Investigator / Platform Research Area Position
Aikawa, Masanori Vascular Biology, Macrophage Biology, Immunology, AI-powered target discovery Postdoctoral Fellow in Macrophage Biology
Singh, Sasha A. Postdoctoral Fellowship Position in Bioinformatics for Mass Spectrometry-based Proteomics Research

If you are interested in any of the positions listed below, please send your CV, an outline of your research interests, and names, email addresses, and telephone numbers of three references to Dr. William Terry

Position: Postdoctoral Fellow in Macrophage Biology

Research Area: Vascular Biology, Macrophage Biology, Immunology, AI-powered target discovery

Full/Part Time: Full Time

Investigator: Aikawa, Masanori

Date Posted: 2020-10-27

Description: The Center for Interdisciplinary Cardiovascular Sciences (CICS; Director: Masanori Aikawa, MD, PhD) at the Brigham and Women’s Hospital and Harvard Medical School is seeking highly motivated postdoctoral fellow candidates for our target discovery research efforts in macrophage biology. Applications are invited for a position of Research Fellow in Medicine at Brigham and Women’s Hospital and Harvard Medical School. Our research focus areas include: 1) exploring novel mechanisms for macrophage activation and heterogeneity; 2) developing novel therapeutics for cardiovascular inflammation; and 3) examining the heterogeneity in inflammatory cardiovascular diseases using the electronic health records and machine learning. The successful candidates will enjoy excellent training opportunities in a collaborative research environment, and a wide array of updated molecular and cell biology protocols, cutting-edge technologies and devices, innovative animal models, molecular imaging, mass spectrometry-based proteomics, systems biology, and artificial intelligence. In 2009, we launched CICS in collaboration with the Japanese pharmaceutical company Kowa to speed translation of basic research into drug development. CICS occupies a fully-equipped, state-of-the-art 24,000-sq.ft. space on the 17th floor of the Center for Life Science in Longwood Medical Area, the heart of Boston’s research community. We conduct multidisciplinary research with scientists from academia and industry working together in a shared space. Our intent is to establish a diverse, active, and innovative working environment. We seek enthusiastic candidates with excellent interpersonal skills.

Responsibilities: The successful applicant will plan and conduct experiments, discuss the data with his/her supervisor regularly, record all the experimental results in laboratory notebooks, further develop presentation and writing skills, and present at internal meetings and scientific conferences, and publish scientific manuscripts.

Requirements: The candidate requires an MD, PhD, or equivalent doctoral degree, and excellent experimental and analytical skills in cellular and molecular biology, and a record of publications in related fields. Expertise with drug discovery research is advantageous but not essential. The position requires the ability to work independently and also to perform effectively within a team. Excellent organizational, communication, and writing skills are essential. We expect a strong interest in the mechanisms of disease, outstanding motivation, innovative spirit, and a firm commitment to productivity and data integrity.

Position: Postdoctoral Fellowship Position in Bioinformatics for Mass Spectrometry-based Proteomics Research

Full/Part Time: Full Time

Investigator: Singh, Sasha A.

Date Posted: 2020-02-12

Description: We are seeking an individual to join our team to undertake the following research projects: 1) Analysis of high dimensional data acquired from multi-omics studies that include one or more of proteomics, metabolomics and transcriptomics for drug target discovery. 2) Posttranslational modification analyses using advanced mass spectrometric workflows. 3) Targeted proteomics or metabolomics, and implementation of spectral libraries for peptide or metabolite identifications. Additional projects that would interest the candidate include single-cell transcript profiling, and systems biology and artificial intelligence-driven studies aimed to predict the beneficial and off-target effects of putative therapeutics. The successful candidate will be able to collaborate with a number of talented researchers, will guide them through their research endeavors and will be a co-author on publications arising from these projects.

Requirements: The candidate must have a PhD or equivalent experience. Candidates with experience in mass spectrometry data analysis are preferred, however those with a keen interest in learning about mass spectrometry are encouraged to apply. Specific skill requirements include data analysis with statistics, script languages such as R and Python, programming languages such as C, C++, C# or JAVA, and scripting in Linux/UNIX. Experience with computational mass spectrometry analysis is preferred; however, basic knowledge of mass spectrometry or equivalent biochemistry is a benefit. Experience in systems biology and/or machine learning is also advantageous. We also are looking for an individual with outstanding motivation, a firm commitment to productivity, and who has strong communication and writing skills. Please send your application to Sasha Singh - <a href="sasingh@bwh.harvard.edu">sasingh@bwh.harvard.edu</a>