Pantaleao AN, Figueiredo FA, Mutarelli A, Guarçoni BV, Carvalho H, Fonseca I, Dahan S, Kang J, Sindre R, Oliveira JRS, Aikawa E, Levine RA, Nunes MCP, PRIMA Network

Improvement in left atrial strain after percutaneous mitral valvuloplasty is an independent prognostic marker in patients with rheumatic mitral stenosis.
Front Cardiovasc Med. 2026;13:1719283 - PMID: 42222110 - PMCID: PMC13219354 - DOI: 10.3389/fcvm.2026.1719283

Wang JG, Ito S, Hosokawa D, Nihira K, Decano JL, Lee LH, Higashi H, Halu A, Mattson PC, Amaral G, Abib AL, Mojcher A, Mlynarchik AK, Whelan M, Anderson DG, Aikawa E, Singh SA, Uchida S, Aikawa M

The long noncoding RNA lnc-FAM164A1-ACLY axis promotes pro-inflammatory responses in human primary macrophages: a systems approach.
Front Immunol. 2026;17:1776849 - PMID: 42148116 - PMCID: PMC13175867 - DOI: 10.3389/fimmu.2026.1776849

Itagawa R, Okui T, Tanaka T, Nakamura Y, Hosokawa D, Clift CL, Blaser MC, Kasai T, Weiss L, Turner ME, Billaud M, Aikawa M, Singh SA, Aikawa E

Mitochondrial Extracellular Vesicles Enhance Aortic Valve Calcification Via Carnitine O-Octanoyltransferase.
Arterioscler Thromb Vasc Biol. 2026;46(7):e324456 - PMID: 42093641 - PMCID: PMC13155380 - DOI: 10.1161/ATVBAHA.126.324456

Matienzo N, Kress Z, Singh SA, Aikawa M, Soni RK, Li Y, Reyes-Soffer G

Comparative Proteomic Analysis of Lipoprotein(a): Method-Dependent Profiles and Disease Pathways.
J Clin Med. 2026;15(7):ePub - PMID: 41976861 - PMCID: PMC13073900 - DOI: 10.3390/jcm15072559

Yuan XM, Singh SA

Editorial: Proteomics in atherosclerosis.
Front Cardiovasc Med. 2026;13:1792281 - PMID: 41969690 - PMCID: PMC13065504 - DOI: 10.3389/fcvm.2026.1792281

Chelvanambi S, Bernhagen J, Fredman G, Labarrere CA, Winkels H, Aikawa M

Editorial: Immunity, atherosclerosis, and cardiovascular disease: an interdisciplinary approach to cardiometabolic health.
Front Cardiovasc Med. 2026;13:1787241 - PMID: 41878482 - PMCID: PMC13006318 - DOI: 10.3389/fcvm.2026.1787241

Kasai T, Weiss L, Wohlfahrt J, Matamalas JT, Shlayen G, Kirsch ZJ, Aikawa M, Aikawa E, Singh SA

Impact of Variations in Commercial Standard Operating Procedure on Plasma Proteome Recovery.
J Proteome Res. 2026;25(4):1941-1950 - PMID: 41879802 - PMCID: PMC13054859 - DOI: 10.1021/acs.jproteome.5c01012

Mutarelli A, Pantaleao AN, Melo PHC, Nogueira W, Nogueira A, Felix N, Generoso G, Cardoso R, Lupieri A, Aikawa E, Levine RA, Nunes MCP

Global prevalence and sex differences in rheumatic heart disease: a systematic review and updated meta-analysis.
Front Cardiovasc Med. 2025;12:1615158 - PMID: 41282342 - PMCID: PMC12631635 - DOI: 10.3389/fcvm.2025.1615158

Yao J, Farrar CT, Aikawa E, Sosnovik DE, Moon BF, Kulkarni A, Ackerman JL

Ex Vivo Phosphorus-31 Solid State Magnetic Resonance Spectroscopy Identifies Compositional Differences Between Bone Mineral and Calcified Vascular Tissues.
medRxiv. 2025;:ePub - PMID: 41256110 - PMCID: PMC12622083 - DOI: 10.1101/2025.09.27.25336805

Hall IF, Aikawa E, Sluimer J, Baker AH, Kovacic JC

Endothelial to mesenchymal transition in cardiovascular diseases: molecular insights and clinical perspectives.
Eur Heart J. 2025;47(10):1144-1158 - PMID: 41128016 - PMCID: PMC13016786 - DOI: 10.1093/eurheartj/ehaf670

Jha PK, Chelvanambi S, Nakamura Y, Itto LYU, Vijay A, Lupieri A, Barbeiro MC, Le TD, Nascimento CB, Kasai T, Whelan MC, Hosokawa D, Becker-Greene D, Singh SA, Aikawa E, Uchida S, Aikawa M

A systems approach to target discovery identifies the role of lncRNA-SPANXA2-OT1 in macrophage chemotaxis.
JCI Insight. 2025;10(21):ePub - PMID: 41066194 - PMCID: PMC12643516 - DOI: 10.1172/jci.insight.191274

Song N, Yu J, Ji E, Yoon J, Choi KH, Yu JE, Kim B, Kim J, Kim M, Lee S, Kim K, Aikawa E

Characterization of Proteome Features in Patients With Aortic Stenosis Using Data-Independent Acquisition-Based Proteomic Analysis.
Korean Circ J. 2025;56(1):80-96 - PMID: 41044724 - PMCID: PMC12834629 - DOI: 10.4070/kcj.2025.0137

Parthasarathy S, Saenjamsai P, Hao H, Ferkul A, Pfannenstiel JJ, Bejan DS, Chen Y, Suder EL, Schwarting N, Aikawa M, Muhlberger E, Hume AJ, Orozco RC, Sullivan CS, Cohen MS, Davido DJ, Fehr AR

PARP14 is an interferon-induced host factor that promotes IFN production and affects the replication of multiple viruses.
mBio. 2025;16(10):e0229925 - PMID: 40937852 - PMCID: PMC12505956 - DOI: 10.1128/mbio.02299-25

Santinelli-Pestana DV, Delwarde C, Kasai T, Kuraoka S, Nakamura Y, Okada T, Decano JL, Chelvanambi S, Ge R, Mlynarchik AK, Perez K, Campedelli A, Sonawane AR, Aikawa E, Singh SA, Aikawa M

ADP-Ribosylation in Experimental Atherosclerosis: A Potential Link Between Dyslipidemia and Inflammation in Cardiovascular Disease.
Arterioscler Thromb Vasc Biol. 2025;45(11):2137-2139 - PMID: 40905119 - PMCID: PMC12542996 - DOI: 10.1161/ATVBAHA.125.322497

Goody PR, Christmann D, Goody D, Hildebrand S, Billig H, Nehl D, Chennupati R, Gladka M, Wilhelm-Jüngling K, Uchida S, Iris-Bibli S, Moore JB, Hamdani N, Paneni F, Pullamsetti SS, Zimmer S, Jansen F, Bakhtiary F, Aikawa E, Pfeifer A, Nickenig G, Hosen MR

Calcific aortic valve disease augments vesicular microRNA-145-5p to regulate the calcification of valvular interstitial cells via cellular crosstalk.
Basic Res Cardiol. 2025;120(5):991-1010 - PMID: 40847220 - PMCID: PMC12518376 - DOI: 10.1007/s00395-025-01133-w

Clift CL, Blaser MC, Bartoli-Leonard F, Schlotter F, Higashi H, Kuraoka S, Kasai T, Turner ME, Pham T, Perez KA, Robson SC, Body SC, Muehlschlegel JD, Aikawa M, Singh SA, Aikawa E

Sexual Dimorphism of Plasma and Tissue Proteomes in Human Calcific Aortic Valve Stenosis Pathogenesis.
Arterioscler Thromb Vasc Biol. 2025;45(10):1928-1934 - PMID: 40808650 - DOI: 10.1161/ATVBAHA.125.322560

Sun J, Aikawa M, Ashktorab H, Beckmann ND, Enger ML, Espinosa JM, Gai X, Horne BD, Keim P, Lasky-Su J, Letts R, Maier CL, Mandal M, Nichols L, Roan NR, Russell MW, Rutter J, Saade GR, Sharma K, Shiau S, Thibodeau SN, Yang S, Miele L, NIH Researching COVID to Enhance Recovery (RECOVER) Consortium

A multi-omics strategy to understand PASC through the RECOVER cohorts: a paradigm for a systems biology approach to the study of chronic conditions.
Front Syst Biol. 2025;4:1422384 - PMID: 40809128 - PMCID: PMC12342036 - DOI: 10.3389/fsysb.2024.1422384

Jha PK, Aikawa M, Aikawa E

Indoxyl sulfate: fuelling cardiovascular inflammation and calcification.
Cardiovasc Res. 2025;121(11):1642-1644 - PMID: 40795292 - PMCID: PMC12477674 - DOI: 10.1093/cvr/cvaf134

Clift CL, Goudot G, Bogut G, Kasai T, van Kampen A, Negrao Pantaleao A, Messas E, Aikawa M, Singh SA, Levine RA, Pernot M, Aikawa E

Short- and Long-Term Effects of Pulsed Ultrasound Cavitation Therapy of Calcified Valvular Interstitial Cells in Culture.
Ultrasound Med Biol. 2025;51(11):1936-1944 - PMID: 40796501 - DOI: 10.1016/j.ultrasmedbio.2025.06.026

Chelvanambi S, Chen H, De Vries MR, Fang Y, Fredman G, Gomez D, Iwata H, Uchida S, Yanagisawa H, Aikawa M

Editorial: New trends in vascular biology 2024.
Front Cardiovasc Med. 2025;12:1649558 - PMID: 40777568 - PMCID: PMC12328353 - DOI: 10.3389/fcvm.2025.1649558

Delwarde C, Matamalas JT, Chelvanambi S, Kasai T, Shlayen G, Santinelli-Pestana DV, Zamani M, Aikawa E, Aikawa M, Singh SA

Nanoparticle-enabled plasma proteomics of a mouse atherosclerosis model.
bioRxiv. 2025;:ePub - PMID: 40766711 - PMCID: PMC12324543 - DOI: 10.1101/2025.08.01.667173

Boeck M, Yagi H, Lundgren P, Pivodic A, Nilsson AK, Zeng Y, Chen CT, Kasai T, Lee D, Nian S, Hirst V, Neilsen K, Wang C, Lee J, Yu M, McCutcheon A, Singh SA, Aikawa M, Bazinet RP, Fu Z, Hellström A, Smith LE

Combined dietary omega-3 and omega-6 fatty acids protect against hyperglycemia-associated retinopathy in neonatal mice.
Pharmacol Res. 2025;219:107877 - PMID: 40706777 - PMCID: PMC12445345 - DOI: 10.1016/j.phrs.2025.107877

Cahalane RME, Meuris B, Matamalas JT, Blaser MC, Billaud M, Kasai T, Hendrickx A, Goeminne LJE, Muehlschlegel J, Rega F, Aikawa M, McNamara L, Singh SA, Clift CL, Aikawa E

Cross-species proteomics quantification pipeline distinguishes donor versus host extracellular matrix in explanted biomaterials.
bioRxiv. 2025;:ePub - PMID: 40667106 - PMCID: PMC12262681 - DOI: 10.1101/2025.06.24.661315

Weiss L, Aikawa E

Glycolysis hijacked: a novel pathogenic role of lipoprotein(a) in valve disease.
Eur Heart J Open. 2025;5(4):oeaf069 - PMID: 40654528 - PMCID: PMC12246370 - DOI: 10.1093/ehjopen/oeaf069

Lupieri A, Becker-Greene D, Le TD, Roschel MM, Jha PK, Sonawane AR, Mullick A, Tsimikas S, Kuraoka S, Singh SA, Aikawa M, Aikawa E

Antisense Oligonucleotide Targeting Sortilin Reduces Vascular Calcification in Mice in a Sex-Dependent Manner.
Arterioscler Thromb Vasc Biol. 2025;45(8):1398-1415 - PMID: 40501380 - PMCID: PMC12503371 - DOI: 10.1161/ATVBAHA.124.321999

Higuita ML, Ajenu EO, Bolger-Chen M, Olverson G, Akbari Ghavimi SA, Lee SY, Kasai T, Michaud W, Chijioke C, Ruidas B, Pitti A, Minie N, Catricala J, Vincent D, Li S, D'Alessandro D, Aikawa E, Singh SA, Billaud M, Osho AA, Tessier SN, Rabi SA

Alternative preservation strategies of DCD hearts: Effect of cold ischemia time before normothermic machine perfusion.
medRxiv. 2025;:ePub - PMID: 40502597 - PMCID: PMC12154999 - DOI: 10.1101/2025.06.04.25329001

Raju S, Turner ME, Cao C, Abdul-Samad M, Punwasi N, Blaser MC, Cahalane RME, Botts SR, Prajapati K, Patel S, Wu R, Gustafson D, Galant NJ, Fiddes L, Chemaly M, Hedin U, Matic L, Seidman MA, Subasri V, Singh SA, Aikawa E, Fish JE, Howe KL

Multiomic Landscape of Extracellular Vesicles in Human Carotid Atherosclerotic Plaque Reveals Endothelial Communication Networks.
Arterioscler Thromb Vasc Biol. 2025;45(7):1277-1305 - PMID: 40438929 - PMCID: PMC12188822 - DOI: 10.1161/ATVBAHA.124.322324

Lupieri A, Aikawa E

Decoding calcific aortic valve disease: is liver X receptor the key to lipid metabolism?
Cardiovasc Res. 2025;121(6):844-846 - PMID: 40389228 - DOI: 10.1093/cvr/cvaf080

Yagi H, Qiu C, Zeng Y, Boeck M, Nian S, Chen CT, Harman JC, Kasai T, Lee J, Hirst V, Neilsen K, Wang C, Bora K, Maurya M, Rodrick T, Grumbine M, Yang Y, Hua Z, Sweet IR, Singh SA, Aikawa M, Chen J, Fu Z

Serine supplementation suppresses hypoxia-induced pathological retinal angiogenesis.
Theranostics. 2025;15(11):5087-5105 - PMID: 40303351 - PMCID: PMC12036884 - DOI: 10.7150/thno.105299

Jung B, Yagi H, Kuo A, Dorweiler TF, Aikawa M, Kasai T, Singh SA, Dannenberg AJ, Fu Z, Niaudet C, Smith LEH, Hla T

ApoM-bound S1P acts via endothelial S1PR1 to suppress choroidal neovascularization and vascular leakage.
Angiogenesis. 2025;28(2):24 - PMID: 40266369 - PMCID: PMC12018641 - DOI: 10.1007/s10456-025-09975-7

Bortolin RH, de Souza Leite F, Luchessi AD, Esposito J, Barbosa IN, Costa de Freitas RC, Sonawane AR, Singh SA, Aikawa E, Silva KAT, Hirata TDC, Neta APR, Goulart E, Caires-Júnior LC, Mata Martins TMD, Semedo P, de Paula Moreira D, Naslavsky M, Faludi AA, Gonçalves RM, Araujo DB, Malaquias VB, Ferreira GM, DeOcesano-Pereira C, Chudzinski-Tavassi AM, Pu WT, Zatz M, Hirata RDC, Hirata MH

Translational insights into statin-induced myotoxicity: differential impact of lipophilic and hydrophilic statins on iPSC-derived skeletal muscle cells from patients with familial hypercholesterolemia.
Toxicology. 2025;515:154159 - PMID: 40254247 - DOI: 10.1016/j.tox.2025.154159

Jha PK, Nakano T, Itto LYU, Barbeiro MC, Lupieri A, Aikawa E, Aikawa M

Vascular inflammation in chronic kidney disease: the role of uremic toxins in macrophage activation.
Front Cardiovasc Med. 2025;12:1574489 - PMID: 40201789 - PMCID: PMC11975941 - DOI: 10.3389/fcvm.2025.1574489

Lupieri A, Jha PK, Nizet V, Dutra WO, Nunes MCP, Levine RA, Aikawa E

Rheumatic heart valve disease: navigating the challenges of an overlooked autoimmune disorder.
Front Cardiovasc Med. 2025;12:1537104 - PMID: 40182432 - PMCID: PMC11966398 - DOI: 10.3389/fcvm.2025.1537104

Song N, Ji E, Yu JE, Choi KH, Kim DH, Song JM, Kang DH, Song JK, Yu J, Kim K, Lee S, Aikawa E

Spermidine Enhances Mitochondrial Function and Mitigates Aortic Valve Calcification: Implications for DNA Methyltransferase-1 Activity.
JACC Basic Transl Sci. 2025;10(3):345-366 - PMID: 40139876 - PMCID: PMC12013848 - DOI: 10.1016/j.jacbts.2024.11.011

Aikawa E, Blaser MC, Singh SA, Levine RA, Yacoub MH

Challenges and Opportunities in Valvular Heart Disease: From Molecular Mechanisms to the Community.
Arterioscler Thromb Vasc Biol. 2024;44(4):763-767 - PMID: 38536897 - PMCID: PMC10977651 - DOI: 10.1161/ATVBAHA.123.319563

Yagi H, Boeck M, Nian S, Neilsen K, Wang C, Lee J, Zeng Y, Grumbine M, Sweet IR, Kasai T, Negishi K, Singh SA, Aikawa M, Hellström A, Smith LEH, Fu Z

Mitochondrial control of hypoxia-induced pathological retinal angiogenesis.
Angiogenesis. 2024;27(4):691-699 - PMID: 39096357 - PMCID: PMC11564381 - DOI: 10.1007/s10456-024-09940-w

Okui T, Kuraoka S, Iwashita M, Itagawa R, Kasai T, Aikawa M, Singh SA, Aikawa E

Carnitine O-octanoyltransferase (CROT) deficiency in mice leads to an increase of omega-3 fatty acids.
Front Mol Biosci. 2024;11:1374316 - PMID: 39076376 - PMCID: PMC11284101 - DOI: 10.3389/fmolb.2024.1374316

Yagi H, Boeck M, Petrishka-Lozenska M, Lundgren P, Kasai T, Cagnone G, gael.cagnone.1@gmail.com, Wang C, Lee J, Tomita Y, Singh SA, Joyal JS, Aikawa M, Negishi K, Fu Z, Hellström A, Smith LEH

Timed topical dexamethasone eye drops improve mitochondrial function to prevent severe retinopathy of prematurity.
Res Sq. 2024;:ePub - PMID: 38978601 - PMCID: PMC11230485 - DOI: 10.21203/rs.3.rs-4619093/v1

Raju S, Turner ME, Cao C, Abdul-Samad M, Punwasi N, Blaser MC, Cahalane RM, Botts SR, Prajapati K, Patel S, Wu R, Gustafson D, Galant NJ, Fiddes L, Chemaly M, Hedin U, Matic L, Seidman M, Subasri V, Singh SA, Aikawa E, Fish JE, Howe KL

Multi-omic Landscape of Extracellular Vesicles in Human Carotid Atherosclerotic Plaque Reveals Endothelial Communication Networks.
bioRxiv. 2024;:ePub - PMID: 38979218 - PMCID: PMC11230219 - DOI: 10.1101/2024.06.21.599781

Chen ZB, Aikawa E, Alfaidi M, Ali K, Clift CL, Erbay E, Fredman G, Gomez D, Huang NF, Lu HS, Nguyen PK, Darc Oliveira S, Rodriguez-Miguelez P, SenthilKumar G, Zhang H, by the ATVB WLC

Institutional Support for the Career Advancement of Women Faculty in Science and Academic Medicine: Successes, Challenges, and Future Directions.
Arterioscler Thromb Vasc Biol. 2024;44(9):1916-1924 - PMID: 38957985 - PMCID: PMC11338710 - DOI: 10.1161/ATVBAHA.124.320910

Aikawa E, Allison MA, Iruela Arispe L, Bendeck MP, Chen Y, Gardiner EE, Golledge J, Suzuki-Inoue K, Marelli-Berg F, Powell JT, Ramasamy R, Sarpong DF, Sorci-Thomas MG, Daugherty A, Hegele RA, Schmidt AM

Honoring the Life and Legacy of Dr David A. Dichek.
Arterioscler Thromb Vasc Biol. 2024;44(7):1459-1461 - PMID: 38924433 - DOI: 10.1161/ATVBAHA.124.321293

Small AM, Yutzey KE, Binstadt BA, Voigts Key K, Bouatia-Naji N, Milan D, Aikawa E, Otto CM, St Hilaire C, American Heart Association Council on Genomic and Precision Medicine Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation and Council on Cardiovascular and Stroke Nursing

Unraveling the Mechanisms of Valvular Heart Disease to Identify Medical Therapy Targets: A Scientific Statement From the American Heart Association.
Circulation. 2024;150(6):e109-e128 - PMID: 38881493 - PMCID: PMC11542557 - DOI: 10.1161/CIR.0000000000001254

Gordon LB, Basso S, Maestranzi J, Aikawa E, Clift CL, Cammardella AG, Danesi TH, Del Nido PJ, Edelman ER, Hamdy A, Hegde SM, Kleinman ME, Maschietto N, Mehra MR, Mukundan S, Musumeci F, Russo M, Rybicki FJ, Shah PB, Suarez WA, Tuminelli K, Zaleski K, Prakash A, Gerhard-Herman M

Intervention for critical aortic stenosis in Hutchinson-Gilford progeria syndrome.
Front Cardiovasc Med. 2024;11:1356010 - PMID: 38725831 - PMCID: PMC11079313 - DOI: 10.3389/fcvm.2024.1356010

Parthasarathy S, Saenjamsai P, Hao H, Ferkul A, Pfannenstiel JJ, Suder EL, Bejan DS, Chen Y, Schwarting N, Aikawa M, Muhlberger E, Orozco RC, Sullivan CS, Cohen MS, Davido DJ, Hume AJ, Fehr AR

PARP14 is pro- and anti-viral host factor that promotes IFN production and affects the replication of multiple viruses.
bioRxiv. 2024;:ePub - PMID: 38712082 - PMCID: PMC11071520 - DOI: 10.1101/2024.04.26.591186

Reyes-Soffer G, Matveyenko A, Lignos J, Matienzo N, Santos Baez LS, Hernandez-One A, Yung L, Nandakumar R, Singh SA, Aikawa M, George R, Ginsberg HN

Effects of Recombinant Human Lecithin Cholesterol Acyltransferase on Lipoprotein Metabolism in Humans.
Arterioscler Thromb Vasc Biol. 2024;44(6):1407-1418 - PMID: 38695168 - PMCID: PMC12462640 - DOI: 10.1161/ATVBAHA.123.320387

Raju S, Botts SR, Blaser MC, Abdul-Samad M, Prajapati K, Khosraviani N, Ho TWW, Breda LCD, Ching C, Galant NJ, Fiddes L, Wu R, Clift CL, Pham T, Lee WL, Singh SA, Aikawa E, Fish JE, Howe KL

Directional Endothelial Communication by Polarized Extracellular Vesicle Release.
Circ Res. 2024;134(3):269-289 - PMID: 38174557 - PMCID: PMC10826926 - DOI: 10.1161/CIRCRESAHA.123.322993

Kumar Jha P, Aikawa M, Aikawa E

Macrophage Heterogeneity and Efferocytosis: Beyond the M1/M2 Dichotomy.
Circ Res. 2024;134(2):186-188 - PMID: 38236949 - PMCID: PMC10798221 - DOI: 10.1161/CIRCRESAHA.123.324011

Turner ME, Beck L, Hill Gallant KM, Chen Y, Moe OW, Kuro-O M, Moe S, Aikawa E

Phosphate in Cardiovascular Disease: From New Insights Into Molecular Mechanisms to Clinical Implications.
Arterioscler Thromb Vasc Biol. 2024;44(3):584-602 - PMID: 38205639 - PMCID: PMC10922848 - DOI: 10.1161/ATVBAHA.123.319198

Shelbaya K, Arthur V, Yang Y, Dorbala P, Buckley L, Claggett B, Skali H, Dufresne L, Yang TY, Engert JC, Thanassoulis G, Floyd J, Austin TR, Bortnick A, Kizer J, Freitas RCC, Singh SA, Aikawa E, Hoogeveen RC, Ballantyne C, Yu B, Coresh J, Blaha MJ, Matsushita K, Shah AM

Large-Scale Proteomics Identifies Novel Biomarkers and Circulating Risk Factors for Aortic Stenosis.
J Am Coll Cardiol. 2024;83(5):577-591 - PMID: 38296402 - PMCID: PMC12582517 - DOI: 10.1016/j.jacc.2023.11.021

Hashmi S, Shah PW, Aherrahrou Z, Aikawa E, Aherrahrou R

Beyond the Basics: Unraveling the Complexity of Coronary Artery Calcification.
Cells. 2023;12(24):ePub - PMID: 38132141 - PMCID: PMC10742130 - DOI: 10.3390/cells12242822
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