugano T, Yamabi M, Yano W, Faits T, Yabusaki K, Zhang H, Mlynarchik AK, Inoue K, Mizuno K, Aikawa M

Angiopoietin Like Protein 2 (ANGPTL2) Promotes Adipose Tissue Macrophage and T lymphocyte Accumulation and Leads to Insulin Resistance.
PLOS One. 2015;10(7):e0131176 - PMID: 26132105 - PMCID: PMC4489192 - DOI: 10.1371/journal.pone.0131176

Rogers MA, Aikawa E

A Not-so-Little Role for Lp(a) in the Development of Calcific Aortic Valve Disease.
Circulation. 2015;132(8):621-3 - PMID: 26224809 - PMCID: PMC4550561 - DOI: 10.1161/CIRCULATIONAHA.115.018139

Hjortnaes J, Shapero K, Goettsch C, Hutcheson JD, Keegan J, Kluin J, Mayer JE, Bischoff J, Aikawa E

Valvular interstitial cells suppress calcification of valvular endothelial cells.
Atherosclerosis. 2015;242(1):251-260 - PMID: 26232165 - PMCID: PMC4546848 - DOI: 10.1016/j.atherosclerosis.2015.07.008

Ricchiuto P, Iwata H, Yabusaki K, Yamada I, Pieper B, Sharma A, Aikawa M, Singh SA

mIMT-visHTS: A novel method for multiplexing isobaric mass tagged datasets with an accompanying visualization high throughput screening tool for protein profiling.
J Proteomics. 2015;128:132-140 - PMID: 26232111 - DOI: 10.1016/j.jprot.2015.07.024

Singh SA, Miyosawa K, Aikawa M

Mass spectrometry meets the challenge of understanding the complexity of the lipoproteome: recent findings regarding proteins involved in dyslipidemia and cardiovascular disease.
Expert Rev Proteomics. 2015;12(5):519-32 - PMID: 26325144 - DOI: 10.1586/14789450.2015.1078731

Hutcheson JD, Goettsch C, Rogers MA, Aikawa E

Revisiting Cardiovascular Calcification: A Multifaceted Disease Requiring a Multidisciplinary Approach.
Semin Cell Dev Biol. 2015;46:68-77 - PMID: 26358815 - DOI: 10.1016/j.semcdb.2015.09.004

Shibasaki M, Wang JG, Figueiredo JL, New SE, Quillard T, Goettsch C, Koga JI, Sonoki H, Matsumoto J, Aikawa M, Aikawa E

Pitavastatin Reduces Inflammation in Atherosclerotic Plaques in Apolipoprotein E-Deficient Mice with Late Stage Renal Disease.
PLOS One. 2015;10(9):e0138047 - PMID: 26367531 - PMCID: PMC4569429 - DOI: 10.1371/journal.pone.0138047

Wang JG, Aikawa M

Toll-Like Receptors and Src-Family Kinases in Atherosclerosis　- Focus on Macrophages.
Circ J. 2015;79(11):2332-2334 - PMID: 26467082 - DOI: 10.1253/circj.CJ-15-1039

Levine RA, Hagége AA, Judge DP, Padala M, Dal-Bianco JP, Aikawa E, Beaudoin J, Bischoff J, Bouatia-Naji N, Bruneval P, Butcher JT, Carpentier A, Chaput M, Chester AH, Clusel C, Delling FN, Dietz HC, Dina C, Durst R, Fernandez-Friera L, Handschumacher MD, Jensen MO, Jeunemaitre XP, Marec HL, Tourneau TL, Markwald RR, Mérot J, Messas E, Milan DP, Neri T, Norris RA, Peal D, Perrocheau M, Probst V, Pucéat M, Rosenthal N, Solis J, Schott JJ, Schwammenthal E, Slaugenhaupt SA, Song JK, Yacoub MH,

Mitral valve disease-morphology and mechanisms.
Nat Rev Cardiol. 2015;12(12):689-710 - PMID: 26483167 - PMCID: PMC4804623 - DOI: 10.1038/nrcardio.2015.161

Sun X, Haas ME, Miao J, Mehta A, Graham MJ, Crooke RM, de Barros JP, Wang JG, Aikawa M, Masson D, Biddinger SB

Insulin dissociates the effects of Liver X Receptor on lipogenesis, endoplasmic reticulum stress and inflammation.
J Biol Chem. 2015;291(3):1115-1122 - PMID: 26511317 - PMCID: PMC4714195 - DOI: 10.1074/jbc.M115.668269

Hutcheson JD, Goettsch C, Bertazzo S, Maldonado N, Ruiz JL, Goh W, Yabusaki K, Faits T, Bouten C, Franck G, Quillard T, Libby P, Aikawa M, Weinbaum S, Aikawa E

Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques.
Nat Mater. 2016;15(3):335-43 - PMID: 26752654 - PMCID: PMC4767675 - DOI: 10.1038/nmat4519

Krohn JB, Hutcheson JD, Martínez-Martínez E, Irvin WS, Bouten CV, Bertazzo S, Bendeck MP, Aikawa E

Discoidin Domain Receptor-1 Regulates Calcific Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response via Transforming Growth Factor-β Signaling.
Arterioscler Thromb Vasc Biol. 2016;36(3):525-33 - PMID: 26800565 - PMCID: PMC4767541 - DOI: 10.1161/ATVBAHA.115.307009

Dal-Bianco JP, Aikawa E, Bischoff J, Guerrero JL, Hjortnaes J, Beaudoin J, Szymanski C, Bartko PE, Seybolt MM, Handschumacher MD, Sullivan S, Garcia ML, Mauskapf A, Titus JS, Wylie-Sears J, Irvin WS, Chaput M, Messas E, Hagège AA, Carpentier A, Levine RA,

Myocardial Infarction Alters Adaptation of the Tethered Mitral Valve.
J Am Coll Cardiol. 2016;67(3):275-87 - PMID: 26796392 - PMCID: PMC5099077 - DOI: 10.1016/j.jacc.2015.10.092

Krohn JB, Hutcheson JD, Martínez-Martínez E, Aikawa E

Extracellular vesicles in cardiovascular calcification: Expanding current paradigms.
J Physiol. 2016;594(11):2895-903 - PMID: 26824781 - PMCID: PMC4887674 - DOI: 10.1113/JP271338

Singh SA, Andraski AB, Pieper B, Goh W, Mendivil CO, Sacks FM, Aikawa M

Multiple apolipoprotein kinetics measured in human HDL by high resolution/accurate mass parallel reaction monitoring.
J Lipid Res. 2016;57(4):714-28 - PMID: 26862155 - PMCID: PMC4808760 - DOI: 10.1194/jlr.D061432

Goettsch C, Hutcheson JD, Aikawa M, Iwata H, Pham T, Nykjaer A, Kjolby M, Rogers M, Michel T, Shibasaki M, Hagita S, Kramann R, Rader DJ, Libby P, Singh SA, Aikawa E

Sortilin mediates vascular calcification via its recruitment into extracellular vesicles.
J Clin Invest. 2016;126(4):1323-1336 - PMID: 26950419 - PMCID: PMC4811143 - DOI: 10.1172/JCI80851

Dal-Bianco JP, Bartko PE, Beaudoin J, Aikawa E, Bischoff J, Levine RA

3D Ultrasound: seeing is understanding-from imaging to pathophysiology to developing therapies in secondary MR.
Eur Heart J Cardiovasc Imaging. 2016;17(5):510-1 - PMID: 26976355 - PMCID: PMC4829123 - DOI: 10.1093/ehjci/jew029

Hjortnaes J, Goettsch C, Hutcheson JD, Camci-Unal G, Lax L, Scherer K, Body S, Schoen FJ, Kluin J, Khademhosseini A, Aikawa E

Simulation of early calcific aortic valve disease in a 3D platform: A role for myofibroblast differentiation.
J Mol Cell Cardiol. 2016;94:13-20 - PMID: 26996755 - PMCID: PMC4906202 - DOI: 10.1016/j.yjmcc.2016.03.004

Ruiz JL, Weinbaum S, Aikawa E, Hutcheson JD

Zooming in on the genesis of atherosclerotic plaque microcalcifications.
J Physiol. 2016;594(11):2915-27 - PMID: 27040360 - PMCID: PMC4887667 - DOI: 10.1113/JP271339

Iwata H, Goettsch C, Sharma A, Ricchiuto P, Goh WW, Halu A, Yamada I, Yoshida H, Hara T, Wei M, Inoue N, Fukuda D, Mojcher A, Mattson PC, Barabási AL, Boothby M, Aikawa E, Singh SA, Aikawa M

PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation.
Nat Commun. 2016;7:12849 - PMID: 27796300 - PMCID: PMC5095532 - DOI: 10.1038/ncomms12849

Atkins SK, Cao K, Rajamannan NM, Sucosky P

Bicuspid aortic valve hemodynamics induces abnormal medial remodeling in the convexity of porcine ascending aortas.
Biomech Model Mechanobiol. 2014;13(6):1209-25 - PMID: 24599392 - DOI: 10.1007/s10237-014-0567-7

Atkins SK, Sucosky P

Etiology of bicuspid aortic valve disease: Focus on hemodynamics.
World J Cardiol. 2014;6(12):1227-33 - PMID: 25548612 - PMCID: PMC4278157 - DOI: 10.4330/wjc.v6.i12.1227

Atkins SK, Moore AN, Sucosky P

Bicuspid aortic valve hemodynamics does not promote remodeling in porcine aortic wall concavity.
World J Cardiol. 2016;8(1):89-97 - PMID: 26839660 - PMCID: PMC4728110 - DOI: 10.4330/wjc.v8.i1.89

Atkins SK, McNally A, Sucosky P

Mechanobiology in Cardiovascular Disease Management: Potential Strategies and Current Needs.
Front Bioeng Biotechnol. 2016;4:79 - PMID: 27777927 - PMCID: PMC5056184 - DOI: 10.3389/fbioe.2016.00079

Cao K, Atkins SK, McNally A, Liu J, Sucosky P

Simulations of morphotype-dependent hemodynamics in non-dilated bicuspid aortic valve aortas.
J Biomech. 2016;50:63-70 - PMID: 27855987 - DOI: 10.1016/j.jbiomech.2016.11.024

Schlotter F, de Waha S, Eitel I, Desch S, Fuernau G, Thiele H

Interventional post-myocardial infarction ventricular septal defect closure: a systematic review of current evidence.
EuroIntervention. 2016;12(1):94-102

Mangner N, Woitek F, Haussig S, Schlotter F, Stachel G, Höllriegel R, Wilde J, Lindner A, Holzhey D, Leontyev S, Mohr FW, Schuler G, Linke A

Incidence, Predictors, and Outcome of Patients Developing Infective Endocarditis Following Transfemoral Transcatheter Aortic Valve Replacement.
J Am Coll Cardiol. 2016;67(24):2907-8

Hjortnaes J, Keegan J, Bruneval P, Schwartz E, Schoen FJ, Carpentier A, Levine RA, Hagège A, Aikawa E

Comparative Histopathological Analysis of Mitral Valves in Barlow Disease and Fibroelastic Deficiency.
Semin Thorac Cardiovasc Surg. 2016;28(4):757-767 - PMID: 28417861 - DOI: 10.1053/j.semtcvs.2016.08.015

Hjortnaes J, Keegan J, Bruneval P, Schwartz E, Schoen FJ, Carpentier A, Levine RA, Hagège A, Aikawa E

Comparative Histopathological Analysis of Mitral Valves in Barlow Disease and Fibroelastic Deficiency.
Semin Thorac Cardiovasc Surg. 2016;28(4):757-767

Singh SA, Aikawa M

Unbiased and targeted mass spectrometry for the HDL proteome.
Curr Opin Lipidol. 2016;28(1):68-77 - PMID: 28002079 - PMCID: PMC6211176 - DOI: 10.1097/MOL.0000000000000374

Yabusaki K, Hutcheson JD, Vyas P, Bertazzo S, Body SC, Aikawa M, Aikawa E

Quantification of Calcified Particles in Human Valve Tissue Reveals Asymmetry of Calcific Aortic Valve Disease Development.
Front Cardiovasc Med. 2016;3:44 - PMID: 27867942 - PMCID: PMC5095138 - DOI: 10.3389/fcvm.2016.00044

Lee LH, Andraski AB, Pieper B, Higashi H, Sacks FM, Aikawa M, Singh SA

Automation of PRM-dependent D3-Leu tracer enrichment in HDL to study the metabolism of apoA-I, LCAT and other apolipoproteins.
Proteomics. 2016;17(1-2):ePub - PMID: 27862954 - PMCID: PMC5572145 - DOI: 10.1002/pmic.201600085

Bischoff J, Casanovas G, Wylie-Sears J, Kim DH, Bartko P, Guerrero J, Dal-Bianco J, Beaudoin J, Garcia M, Sullivan , Seybolt M, Morris B, Keegan J, Irvin W, Aikawa E, Levine R

CD45 Expression in Mitral Valve Endothelial Cells After Myocardial Infarction.
Circ Res. 2016;119(11):1215-1225 - PMID: 27750208 - PMCID: PMC5215059 - DOI: 10.1161/CIRCRESAHA.116.309598

Dweck MR, Aikawa E, Newby DE, Tarkin JM, Rudd JH, Narula J, Fayad ZA

Noninvasive Molecular Imaging of Disease Activity in Atherosclerosis.
Circ Res. 2016;119(2):330-40 - PMID: 27390335 - PMCID: PMC4939871 - DOI: 10.1161/CIRCRESAHA.116.307971

Aikawa E

Extracellular vesicles in cardiovascular disease: focus on vascular calcification.
J Physiol. 2016;594(11):2877-80

O'Rourke C, Shelton G, Hutcheson JD, Burke MF, Martyn T, Thayer TE, Shakartzi HR, Buswell MD, Tainsh RE, Yu B, Bagchi A, Rhee DK, Wu C, Derwall M, Buys ES, Yu PB, Bloch KD, Aikawa E, Bloch DB, Malhotra R

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation.
J Vis Exp. 2016;(111):ePub - PMID: 27284788 - PMCID: PMC4927747 - DOI: 10.3791/54017

Ghiassian SD, Menche J, Chasman DI, Giulianini F, Wang R, Ricchiuto P, Aikawa M, Iwata H, Müller C, Zeller T, Sharma A, Wild P, Lackner K, Singh S, Ridker PM, Blankenberg S, Barabási AL, Loscalzo J

Endophenotype Network Models: Common Core of Complex Diseases.
Sci Rep. 2016;6:27414 - PMID: 27278246 - PMCID: PMC4899691 - DOI: 10.1038/srep27414

Aikawa E

Extracellular vesicles in cardiovascular disease: focus on vascular calcification.
J Physiol. 2016;594(11):2877-80 - PMID: 27246548 - PMCID: PMC4887668 - DOI: 10.1113/JP272112

Goettsch C, Hutcheson JD, Hagita S, Rogers MA, Creager MD, Pham T, Choi J, Mlynarchik AK, Pieper B, Kjolby M, Aikawa M, Aikawa E

A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification.
Atherosclerosis. 2016;251:109-118 - PMID: 27318830 - PMCID: PMC4983246 - DOI: 10.1016/j.atherosclerosis.2016.06.011

Mosch J, Gleissner CA, Body S, Aikawa E

Histopathological assessment of calcification and inflammation of calcific aortic valves from patients with and without diabetes mellitus.
Histol Histopathol. 2016;32(3):293-306 - PMID: 27353274 - PMCID: PMC5199639 - DOI: 10.14670/HH-11-797

Nakano T, Fukuda D, Koga JI, Aikawa M

Delta-Like Ligand 4-Notch Signaling in Macrophage Activation.
Arterioscler Thromb Vasc Biol. 2016;36(10):2038-47 - PMID: 27562914 - PMCID: PMC5033717 - DOI: 10.1161/ATVBAHA.116.306926
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