Center for Interdisciplinary Cardiovascular Sciences

New SE, Goettsch C, Aikawa M, Marchini JF, Shibasaki M, Yabusaki K, Libby P, Shanahan CM, Croce K, Aikawa E

Macrophage-Derived Matrix Vesicles: An Alternative Novel Mechanism for Microcalcification in Atherosclerotic Plaques.

Circ Res. 2013;113(1):72-77 - PMID: 23616621 - PMCID: PMC3703850 - DOI: 10.1161/CIRCRESAHA.113.301036

Miyazaki T, Chiuve S, Sacks FM, Ridker PM, Libby P, Aikawa M

Plasma Pentraxin 3 Levels Do Not Predict Coronary Events but Reflect Metabolic Disorders in Patients with Coronary Artery Disease in the CARE Trial.

PLOS One. 2014;9(4):e94073 - PMID: 24705587 - PMCID: PMC3976379 - DOI: 10.1371/journal.pone.0094073

Rogers MA, Aikawa E

Modifying Vascular Calcification in Diabetes Mellitus: Contribution of O-GlcNAcylation.

Circ Res. 2014;114(7):1074-6 - PMID: 24677232 - PMCID: PMC3989539 - DOI: 10.1161/CIRCRESAHA.114.303684

Yabusaki K, Faits T, McMullen E, Figueiredo JL, Aikawa M, Aikawa E

A novel quantitative approach for eliminating sample-to-sample variation using a hue saturation value analysis program.

PLOS One. 2014;9(3):e89627 - PMID: 24595280 - PMCID: PMC3940696 - DOI: 10.1371/journal.pone.0089627

Itou T, Maldonado N, Yamada I, Goettsch C, Matsumoto J, Aikawa M, Singh S, Aikawa E

Cystathionine γ-lyase Accelerates Osteoclast Differentiation: Identification of a Novel Regulator of Osteoclastogenesis by Proteomic Analysis.

Arterioscler Thromb Vasc Biol. 2013;34(3):626-634 - PMID: 24357058 - PMCID: PMC3959796 - DOI: 10.1161/ATVBAHA.113.302576

Rogers M, Goettsch C, Aikawa E

Medial and intimal calcification in chronic kidney disease: stressing the contributions.

J Am Heart Assoc. 2013;2(5):e000481 - PMID: 24060959 - PMCID: PMC3835265 - DOI: 10.1161/JAHA.113.000481

Fukuda D, Aikawa M

Expanding Role of Delta-Like 4 Mediated Notch Signaling in Cardiovascular and Metabolic Diseases.

Circ J. 2013;77(10):2462-8 - PMID: 24025398 - PMCID: PMC4545641 - DOI: 10.1253/circj.cj-13-0873

New SE, Aikawa E

Role of Extracellular Vesicles in De Novo Mineralization: An Additional Novel Mechanism of Cardiovascular Calcification.

Arterioscler Thromb Vasc Biol. 2013;33(8):1753-8 - PMID: 23766262 - PMCID: PMC3788633 - DOI: 10.1161/ATVBAHA.112.300128

Wang JG, Aikawa E, Aikawa M

Leukocyte-derived Microparticles as Pro-inflammatory Mediators in Atherosclerosis.

J Am Coll Cardiol. 2013;62(16):1442-1445 - PMID: 23707315 - DOI: 10.1016/j.jacc.2013.04.054

Zheng C, Morishige K, Aikawa M

Functional Molecular Imaging Linking Macrophages to Reverse Cholesterol Transport.

Circ J. 2013;77(6):1403-1406 - PMID: 23685734 - DOI: 10.1253/circj.cj-13-0566

Goettsch C, Iwata H, Aikawa E

Parathyroid hormone: critical bridge between bone metabolism and cardiovascular disease.

Arterioscler Thromb Vasc Biol. 2014;34(7):1333-5 - PMID: 24951650 - PMCID: PMC4094346 - DOI: 10.1161/ATVBAHA.114.303637

Goettsch C, Hutcheson JD, Aikawa E

MicroRNA in Cardiovascular Calcification: Focus on Targets and Extracellular Vesicle Delivery Mechanisms.

Circ Res. 2013;112(7):1073-84 - PMID: 23538277 - PMCID: PMC3668680 - DOI: 10.1161/CIRCRESAHA.113.300937

Iwata H, Aikawa M

Liver-Artery Interactions via the Plasminogen-CD36 Axis in Macrophage Foam Cell Formation: New Evidence for the Role of Remote Organ Crosstalk in Atherosclerosis.

Circulation. 2013;127(11):1173-6 - PMID: 23509031 - DOI: 10.1161/CIRCULATIONAHA.113.001461

Hutcheson JD, Chen J, Sewell-Loftin MK, Ryzhova LM, Fisher CI, Su YR, Merryman WD

Cadherin-11 regulates cell-cell tension necessary for calcific nodule formation by valvular myofibroblasts.

Arterioscler Thromb Vasc Biol. 2012;33(1):114-20 - PMID: 23162011 - PMCID: PMC3536033 - DOI: 10.1161/ATVBAHA.112.300278

Zheng C, Aikawa M

High-Density Lipoproteins: From Function to Therapy.

J Am Coll Cardiol. 2012;60(23):2380-3 - PMID: 23141492 - DOI: 10.1016/j.jacc.2012.08.999

Yoshida H, Ashikawa Y, Itoh S, Nakagawa T, Asanuma A, Tanabe S, Inoue Y, Hidaka H

K-134, a phosphodiesterase 3 inhibitor, prevents brain damage by inhibiting thrombus formation in a rat cerebral infarction model.

PLOS One. 2012;7(10):e46432 - PMID: 23110051 - PMCID: PMC3479105 - DOI: 10.1371/journal.pone.0046432

Hutcheson JD, Schlicher RK, Hicks HK, Prausnitz MR

Saving cells from ultrasound-induced apoptosis: quantification of cell death and uptake following sonication and effects of targeted calcium chelation.

Ultrasound Med Biol. 2010;36(6):1008-21 - PMID: 20447754 - PMCID: PMC2878894 - DOI: 10.1016/j.ultrasmedbio.2010.03.011

Kamaev PP, Hutcheson JD, Wilson ML, Prausnitz MR

Quantification of optison bubble size and lifetime during sonication dominant role of secondary cavitation bubbles causing acoustic bioeffects.

J Acoust Soc Am. 2004;115(4):1818-25 - PMID: 15101659 - DOI: 10.1121/1.1624073

Choi SO, Kim YC, Park JH, Hutcheson J, Gill HS, Yoon YK, Prausnitz MR, Allen MG

An electrically active microneedle array for electroporation.

Biomed Microdevices. 2010;12(2):263-73 - PMID: 20012696 - PMCID: PMC2905216 - DOI: 10.1007/s10544-009-9381-x

Schlicher RK, Hutcheson JD, Radhakrishna H, Apkarian RP, Prausnitz MR

Changes in cell morphology due to plasma membrane wounding by acoustic cavitation.

Ultrasound Med Biol. 2010;36(4):677-92 - PMID: 20350691 - PMCID: PMC2848178 - DOI: 10.1016/j.ultrasmedbio.2010.01.010

Hutcheson JD, Goettsch C, Rogers MA, Aikawa E

Revisiting Cardiovascular Calcification: A Multifaceted Disease Requiring a Multidisciplinary Approach.

Semin Cell Dev Biol. 2015;46:68-77 - PMID: 26358815 - DOI: 10.1016/j.semcdb.2015.09.004

Atkins SK, Cao K, Rajamannan NM, Sucosky P

Bicuspid aortic valve hemodynamics induces abnormal medial remodeling in the convexity of porcine ascending aortas.

Biomech Model Mechanobiol. 2014;13(6):1209-25 - PMID: 24599392 - DOI: 10.1007/s10237-014-0567-7

Atkins SK, Sucosky P

Etiology of bicuspid aortic valve disease: Focus on hemodynamics.

World J Cardiol. 2014;6(12):1227-33 - PMID: 25548612 - PMCID: PMC4278157 - DOI: 10.4330/wjc.v6.i12.1227

Schlotter F, Matsumoto Y, Mangner N, Schuler G, Linke A, Adams V

Regular exercise or changing diet does not influence aortic valve disease progression in LDLR deficient mice.

PLOS One. 2012;7(5):e37298 - PMCID: PMC3351435

Joshi D, Mazimba S, Neal Kay G, Nanda NC, Fan P, Schlotter F, Venkataraman R, Dumaswala B, Dumaswala K

Role of live/real time three-dimensional transesophageal echocardiography in the percutaneous epicardial closure of the left atrial appendage.

Echocardiography. 2012;29(10):1256-60

Schlotter F, Haussig S, Schuler G, Linke A

Valve-in-valve Medtronic CoreValve implantation into a degenerated transapical Ventor Embracer aortic valve bioprosthesis.

Clin Res Cardiol. 2015;104(10):908-10

Sun X, Haas ME, Miao J, Mehta A, Graham MJ, Crooke RM, de Barros JP, Wang JG, Aikawa M, Masson D, Biddinger SB

Insulin dissociates the effects of Liver X Receptor on lipogenesis, endoplasmic reticulum stress and inflammation.

J Biol Chem. 2015;291(3):1115-1122 - PMID: 26511317 - PMCID: PMC4714195 - DOI: 10.1074/jbc.M115.668269

Levine RA, Hagége AA, Judge DP, Padala M, Dal-Bianco JP, Aikawa E, Beaudoin J, Bischoff J, Bouatia-Naji N, Bruneval P, Butcher JT, Carpentier A, Chaput M, Chester AH, Clusel C, Delling FN, Dietz HC, Dina C, Durst R, Fernandez-Friera L, Handschumacher MD, Jensen MO, Jeunemaitre XP, Marec HL, Tourneau TL, Markwald RR, Mérot J, Messas E, Milan DP, Neri T, Norris RA, Peal D, Perrocheau M, Probst V, Pucéat M, Rosenthal N, Solis J, Schott JJ, Schwammenthal E, Slaugenhaupt SA, Song JK, Yacoub MH,

Mitral valve disease-morphology and mechanisms.

Nat Rev Cardiol. 2015;12(12):689-710 - PMID: 26483167 - PMCID: PMC4804623 - DOI: 10.1038/nrcardio.2015.161

Wang JG, Aikawa M

Toll-Like Receptors and Src-Family Kinases in Atherosclerosis　- Focus on Macrophages.

Circ J. 2015;79(11):2332-2334 - PMID: 26467082 - DOI: 10.1253/circj.CJ-15-1039

Shibasaki M, Wang JG, Figueiredo JL, New SE, Quillard T, Goettsch C, Koga JI, Sonoki H, Matsumoto J, Aikawa M, Aikawa E

Pitavastatin Reduces Inflammation in Atherosclerotic Plaques in Apolipoprotein E-Deficient Mice with Late Stage Renal Disease.

PLOS One. 2015;10(9):e0138047 - PMID: 26367531 - PMCID: PMC4569429 - DOI: 10.1371/journal.pone.0138047

Hutcheson JD, Setola V, Roth BL, Merryman WD

Serotonin receptors and heart valve disease--it was meant 2B.

Pharmacol Ther. 2011;132(2):146-57 - PMID: 21440001 - PMCID: PMC3179857 - DOI: 10.1016/j.pharmthera.2011.03.008

Singh SA, Miyosawa K, Aikawa M

Mass spectrometry meets the challenge of understanding the complexity of the lipoproteome: recent findings regarding proteins involved in dyslipidemia and cardiovascular disease.

Expert Rev Proteomics. 2015;12(5):519-32 - PMID: 26325144 - DOI: 10.1586/14789450.2015.1078731

Ricchiuto P, Iwata H, Yabusaki K, Yamada I, Pieper B, Sharma A, Aikawa M, Singh SA

mIMT-visHTS: A novel method for multiplexing isobaric mass tagged datasets with an accompanying visualization high throughput screening tool for protein profiling.

J Proteomics. 2015;128:132-140 - PMID: 26232111 - DOI: 10.1016/j.jprot.2015.07.024

Hjortnaes J, Shapero K, Goettsch C, Hutcheson JD, Keegan J, Kluin J, Mayer JE, Bischoff J, Aikawa E

Valvular interstitial cells suppress calcification of valvular endothelial cells.

Atherosclerosis. 2015;242(1):251-260 - PMID: 26232165 - PMCID: PMC4546848 - DOI: 10.1016/j.atherosclerosis.2015.07.008

Rogers MA, Aikawa E

A Not-so-Little Role for Lp(a) in the Development of Calcific Aortic Valve Disease.

Circulation. 2015;132(8):621-3 - PMID: 26224809 - PMCID: PMC4550561 - DOI: 10.1161/CIRCULATIONAHA.115.018139

Sasaki Y, Ohta M, Desai D, Figueiredo JL, Whelan MC, Sugano T, Yamabi M, Yano W, Faits T, Yabusaki K, Zhang H, Mlynarchik AK, Inoue K, Mizuno K, Aikawa M

Angiopoietin Like Protein 2 (ANGPTL2) Promotes Adipose Tissue Macrophage and T lymphocyte Accumulation and Leads to Insulin Resistance.

PLOS One. 2015;10(7):e0131176 - PMID: 26132105 - PMCID: PMC4489192 - DOI: 10.1371/journal.pone.0131176

Miyosawa K, Watanabe Y, Murakami K, Murakami T, Shibata H, Iwashita M, Yamazaki H, Yamazaki K, Ohgiya T, Shibuya K, Mizuno K, Tanabe S, Singh SA, Aikawa M

New CETP Inhibitor K-312 Reduces PCSK9 Expression: A Potential Effect on LDL Cholesterol Metabolism.

Am J Physiol Endocrinol Metab. 2015;309(2):E177-90 - PMID: 26015437 - DOI: 10.1152/ajpendo.00528.2014

Lei Y, Iwashita M, Choi J, Aikawa M, Aikawa E

N-acetylglucosamine-1-Phosphate Transferase Suppresses Lysosomal Hydrolases in Dysfunctional Osteoclasts: A Potential Mechanism for Vascular Calcification

J. Cardiovasc. Dev. Dis. 2015;2:31-47 - PMID: 29371511 - PMCID: PMC5753093 - DOI: 10.3390/jcdd2020031

Ruiz JL, Hutcheson JD, Aikawa E

Cardiovascular calcification: current controversies and novel concepts.

Cardiovasc Pathol. 2015;24(4):207-212 - PMID: 25797772 - DOI: 10.1016/j.carpath.2015.03.002

Hutcheson JD, Maldonado N, Aikawa E

Small entities with large impact: microcalcifications and atherosclerotic plaque vulnerability.

Curr Opin Lipidol. 2014;25(5):327-332 - PMID: 25188916 - PMCID: PMC4166045 - DOI: 10.1097/MOL.0000000000000105

Kataoka K, Nannya Y, Iwata H, Seo S, Kumano K, Takahashi T, Nagai R, Kurokawa M

Plasma brain natriuretic peptide is associated with hepatic veno-occlusive disease and early mortality after allogeneic hematopoietic stem cell transplantation.

Bone Marrow Transplant. 2010;45(11):1631-7 - PMID: 20173786 - DOI: 10.1038/bmt.2010.26

Takeda N, Manabe I, Shindo T, Iwata H, Iimuro S, Kagechika H, Shudo K, Nagai R

Synthetic retinoid Am80 reduces scavenger receptor expression and atherosclerosis in mice by inhibiting IL-6.

Arterioscler Thromb Vasc Biol. 2006;26(5):1177-83 - PMID: 16484594 - DOI: 10.1161/01.ATV.0000214296.94849.1c

Iwata H, Sata M

Potential contribution of bone marrow-derived precursors to vascular repair and lesion formation: lessons from animal models of vascular diseases.

Front Biosci. 2007;12:4157-67 - PMID: 17485364 - DOI: 10.2741/2377

Nakamura K, Sata M, Iwata H, Sakai Y, Hirata Y, Kugiyama K, Nagai R

A synthetic small molecule, ONO-1301, enhances endogenous growth factor expression and augments angiogenesis in the ischaemic heart.

Clin Sci (Lond). 2007;112(12):607-16 - PMID: 17263691 - DOI: 10.1042/CS20060301

Iwata H, Ako J, Nagai R

Recurrence of late-acquired incomplete stent apposition following sirolimus-eluting stent implantation.

J Invasive Cardiol. 2008;20(9):E265-8 - PMID: 18762685

Iwata H, Sata M

Origin of cells that contribute to neointima growth.

Circulation. 2008;117(24):3060-1 - PMID: 18559712 - DOI: 10.1161/CIRCULATIONAHA.108.782961

Iwata H, Nakamura K, Sumi M, Ninomiya M, Sakai Y, Hirata Y, Akaike M, Igarashi T, Takamoto S, Nagai R, Sata M

Local delivery of synthetic prostacycline agonist augments collateral growth and improves cardiac function in a swine chronic cardiac ischemia model.

Life Sci. 2009;85(5-6):255-61 - PMID: 19527738 - DOI: 10.1016/j.lfs.2009.06.002

Higashikuni Y, Sainz J, Nakamura K, Takaoka M, Enomoto S, Iwata H, Sahara M, Tanaka K, Koibuchi N, Ito S, Kusuhara H, Sugiyama Y, Hirata Y, Nagai R, Sata M

The ATP-binding cassette transporter BCRP1/ABCG2 plays a pivotal role in cardiac repair after myocardial infarction via modulation of microvascular endothelial cell survival and function.

Arterioscler Thromb Vasc Biol. 2010;30(11):2128-35 - PMID: 20829509 - DOI: 10.1161/ATVBAHA.110.211755

Iwata H, Manabe I, Fujiu K, Yamamoto T, Takeda N, Eguchi K, Furuya A, Kuro-o M, Sata M, Nagai R

Bone marrow-derived cells contribute to vascular inflammation but do not differentiate into smooth muscle cell lineages.

Circulation. 2010;122(20):2048-57 - PMID: 21041690 - DOI: 10.1161/CIRCULATIONAHA.110.965202

Iwata H, Sata M, Ando J, Fujita H, Morita T, Sawaki D, Takahashi M, Hirata Y, Takanashi S, Tabata M, Hirata Y, Nagai R

Impact of primitive cells in intracoronary thrombi on lesion prognosis: temporal analysis of cellular constituents of thrombotic material obtained from patients with acute coronary syndrome.

Heart. 2010;96(10):748-55 - PMID: 20448125 - DOI: 10.1136/hrt.2009.181040