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Decano JL, Mattson PC, Aikawa M
Macrophages in Vascular Inflammation: Origins and Functions.
Curr Atheroscler Rep. 2016;18(6):34 - PMID: 27125207 - DOI: 10.1007/s11883-016-0585-2
Yabusaki K, Faits T, McMullen E, Figueiredo JL, Aikawa M, Aikawa E
A novel quantitative approach for eliminating sample-to-sample variation using a hue saturation value analysis program.
PLOS One. 2014;9(3):e89627 - PMID: 24595280 - PMCID: PMC3940696 - DOI: 10.1371/journal.pone.0089627
Rogers MA, Aikawa E
Modifying Vascular Calcification in Diabetes Mellitus: Contribution of O-GlcNAcylation.
Circ Res. 2014;114(7):1074-6 - PMID: 24677232 - PMCID: PMC3989539 - DOI: 10.1161/CIRCRESAHA.114.303684
Miyazaki T, Chiuve S, Sacks FM, Ridker PM, Libby P, Aikawa M
Plasma Pentraxin 3 Levels Do Not Predict Coronary Events but Reflect Metabolic Disorders in Patients with Coronary Artery Disease in the CARE Trial.
PLOS One. 2014;9(4):e94073 - PMID: 24705587 - PMCID: PMC3976379 - DOI: 10.1371/journal.pone.0094073
Goettsch C, Iwata H, Aikawa E
Parathyroid hormone: critical bridge between bone metabolism and cardiovascular disease.
Arterioscler Thromb Vasc Biol. 2014;34(7):1333-5 - PMID: 24951650 - PMCID: PMC4094346 - DOI: 10.1161/ATVBAHA.114.303637
Hutcheson JD, Maldonado N, Aikawa E
Small entities with large impact: microcalcifications and atherosclerotic plaque vulnerability.
Curr Opin Lipidol. 2014;25(5):327-332 - PMID: 25188916 - PMCID: PMC4166045 - DOI: 10.1097/MOL.0000000000000105
Ruiz JL, Hutcheson JD, Aikawa E
Cardiovascular calcification: current controversies and novel concepts.
Cardiovasc Pathol. 2015;24(4):207-212 - PMID: 25797772 - DOI: 10.1016/j.carpath.2015.03.002
Lei Y, Iwashita M, Choi J, Aikawa M, Aikawa E
N-acetylglucosamine-1-Phosphate Transferase Suppresses Lysosomal Hydrolases in Dysfunctional Osteoclasts: A Potential Mechanism for Vascular Calcification
J. Cardiovasc. Dev. Dis. 2015;2:31-47 - PMID: 29371511 - PMCID: PMC5753093 - DOI: 10.3390/jcdd2020031
Miyosawa K, Watanabe Y, Murakami K, Murakami T, Shibata H, Iwashita M, Yamazaki H, Yamazaki K, Ohgiya T, Shibuya K, Mizuno K, Tanabe S, Singh SA, Aikawa M
New CETP Inhibitor K-312 Reduces PCSK9 Expression: A Potential Effect on LDL Cholesterol Metabolism.
Am J Physiol Endocrinol Metab. 2015;309(2):E177-90 - PMID: 26015437 - DOI: 10.1152/ajpendo.00528.2014
Sasaki Y, Ohta M, Desai D, Figueiredo JL, Whelan MC, Sugano T, Yamabi M, Yano W, Faits T, Yabusaki K, Zhang H, Mlynarchik AK, Inoue K, Mizuno K, Aikawa M
Angiopoietin Like Protein 2 (ANGPTL2) Promotes Adipose Tissue Macrophage and T lymphocyte Accumulation and Leads to Insulin Resistance.
PLOS One. 2015;10(7):e0131176 - PMID: 26132105 - PMCID: PMC4489192 - DOI: 10.1371/journal.pone.0131176
Rogers MA, Aikawa E
A Not-so-Little Role for Lp(a) in the Development of Calcific Aortic Valve Disease.
Circulation. 2015;132(8):621-3 - PMID: 26224809 - PMCID: PMC4550561 - DOI: 10.1161/CIRCULATIONAHA.115.018139
Hjortnaes J, Shapero K, Goettsch C, Hutcheson JD, Keegan J, Kluin J, Mayer JE, Bischoff J, Aikawa E
Valvular interstitial cells suppress calcification of valvular endothelial cells.
Atherosclerosis. 2015;242(1):251-260 - PMID: 26232165 - PMCID: PMC4546848 - DOI: 10.1016/j.atherosclerosis.2015.07.008
Ricchiuto P, Iwata H, Yabusaki K, Yamada I, Pieper B, Sharma A, Aikawa M, Singh SA
mIMT-visHTS: A novel method for multiplexing isobaric mass tagged datasets with an accompanying visualization high throughput screening tool for protein profiling.
J Proteomics. 2015;128:132-140 - PMID: 26232111 - DOI: 10.1016/j.jprot.2015.07.024
Singh SA, Miyosawa K, Aikawa M
Mass spectrometry meets the challenge of understanding the complexity of the lipoproteome: recent findings regarding proteins involved in dyslipidemia and cardiovascular disease.
Expert Rev Proteomics. 2015;12(5):519-32 - PMID: 26325144 - DOI: 10.1586/14789450.2015.1078731
Hutcheson JD, Goettsch C, Rogers MA, Aikawa E
Revisiting Cardiovascular Calcification: A Multifaceted Disease Requiring a Multidisciplinary Approach.
Semin Cell Dev Biol. 2015;46:68-77 - PMID: 26358815 - DOI: 10.1016/j.semcdb.2015.09.004
Shibasaki M, Wang JG, Figueiredo JL, New SE, Quillard T, Goettsch C, Koga JI, Sonoki H, Matsumoto J, Aikawa M, Aikawa E
Pitavastatin Reduces Inflammation in Atherosclerotic Plaques in Apolipoprotein E-Deficient Mice with Late Stage Renal Disease.
PLOS One. 2015;10(9):e0138047 - PMID: 26367531 - PMCID: PMC4569429 - DOI: 10.1371/journal.pone.0138047
Wang JG, Aikawa M
Toll-Like Receptors and Src-Family Kinases in Atherosclerosis　- Focus on Macrophages.
Circ J. 2015;79(11):2332-2334 - PMID: 26467082 - DOI: 10.1253/circj.CJ-15-1039
Levine RA, Hagége AA, Judge DP, Padala M, Dal-Bianco JP, Aikawa E, Beaudoin J, Bischoff J, Bouatia-Naji N, Bruneval P, Butcher JT, Carpentier A, Chaput M, Chester AH, Clusel C, Delling FN, Dietz HC, Dina C, Durst R, Fernandez-Friera L, Handschumacher MD, Jensen MO, Jeunemaitre XP, Marec HL, Tourneau TL, Markwald RR, Mérot J, Messas E, Milan DP, Neri T, Norris RA, Peal D, Perrocheau M, Probst V, Pucéat M, Rosenthal N, Solis J, Schott JJ, Schwammenthal E, Slaugenhaupt SA, Song JK, Yacoub MH,
Mitral valve disease-morphology and mechanisms.
Nat Rev Cardiol. 2015;12(12):689-710 - PMID: 26483167 - PMCID: PMC4804623 - DOI: 10.1038/nrcardio.2015.161
Sun X, Haas ME, Miao J, Mehta A, Graham MJ, Crooke RM, de Barros JP, Wang JG, Aikawa M, Masson D, Biddinger SB
Insulin dissociates the effects of Liver X Receptor on lipogenesis, endoplasmic reticulum stress and inflammation.
J Biol Chem. 2015;291(3):1115-1122 - PMID: 26511317 - PMCID: PMC4714195 - DOI: 10.1074/jbc.M115.668269
Hutcheson JD, Goettsch C, Bertazzo S, Maldonado N, Ruiz JL, Goh W, Yabusaki K, Faits T, Bouten C, Franck G, Quillard T, Libby P, Aikawa M, Weinbaum S, Aikawa E
Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques.
Nat Mater. 2016;15(3):335-43 - PMID: 26752654 - PMCID: PMC4767675 - DOI: 10.1038/nmat4519
Krohn JB, Hutcheson JD, Martínez-Martínez E, Irvin WS, Bouten CV, Bertazzo S, Bendeck MP, Aikawa E
Discoidin Domain Receptor-1 Regulates Calcific Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response via Transforming Growth Factor-β Signaling.
Arterioscler Thromb Vasc Biol. 2016;36(3):525-33 - PMID: 26800565 - PMCID: PMC4767541 - DOI: 10.1161/ATVBAHA.115.307009
Dal-Bianco JP, Aikawa E, Bischoff J, Guerrero JL, Hjortnaes J, Beaudoin J, Szymanski C, Bartko PE, Seybolt MM, Handschumacher MD, Sullivan S, Garcia ML, Mauskapf A, Titus JS, Wylie-Sears J, Irvin WS, Chaput M, Messas E, Hagège AA, Carpentier A, Levine RA,
Myocardial Infarction Alters Adaptation of the Tethered Mitral Valve.
J Am Coll Cardiol. 2016;67(3):275-87 - PMID: 26796392 - PMCID: PMC5099077 - DOI: 10.1016/j.jacc.2015.10.092
Krohn JB, Hutcheson JD, Martínez-Martínez E, Aikawa E
Extracellular vesicles in cardiovascular calcification: Expanding current paradigms.
J Physiol. 2016;594(11):2895-903 - PMID: 26824781 - PMCID: PMC4887674 - DOI: 10.1113/JP271338
Singh SA, Andraski AB, Pieper B, Goh W, Mendivil CO, Sacks FM, Aikawa M
Multiple apolipoprotein kinetics measured in human HDL by high resolution/accurate mass parallel reaction monitoring.
J Lipid Res. 2016;57(4):714-28 - PMID: 26862155 - PMCID: PMC4808760 - DOI: 10.1194/jlr.D061432
Goettsch C, Hutcheson JD, Aikawa M, Iwata H, Pham T, Nykjaer A, Kjolby M, Rogers M, Michel T, Shibasaki M, Hagita S, Kramann R, Rader DJ, Libby P, Singh SA, Aikawa E
Sortilin mediates vascular calcification via its recruitment into extracellular vesicles.
J Clin Invest. 2016;126(4):1323-1336 - PMID: 26950419 - PMCID: PMC4811143 - DOI: 10.1172/JCI80851
Dal-Bianco JP, Bartko PE, Beaudoin J, Aikawa E, Bischoff J, Levine RA
3D Ultrasound: seeing is understanding-from imaging to pathophysiology to developing therapies in secondary MR.
Eur Heart J Cardiovasc Imaging. 2016;17(5):510-1 - PMID: 26976355 - PMCID: PMC4829123 - DOI: 10.1093/ehjci/jew029
Hjortnaes J, Goettsch C, Hutcheson JD, Camci-Unal G, Lax L, Scherer K, Body S, Schoen FJ, Kluin J, Khademhosseini A, Aikawa E
Simulation of early calcific aortic valve disease in a 3D platform: A role for myofibroblast differentiation.
J Mol Cell Cardiol. 2016;94:13-20 - PMID: 26996755 - PMCID: PMC4906202 - DOI: 10.1016/j.yjmcc.2016.03.004
Ruiz JL, Weinbaum S, Aikawa E, Hutcheson JD
Zooming in on the genesis of atherosclerotic plaque microcalcifications.
J Physiol. 2016;594(11):2915-27 - PMID: 27040360 - PMCID: PMC4887667 - DOI: 10.1113/JP271339
Iwata H, Goettsch C, Sharma A, Ricchiuto P, Goh WW, Halu A, Yamada I, Yoshida H, Hara T, Wei M, Inoue N, Fukuda D, Mojcher A, Mattson PC, Barabási AL, Boothby M, Aikawa E, Singh SA, Aikawa M
PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation.
Nat Commun. 2016;7:12849 - PMID: 27796300 - PMCID: PMC5095532 - DOI: 10.1038/ncomms12849
Atkins SK, Cao K, Rajamannan NM, Sucosky P
Bicuspid aortic valve hemodynamics induces abnormal medial remodeling in the convexity of porcine ascending aortas.
Biomech Model Mechanobiol. 2014;13(6):1209-25 - PMID: 24599392 - DOI: 10.1007/s10237-014-0567-7
Atkins SK, Sucosky P
Etiology of bicuspid aortic valve disease: Focus on hemodynamics.
World J Cardiol. 2014;6(12):1227-33 - PMID: 25548612 - PMCID: PMC4278157 - DOI: 10.4330/wjc.v6.i12.1227
Atkins SK, Moore AN, Sucosky P
Bicuspid aortic valve hemodynamics does not promote remodeling in porcine aortic wall concavity.
World J Cardiol. 2016;8(1):89-97 - PMID: 26839660 - PMCID: PMC4728110 - DOI: 10.4330/wjc.v8.i1.89
Atkins SK, McNally A, Sucosky P
Mechanobiology in Cardiovascular Disease Management: Potential Strategies and Current Needs.
Front Bioeng Biotechnol. 2016;4:79 - PMID: 27777927 - PMCID: PMC5056184 - DOI: 10.3389/fbioe.2016.00079
Cao K, Atkins SK, McNally A, Liu J, Sucosky P
Simulations of morphotype-dependent hemodynamics in non-dilated bicuspid aortic valve aortas.
J Biomech. 2016;50:63-70 - PMID: 27855987 - DOI: 10.1016/j.jbiomech.2016.11.024
Schlotter F, de Waha S, Eitel I, Desch S, Fuernau G, Thiele H
Interventional post-myocardial infarction ventricular septal defect closure: a systematic review of current evidence.
EuroIntervention. 2016;12(1):94-102
Mangner N, Woitek F, Haussig S, Schlotter F, Stachel G, Höllriegel R, Wilde J, Lindner A, Holzhey D, Leontyev S, Mohr FW, Schuler G, Linke A
Incidence, Predictors, and Outcome of Patients Developing Infective Endocarditis Following Transfemoral Transcatheter Aortic Valve Replacement.
J Am Coll Cardiol. 2016;67(24):2907-8
Hjortnaes J, Keegan J, Bruneval P, Schwartz E, Schoen FJ, Carpentier A, Levine RA, Hagège A, Aikawa E
Comparative Histopathological Analysis of Mitral Valves in Barlow Disease and Fibroelastic Deficiency.
Semin Thorac Cardiovasc Surg. 2016;28(4):757-767 - PMID: 28417861 - DOI: 10.1053/j.semtcvs.2016.08.015
Hjortnaes J, Keegan J, Bruneval P, Schwartz E, Schoen FJ, Carpentier A, Levine RA, Hagège A, Aikawa E
Comparative Histopathological Analysis of Mitral Valves in Barlow Disease and Fibroelastic Deficiency.
Semin Thorac Cardiovasc Surg. 2016;28(4):757-767
Singh SA, Aikawa M
Unbiased and targeted mass spectrometry for the HDL proteome.
Curr Opin Lipidol. 2016;28(1):68-77 - PMID: 28002079 - PMCID: PMC6211176 - DOI: 10.1097/MOL.0000000000000374
Yabusaki K, Hutcheson JD, Vyas P, Bertazzo S, Body SC, Aikawa M, Aikawa E
Quantification of Calcified Particles in Human Valve Tissue Reveals Asymmetry of Calcific Aortic Valve Disease Development.
Front Cardiovasc Med. 2016;3:44 - PMID: 27867942 - PMCID: PMC5095138 - DOI: 10.3389/fcvm.2016.00044
Lee LH, Andraski AB, Pieper B, Higashi H, Sacks FM, Aikawa M, Singh SA
Automation of PRM-dependent D3-Leu tracer enrichment in HDL to study the metabolism of apoA-I, LCAT and other apolipoproteins.
Proteomics. 2016;17(1-2):ePub - PMID: 27862954 - PMCID: PMC5572145 - DOI: 10.1002/pmic.201600085
Bischoff J, Casanovas G, Wylie-Sears J, Kim DH, Bartko P, Guerrero J, Dal-Bianco J, Beaudoin J, Garcia M, Sullivan , Seybolt M, Morris B, Keegan J, Irvin W, Aikawa E, Levine R
CD45 Expression in Mitral Valve Endothelial Cells After Myocardial Infarction.
Circ Res. 2016;119(11):1215-1225 - PMID: 27750208 - PMCID: PMC5215059 - DOI: 10.1161/CIRCRESAHA.116.309598
Dweck MR, Aikawa E, Newby DE, Tarkin JM, Rudd JH, Narula J, Fayad ZA
Noninvasive Molecular Imaging of Disease Activity in Atherosclerosis.
Circ Res. 2016;119(2):330-40 - PMID: 27390335 - PMCID: PMC4939871 - DOI: 10.1161/CIRCRESAHA.116.307971
Aikawa E
Extracellular vesicles in cardiovascular disease: focus on vascular calcification.
J Physiol. 2016;594(11):2877-80
O'Rourke C, Shelton G, Hutcheson JD, Burke MF, Martyn T, Thayer TE, Shakartzi HR, Buswell MD, Tainsh RE, Yu B, Bagchi A, Rhee DK, Wu C, Derwall M, Buys ES, Yu PB, Bloch KD, Aikawa E, Bloch DB, Malhotra R
Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation.
J Vis Exp. 2016;(111):ePub - PMID: 27284788 - PMCID: PMC4927747 - DOI: 10.3791/54017
Ghiassian SD, Menche J, Chasman DI, Giulianini F, Wang R, Ricchiuto P, Aikawa M, Iwata H, Müller C, Zeller T, Sharma A, Wild P, Lackner K, Singh S, Ridker PM, Blankenberg S, Barabási AL, Loscalzo J
Endophenotype Network Models: Common Core of Complex Diseases.
Sci Rep. 2016;6:27414 - PMID: 27278246 - PMCID: PMC4899691 - DOI: 10.1038/srep27414
Aikawa E
Extracellular vesicles in cardiovascular disease: focus on vascular calcification.
J Physiol. 2016;594(11):2877-80 - PMID: 27246548 - PMCID: PMC4887668 - DOI: 10.1113/JP272112
Goettsch C, Hutcheson JD, Hagita S, Rogers MA, Creager MD, Pham T, Choi J, Mlynarchik AK, Pieper B, Kjolby M, Aikawa M, Aikawa E
A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification.
Atherosclerosis. 2016;251:109-118 - PMID: 27318830 - PMCID: PMC4983246 - DOI: 10.1016/j.atherosclerosis.2016.06.011
Mosch J, Gleissner CA, Body S, Aikawa E
Histopathological assessment of calcification and inflammation of calcific aortic valves from patients with and without diabetes mellitus.
Histol Histopathol. 2016;32(3):293-306 - PMID: 27353274 - PMCID: PMC5199639 - DOI: 10.14670/HH-11-797
Nakano T, Fukuda D, Koga JI, Aikawa M
Delta-Like Ligand 4-Notch Signaling in Macrophage Activation.
Arterioscler Thromb Vasc Biol. 2016;36(10):2038-47 - PMID: 27562914 - PMCID: PMC5033717 - DOI: 10.1161/ATVBAHA.116.306926
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