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Phillippi JA, Aikawa E, Hutcheson J
Editorial: Exploring the Frontiers of Regenerative Cardiovascular Medicine.
Front Cardiovasc Med. 2019;6:13 - PMID: 30873414 - PMCID: PMC6401650 - DOI: 10.3389/fcvm.2019.00013
Higashi H, Maejima T, Lee LH, Yamazaki Y, Hottiger MO, Singh SA, Aikawa M
A study into the ADP-ribosylome of IFN-γ-stimulated THP-1 human macrophage-like cells identifies ARTD8/PARP14 and ARTD9/PARP9 ADP-ribosylation.
J Proteome Res. 2019;18(4):1607-1622 - PMID: 30848916 - PMCID: PMC6456868 - DOI: 10.1021/acs.jproteome.8b00895
Goto S, Rogers MA, Blaser MC, Higashi H, Lee LH, Schlotter F, Body SC, Aikawa M, Singh SA, Aikawa E
Standardization of Human Calcific Aortic Valve Disease in vitro Modeling Reveals Passage-Dependent Calcification.
Front Cardiovasc Med. 2019;6:49 - PMID: 31041314 - PMCID: PMC6476921 - DOI: 10.3389/fcvm.2019.00049
Zheng KH, Tsimikas S, Pawade T, Kroon J, Jenkins WSA, Doris MK, White AC, Timmers NKLM, Hjortnaes J, Rogers MA, Aikawa E, Arsenault BJ, Witztum JL, Newby DE, Koschinsky ML, Fayad ZA, Stroes ESG, Boekholdt SM, Dweck MR
Lipoprotein(a) and Oxidized Phospholipids Promote Valve Calcification in Patients With Aortic Stenosis.
J Am Coll Cardiol. 2019;73(17):2150-2162 - PMID: 31047003 - PMCID: PMC6494952 - DOI: 10.1016/j.jacc.2019.01.070
Grunewald ME, Chen Y, Kuny C, Maejima T, Lease R, Ferraris D, Aikawa M, Sullivan CS, Perlman S, Fehr AR
The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression.
PLoS Pathog. 2019;15(5):e1007756 - PMID: 31095648 - PMCID: PMC6521996 - DOI: 10.1371/journal.ppat.1007756
Fruchart JC, Santos RD, Aguilar-Salinas C, Aikawa M, Al Rasadi K, Amarenco P, Barter PJ, Ceska R, Corsini A, Després JP, Duriez P, Eckel RH, Ezhov MV, Farnier M, Ginsberg HN, Hermans MP, Ishibashi S, Karpe F, Kodama T, Koenig W, Krempf M, Lim S, Lorenzatti AJ, McPherson R, Nuñez-Cortes JM, Nordestgaard BG, Ogawa H, Packard CJ, Plutzky J, Ponte-Negretti CI, Pradhan A, Ray KK, Reiner Ž, Ridker PM, Ruscica M, Sadikot S, Shimano H, Sritara P, Stock JK, Su TC, Susekov AV, Tartar A, Taskinen MR, Tenenbaum A, Tokgözoğlu LS, Tomlinson B, Tybjærg-Hansen A, Valensi P, Vrablík M, Wahli W, Watts GF, Yamashita S, Yokote K, Zambon A, Libby P
The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: conceptual framework and therapeutic potential : A consensus statement from the International Atherosclerosis Society (IAS) and the Residual Risk Reduction Initiative (R3i) Foundation.
Cardiovasc Diabetol. 2019;18(1):71 - PMID: 31164165 - PMCID: PMC6549355 - DOI: 10.1186/s12933-019-0864-7
Atkins SK, Aikawa E
Valve under the microscope: shining a light on emerging technologies elucidating disease mechanisms.
Heart. 2019;105(21):1610-1611 - PMID: 31296591 - PMCID: PMC6855786 - DOI: 10.1136/heartjnl-2019-315236
Aikawa M, Manabe I, Marx N
Editorial: New Trends in Vascular Inflammation Research: From Biology to Therapy.
Front Cardiovasc Med. 2019;6:102 - PMID: 31555666 - PMCID: PMC6722177 - DOI: 10.3389/fcvm.2019.00102
Andraski AB, Singh SA, Lee LH, Higashi H, Smith N, Zhang B, Aikawa M, Sacks FM
Effects of Replacing Dietary Monounsaturated Fat With Carbohydrate on HDL (High-Density Lipoprotein) Protein Metabolism and Proteome Composition in Humans.
Arterioscler Thromb Vasc Biol. 2019;39(11):2411-2430 - PMID: 31554421 - PMCID: PMC6874109 - DOI: 10.1161/ATVBAHA.119.312889
Arima N, Sasaki Y, Lee LH, Zhang H, Figueiredo JL, Mlynarchik AK, Qiao J, Yamada I, Higashi H, Ha AH, Halu A, Mizuno K, Singh SA, Yamazaki Y, Aikawa M
Multi-organ systems study reveals Igfbp7 as a suppressor of gluconeogenesis after gastric bypass surgery.
J Proteome Res. 2019;19(1):129-143 - PMID: 31661273 - DOI: 10.1021/acs.jproteome.9b00441
Rogers MA, Aikawa E
MicroRNA Extracellular Vesicle Stowaways in Cell-Cell Communication and Organ Crosstalk.
Arterioscler Thromb Vasc Biol. 2019;39(12):2448-2450 - PMID: 31770027 - PMCID: PMC6980729 - DOI: 10.1161/ATVBAHA.119.313533
Rogers MA, Chen J, Nallamshetty S, Pham T, Goto S, Muehlschlegel JD, Libby P, Aikawa M, Aikawa E, Plutzky J
Retinoids Repress Human Cardiovascular Cell Calcification With Evidence for Distinct Selective Retinoid Modulator Effects.
Arterioscler Thromb Vasc Biol. 2019;40(3):656-669 - PMID: 31852220 - PMCID: PMC7047603 - DOI: 10.1161/ATVBAHA.119.313366
Nakato R, Wada Y, Nakaki R, Nagae G, Katou Y, Tsutsumi S, Nakajima N, Fukuhara H, Iguchi A, Kohro T, Kanki Y, Saito Y, Kobayashi M, Izumi-Taguchi A, Osato N, Tatsuno K, Kamio A, Hayashi-Takanaka Y, Wada H, Ohta S, Aikawa M, Nakajima H, Nakamura M, McGee RC, Heppner KW, Kawakatsu T, Genno M, Yanase H, Kume H, Senbonmatsu T, Homma Y, Nishimura S, Mitsuyama T, Aburatani H, Kimura H, Shirahige K
Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells.
Epigenetics Chromatin. 2019;12(1):77 - PMID: 31856914 - PMCID: PMC6921469 - DOI: 10.1186/s13072-019-0319-0
Marsit O, Clavel MA, Côté-Laroche C, Hadjadj S, Bouchard MA, Handschumacher MD, Clisson M, Drolet MC, Boulanger MC, Kim DH, Guerrero JL, Bartko PE, Couet J, Arsenault M, Mathieu P, Pibarot P, Aïkawa E, Bischoff J, Levine RA, Beaudoin J
Attenuated Mitral Leaflet Enlargement Contributes to Functional Mitral Regurgitation After Myocardial Infarction.
J Am Coll Cardiol. 2020;75(4):395-405 - PMID: 32000951 - PMCID: PMC7946170 - DOI: 10.1016/j.jacc.2019.11.039
Fehr AR, Singh SA, Kerr CM, Mukai S, Higashi H, Aikawa M
The impact of PARPs and ADP-ribosylation on inflammation and host-pathogen interactions.
Genes Dev. 2020;34(5-6):341-359 - PMID: 32029454 - PMCID: PMC7050484 - DOI: 10.1101/gad.334425.119
Rogers MA, Aikawa E
Complex association of lipoprotein(a) with aortic stenosis.
Heart. 2020;106(10):711-712 - PMID: 32086294 - DOI: 10.1136/heartjnl-2019-316498
Engelbrecht E, Levesque MV, He L, Vanlandewijck M, Nitzsche A, Niazi H, Kuo A, Singh SA, Aikawa M, Holton K, Proia RL, Kono M, Pu WT, Camerer E, Betsholtz C, Hla T
Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta.
Elife. 2020;9:ePub - PMID: 32091396 - PMCID: PMC7054001 - DOI: 10.7554/eLife.52690
Figueiredo JL, Santa-Cruz F, Lima-Filho JL, Hilgendorf I, Aikawa M, Pittet MJ, Nahrendorf M, Weissleder R, Swirski FK, Robbins CS
A durable murine model of spleen transplantation with arterial and venous anastomoses.
Sci Rep. 2020;10(1):3979 - PMID: 32132617 - PMCID: PMC7055260 - DOI: 10.1038/s41598-020-60983-7
Passos LSA, Lupieri A, Becker-Greene D, Aikawa E
Innate and adaptive immunity in cardiovascular calcification.
Atherosclerosis. 2020;306:59-67 - PMID: 32222287 - PMCID: PMC7483874 - DOI: 10.1016/j.atherosclerosis.2020.02.016
Toyohara T, Roudnicky F, Florido MHC, Nakano T, Yu H, Katsuki S, Lee M, Meissner T, Friesen M, Davidow LS, Ptaszek L, Abe T, Rubin LL, Pereira AC, Aikawa M, Cowan CA
Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis.
Cell Stem Cell. 2020;27(1):147-157.e7 - PMID: 32413331 - PMCID: PMC8530449 - DOI: 10.1016/j.stem.2020.04.018
Watanabe Y, Takase K, Okada K, Aikawa M, Okamoto K, Koyama I
Portal vein aneurysm with complete spontaneous regression after 10 years using conservative treatment.
Clin J Gastroenterol. 2020;13(5):940-945 - PMID: 32449089 - DOI: 10.1007/s12328-020-01131-6
Kawakami R, Katsuki S, Travers R, Romero DC, Becker-Greene D, Araujo Passos LS, Higashi H, Blaser MC, Sukhova GK, Buttigieg J, Kopriva D, Schmidt AM, Anderson DG, Singh SA, Cardoso L, Weinbaum S, Libby P, Aikawa M, Croce K, Aikawa E
S100A9-RAGE Axis Accelerates Formation of Macrophage-Mediated Extracellular Vesicle Microcalcification in Diabetes Mellitus.
Arterioscler Thromb Vasc Biol. 2020;40(8):1838-1853 - PMID: 32460581 - PMCID: PMC7377960 - DOI: 10.1161/ATVBAHA.118.314087
Toyohara T, Roudnicky F, Florido MHC, Nakano T, Yu H, Katsuki S, Lee M, Meissner T, Friesen M, Davidow LS, Ptaszek L, Abe T, Rubin LL, Pereira AC, Aikawa M, Cowan CA
Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis.
Cell Stem Cell. 2020;27(1):178-180 - PMID: 32619513 - DOI: 10.1016/j.stem.2020.05.013
Christensen JL, Tan S, Chung HE, Ghosalkar DS, Qureshi R, Chu A, Yu W, Berus J, Shah NR, Wu WC, Chun H, Aikawa E, Choudhary G, Morrison AR
Aortic valve calcification predicts all-cause mortality independent of coronary calcification and severe stenosis.
Atherosclerosis. 2020;307:16-20 - PMID: 32702536 - PMCID: PMC7583087 - DOI: 10.1016/j.atherosclerosis.2020.06.019
Masoumi N, Copper D, Chen P, Cubberley A, Guo K, Lin RZ, Ahmed B, Martin D, Aikawa E, Melero-Martin J, Mayer J
Elastomeric Fibrous Hybrid Scaffold Supports In Vitro and In Vivo Tissue Formation.
Adv Funct Mater. 2017;27(27):ePub - PMID: 32863817 - PMCID: PMC7450820 - DOI: 10.1002/adfm.201606614
Rogers MA, Buffolo F, Schlotter F, Atkins SK, Lee LH, Halu A, Blaser MC, Tsolaki E, Higashi H, Luther K, Daaboul G, Bouten CVC, Body SC, Singh SA, Bertazzo S, Libby P, Aikawa M, Aikawa E
Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis.
Sci Adv. 2020;6(38):ePub - PMID: 32938681 - PMCID: PMC7494353 - DOI: 10.1126/sciadv.abb1244
Nunes MCP, Levine RA, Braulio R, Pascoal-Xavier MA, Elmariah S, Gomes NFA, Soares JR, Esteves WAM, Zeng X, Dal-Bianco JP, Passos LSA, Passaglia LG, Ribeiro VT, Gelape CL, Costa PHN, Lodi-Junqueira L, Dutra W, Tan TC, Aikawa E, Hung J
Mitral Regurgitation After Percutaneous Mitral Valvuloplasty: Insights Into Mechanisms and Impact on Clinical Outcomes.
JACC Cardiovasc Imaging. 2020;13(12):2513-2526 - PMID: 32950446 - PMCID: PMC7861508 - DOI: 10.1016/j.jcmg.2020.07.020
Brandão SCS, Ramos JOX, Dompieri LT, Godoi ETAM, Figueiredo JL, Sarinho ESC, Chelvanambi S, Aikawa M
Is Toll-like receptor 4 involved in the severity of COVID-19 pathology in patients with cardiometabolic comorbidities?
Cytokine Growth Factor Rev. 2020;58:102-110 - PMID: 32988728 - PMCID: PMC7505161 - DOI: 10.1016/j.cytogfr.2020.09.002
Rogers MA, Aikawa E
An (Auto)Taxing Effort to Mechanistically Link Obesity and Calcific Aortic Valve Disease.
JACC Basic Transl Sci. 2020;5(9):898-900 - PMID: 33016951 - PMCID: PMC7524779 - DOI: 10.1016/j.jacbts.2020.04.016
Aikawa E, Blaser MC
2020 Jeffrey M. Hoeg Award Lecture: Calcifying Extracellular Vesicles as Building Blocks of Microcalcifications in Cardiovascular Disorders.
Arterioscler Thromb Vasc Biol. 2020;41(1):117-127 - PMID: 33115271 - PMCID: PMC7832175 - DOI: 10.1161/ATVBAHA.120.314704
Bartoli-Leonard F, Aikawa E
Heart Valve Disease: Challenges and New Opportunities.
Front Cardiovasc Med. 2020;7:602271 - PMID: 33195488 - PMCID: PMC7642276 - DOI: 10.3389/fcvm.2020.602271
Iqbal F, Lupieri A, Aikawa M, Aikawa E
Harnessing Single-Cell RNA Sequencing to Better Understand How Diseased Cells Behave the Way They Do in Cardiovascular Disease.
Arterioscler Thromb Vasc Biol. 2020;41(2):585-600 - PMID: 33327741 - PMCID: PMC8105278 - DOI: 10.1161/ATVBAHA.120.314776
Schlotter F, de Freitas RCC, Rogers MA, Blaser MC, Wu PJ, Higashi H, Halu A, Iqbal F, Andraski AB, Rodia CN, Kuraoka S, Wen JR, Creager M, Pham T, Hutcheson JD, Body SC, Kohan AB, Sacks FM, Aikawa M, Singh SA, Aikawa E
ApoC-III is a novel inducer of calcification in human aortic valves.
J Biol Chem. 2020;296:100193 - PMID: 33334888 - PMCID: PMC7948477 - DOI: 10.1074/jbc.RA120.015700
Singh SA, Andraski AB, Higashi H, Lee LH, Ramsaroop A, Sacks FM, Aikawa M
Metabolism of PLTP, CETP, and LCAT on multiple HDL sizes using the Orbitrap Fusion Lumos.
JCI Insight. 2020;6(3):ePub - PMID: 33351780 - PMCID: PMC7934878 - DOI: 10.1172/jci.insight.143526
Okui T, Iwashita M, Rogers MA, Halu A, Atkins SK, Kuraoka S, Abdelhamid I, Higashi H, Ramsaroop A, Aikawa M, Singh SA, Aikawa E
CROT (Carnitine O-Octanoyltransferase) Is a Novel Contributing Factor in Vascular Calcification via Promoting Fatty Acid Metabolism and Mitochondrial Dysfunction.
Arterioscler Thromb Vasc Biol. 2020;41(2):755-768 - PMID: 33356393 - PMCID: PMC8105275 - DOI: 10.1161/ATVBAHA.120.315007
Atkins SK, Singh SA, Aikawa E
Calcific Aortic Valve Disease "Omics"; Is Timely, But Are We Looking Too Late?
JACC Basic Transl Sci. 2020;5(12):1178-1180 - PMID: 33427821 - PMCID: PMC7775952 - DOI: 10.1016/j.jacbts.2020.11.001
Uiterwijk M, Smits AIPM, van Geemen D, van Klarenbosch B, Dekker S, Cramer MJ, van Rijswijk JW, Lurier EB, Di Luca A, Brugmans MCP, Mes T, Bosman AW, Aikawa E, Gründeman PF, Bouten CVC, Kluin J
In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Elastomeric Tissue-Engineered Heart Valves.
JACC Basic Transl Sci. 2020;5(12):1187-1206 - PMID: 33426376 - PMCID: PMC7775962 - DOI: 10.1016/j.jacbts.2020.09.011
Passos LSA, Nunes MCP, Zilla P, Yacoub MH, Aikawa E
Raising awareness for rheumatic mitral valve disease.
Glob Cardiol Sci Pract. 2020;2020(2):e202026 - PMID: 33426043 - PMCID: PMC7768627 - DOI: 10.21542/gcsp.2020.26
Rogers MA, Hutcheson JD, Okui T, Goettsch C, Singh SA, Halu A, Schlotter F, Higashi H, Wang L, Whelan MC, Mlynarchik AK, Daugherty A, Nomura M, Aikawa M, Aikawa E
Dynamin-related protein 1 inhibition reduces hepatic PCSK9 secretion.
Cardiovasc Res. 2021;117(11):2340-2353 - PMID: 33523181 - PMCID: PMC8479802 - DOI: 10.1093/cvr/cvab034
Passos LSA, Nunes MCP, Aikawa E
Rheumatic Heart Valve Disease Pathophysiology and Underlying Mechanisms.
Front Cardiovasc Med. 2021;7:612716 - PMID: 33537348 - PMCID: PMC7848031 - DOI: 10.3389/fcvm.2020.612716
Majumdar U, Manivannan S, Basu M, Ueyama Y, Blaser MC, Cameron E, McDermott MR, Lincoln J, Cole SE, Wood S, Aikawa E, Lilly B, Garg V
Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling.
Sci Adv. 2021;7(6):ePub - PMID: 33547080 - PMCID: PMC7864581 - DOI: 10.1126/sciadv.abe3706
Silva VR, Neves EGA, Passos LSA, Cristina de Melo F, Teixeira-Carvalho A, Nassif MCL, Junqueira LL, Aikawa E, Dutra WO, Nunes MCP
Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis.
Front Cardiovasc Med. 2021;7:604826 - PMID: 33614739 - PMCID: PMC7888299 - DOI: 10.3389/fcvm.2020.604826
Kraler S, Wenzl FA, Akhmedov A, Blaser MC, Aikawa E, Lüscher TF
ApoA-I mimetics improve aortic stenosis-associated left-ventricular diastolic dysfunction but fail to benefit rabbit models with normal aortic valves.
Int J Cardiol. 2021;332:159-161 - PMID: 33626387 - DOI: 10.1016/j.ijcard.2021.02.044
Decano JL, Singh SA, Bueno CG, Lee LH, Halu A, Chelvanambi S, Matamalas JT, Zhang H, Mlynarchik AK, Qiao J, Sharma A, Mukai S, Wang J, Anderson DG, Ozaki CK, Libby P, Aikawa E, Aikawa M
Systems Approach to Discovery of Therapeutic Targets for Vein Graft Disease PPARα Pivotally Regulates Metabolism, Activation, and Heterogeneity of Macrophages and Lesion Development.
Circulation. 2021;143(25):2454-2470 - PMID: 33821665 - PMCID: PMC8212880 - DOI: 10.1161/CIRCULATIONAHA.119.043724
de Freitas RCC, Hirata RDC, Hirata MH, Aikawa E
Circulating Extracellular Vesicles As Biomarkers and Drug Delivery Vehicles in Cardiovascular Diseases.
Biomolecules. 2021;11(3):ePub - PMID: 33808038 - PMCID: PMC8001426 - DOI: 10.3390/biom11030388
Ruiz JL, Hutcheson JD, Cardoso L, Bakhshian Nik A, Condado de Abreu A, Pham T, Buffolo F, Busatto S, Federici S, Ridolfi A, Aikawa M, Bertazzo S, Bergese P, Weinbaum S, Aikawa E
Nanoanalytical analysis of bisphosphonate-driven alterations of microcalcifications using a 3D hydrogel system and in vivo mouse model.
Proc Natl Acad Sci U S A. 2021;118(14):ePub - PMID: 33795519 - PMCID: PMC8040669 - DOI: 10.1073/pnas.1811725118
Jha PK, Vijay A, Halu A, Uchida S, Aikawa M
Gene Expression Profiling Reveals the Shared and Distinct Transcriptional Signatures in Human Lung Epithelial Cells Infected With SARS-CoV-2, MERS-CoV, or SARS-CoV: Potential Implications in Cardiovascular Complications of COVID-19.
Front Cardiovasc Med. 2021;7:623012 - PMID: 33521069 - PMCID: PMC7844200 - DOI: 10.3389/fcvm.2020.623012
Blaser MC, Kraler S, Lüscher TF, Aikawa E
Multi-Omics Approaches to Define Calcific Aortic Valve Disease Pathogenesis.
Circ Res. 2021;128(9):1371-1397 - PMID: 33914608 - PMCID: PMC8095729 - DOI: 10.1161/CIRCRESAHA.120.317979
Bartoli-Leonard F, Aikawa E
Old Drugs for an Old Pathology? Drug Repurposing for Calcific Aortic Valve Disease.
Circ Res. 2021;128(9):1317-1319 - PMID: 33914606 - PMCID: PMC8095786 - DOI: 10.1161/CIRCRESAHA.121.319149
Rogers MA, Aikawa E
Unbiased omics identifies mechanistic regulators of calcific aortic valve disease.
Eur Heart J. 2021;42(30):2948-2950 - PMID: 34179985 - PMCID: PMC8347449 - DOI: 10.1093/eurheartj/ehab381
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