Aikawa, Masanori
Yoshihiro Miwa Distinguished Chair & Founding Director,
Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women’s Hospital;
Professor of Medicine, Harvard Medical School
Dr. Masanori Aikawa serves as Director of the Center for Interdisciplinary Cardiovascular Sciences (CICS) at the Brigham and Women’s Hospital (BWH). He trained as a cardiologist in Japan and has worked at BWH and Harvard Medical School since 1995. His research interests include the pathogenesis of atherosclerosis and metabolic disorders, macrophage biology, and the pro-inflammatory role of dyslipidemia. Dr. Aikawa’s studies, documented in over 100 articles, received worldwide recognition and spurred lectureship initiations and opportunities to serve as a reviewer for research grants and reports. He is an editorial board member for several major medical journals, including Circulation, Circulation Research, Arteriosclerosis Thrombosis and Vascular. Biology, and PLOS ONE. He is International Associate Editor for Circluation Journal the Japanese Circulation Society. He is also co-Chief Editor of Frontiers in Cardiovascular Medicine. Dr. Aikawa also serves as Chair of the Development Committee of the North American Vascular Biology Organization (NAVBO). He is a member of the Organizing Committee and chairs the Sponsorship Committee of the International Vascular Biology Meeting 2016 (IVBM2016) . Dr. Aikawa has received many awards and honors, including Yagi Award from the Japanese Circulation Society, Young Investigator Award for the Distinguished Atherosclerosis Research from the Japan Atherosclerosis Society, and the Fifth Trucker Collins Lectureship at Harvard Medical School’s Vascular Biology Seminar Series. In November 2013, he received the Special Recognition Award in Vascular Biology from the Arteriosclerosis and Vascular Biology Council of the American Heart Association Dr. Aikawa’s ultimate goal is to translate basic research findings into clinical practice through multidisciplinary efforts. His role as Founding Director of CICS represents this goal, where explorations for new therapeutic targets for cardiometabolic diseases are carried out in transpacific collaboration with Kowa Company, Ltd. a Japanese pharmaceutical company. While he has established a new model of the academia – industry collaboration, Dr. Aikawa continues his pre-existing research laboratory in the, Center for Excellence in Vascular Biology at BWH primarily supported by grants from the National Institutes of Health and the American Heart Association, where he studies novel triggering mechanisms of macrophage activation in the contexts of atherosclerosis and metabolic disorders. After his clinical training at Juntendo University School of Medicine, Tokyo, Japan, Dr. Aikawa began his initial research at the University of Tokyo under the supervision of Dr. Ryozo Nagai. This research led to the cloning of human smooth muscle and non-muscle myosin heavy chain isoforms (SM1, SM2, and SMemb/MHC-B). Using these molecules as markers of differentiation, his studies demonstrated diversity of SMC phenotype in developing human arteries and during progression of atherosclerosis and restenosis. For this work, he received several awards. Dr. Aikawa’s earlier studies as Research Fellow at the Peter Libby laboratory in BWH used rabbit models to establish that cholesterol lowering by either diet or statins improves various features typical of so-called “vulnerable” atherosclerotic plaque prone to rupture and clinical complications (e.g., reduction of macrophage accumulation, MMP expression, and tissue factor activity). Through a series of rabbit studies, Drs. Libby and Aikawa pioneered the concept that lipid lowering is an anti-inflammatory therapy, providing molecular bases for the observed beneficial outcomes of statin mega trials. As a faculty member, Dr. Aikawa extended his research interest in the role of macrophages in atherogenesis by testing the hypothesis that MMP-collagenases regulate collagen accumulation. Three studies employed genetically altered mouse strains to establish the first direct in vivo evidence of the role of collagenases in arterial collagen architecture. Over the past several years, Dr. Aikawa’s laboratory has explored new mechanisms that trigger macrophage activation, including the Delta like 4-Notch axis, the Akt/β catenin pathway, and the pro-inflammatory action of apolipoprotein CIII. His studies aim to address the role of macrophage activation in atherosclerosis, obesity, insulin resistance, and fatty liver. His laboratory uses various approaches in vitro and in vivo, including macrophage-selective knockout and transgenic mice and molecular imaging of atherosclerotic plaque macrophages. In 2009, CICS was launched at BWH in collaboration with Kowa.
Publications
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Chelvanambi S, Decano JL, Winkels H, Giannarelli C, Aikawa M
Decoding Macrophage Heterogeneity to Unravel Vascular Inflammation as a Path to Precision Medicine.
Yagi H, Boeck M, Nian S, Neilsen K, Wang C, Lee J, Zeng Y, Grumbine M, Sweet IR, Kasai T, Negishi K, Singh SA, Aikawa M, Hellström A, Smith LEH, Fu Z
Correction: Mitochondrial control of hypoxia-induced pathological retinal angiogenesis.
Yagi H, Boeck M, Petrishka-Lozenska M, Lundgren P, Kasai T, Cagnone G, Neilsen K, Wang C, Lee J, Tomita Y, Singh SA, Joyal JS, Aikawa M, Negishi K, Fu Z, Hellström A, Smith LEH
Timed topical dexamethasone eye drops improve mitochondrial function to prevent severe retinopathy of prematurity.
Peng Q, Arulsamy K, Lu YW, Wu H, Zhu B, Singh B, Cui K, Wylie-Sears J, Li KS, Wong S, Cowan DB, Aikawa M, Wang DZ, Bischoff J, Chen K, Chen H
Novel Role of Endothelial CD45 in Regulating Endothelial-to-Mesenchymal Transition in Atherosclerosis.
Matamalas JT, Chelvanambi S, Decano JL, França RF, Halu A, Santinelli-Pestana DV, Aikawa E, Malhotra R, Aikawa M
Obesity and age are transmission risk factors for SARS-CoV-2 infection among exposed individuals.
Bhattacharjee S, Gao J, Lu YW, Eisa-Beygi S, Wu H, Li K, Birsner AE, Wong S, Song Y, Shyy JY, Cowan DB, Wei W, Aikawa M, Shi J, Chen H
Interplay Between FoxM1 and Dab2 Promotes Endothelial Cell Responses in Diabetic Wound Healing.
Delwarde C, Aikawa M
Novel Mouse Model of Late-Stage Coronary Atherosclerosis With Features of Plaque Rupture and Stroke.
Yagi H, Boeck M, Nian S, Neilsen K, Wang C, Lee J, Zeng Y, Grumbine M, Sweet IR, Kasai T, Negishi K, Singh SA, Aikawa M, Hellström A, Smith LEH, Fu Z
Mitochondrial control of hypoxia-induced pathological retinal angiogenesis.
Katsuki S, Jha PK, Aikawa E, Aikawa M
The role of proprotein convertase subtilisin/kexin 9 (PCSK9) in macrophage activation: a focus on its LDL receptor-independent mechanisms.
Okui T, Kuraoka S, Iwashita M, Itagawa R, Kasai T, Aikawa M, Singh SA, Aikawa E
Carnitine O-octanoyltransferase (CROT) deficiency in mice leads to an increase of omega-3 fatty acids.
Yagi H, Boeck M, Petrishka-Lozenska M, Lundgren P, Kasai T, Cagnone G, gael.cagnone.1@gmail.com, Wang C, Lee J, Tomita Y, Singh SA, Joyal JS, Aikawa M, Negishi K, Fu Z, Hellström A, Smith LEH
Timed topical dexamethasone eye drops improve mitochondrial function to prevent severe retinopathy of prematurity.
Reyes-Soffer G, Matveyenko A, Lignos J, Matienzo N, Santos Baez LS, Hernandez-One A, Yung L, Nandakumar R, Singh SA, Aikawa M, George R, Ginsberg HN
Effects of Recombinant Human Lecithin Cholesterol Acyltransferase on Lipoprotein Metabolism in Humans.
Parthasarathy S, Saenjamsai P, Hao H, Ferkul A, Pfannenstiel JJ, Suder EL, Bejan DS, Chen Y, Schwarting N, Aikawa M, Muhlberger E, Orozco RC, Sullivan CS, Cohen MS, Davido DJ, Hume AJ, Fehr AR
PARP14 is pro- and anti-viral host factor that promotes IFN production and affects the replication of multiple viruses.
Cahalane RME, Turner ME, Clift CL, Blaser MC, Bogut G, Levy S, Kasai T, Driedonks TAP, Nolte-'t Hoen ENM, Aikawa M, Singh SA, Aikawa E
Polycarbonate Ultracentrifuge Tube Re-use in Proteomic Analyses of Extracellular Vesicles.
Clift CL, Blaser MC, Gerrits W, Turner ME, Sonawane A, Pham T, Andresen JL, Fenton OS, Grolman JM, Campedelli A, Buffolo F, Schoen FJ, Hjortnaes J, Muehlschlegel JD, Mooney DJ, Aikawa M, Singh SA, Langer R, Aikawa E
Intracellular proteomics and extracellular vesiculomics as a metric of disease recapitulation in 3D-bioprinted aortic valve arrays.
Kumar Jha P, Aikawa M, Aikawa E
Macrophage Heterogeneity and Efferocytosis: Beyond the M1/M2 Dichotomy.
Andraski AB, Sacks FM, Aikawa M, Singh SA
Understanding HDL Metabolism and Biology Through In Vivo Tracer Kinetics.
Tzani A, Haemmig S, Cheng HS, Perez-Cremades D, Heuschkel MA, Jamaiyar A, Singh S, Aikawa M, Yu P, Wang T, Ye S, Feinberg MW, Plutzky J
FAM222A, Part of the BET-Regulated Basal Endothelial Transcriptome, Is a Novel Determinant of Endothelial Biology and Angiogenesis.
Rogers MA, Bartoli-Leonard F, Zheng KH, Small AM, Chen HY, Clift CL, Asano T, Kuraoka S, Blaser MC, Perez KA, Natarajan P, Yeang C, Stroes ESG, Tsimikas S, Engert JC, Thanassoulis G, O'Donnell CJ, Aikawa M, Singh SA, Aikawa E
Major Facilitator Superfamily Domain Containing 5 Inhibition Reduces Lipoprotein(a) Uptake and Calcification in Valvular Heart Disease.
Kip P, Sluiter TJ, MacArthur MR, Tao M, Jung J, Mitchell SJ, Kooijman S, Kruit N, Gorham J, Seidman JG, Quax PHA, Aikawa M, Ozaki CK, Mitchell JR, de Vries MR
Short-term Pre-operative Methionine Restriction Induces Browning of Perivascular Adipose Tissue and Improves Vein Graft Remodeling in Mice.
Decano JL, Maiorino E, Matamalas JT, Chelvanambi S, Tiemeijer BM, Yanagihara Y, Mukai S, Jha PK, Pestana DVS, D'Souza E, Whelan M, Ge R, Asano T, Sharma A, Libby P, Singh SA, Aikawa E, Aikawa M
Cellular Heterogeneity of Activated Primary Human Macrophages and Associated Drug-Gene Networks: From Biology to Precision Therapeutics.
Velissari R, Ilieva M, Dao J, Miller HE, Madsen JH, Gorodkin J, Aikawa M, Ishii H, Uchida S
Systematic analysis and characterization of long non-coding RNA genes in inflammatory bowel disease.
Kasai T, Kuraoka S, Higashi H, Delanghe B, Aikawa M, Singh SA
A Combined Gas-Phase Separation Strategy for ADP-ribosylated Peptides.
Santinelli-Pestana DV, Aikawa E, Singh SA, Aikawa M
PARPs and ADP-Ribosylation in Chronic Inflammation: A Focus on Macrophages.
Blaser MC, Buffolo F, Halu A, Turner ME, Schlotter F, Higashi H, Pantano L, Clift CL, Saddic LA, Atkins SK, Rogers MA, Pham T, Vromman A, Shvartz E, Sukhova GK, Monticone S, Camussi G, Robson SC, Body SC, Muehlschlegel JD, Singh SA, Aikawa M, Aikawa E
Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis.
Bartoli-Leonard F, Chelvanambi S, Pham T, Turner ME, Blaser MC, Caputo M, Aikawa M, Pang A, Muehlschlegel J, Aikawa E
Single-cell T cell receptor sequencing of paired tissue and blood samples reveals clonal expansion of CD8+ effector T cells in patients with calcific aortic valve disease.
Distefano R, Ilieva M, Madsen JH, Ishii H, Aikawa M, Rennie S, Uchida S
T2DB: A Web Database for Long Non-Coding RNA Genes in Type II Diabetes.
Andraski AB, Singh SA, Higashi H, Lee LH, Aikawa M, Sacks FM
The distinct metabolism between large and small HDL indicates unique origins of human apolipoprotein A4.
Bartoli-Leonard F, Zimmer J, Sonawane AR, Perez K, Turner ME, Kuraoka S, Pham T, Li F, Aikawa M, Singh S, Brewster L, Aikawa E
NLRP3 Inflammasome Activation in Peripheral Arterial Disease.
Iqbal F, Schlotter F, Becker-Greene D, Lupieri A, Goettsch C, Hutcheson JD, Rogers MA, Itoh S, Halu A, Lee LH, Blaser MC, Mlynarchik AK, Hagita S, Kuraoka S, Chen HY, Engert JC, Passos LSA, Jha PK, Osborn EA, Jaffer FA, Body SC, Robson SC, Thanassoulis G, Aikawa M, Singh SA, Sonawane AR, Aikawa E
Sortilin enhances fibrosis and calcification in aortic valve disease by inducing interstitial cell heterogeneity.
Wang Z, Tang M, Luan X, Tevaearai Stahel H, Aikawa M, Xie M, Ge S, Zhang S
Editorial: What do we know about COVID-19 implications for cardiovascular disease?
Kum AST, De Moura DTH, Proença IM, Aikawa M, Sánchez-Luna SA, Ribeiro IB, Sasso JGRJ, Bestetti AM, Bernardo WM, Hourneaux de Moura EG
Gastroesophageal Reflux Waning Over Time in Endoscopic Versus Surgical Myotomy for the Treatment of Achalasia: A Systematic Review and Meta-Analysis.
Krohn JB, Aikawa E, Aikawa M, Hutcheson JD, Sahoo S, Fish JE
Editorial: Extracellular vesicles in cardiovascular inflammation and calcification.
Katsuki S, Kumar Jha P, Lupieri A, Nakano T, Passos LSA, Rogers MA, Becker-Greene D, Le TD, Decano JL, Ho Lee L, Guimaraes GC, Abdelhamid I, Halu A, Muscoloni A, Vittorio Cannistraci C, Higashi H, Zhang H, Vromman A, Libby P, Keith Ozaki C, Sharma A, Singh SA, Aikawa E, Aikawa M
Proprotein Convertase Subtilisin/Kexin 9 Promotes Macrophage Activation via LDL Receptor-Independent Mechanisms.
Kuo A, Checa A, Niaudet C, Jung B, Fu Z, Wheelock CE, Singh SA, Aikawa M, Smith LEH, Proia RL, Hla T
Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasi.
Morgan S, Lee LH, Halu A, Nicolau JS, Higashi H, Ha AH, Wen JR, Daugherty A, Libby P, Cameron SJ, Mix D, Aikawa E, Owens AP, Singh SA, Aikawa M
Identifying novel mechanisms of abdominal aortic aneurysm via unbiased proteomics and systems biology.
Uchida S, Yu J, Goldman M, Asmis R, Yang X, Aikawa E, Bourantas C, Aikawa M, Tevaearai Stahel H
Editorial: Research reproducibility and preventing fraud.
Atkins SK, Sonawane AR, Brouwhuis R, Barrientos J, Ha A, Rogers M, Tanaka T, Okui T, Kuraoka S, Singh SA, Aikawa M, Aikawa E
Induced pluripotent stem cell-derived smooth muscle cells to study cardiovascular calcification.
Bartoli-Leonard F, Turner ME, Zimmer J, Chapurlat R, Pham T, Aikawa M, Pradhan AD, Szulc P, Aikawa E
Elevated lipoprotein(a) as a predictor for coronary events in older men.
Wang L, Xu GE, Pan L, Aikawa E, Aikawa M, Xiao J, Huang NF
Editorial: Frontiers in Cardiovascular Medicine: Rising Stars 2021.
Dacano JL, Aikawa M, Singh SA
Promise of a Novel Bedside-to-Bench Paradigm: Can Percutaneous Coronary Intervention Proteomics Balloon Into Clinical Practice?
Sonawane AR, Aikawa E, Aikawa M
Connections for Matters of the Heart: Network Medicine in Cardiovascular Diseases.
Garelnabi M, Cowdin M, Fang Y, Shrestha B, Ushio-Fukai M, Aikawa E, Graham G, Molema G, Yanagisawa H, Aikawa M
Embracing Diversity, Equity, and Inclusion in the Scientific Community-Viewpoints of the Diversity, Equity, and Inclusion Committee of the North American Vascular Biology Organization.
Decano JL, Iwamoto Y, Goto S, Lee JY, Matamalas JT, Halu A, Blaser M, Lee LH, Pieper B, Chelvanambi S, Silva-Nicolau J, Bartoli-Leonard F, Higashi H, Shibata H, Vyas P, Wang J, Gostjeva E, Body SC, Singh SA, Aikawa M, Aikawa E
A disease-driver population within interstitial cells of human calcific aortic valves identified via single-cell and proteomic profiling.
Asano T, Chelvanambi S, Decano JL, Whelan MC, Aikawa E, Aikawa M
In silico Drug Screening Approach Using L1000-Based Connectivity Map and Its Application to COVID-19.
Passos LSA, Jha PK, Becker-Greene D, Blaser MC, Romero D, Lupieri A, Sukhova GK, Libby P, Singh SA, Dutra WO, Aikawa M, Levine RA, Nunes MCP, Aikawa E
Prothymosin Alpha: A Novel Contributor to Estradiol Receptor Alpha-Mediated CD8+ T-Cell Pathogenic Responses and Recognition of Type 1 Collagen in Rheumatic Heart Valve Disease.
Sawada H, Katsumata Y, Higashi H, Zhang C, Li Y, Morgan S, Lee LH, Singh SA, Chen JZ, Franklin MK, Moorleghen JJ, Howatt DA, Rateri DL, Shen YH, LeMaire SA, Aikawa M, Majesky MW, Lu HS, Daugherty A
Second Heart Field-derived Cells Contribute to Angiotensin II-mediated Ascending Aortopathies.
Rogers MA, Atkins SK, Zheng KH, Singh SA, Chelvanambi S, Pham TH, Kuraoka S, Stroes ESG, Aikawa M, Aikawa E
Lipoprotein(a) Induces Vesicular Cardiovascular Calcification Revealed With Single-Extracellular Vesicle Analysis.
Tanaka T, Asano T, Okui T, Kuraoka S, Singh SA, Aikawa M, Aikawa E
Computational Screening Strategy for Drug Repurposing Identified Niclosamide as Inhibitor of Vascular Calcification.
Iwata H, Osborn EA, Ughi GJ, Murakami K, Goettsch C, Hutcheson JD, Mauskapf A, Mattson PC, Libby P, Singh SA, Matamalas J, Aikawa E, Tearney GJ, Aikawa M, Jaffer FA
Highly Selective PPARα (Peroxisome Proliferator-Activated Receptor α) Agonist Pemafibrate Inhibits Stent Inflammation and Restenosis Assessed by Multimodality Molecular-Microstructural Imaging.
Kuraoka S, Higashi H, Yanagihara Y, Sonawane AR, Mukai S, Mlynarchik AK, Whelan MC, Hottiger MO, Nasir W, Delanghe B, Aikawa M, Singh SA
A Novel Spectral Annotation Strategy Streamlines Reporting of mono-ADP-ribosylated Peptides Derived from Mouse Liver and Spleen in Response to IFN-γ.
Hutcheson JD, Schlotter F, Creager MD, Li X, Pham T, Vyas P, Higashi H, Body SC, Aikawa M, Singh SA, Kos L, Aikawa E
Elastogenesis Correlates With Pigment Production in Murine Aortic Valve Leaflets.
Decano JL, Singh SA, Bueno CG, Lee LH, Halu A, Chelvanambi S, Matamalas JT, Zhang H, Mlynarchik AK, Qiao J, Sharma A, Mukai S, Wang J, Anderson DG, Ozaki CK, Libby P, Aikawa E, Aikawa M
Systems Approach to Discovery of Therapeutic Targets for Vein Graft Disease PPARα Pivotally Regulates Metabolism, Activation, and Heterogeneity of Macrophages and Lesion Development.
Ruiz JL, Hutcheson JD, Cardoso L, Bakhshian Nik A, Condado de Abreu A, Pham T, Buffolo F, Busatto S, Federici S, Ridolfi A, Aikawa M, Bertazzo S, Bergese P, Weinbaum S, Aikawa E
Nanoanalytical analysis of bisphosphonate-driven alterations of microcalcifications using a 3D hydrogel system and in vivo mouse model.
Rogers MA, Hutcheson JD, Okui T, Goettsch C, Singh SA, Halu A, Schlotter F, Higashi H, Wang L, Whelan MC, Mlynarchik AK, Daugherty A, Nomura M, Aikawa M, Aikawa E
Dynamin-related protein 1 inhibition reduces hepatic PCSK9 secretion.
Jha PK, Vijay A, Halu A, Uchida S, Aikawa M
Gene Expression Profiling Reveals the Shared and Distinct Transcriptional Signatures in Human Lung Epithelial Cells Infected With SARS-CoV-2, MERS-CoV, or SARS-CoV: Potential Implications in Cardiovascular Complications of COVID-19.
Okui T, Iwashita M, Rogers MA, Halu A, Atkins SK, Kuraoka S, Abdelhamid I, Higashi H, Ramsaroop A, Aikawa M, Singh SA, Aikawa E
CROT (Carnitine O-Octanoyltransferase) Is a Novel Contributing Factor in Vascular Calcification via Promoting Fatty Acid Metabolism and Mitochondrial Dysfunction.
Singh SA, Andraski AB, Higashi H, Lee LH, Ramsaroop A, Sacks FM, Aikawa M
Metabolism of PLTP, CETP, and LCAT on multiple HDL sizes using the Orbitrap Fusion Lumos.
Iqbal F, Lupieri A, Aikawa M, Aikawa E
Harnessing Single-Cell RNA Sequencing to Better Understand How Diseased Cells Behave the Way They Do in Cardiovascular Disease.
Schlotter F, de Freitas RCC, Rogers MA, Blaser MC, Wu PJ, Higashi H, Halu A, Iqbal F, Andraski AB, Rodia CN, Kuraoka S, Wen JR, Creager M, Pham T, Hutcheson JD, Body SC, Kohan AB, Sacks FM, Aikawa M, Singh SA, Aikawa E
ApoC-III is a novel inducer of calcification in human aortic valves.
Brandão SCS, Ramos JOX, Dompieri LT, Godoi ETAM, Figueiredo JL, Sarinho ESC, Chelvanambi S, Aikawa M
Is Toll-like receptor 4 involved in the severity of COVID-19 pathology in patients with cardiometabolic comorbidities?
Rogers MA, Buffolo F, Schlotter F, Atkins SK, Lee LH, Halu A, Blaser MC, Tsolaki E, Higashi H, Luther K, Daaboul G, Bouten CVC, Body SC, Singh SA, Bertazzo S, Libby P, Aikawa M, Aikawa E
Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis.
Toyohara T, Roudnicky F, Florido MHC, Nakano T, Yu H, Katsuki S, Lee M, Meissner T, Friesen M, Davidow LS, Ptaszek L, Abe T, Rubin LL, Pereira AC, Aikawa M, Cowan CA
Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis.
Kawakami R, Katsuki S, Travers R, Romero DC, Becker-Greene D, Araujo Passos LS, Higashi H, Blaser MC, Sukhova GK, Buttigieg J, Kopriva D, Schmidt AM, Anderson DG, Singh SA, Cardoso L, Weinbaum S, Libby P, Aikawa M, Croce K, Aikawa E
S100A9-RAGE Axis Accelerates Formation of Macrophage-Mediated Extracellular Vesicle Microcalcification in Diabetes Mellitus.
Watanabe Y, Takase K, Okada K, Aikawa M, Okamoto K, Koyama I
Portal vein aneurysm with complete spontaneous regression after 10 years using conservative treatment.
Toyohara T, Roudnicky F, Florido MHC, Nakano T, Yu H, Katsuki S, Lee M, Meissner T, Friesen M, Davidow LS, Ptaszek L, Abe T, Rubin LL, Pereira AC, Aikawa M, Cowan CA
Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis.
Figueiredo JL, Santa-Cruz F, Lima-Filho JL, Hilgendorf I, Aikawa M, Pittet MJ, Nahrendorf M, Weissleder R, Swirski FK, Robbins CS
A durable murine model of spleen transplantation with arterial and venous anastomoses.
Engelbrecht E, Levesque MV, He L, Vanlandewijck M, Nitzsche A, Niazi H, Kuo A, Singh SA, Aikawa M, Holton K, Proia RL, Kono M, Pu WT, Camerer E, Betsholtz C, Hla T
Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta.
Fehr AR, Singh SA, Kerr CM, Mukai S, Higashi H, Aikawa M
The impact of PARPs and ADP-ribosylation on inflammation and host-pathogen interactions.
Rogers MA, Chen J, Nallamshetty S, Pham T, Goto S, Muehlschlegel JD, Libby P, Aikawa M, Aikawa E, Plutzky J
Retinoids Repress Human Cardiovascular Cell Calcification With Evidence for Distinct Selective Retinoid Modulator Effects.
Nakato R, Wada Y, Nakaki R, Nagae G, Katou Y, Tsutsumi S, Nakajima N, Fukuhara H, Iguchi A, Kohro T, Kanki Y, Saito Y, Kobayashi M, Izumi-Taguchi A, Osato N, Tatsuno K, Kamio A, Hayashi-Takanaka Y, Wada H, Ohta S, Aikawa M, Nakajima H, Nakamura M, McGee RC, Heppner KW, Kawakatsu T, Genno M, Yanase H, Kume H, Senbonmatsu T, Homma Y, Nishimura S, Mitsuyama T, Aburatani H, Kimura H, Shirahige K
Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells.
Arima N, Sasaki Y, Lee LH, Zhang H, Figueiredo JL, Mlynarchik AK, Qiao J, Yamada I, Higashi H, Ha AH, Halu A, Mizuno K, Singh SA, Yamazaki Y, Aikawa M
Multi-organ systems study reveals Igfbp7 as a suppressor of gluconeogenesis after gastric bypass surgery.
Andraski AB, Singh SA, Lee LH, Higashi H, Smith N, Zhang B, Aikawa M, Sacks FM
Effects of Replacing Dietary Monounsaturated Fat With Carbohydrate on HDL (High-Density Lipoprotein) Protein Metabolism and Proteome Composition in Humans.
Aikawa M, Manabe I, Marx N
Editorial: New Trends in Vascular Inflammation Research: From Biology to Therapy.
Fruchart JC, Santos RD, Aguilar-Salinas C, Aikawa M, Al Rasadi K, Amarenco P, Barter PJ, Ceska R, Corsini A, Després JP, Duriez P, Eckel RH, Ezhov MV, Farnier M, Ginsberg HN, Hermans MP, Ishibashi S, Karpe F, Kodama T, Koenig W, Krempf M, Lim S, Lorenzatti AJ, McPherson R, Nuñez-Cortes JM, Nordestgaard BG, Ogawa H, Packard CJ, Plutzky J, Ponte-Negretti CI, Pradhan A, Ray KK, Reiner Ž, Ridker PM, Ruscica M, Sadikot S, Shimano H, Sritara P, Stock JK, Su TC, Susekov AV, Tartar A, Taskinen MR, Tenenbaum A, Tokgözoğlu LS, Tomlinson B, Tybjærg-Hansen A, Valensi P, Vrablík M, Wahli W, Watts GF, Yamashita S, Yokote K, Zambon A, Libby P
The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: conceptual framework and therapeutic potential : A consensus statement from the International Atherosclerosis Society (IAS) and the Residual Risk Reduction Initiative (R3i) Foundation.
Grunewald ME, Chen Y, Kuny C, Maejima T, Lease R, Ferraris D, Aikawa M, Sullivan CS, Perlman S, Fehr AR
The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression.
Goto S, Rogers MA, Blaser MC, Higashi H, Lee LH, Schlotter F, Body SC, Aikawa M, Singh SA, Aikawa E
Standardization of Human Calcific Aortic Valve Disease in vitro Modeling Reveals Passage-Dependent Calcification.
Higashi H, Maejima T, Lee LH, Yamazaki Y, Hottiger MO, Singh SA, Aikawa M
A study into the ADP-ribosylome of IFN-γ-stimulated THP-1 human macrophage-like cells identifies ARTD8/PARP14 and ARTD9/PARP9 ADP-ribosylation.
Higashi H, Maejima T, Lee LH, Yamazaki Y, Hottiger MO, Singh SA, Aikawa M
A study into the ADP-ribosylome of IFN-γ-stimulated THP-1 human macrophage-like cells identifies ARTD8/PARP14 and ARTD9/PARP9 ADP-ribosylation.
Hutcheson JD, Goergen CJ, Schoen FJ, Aikawa M, Zilla P, Aikawa E, Gaudette GR
After 50 Years of Heart Transplants: What Does the Next 50 Years Hold for Cardiovascular Medicine? A Perspective From the International Society for Applied Cardiovascular Biology.
Creager MD, Hohl T, Hutcheson JD, Moss AJ, Schlotter F, Blaser MC, Park MA, Lee LH, Singh SA, Alcaide-Corral CJ, Tavares AAS, Newby DE, Kijewski MF, Aikawa M, Di Carli M, Dweck MR, Aikawa E
18F-Fluoride Signal Amplification Identifies Microcalcifications Associated With Atherosclerotic Plaque Instability in Positron Emission Tomography/Computed Tomography Images.
Lee LH, Halu A, Morgan S, Iwata H, Aikawa M, Singh SA
XINA: A Workflow for the Integration of Multiplexed Proteomics Kinetics Data with Network Analysis.
Halu A, Wang JG, Iwata H, Mojcher A, Abib AL, Singh SA, Aikawa M, Sharma A
Context-enriched interactome powered by proteomics helps the identification of novel regulators of macrophage activation.
Decano JL, Aikawa M
Dynamic Macrophages: Understanding Mechanisms of Activation as Guide to Therapy for Atherosclerotic Vascular Disease.
Sharma A, Halu A, Decano JL, Padi M, Liu YY, Prasad RB, Fadista J, Santolini M, Menche J, Weiss ST, Vidal M, Silverman EK, Aikawa M, Barabási AL, Groop L, Loscalzo J
Controllability in an islet specific regulatory network identifies the transcriptional factor NFATC4, which regulates Type 2 Diabetes associated genes.
Hagita S, Rogers MA, Pham T, Wen JR, Mlynarchik AK, Aikawa M, Aikawa E
Transcriptional control of intestinal cholesterol absorption, adipose energy expenditure and lipid handling by Sortilin.
van der Valk DC, van der Ven CFT, Blaser MC, Grolman JM, Wu PJ, Fenton OS, Lee LH, Tibbitt MW, Andresen JL, Wen JR, Ha AH, Buffolo F, van Mil A, Bouten CVC, Body SC, Mooney DJ, Sluijter JPG, Aikawa M, Hjortnaes J, Langer R, Aikawa E
Engineering a 3D-Bioprinted Model of Human Heart Valve Disease Using Nanoindentation-Based Biomechanics.
Schlotter F, Halu A, Goto S, Blaser MC, Body SC, Lee LH, Higashi H, DeLaughter DM, Hutcheson JD, Vyas P, Pham T, Rogers MA, Sharma A, Seidman CE, Loscalzo J, Seidman JG, Aikawa M, Singh SA, Aikawa E
Spatiotemporal Multi-omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving Disease.
Itoh S, Mizuno K, Aikawa M, Aikawa E
Dimerization of sortilin regulates its trafficking to extracellular vesicles.
Rogers M, Maldonado-Martinez N, Hutcheson JD, Goettsch C, Goto S, Yamada I, Faits T, Sesaki H, Aikawa M, Aikawa E
Dynamin-Related Protein 1 Inhibition Attenuates Cardiovascular Calcification in the Presence of Oxidative Stress.
Rogers MA, Aikawa M, Aikawa E
Macrophage Heterogeneity Complicates Reversal of Calcification in Cardiovascular Tissues.
Goettsch C, Iwata H, Hutcheson JD, O'Donnell CJ, Chapurlat R, Cook NR, Aikawa M, Szulc P, Aikawa E
Serum Sortilin Associates With Aortic Calcification and Cardiovascular Risk in Men.
Singh SA, Aikawa M
Unbiased and targeted mass spectrometry for the HDL proteome.
Lee LH, Andraski AB, Pieper B, Higashi H, Sacks FM, Aikawa M, Singh SA
Automation of PRM-dependent D3-Leu tracer enrichment in HDL to study the metabolism of apoA-I, LCAT and other apolipoproteins.
Yabusaki K, Hutcheson JD, Vyas P, Bertazzo S, Body SC, Aikawa M, Aikawa E
Quantification of Calcified Particles in Human Valve Tissue Reveals Asymmetry of Calcific Aortic Valve Disease Development.
Iwata H, Goettsch C, Sharma A, Ricchiuto P, Goh WW, Halu A, Yamada I, Yoshida H, Hara T, Wei M, Inoue N, Fukuda D, Mojcher A, Mattson PC, Barabási AL, Boothby M, Aikawa E, Singh SA, Aikawa M
PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation.
Nakano T, Fukuda D, Koga JI, Aikawa M
Delta-Like Ligand 4-Notch Signaling in Macrophage Activation.
Singh SA, Aikawa E, Aikawa M
Current Trends and Future Perspectives of State-of-the-Art Proteomics Technologies Applied to Cardiovascular Disease Research.
Ghiassian SD, Menche J, Chasman DI, Giulianini F, Wang R, Ricchiuto P, Aikawa M, Iwata H, Müller C, Zeller T, Sharma A, Wild P, Lackner K, Singh S, Ridker PM, Blankenberg S, Barabási AL, Loscalzo J
Endophenotype Network Models: Common Core of Complex Diseases.
Goettsch C, Hutcheson JD, Hagita S, Rogers MA, Creager MD, Pham T, Choi J, Mlynarchik AK, Pieper B, Kjolby M, Aikawa M, Aikawa E
A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification.
Decano JL, Mattson PC, Aikawa M
Macrophages in Vascular Inflammation: Origins and Functions.
Goettsch C, Hutcheson JD, Aikawa M, Iwata H, Pham T, Nykjaer A, Kjolby M, Rogers M, Michel T, Shibasaki M, Hagita S, Kramann R, Rader DJ, Libby P, Singh SA, Aikawa E
Sortilin mediates vascular calcification via its recruitment into extracellular vesicles.
Singh SA, Andraski AB, Pieper B, Goh W, Mendivil CO, Sacks FM, Aikawa M
Multiple apolipoprotein kinetics measured in human HDL by high resolution/accurate mass parallel reaction monitoring.
Hutcheson JD, Goettsch C, Bertazzo S, Maldonado N, Ruiz JL, Goh W, Yabusaki K, Faits T, Bouten C, Franck G, Quillard T, Libby P, Aikawa M, Weinbaum S, Aikawa E
Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques.
Sun X, Haas ME, Miao J, Mehta A, Graham MJ, Crooke RM, de Barros JP, Wang JG, Aikawa M, Masson D, Biddinger SB
Insulin dissociates the effects of Liver X Receptor on lipogenesis, endoplasmic reticulum stress and inflammation.
Wang JG, Aikawa M
Toll-Like Receptors and Src-Family Kinases in Atherosclerosis - Focus on Macrophages.
Koga JI, Nakano T, Dahlman JE, Figueiredo JL, Zhang H, Decano J, Khan OF, Niida T, Iwata H, Aster JC, Yagita H, Anderson DG, Ozaki CK, Aikawa M
Macrophage Notch Ligand Delta-Like 4 Promotes Vein Graft Lesion Development: Implications for the Treatment of Vein Graft Failure.
Shibasaki M, Wang JG, Figueiredo JL, New SE, Quillard T, Goettsch C, Koga JI, Sonoki H, Matsumoto J, Aikawa M, Aikawa E
Pitavastatin Reduces Inflammation in Atherosclerotic Plaques in Apolipoprotein E-Deficient Mice with Late Stage Renal Disease.
Singh SA, Miyosawa K, Aikawa M
Mass spectrometry meets the challenge of understanding the complexity of the lipoproteome: recent findings regarding proteins involved in dyslipidemia and cardiovascular disease.
Ricchiuto P, Iwata H, Yabusaki K, Yamada I, Pieper B, Sharma A, Aikawa M, Singh SA
mIMT-visHTS: A novel method for multiplexing isobaric mass tagged datasets with an accompanying visualization high throughput screening tool for protein profiling.
Sasaki Y, Ohta M, Desai D, Figueiredo JL, Whelan MC, Sugano T, Yamabi M, Yano W, Faits T, Yabusaki K, Zhang H, Mlynarchik AK, Inoue K, Mizuno K, Aikawa M
Angiopoietin Like Protein 2 (ANGPTL2) Promotes Adipose Tissue Macrophage and T lymphocyte Accumulation and Leads to Insulin Resistance.
Miyosawa K, Watanabe Y, Murakami K, Murakami T, Shibata H, Iwashita M, Yamazaki H, Yamazaki K, Ohgiya T, Shibuya K, Mizuno K, Tanabe S, Singh SA, Aikawa M
New CETP Inhibitor K-312 Reduces PCSK9 Expression: A Potential Effect on LDL Cholesterol Metabolism.
Lei Y, Iwashita M, Choi J, Aikawa M, Aikawa E
N-acetylglucosamine-1-Phosphate Transferase Suppresses Lysosomal Hydrolases in Dysfunctional Osteoclasts: A Potential Mechanism for Vascular Calcification
Lu H, Aikawa M
Many faces of matrix metalloproteinases in aortic aneurysms.
Figueiredo JL, Aikawa M, Zheng C, Aaron J, Lax L, Libby P, de Lima Filho JL, Gruener S, Fingerle J, Haap W, Hartmann G, Aikawa E
Selective Cathepsin S Inhibition Attenuates Atherosclerosis in Apolipoprotein E-Deficient Mice with Chronic Renal Disease.
Okamoto K, Koyama I, Hara K, Aikawa M, Okada K, Watanabe Y, Miyazawa M
Fibrin glue closure for intractable pancreatic fistulae after pancreaticoduodenectomy.
Hutcheson JD, Goettsch C, Pham T, Iwashita M, Aikawa M, Singh SA, Aikawa E
Enrichment of calcifying extracellular vesicles using density-based ultracentrifugation protocol.
Koga J, Aikawa M
Application of anti-ligand antibodies to inhibit notch signaling.
Miyazaki T, Chiuve S, Sacks FM, Ridker PM, Libby P, Aikawa M
Plasma Pentraxin 3 Levels Do Not Predict Coronary Events but Reflect Metabolic Disorders in Patients with Coronary Artery Disease in the CARE Trial.
Yabusaki K, Faits T, McMullen E, Figueiredo JL, Aikawa M, Aikawa E
A novel quantitative approach for eliminating sample-to-sample variation using a hue saturation value analysis program.
Itou T, Maldonado N, Yamada I, Goettsch C, Matsumoto J, Aikawa M, Singh S, Aikawa E
Cystathionine γ-lyase Accelerates Osteoclast Differentiation: Identification of a Novel Regulator of Osteoclastogenesis by Proteomic Analysis.
Fukuda D, Aikawa M
Expanding Role of Delta-Like 4 Mediated Notch Signaling in Cardiovascular and Metabolic Diseases.
Wang JG, Aikawa E, Aikawa M
Leukocyte-derived Microparticles as Pro-inflammatory Mediators in Atherosclerosis.
Zheng C, Morishige K, Aikawa M
Functional Molecular Imaging Linking Macrophages to Reverse Cholesterol Transport.
New SE, Goettsch C, Aikawa M, Marchini JF, Shibasaki M, Yabusaki K, Libby P, Shanahan CM, Croce K, Aikawa E
Macrophage-Derived Matrix Vesicles: An Alternative Novel Mechanism for Microcalcification in Atherosclerotic Plaques.
Iwata H, Aikawa M
Liver-Artery Interactions via the Plasminogen-CD36 Axis in Macrophage Foam Cell Formation: New Evidence for the Role of Remote Organ Crosstalk in Atherosclerosis.
Zheng C, Aikawa M
High-Density Lipoproteins: From Function to Therapy.
Zheng C, Azcutia V, Aikawa E, Figueiredo JL, Croce K, Sonoki H, Sacks FM, Luscinskas FW, Aikawa M
Statins suppress apolipoprotein CIII-induced vascular endothelial cell activation and monocyte adhesion.
Azcutia V, Stefanidakis M, Tsuboi N, Mayadas T, Croce KJ, Fukuda D, Aikawa M, Newton G, Luscinskas FW
Endothelial CD47 Promotes Vascular Endothelial-Cadherin Tyrosine Phosphorylation and Participates in T Cell Recruitment at Sites of Inflammation In Vivo.
Fukuda D, Aikawa E, Swirski FK, Novobrantseva TI, Kotelianski V, Gorgun CZ, Chudnovskiy A, Yamazaki H, Croce K, Weissleder R, Aster JC, Hotamisligil GS, Yagita H, Aikawa M
Notch ligand Delta-like 4 blockade attenuates atherosclerosis and metabolic disorders.
Aikawa M, Manabe I, Chester A, Aikawa E
Cardiovascular inflammation.
Koga JI, Aikawa M
Crosstalk between macrophages and smooth muscle cells in atherosclerotic vascular diseases.
Quillard T, Tesmenitsky Y, Croce K, Travers R, Shvartz E, Koskinas KC, Sukhova GK, Aikawa E, Aikawa M, Libby P
Selective inhibition of matrix metalloproteinase-13 increases collagen content of established mouse atherosclerosis.
Umeda H, Aikawa M, Libby P
Liberation of desmosine and isodesmosine as amino acids from insoluble elastin by elastolytic proteases.
Fukuda D, Aikawa M
Intimal smooth muscle cells: the context-dependent origin.
Morishige K, Kacher DF, Libby P, Josephson L, Ganz P, Weissleder R, Aikawa M
High-resolution magnetic resonance imaging enhanced with superparamagnetic nanoparticles measures macrophage burden in atherosclerosis.
Bu DX, Tarrio M, Grabie N, Zhang Y, Yamazaki H, Stavrakis G, Maganto-Garcia E, Pepper-Cunningham Z, Jarolim P, Aikawa M, García-Cardeña G, Lichtman AH
Statin-induced Krüppel-like factor 2 expression in human and mouse T cells reduces inflammatory and pathogenic responses.
Deguchi JO, Yamazaki H, Aikawa E, Aikawa M
Chronic hypoxia activates the Akt and beta-catenin pathways in human macrophages.
Aikawa E, Aikawa M, Libby P, Figueiredo JL, Rusanescu G, Iwamoto Y, Fukuda D, Kohler RH, Shi GP, Jaffer FA, Weissleder R
Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease.
Deguchi JO, Huang H, Libby P, Aikawa E, Whittaker P, Sylvan J, Lee RT, Aikawa M
Genetically engineered resistance for MMP collagenases promotes abdominal aortic aneurysm formation in mice infused with angiotensin II.
Sun Y, Ishibashi M, Seimon T, Lee M, Sharma SM, Fitzgerald KA, Samokhin AO, Wang Y, Sayers S, Aikawa M, Jerome WG, Ostrowski MC, Bromme D, Libby P, Tabas IA, Welch CL, Tall AR
Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K.
Minami M, Shimizu K, Okamoto Y, Folco E, Ilasaca ML, Feinberg MW, Aikawa M, Libby P
Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation.
Schneider F, Sukhova GK, Aikawa M, Canner J, Gerdes N, Tang SM, Shi GP, Apte SS, Libby P
Matrix-metalloproteinase-14 deficiency in bone-marrow-derived cells promotes collagen accumulation in mouse atherosclerotic plaques.
Aikawa E, Nahrendorf M, Figueiredo JL, Swirski FK, Shtatland T, Kohler RH, Jaffer FA, Aikawa M, Weissleder R
Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo.
Aikawa M
The balance of power: the law of Yin and Yang in smooth muscle cell fate. Is YY1 a vascular protector?
Ahluwalia N, Lin AY, Tager AM, Pruitt IE, Anderson TJ, Kristo F, Shen D, Cruz AR, Aikawa M, Luster AD, Gerszten RE
Inhibited aortic aneurysm formation in BLT1-deficient mice.
Fung E, Tang SM, Canner JP, Morishige K, Arboleda-Velasquez JF, Cardoso AA, Carlesso N, Aster JC, Aikawa M
Delta-like 4 induces notch signaling in macrophages: implications for inflammation.
Aikawa E, Nahrendorf M, Sosnovik D, Lok VM, Jaffer FA, Aikawa M, Weissleder R
Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease.
Tsimikas S, Aikawa M, Miller FJ, Miller ER, Torzewski M, Lentz SR, Bergmark C, Heistad DD, Libby P, Witztum JL
Increased plasma oxidized phospholipid:apolipoprotein B-100 ratio with concomitant depletion of oxidized phospholipids from atherosclerotic lesions after dietary lipid-lowering: a potential biomarker of early atherosclerosis regression.
Deguchi JO, Aikawa M, Tung CH, Aikawa E, Kim DE, Ntziachristos V, Weissleder R, Libby P
Inflammation in atherosclerosis: visualizing matrix metalloproteinase action in macrophages in vivo.
Aikawa E, Whittaker P, Farber M, Mendelson K, Padera RF, Aikawa M, Schoen FJ
Human semilunar cardiac valve remodeling by activated cells from fetus to adult: implications for postnatal adaptation, pathology, and tissue engineering.
Sugiyama S, Kugiyama K, Nakamura S, Kataoka K, Aikawa M, Shimizu K, Koide S, Mitchell RN, Ogawa H, Libby P
Characterization of smooth muscle-like cells in circulating human peripheral blood.
Deguchi JO, Aikawa E, Libby P, Vachon JR, Inada M, Krane SM, Whittaker P, Aikawa M
Matrix metalloproteinase-13/collagenase-3 deletion promotes collagen accumulation and organization in mouse atherosclerotic plaques.
Larose E, Yeghiazarians Y, Libby P, Yucel EK, Aikawa M, Kacher DF, Aikawa E, Kinlay S, Schoen FJ, Selwyn AP, Ganz P
Characterization of human atherosclerotic plaques by intravascular magnetic resonance imaging.
Arboleda-Velasquez JF, Rampal R, Fung E, Darland DC, Liu M, Martinez MC, Donahue CP, Navarro-Gonzalez MF, Libby P, D'Amore PA, Aikawa M, Haltiwanger RS, Kosik KS
CADASIL mutations impair Notch3 glycosylation by Fringe.
Rabkin-Aikawa E, Aikawa M, Farber M, Kratz JR, Garcia-Cardena G, Kouchoukos NT, Mitchell MB, Jonas RA, Schoen FJ
Clinical pulmonary autograft valves: pathologic evidence of adaptive remodeling in the aortic site.
Fukumoto Y, Deguchi JO, Libby P, Rabkin-Aikawa E, Sakata Y, Chin MT, Hill CC, Lawler PR, Varo N, Schoen FJ, Krane SM, Aikawa M
Genetically determined resistance to collagenase action augments interstitial collagen accumulation in atherosclerotic plaques.
Rabkin-Aikawa E, Farber M, Aikawa M, Schoen FJ
Dynamic and reversible changes of interstitial cell phenotype during remodeling of cardiac valves.
J Heart Valve Dis. 2004;13(5):841-7 - PMID:
15473488
Aikawa M
Effects of statin therapy on vascular dysfunction.
Sugiyama S, Kugiyama K, Aikawa M, Nakamura S, Ogawa H, Libby P
Hypochlorous acid, a macrophage product, induces endothelial apoptosis and tissue factor expression: involvement of myeloperoxidase-mediated oxidant in plaque erosion and thrombogenesis.
Aikawa M, Libby P
Atherosclerotic plaque inflammation: the final frontier?
Can J Cardiol. 2004;20(6):631-4 - PMID:
15152295
Aikawa M, Libby P
The vulnerable atherosclerotic plaque: pathogenesis and therapeutic approach.
Shimizu K, Aikawa M, Takayama K, Libby P, Mitchell RN
Direct anti-inflammatory mechanisms contribute to attenuation of experimental allograft arteriosclerosis by statins.
Libby P, Aikawa M
Mechanisms of plaque stabilization with statins.
Libby P, Aikawa M
Stabilization of atherosclerotic plaques: new mechanisms and clinical targets.
Aikawa M, Sugiyama S, Hill CC, Voglic SJ, Rabkin E, Fukumoto Y, Schoen FJ, Witztum JL, Libby P
Lipid lowering reduces oxidative stress and endothelial cell activation in rabbit atheroma.
Rabkin E, Hoerstrup SP, Aikawa M, Mayer JE, Schoen FJ
Evolution of cell phenotype and extracellular matrix in tissue-engineered heart valves during in-vitro maturation and in-vivo remodeling.
J Heart Valve Dis. 2002;11(3):308-14; discussion 314 - PMID:
12056720
Libby P, Aikawa M
Vitamin C, collagen, and cracks in the plaque.
Lindsey ML, Gannon J, Aikawa M, Schoen FJ, Rabkin E, Lopresti-Morrow L, Crawford J, Black S, Libby P, Mitchell PG, Lee RT
Selective matrix metalloproteinase inhibition reduces left ventricular remodeling but does not inhibit angiogenesis after myocardial infarction.
Rabkin E, Aikawa M, Stone JR, Fukumoto Y, Libby P, Schoen FJ
Activated interstitial myofibroblasts express catabolic enzymes and mediate matrix remodeling in myxomatous heart valves.
Sakamoto H, Aikawa M, Hill CC, Weiss D, Taylor WR, Libby P, Lee RT
Biomechanical strain induces class a scavenger receptor expression in human monocyte/macrophages and THP-1 cells: a potential mechanism of increased atherosclerosis in hypertension.
Shimizu K, Sugiyama S, Aikawa M, Fukumoto Y, Rabkin E, Libby P, Mitchell RN
Host bone-marrow cells are a source of donor intimal smooth- muscle-like cells in murine aortic transplant arteriopathy.
Aikawa M, Libby P
Vascular inflammation and activation: new targets for lipid lowering.
Eur Heart J. 2001;3:A3-A11
Fukumoto Y, Libby P, Rabkin E, Hill CC, Enomoto M, Hirouchi Y, Shiomi M, Aikawa M
Statins alter smooth muscle cell accumulation and collagen content in established atheroma of watanabe heritable hyperlipidemic rabbits.
Aikawa M, Rabkin E, Sugiyama S, Voglic SJ, Fukumoto Y, Furukawa Y, Shiomi M, Schoen FJ, Libby P
An HMG-CoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro.
Ducharme A, Frantz S, Aikawa M, Rabkin E, Lindsey M, Rohde LE, Schoen FJ, Kelly RA, Werb Z, Libby P, Lee RT
Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction.
Aikawa M, Voglic SJ, Sugiyama S, Rabkin E, Taubman MB, Fallon JT, Libby P
Dietary lipid lowering reduces tissue factor expression in rabbit atheroma.
McConnell MV, Aikawa M, Maier SE, Ganz P, Libby P, Lee RT
MRI of rabbit atherosclerosis in response to dietary cholesterol lowering.
Libby P, Mach F, Schönbeck U, Bourcier T, Aikawa M
Regulation of the thrombotic potential of atheroma.
Thromb Haemost. 1999;82(2):736-41 - PMID:
10605776
Rohde LE, Aikawa M, Cheng GC, Sukhova G, Solomon SD, Libby P, Pfeffer J, Pfeffer MA, Lee RT
Echocardiography-derived left ventricular end-systolic regional wall stress and matrix remodeling after experimental myocardial infarction.
Libby P, Aikawa M
New insights into plaque stabilisation by lipid lowering.
Aikawa M, Rabkin E, Voglic SJ, Shing H, Nagai R, Schoen FJ, Libby P
Lipid lowering promotes accumulation of mature smooth muscle cells expressing smooth muscle myosin heavy chain isoforms in rabbit atheroma.
Aikawa M, Rabkin E, Okada Y, Voglic SJ, Clinton SK, Brinckerhoff CE, Sukhova GK, Libby P
Lipid lowering by diet reduces matrix metalloproteinase activity and increases collagen content of rabbit atheroma: a potential mechanism of lesion stabilization.
Manabe I, Kurabayashi M, Shimomura Y, Kuro-o M, Watanabe N, Watanabe M, Aikawa M, Suzuki T, Yazaki Y, Nagai R
Isolation of the embryonic form of smooth muscle myosin heavy chain (SMemb/NMHC-B) gene and characterization of its 5'-flanking region.
Aikawa M, Sakomura Y, Ueda M, Kimura K, Manabe I, Ishiwata S, Komiyama N, Yamaguchi H, Yazaki Y, Nagai R
Redifferentiation of smooth muscle cells after coronary angioplasty determined via myosin heavy chain expression.
Suzuki J, Isobe M, Aikawa M, Kawauchi M, Shiojima I, Kobayashi N, Tojo A, Suzuki T, Kimura K, Nishikawa T, Sakai T, Sekiguchi M, Yazaki Y, Nagai R
Nonmuscle and smooth muscle myosin heavy chain expression in rejected cardiac allografts. A study in rat and monkey models.
Aikawa M, Sivam PN, Kuro-o M, Kimura K, Nakahara K, Takewaki S, Ueda M, Yamaguchi H, Yazaki Y, Periasamy M
Human smooth muscle myosin heavy chain isoforms as molecular markers for vascular development and atherosclerosis.
Kim HS, Aikawa M, Kimura K, Kuro-o M, Nakahara K, Suzuki T, Katoh H, Okamoto E, Yazaki Y, Nagai R
Ductus arteriosus. Advanced differentiation of smooth muscle cells demonstrated by myosin heavy chain isoform expression in rabbits.