Center for Interdisciplinary Cardiovascular Sciences

Passos LSA, Nunes MCP, Aikawa E

Rheumatic Heart Valve Disease Pathophysiology and Underlying Mechanisms.

Front Cardiovasc Med. 2021;7:612716 - PMID: 33537348 - PMCID: PMC7848031 - DOI: 10.3389/fcvm.2020.612716

Majumdar U, Manivannan S, Basu M, Ueyama Y, Blaser MC, Cameron E, McDermott MR, Lincoln J, Cole SE, Wood S, Aikawa E, Lilly B, Garg V

Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling.

Sci Adv. 2021;7(6):ePub - PMID: 33547080 - PMCID: PMC7864581 - DOI: 10.1126/sciadv.abe3706

Silva VR, Neves EGA, Passos LSA, Cristina de Melo F, Teixeira-Carvalho A, Nassif MCL, Junqueira LL, Aikawa E, Dutra WO, Nunes MCP

Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis.

Front Cardiovasc Med. 2021;7:604826 - PMID: 33614739 - PMCID: PMC7888299 - DOI: 10.3389/fcvm.2020.604826

Kraler S, Wenzl FA, Akhmedov A, Blaser MC, Aikawa E, Lüscher TF

ApoA-I mimetics improve aortic stenosis-associated left-ventricular diastolic dysfunction but fail to benefit rabbit models with normal aortic valves.

Int J Cardiol. 2021;332:159-161 - PMID: 33626387 - DOI: 10.1016/j.ijcard.2021.02.044

Decano JL, Singh SA, Bueno CG, Lee LH, Halu A, Chelvanambi S, Matamalas JT, Zhang H, Mlynarchik AK, Qiao J, Sharma A, Mukai S, Wang J, Anderson DG, Ozaki CK, Libby P, Aikawa E, Aikawa M

Systems Approach to Discovery of Therapeutic Targets for Vein Graft Disease PPARα Pivotally Regulates Metabolism, Activation, and Heterogeneity of Macrophages and Lesion Development.

Circulation. 2021;143(25):2454-2470 - PMID: 33821665 - PMCID: PMC8212880 - DOI: 10.1161/CIRCULATIONAHA.119.043724

de Freitas RCC, Hirata RDC, Hirata MH, Aikawa E

Circulating Extracellular Vesicles As Biomarkers and Drug Delivery Vehicles in Cardiovascular Diseases.

Biomolecules. 2021;11(3):ePub - PMID: 33808038 - PMCID: PMC8001426 - DOI: 10.3390/biom11030388

Ruiz JL, Hutcheson JD, Cardoso L, Bakhshian Nik A, Condado de Abreu A, Pham T, Buffolo F, Busatto S, Federici S, Ridolfi A, Aikawa M, Bertazzo S, Bergese P, Weinbaum S, Aikawa E

Nanoanalytical analysis of bisphosphonate-driven alterations of microcalcifications using a 3D hydrogel system and in vivo mouse model.

Proc Natl Acad Sci U S A. 2021;118(14):ePub - PMID: 33795519 - PMCID: PMC8040669 - DOI: 10.1073/pnas.1811725118

Jha PK, Vijay A, Halu A, Uchida S, Aikawa M

Gene Expression Profiling Reveals the Shared and Distinct Transcriptional Signatures in Human Lung Epithelial Cells Infected With SARS-CoV-2, MERS-CoV, or SARS-CoV: Potential Implications in Cardiovascular Complications of COVID-19.

Front Cardiovasc Med. 2021;7:623012 - PMID: 33521069 - PMCID: PMC7844200 - DOI: 10.3389/fcvm.2020.623012

Blaser MC, Kraler S, Lüscher TF, Aikawa E

Multi-Omics Approaches to Define Calcific Aortic Valve Disease Pathogenesis.

Circ Res. 2021;128(9):1371-1397 - PMID: 33914608 - PMCID: PMC8095729 - DOI: 10.1161/CIRCRESAHA.120.317979

Bartoli-Leonard F, Aikawa E

Old Drugs for an Old Pathology? Drug Repurposing for Calcific Aortic Valve Disease.

Circ Res. 2021;128(9):1317-1319 - PMID: 33914606 - PMCID: PMC8095786 - DOI: 10.1161/CIRCRESAHA.121.319149

Rogers MA, Aikawa E

Unbiased omics identifies mechanistic regulators of calcific aortic valve disease.

Eur Heart J. 2021;42(30):2948-2950 - PMID: 34179985 - PMCID: PMC8347449 - DOI: 10.1093/eurheartj/ehab381

Hutcheson JD, Schlotter F, Creager MD, Li X, Pham T, Vyas P, Higashi H, Body SC, Aikawa M, Singh SA, Kos L, Aikawa E

Elastogenesis Correlates With Pigment Production in Murine Aortic Valve Leaflets.

Front Cardiovasc Med. 2021;8:678401 - PMID: 34239903 - PMCID: PMC8257952 - DOI: 10.3389/fcvm.2021.678401

Bartoli-Leonard F, Aikawa E

Recapitulating the Complex Pathology of Atherosclerosis: Which Model to Use?

Circ Res. 2021;129(4):491-493 - PMID: 34351800 - PMCID: PMC8352010 - DOI: 10.1161/CIRCRESAHA.121.319721

Lupieri A, Nagata Y, Passos LSA, Beker-Greene D, Kirkwood KA, Wylie-Sears J, Alvandi Z, Higashi H, Hung JW, Singh SA, Bischoff J, Levine RA, Aikawa E

Integration of Functional Imaging, Cytometry, and Unbiased Proteomics Reveals New Features of Endothelial-to-Mesenchymal Transition in Ischemic Mitral Valve Regurgitation in Human Patients.

Front Cardiovasc Med. 2021;8:688396 - PMID: 34458332 - PMCID: PMC8387660 - DOI: 10.3389/fcvm.2021.688396

Bartoli-Leonard F, Zimmer J, Aikawa E

Innate and adaptative immunity: The understudied driving force of heart valve disease.

Cardiovasc Res. 2021;117(13):2506-2524 - PMID: 34432007 - PMCID: PMC8783388 - DOI: 10.1093/cvr/cvab273

Meerman M, Driessen R, van Engeland NCA, Bergsma I, Steenhuijsen JLG, Kozono D, Aikawa E, Hjortnaes J, Bouten CVC

Radiation Induces Valvular Interstitial Cell Calcific Response in an in vitro Model of Calcific Aortic Valve Disease.

Front Cardiovasc Med. 2021;8:687885 - PMID: 34527708 - PMCID: PMC8435633 - DOI: 10.3389/fcvm.2021.687885

Zhang H, Chen ZB, Fredman G, Gomez D, Grumbach IM, Huang NF, Nguyen P, Ouimet M, Sutton NR, Aikawa E

What Makes a Great Mentor: Interviews With Recipients of the ATVB Mentor of Women Award.

Arterioscler Thromb Vasc Biol. 2021;41(11):2641-2647 - PMID: 34547925 - PMCID: PMC8551033 - DOI: 10.1161/ATVBAHA.121.316558

Kuraoka S, Higashi H, Yanagihara Y, Sonawane AR, Mukai S, Mlynarchik AK, Whelan MC, Hottiger MO, Nasir W, Delanghe B, Aikawa M, Singh SA

A Novel Spectral Annotation Strategy Streamlines Reporting of mono-ADP-ribosylated Peptides Derived from Mouse Liver and Spleen in Response to IFN-γ.

Mol Cell Proteomics. 2021;21(4):100153 - PMID: 34592425 - PMCID: PMC9014395 - DOI: 10.1016/j.mcpro.2021.100153

Iwata H, Osborn EA, Ughi GJ, Murakami K, Goettsch C, Hutcheson JD, Mauskapf A, Mattson PC, Libby P, Singh SA, Matamalas J, Aikawa E, Tearney GJ, Aikawa M, Jaffer FA

Highly Selective PPARα (Peroxisome Proliferator-Activated Receptor α) Agonist Pemafibrate Inhibits Stent Inflammation and Restenosis Assessed by Multimodality Molecular-Microstructural Imaging.

J Am Heart Assoc. 2021;10(20):e020834 - PMID: 34632804 - PMCID: PMC8751880 - DOI: 10.1161/JAHA.121.020834

van der Ven CFT, Tibbitt MW, Conde J, van Mil A, Hjortnaes J, Doevendans PA, Sluijter JPG, Aikawa E, Langer RS

Controlled delivery of gold nanoparticle-coupled miRNA therapeutics via an injectable self-healing hydrogel.

Nanoscale. 2021;13(48):20451-20461 - PMID: 34817483 - PMCID: PMC8675028 - DOI: 10.1039/d1nr04973a

Decano JL, Maiorino E, Matamalas JT, Chelvanambi S, Tiemeijer BM, Yanagihara Y, Mukai S, Jha PK, Pestana DVS, D'Souza E, Whelan M, Ge R, Asano T, Sharma A, Libby P, Singh SA, Aikawa E, Aikawa M

Cellular Heterogeneity of Activated Primary Human Macrophages and Associated Drug-Gene Networks: From Biology to Precision Therapeutics.

Circulation. 2023;148(19):1459-78 - PMID: 37850387 - PMCID: PMC10624416 - DOI: 10.1161/CIRCULATIONAHA.123.064794

Cable J, Witwer KW, Coffey RJ, Milosavljevic A, von Lersner AK, Jimenez L, Pucci F, Barr MM, Dekker N, Barman B, Humphrys D, Williams J, de Palma M, Guo W, Bastos N, Hill AF, Levy E, Hantak MP, Crewe C, Aikawa E, Adamczyk AM, Zanotto TM, Ostrowski M, Arab T, Rabe DC, Sheikh A, da Silva DR, Jones JC, Okeoma C, Gaborski T, Zhang Q, Gololobova O

Exosomes, microvesicles, and other extracellular vesicles-a Keystone Symposia report.

Ann N Y Acad Sci. 2023;1523(1):24-37 - PMID: 36961472 - PMCID: PMC10715677 - DOI: 10.1111/nyas.14974

Veulemans V, Billaud M, Nunes MCP, Goettsch C, Aikawa E

Editorial: Women in heart valve disease.

Front Cardiovasc Med. 2023;10:1150169 - PMID: 36994000 - PMCID: PMC10041336 - DOI: 10.3389/fcvm.2023.1150169

Andraski AB, Singh SA, Higashi H, Lee LH, Aikawa M, Sacks FM

The distinct metabolism between large and small HDL indicates unique origins of human apolipoprotein A4.

JCI Insight. 2023;8(8):ePub - PMID: 37092549 - PMCID: PMC10243815 - DOI: 10.1172/jci.insight.162481

Raju S, Botts SR, Blaser M, Prajapati K, Ho TWW, Ching C, Galant NJ, Fiddes L, Wu R, Clift CL, Pham T, Lee WL, Singh SA, Aikawa E, Fish JE, Howe KL

Endothelial cells secrete small extracellular vesicles bidirectionally containing distinct cargo to uniquely reprogram vascular cells in the circulation and vessel wall.

bioRxiv. 2023;:ePub - PMID: 37162986 - PMCID: PMC10168399 - DOI: 10.1101/2023.04.28.538787

Distefano R, Ilieva M, Madsen JH, Ishii H, Aikawa M, Rennie S, Uchida S

T2DB: A Web Database for Long Non-Coding RNA Genes in Type II Diabetes.

Noncoding RNA. 2023;9(3):ePub - PMID: 37218990 - PMCID: PMC10204529 - DOI: 10.3390/ncrna9030030

Nehl D, Goody PR, Maus K, Pfeifer A, Aikawa E, Bakthiary F, Zimmer S, Nickenig G, Jansen F, Hosen MR

Human and porcine aortic valve endothelial and interstitial cell isolation and characterization.

Front Cardiovasc Med. 2023;10:1151028 - PMID: 37408661 - PMCID: PMC10318150 - DOI: 10.3389/fcvm.2023.1151028

Greco E, Vinciguerra M, Sampaio R, Aikawa E

Editorial: New insights in heart valve disease 2022.

Front Cardiovasc Med. 2023;10:1226113 - PMID: 37416925 - PMCID: PMC10321655 - DOI: 10.3389/fcvm.2023.1226113

Blaser MC, Buffolo F, Halu A, Turner ME, Schlotter F, Higashi H, Pantano L, Clift CL, Saddic LA, Atkins SK, Rogers MA, Pham T, Vromman A, Shvartz E, Sukhova GK, Monticone S, Camussi G, Robson SC, Body SC, Muehlschlegel JD, Singh SA, Aikawa M, Aikawa E

Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis.

Circulation. 2023;148(8):661-678 - PMID: 37427430 - PMCID: PMC10527599 - DOI: 10.1161/CIRCULATIONAHA.122.063402

Bartoli-Leonard F, Chelvanambi S, Pham T, Turner ME, Blaser MC, Caputo M, Aikawa M, Pang A, Muehlschlegel J, Aikawa E

Single-cell T cell receptor sequencing of paired tissue and blood samples reveals clonal expansion of CD8+ effector T cells in patients with calcific aortic valve disease.

bioRxiv. 2023;:ePub - PMID: 37461603 - PMCID: PMC10350049 - DOI: 10.1101/2023.07.08.548203

Santinelli-Pestana DV, Aikawa E, Singh SA, Aikawa M

PARPs and ADP-Ribosylation in Chronic Inflammation: A Focus on Macrophages.

Pathogens. 2023;12(7):ePub - PMID: 37513811 - PMCID: PMC10386340 - DOI: 10.3390/pathogens12070964

Perez KA, Deppe DW, Filas A, Singh SA, Aikawa E

Multimodal analytical tools to enhance mechanistic understanding of aortic valve calcification.

Am J Pathol. 2023;194(4):539-550 - PMID: 37517686 - PMCID: PMC10988764 - DOI: 10.1016/j.ajpath.2023.06.017

Ho YC, Geng X, O'Donnell A, Ibarrola J, Fernandez-Celis A, Varshney R, Subramani K, Azartash-Namin ZJ, Kim J, Silasi R, Wylie-Sears J, Alvandi Z, Chen L, Cha B, Chen H, Xia L, Zhou B, Lupu F, Burkhart HM, Aikawa E, Olson LE, Ahamed J, López-Andrés N, Bischoff J, Yutzey KE, Srinivasan RS

PROX1 Inhibits PDGF-B Expression to Prevent Myxomatous Degeneration of Heart Valves.

Circ Res. 2023;133(6):463-480 - PMID: 37555328 - PMCID: PMC10487359 - DOI: 10.1161/CIRCRESAHA.123.323027

Kasai T, Kuraoka S, Higashi H, Delanghe B, Aikawa M, Singh SA

A Combined Gas-Phase Separation Strategy for ADP-ribosylated Peptides.

J Am Soc Mass Spectrom. 2023;34(10):2136-2145 - PMID: 37589412 - PMCID: PMC10557377 - DOI: 10.1021/jasms.3c00129

Rouhollahi A, Willi JN, Haltmeier S, Mehrtash A, Straughan R, Javadikasgari H, Brown J, Itoh A, de la Cruz KI, Aikawa E, Edelman ER, Nezami FR

CardioVision: A fully automated deep learning package for medical image segmentation and reconstruction generating digital twins for patients with aortic stenosis.

Comput Med Imaging Graph. 2023;109:102289 - PMID: 37633032 - PMCID: PMC10599298 - DOI: 10.1016/j.compmedimag.2023.102289

Machaidze Z, D'Amore A, Freitas RCC, Joyce AJ, Bayoumi A, Rich K, Brown DW, Aikawa E, Wagner WR, Sacks MS, Mayer JE

Tissue formation and host remodeling of an elastomeric biodegradable scaffold in an ovine pulmonary leaflet replacement model.

J Biomed Mater Res A. 2023;112(2):276-287 - PMID: 37772456 - PMCID: PMC11034854 - DOI: 10.1002/jbm.a.37622

Velissari R, Ilieva M, Dao J, Miller HE, Madsen JH, Gorodkin J, Aikawa M, Ishii H, Uchida S

Systematic analysis and characterization of long non-coding RNA genes in inflammatory bowel disease.

Brief Funct Genomics. 2023;:ePub - PMID: 37791426 - DOI: 10.1093/bfgp/elad044

Yacoub MH, Tseng YT, Kluin J, Vis A, Stock U, Smail H, Sarathchandra P, Aikawa E, El-Nashar H, Chester AH, Shehata N, Nagy M, El-Sawy A, Li W, Burriesci G, Salmonsmith J, Romeih S, Latif N

Valvulogenesis of a living, innervated pulmonary root induced by an acellular scaffold.

Commun Biol. 2023;6(1):1017 - PMID: 37805576 - PMCID: PMC10560219 - DOI: 10.1038/s42003-023-05383-z

Raju S, Botts SR, Blaser MC, Abdul-Samad M, Prajapati K, Khosraviani N, Ho TWW, Breda LCD, Ching C, Galant NJ, Fiddes L, Wu R, Clift CL, Pham T, Lee WL, Singh SA, Aikawa E, Fish JE, Howe KL

Directional Endothelial Communication by Polarized Extracellular Vesicle Release.

Circ Res. 2024;134(3):269-289 - PMID: 38174557 - PMCID: PMC10826926 - DOI: 10.1161/CIRCRESAHA.123.322993

Aikawa E, Blaser MC, Singh SA, Levine RA, Yacoub MH

Challenges and Opportunities in Valvular Heart Disease: From Molecular Mechanisms to the Community.

Arterioscler Thromb Vasc Biol. 2024;44(4):763-767 - PMID: 38536897 - PMCID: PMC10977651 - DOI: 10.1161/ATVBAHA.123.319563

Cahalane RME, Turner ME, Clift CL, Blaser MC, Bogut G, Levy S, Kasai T, Driedonks TAP, Nolte-'t Hoen ENM, Aikawa M, Singh SA, Aikawa E

Polycarbonate Ultracentrifuge Tube Re-use in Proteomic Analyses of Extracellular Vesicles.

J Vis Exp. 2024;(205):ePub - PMID: 38526125 - DOI: 10.3791/66126

Clift CL, Blaser MC, Gerrits W, Turner ME, Sonawane A, Pham T, Andresen JL, Fenton OS, Grolman JM, Campedelli A, Buffolo F, Schoen FJ, Hjortnaes J, Muehlschlegel JD, Mooney DJ, Aikawa M, Singh SA, Langer R, Aikawa E

Intracellular proteomics and extracellular vesiculomics as a metric of disease recapitulation in 3D-bioprinted aortic valve arrays.

Sci Adv. 2024;10(9):eadj9793 - PMID: 38416823 - PMCID: PMC10901368 - DOI: 10.1126/sciadv.adj9793

Lupieri A, S A Passos L, Levine RA, Nizet V, Aikawa E

Lymphangiogenesis in Rheumatic Heart Valve Disease: A New Factor in the Pathogenic Conundrum.

Arterioscler Thromb Vasc Biol. 2024;44(4):822-825 - PMID: 38357818 - PMCID: PMC10978236 - DOI: 10.1161/ATVBAHA.124.320708

Jansen I, Cahalane R, Hengst R, Akyildiz A, Farrell E, Gijsen F, Aikawa E, van der Heiden K, Wissing T

The interplay of collagen, macrophages, and microcalcification in atherosclerotic plaque cap rupture mechanics.

Basic Res Cardiol. 2024;119(2):193-213 - PMID: 38329498 - PMCID: PMC11008085 - DOI: 10.1007/s00395-024-01033-5

Shelbaya K, Arthur V, Yang Y, Dorbala P, Buckley L, Claggett B, Skali H, Dufresne L, Yang TY, Engert JC, Thanassoulis G, Floyd J, Austin TR, Bortnick A, Kizer J, Freitas RCC, Singh SA, Aikawa E, Hoogeveen RC, Ballantyne C, Yu B, Coresh J, Blaha MJ, Matsushita K, Shah AM

Large-Scale Proteomics Identifies Novel Biomarkers and Circulating Risk Factors for Aortic Stenosis.

J Am Coll Cardiol. 2024;83(5):577-591 - PMID: 38296402 - DOI: 10.1016/j.jacc.2023.11.021

Kumar Jha P, Aikawa M, Aikawa E

Macrophage Heterogeneity and Efferocytosis: Beyond the M1/M2 Dichotomy.

Circ Res. 2024;134(2):186-188 - PMID: 38236949 - PMCID: PMC10798221 - DOI: 10.1161/CIRCRESAHA.123.324011

Turner ME, Beck L, Hill Gallant KM, Chen Y, Moe OW, Kuro-O M, Moe S, Aikawa E

Phosphate in Cardiovascular Disease: From New Insights Into Molecular Mechanisms to Clinical Implications.

Arterioscler Thromb Vasc Biol. 2024;44(3):584-602 - PMID: 38205639 - PMCID: PMC10922848 - DOI: 10.1161/ATVBAHA.123.319198

Yurdagul A, Aikawa E

Discovering a Rare Smooth Muscle Cell Population Specific to Males in Ascending Aortic Aneurysm Using Spatial Transcriptomics.

Arterioscler Thromb Vasc Biol. 2023;43(12):2298-2300 - PMID: 37916413 - PMCID: PMC10842258 - DOI: 10.1161/ATVBAHA.123.320235

Rogers MA, Bartoli-Leonard F, Zheng KH, Small AM, Chen HY, Clift CL, Asano T, Kuraoka S, Blaser MC, Perez KA, Natarajan P, Yeang C, Stroes ESG, Tsimikas S, Engert JC, Thanassoulis G, O'Donnell CJ, Aikawa M, Singh SA, Aikawa E

Major Facilitator Superfamily Domain Containing 5 Inhibition Reduces Lipoprotein(a) Uptake and Calcification in Valvular Heart Disease.

Circulation. 2023;149(5):391-401 - PMID: 37937463 - PMCID: PMC10842618 - DOI: 10.1161/CIRCULATIONAHA.123.066822

Tzani A, Haemmig S, Cheng HS, Perez-Cremades D, Heuschkel MA, Jamaiyar A, Singh S, Aikawa M, Yu P, Wang T, Ye S, Feinberg MW, Plutzky J

FAM222A, Part of the BET-Regulated Basal Endothelial Transcriptome, Is a Novel Determinant of Endothelial Biology and Angiogenesis.

Arterioscler Thromb Vasc Biol. 2023;44(1):143-155 - PMID: 37942611 - PMCID: PMC10840377 - DOI: 10.1161/ATVBAHA.123.319909