Reset

Aikawa E, Hutcheson JD

The Developmental Origin of Calcific Aortic Stenosis.
N Engl J Med. 2022;386(14):1372-1374 - PMID: 35388675 - DOI: 10.1056/NEJMcibr2200439

Turner ME, Aikawa E

Updating the paradigm: inflammation as a targetable modulator of medial vascular calcification.
Cardiovasc Res. 2023;119(13):2259-2261 - PMID: 37875065 - PMCID: PMC10597605 - DOI: 10.1093/cvr/cvad139

Decano JL, Maiorino E, Matamalas JT, Chelvanambi S, Tiemeijer BM, Yanagihara Y, Mukai S, Jha PK, Pestana DVS, D'Souza E, Whelan M, Ge R, Asano T, Sharma A, Libby P, Singh SA, Aikawa E, Aikawa M

Cellular Heterogeneity of Activated Primary Human Macrophages and Associated Drug-Gene Networks: From Biology to Precision Therapeutics.
Circulation. 2023;148(19):1459-78 - PMID: 37850387 - PMCID: PMC10624416 - DOI: 10.1161/CIRCULATIONAHA.123.064794

Yacoub MH, Tseng YT, Kluin J, Vis A, Stock U, Smail H, Sarathchandra P, Aikawa E, El-Nashar H, Chester AH, Shehata N, Nagy M, El-Sawy A, Li W, Burriesci G, Salmonsmith J, Romeih S, Latif N

Valvulogenesis of a living, innervated pulmonary root induced by an acellular scaffold.
Commun Biol. 2023;6(1):1017 - PMID: 37805576 - PMCID: PMC10560219 - DOI: 10.1038/s42003-023-05383-z

Velissari R, Ilieva M, Dao J, Miller HE, Madsen JH, Gorodkin J, Aikawa M, Ishii H, Uchida S

Systematic analysis and characterization of long non-coding RNA genes in inflammatory bowel disease.
Brief Funct Genomics. 2023;23(4):395-405 - PMID: 37791426 - PMCID: PMC11260263 - DOI: 10.1093/bfgp/elad044

Machaidze Z, D'Amore A, Freitas RCC, Joyce AJ, Bayoumi A, Rich K, Brown DW, Aikawa E, Wagner WR, Sacks MS, Mayer JE

Tissue formation and host remodeling of an elastomeric biodegradable scaffold in an ovine pulmonary leaflet replacement model.
J Biomed Mater Res A. 2023;112(2):276-287 - PMID: 37772456 - PMCID: PMC11034854 - DOI: 10.1002/jbm.a.37622

Rouhollahi A, Willi JN, Haltmeier S, Mehrtash A, Straughan R, Javadikasgari H, Brown J, Itoh A, de la Cruz KI, Aikawa E, Edelman ER, Nezami FR

CardioVision: A fully automated deep learning package for medical image segmentation and reconstruction generating digital twins for patients with aortic stenosis.
Comput Med Imaging Graph. 2023;109:102289 - PMID: 37633032 - PMCID: PMC10599298 - DOI: 10.1016/j.compmedimag.2023.102289

Kasai T, Kuraoka S, Higashi H, Delanghe B, Aikawa M, Singh SA

A Combined Gas-Phase Separation Strategy for ADP-ribosylated Peptides.
J Am Soc Mass Spectrom. 2023;34(10):2136-2145 - PMID: 37589412 - PMCID: PMC10557377 - DOI: 10.1021/jasms.3c00129

Ho YC, Geng X, O'Donnell A, Ibarrola J, Fernandez-Celis A, Varshney R, Subramani K, Azartash-Namin ZJ, Kim J, Silasi R, Wylie-Sears J, Alvandi Z, Chen L, Cha B, Chen H, Xia L, Zhou B, Lupu F, Burkhart HM, Aikawa E, Olson LE, Ahamed J, López-Andrés N, Bischoff J, Yutzey KE, Srinivasan RS

PROX1 Inhibits PDGF-B Expression to Prevent Myxomatous Degeneration of Heart Valves.
Circ Res. 2023;133(6):463-480 - PMID: 37555328 - PMCID: PMC10487359 - DOI: 10.1161/CIRCRESAHA.123.323027

Perez KA, Deppe DW, Filas A, Singh SA, Aikawa E

Multimodal analytical tools to enhance mechanistic understanding of aortic valve calcification.
Am J Pathol. 2023;194(4):539-550 - PMID: 37517686 - PMCID: PMC10988764 - DOI: 10.1016/j.ajpath.2023.06.017

Santinelli-Pestana DV, Aikawa E, Singh SA, Aikawa M

PARPs and ADP-Ribosylation in Chronic Inflammation: A Focus on Macrophages.
Pathogens. 2023;12(7):ePub - PMID: 37513811 - PMCID: PMC10386340 - DOI: 10.3390/pathogens12070964

Bartoli-Leonard F, Chelvanambi S, Pham T, Turner ME, Blaser MC, Caputo M, Aikawa M, Pang A, Muehlschlegel J, Aikawa E

Single-cell T cell receptor sequencing of paired tissue and blood samples reveals clonal expansion of CD8+ effector T cells in patients with calcific aortic valve disease.
bioRxiv. 2023;:ePub - PMID: 37461603 - PMCID: PMC10350049 - DOI: 10.1101/2023.07.08.548203

Blaser MC, Buffolo F, Halu A, Turner ME, Schlotter F, Higashi H, Pantano L, Clift CL, Saddic LA, Atkins SK, Rogers MA, Pham T, Vromman A, Shvartz E, Sukhova GK, Monticone S, Camussi G, Robson SC, Body SC, Muehlschlegel JD, Singh SA, Aikawa M, Aikawa E

Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis.
Circulation. 2023;148(8):661-678 - PMID: 37427430 - PMCID: PMC10527599 - DOI: 10.1161/CIRCULATIONAHA.122.063402

Greco E, Vinciguerra M, Sampaio R, Aikawa E

Editorial: New insights in heart valve disease 2022.
Front Cardiovasc Med. 2023;10:1226113 - PMID: 37416925 - PMCID: PMC10321655 - DOI: 10.3389/fcvm.2023.1226113

Nehl D, Goody PR, Maus K, Pfeifer A, Aikawa E, Bakthiary F, Zimmer S, Nickenig G, Jansen F, Hosen MR

Human and porcine aortic valve endothelial and interstitial cell isolation and characterization.
Front Cardiovasc Med. 2023;10:1151028 - PMID: 37408661 - PMCID: PMC10318150 - DOI: 10.3389/fcvm.2023.1151028

Distefano R, Ilieva M, Madsen JH, Ishii H, Aikawa M, Rennie S, Uchida S

T2DB: A Web Database for Long Non-Coding RNA Genes in Type II Diabetes.
Noncoding RNA. 2023;9(3):ePub - PMID: 37218990 - PMCID: PMC10204529 - DOI: 10.3390/ncrna9030030

Raju S, Botts SR, Blaser M, Prajapati K, Ho TWW, Ching C, Galant NJ, Fiddes L, Wu R, Clift CL, Pham T, Lee WL, Singh SA, Aikawa E, Fish JE, Howe KL

Endothelial cells secrete small extracellular vesicles bidirectionally containing distinct cargo to uniquely reprogram vascular cells in the circulation and vessel wall.
bioRxiv. 2023;:ePub - PMID: 37162986 - PMCID: PMC10168399 - DOI: 10.1101/2023.04.28.538787

Andraski AB, Singh SA, Higashi H, Lee LH, Aikawa M, Sacks FM

The distinct metabolism between large and small HDL indicates unique origins of human apolipoprotein A4.
JCI Insight. 2023;8(8):ePub - PMID: 37092549 - PMCID: PMC10243815 - DOI: 10.1172/jci.insight.162481

Veulemans V, Billaud M, Nunes MCP, Goettsch C, Aikawa E

Editorial: Women in heart valve disease.
Front Cardiovasc Med. 2023;10:1150169 - PMID: 36994000 - PMCID: PMC10041336 - DOI: 10.3389/fcvm.2023.1150169

Cable J, Witwer KW, Coffey RJ, Milosavljevic A, von Lersner AK, Jimenez L, Pucci F, Barr MM, Dekker N, Barman B, Humphrys D, Williams J, de Palma M, Guo W, Bastos N, Hill AF, Levy E, Hantak MP, Crewe C, Aikawa E, Adamczyk AM, Zanotto TM, Ostrowski M, Arab T, Rabe DC, Sheikh A, da Silva DR, Jones JC, Okeoma C, Gaborski T, Zhang Q, Gololobova O

Exosomes, microvesicles, and other extracellular vesicles-a Keystone Symposia report.
Ann N Y Acad Sci. 2023;1523(1):24-37 - PMID: 36961472 - PMCID: PMC10715677 - DOI: 10.1111/nyas.14974

Bartoli-Leonard F, Zimmer J, Sonawane AR, Perez K, Turner ME, Kuraoka S, Pham T, Li F, Aikawa M, Singh S, Brewster L, Aikawa E

NLRP3 Inflammasome Activation in Peripheral Arterial Disease.
J Am Heart Assoc. 2023;12(6):e026945 - PMID: 36892058 - PMCID: PMC10111545 - DOI: 10.1161/JAHA.122.026945

Sud K, Narula N, Aikawa E, Arbustini E, Pibarot P, Merlini G, Rosenson RS, Seshan SV, Argulian E, Ahmadi A, Zhou F, Moreira AL, Côté N, Tsimikas S, Fuster V, Gandy S, Bonow RO, Gursky O, Narula J

Author Correction: The contribution of amyloid deposition in the aortic valve to calcification and aortic stenosis.
Nat Rev Cardiol. 2023;20(6):429 - PMID: 36807395 - DOI: 10.1038/s41569-023-00848-4

Natarajan R, Moore K, Sahoo D, Nana-Sinkam P, Fowler AAB, Sime P, Sorci-Thomas M, Aikawa E, ATVB Council, friends, and colleagues

Shobha Ghosh (1958-2021).
Arterioscler Thromb Vasc Biol. 2022;42(3):239-240 - PMID: 36808997 - DOI: 10.1161/ATVBAHA.122.317419

Wang Z, Tang M, Luan X, Tevaearai Stahel H, Aikawa M, Xie M, Ge S, Zhang S

Editorial: What do we know about COVID-19 implications for cardiovascular disease?
Front Cardiovasc Med. 2023;10:1125655 - PMID: 36733303 - PMCID: PMC9887308 - DOI: 10.3389/fcvm.2023.1125655

Blaser MC, Kraler S, Lüscher TF, Aikawa E

Network-Guided Multiomic Mapping of Aortic Valve Calcification.
Arterioscler Thromb Vasc Biol. 2023;43(3):417-426 - PMID: 36727519 - PMCID: PMC9975082 - DOI: 10.1161/ATVBAHA.122.318334

Iqbal F, Schlotter F, Becker-Greene D, Lupieri A, Goettsch C, Hutcheson JD, Rogers MA, Itoh S, Halu A, Lee LH, Blaser MC, Mlynarchik AK, Hagita S, Kuraoka S, Chen HY, Engert JC, Passos LSA, Jha PK, Osborn EA, Jaffer FA, Body SC, Robson SC, Thanassoulis G, Aikawa M, Singh SA, Sonawane AR, Aikawa E

Sortilin enhances fibrosis and calcification in aortic valve disease by inducing interstitial cell heterogeneity.
Eur Heart J. 2023;44(10):885-898 - PMID: 36660854 - PMCID: PMC9991042 - DOI: 10.1093/eurheartj/ehac818

Sud K, Narula N, Aikawa E, Arbustini E, Pibarot P, Merlini G, Rosenson RS, Seshan SV, Argulian E, Ahmadi A, Zhou F, Moreira AL, Côté N, Tsimikas S, Fuster V, Gandy S, Bonow RO, Gursky O, Narula J

The contribution of amyloid deposition in the aortic valve to calcification and aortic stenosis.
Nat Rev Cardiol. 2023;20(6):418-428 - PMID: 36624274 - PMCID: PMC10199673 - DOI: 10.1038/s41569-022-00818-2

Kum AST, De Moura DTH, Proença IM, Aikawa M, Sánchez-Luna SA, Ribeiro IB, Sasso JGRJ, Bestetti AM, Bernardo WM, Hourneaux de Moura EG

Gastroesophageal Reflux Waning Over Time in Endoscopic Versus Surgical Myotomy for the Treatment of Achalasia: A Systematic Review and Meta-Analysis.
Cureus. 2022;14(11):e31756 - PMID: 36569663 - PMCID: PMC9771598 - DOI: 10.7759/cureus.31756

Sutton NR, Malhotra R, Hilaire CS, Aikawa E, Blumenthal RS, Gackenbach G, Goyal P, Johnson A, Nigwekar SU, Shanahan CM, Towler DA, Wolford BN, Chen Y

Molecular Mechanisms of Vascular Health: Insights From Vascular Aging and Calcification.
Arterioscler Thromb Vasc Biol. 2022;43(1):15-29 - PMID: 36412195 - PMCID: PMC9793888 - DOI: 10.1161/ATVBAHA.122.317332

Krohn JB, Aikawa E, Aikawa M, Hutcheson JD, Sahoo S, Fish JE

Editorial: Extracellular vesicles in cardiovascular inflammation and calcification.
Front Cardiovasc Med. 2022;9:1077124 - PMID: 36426218 - PMCID: PMC9680153 - DOI: 10.3389/fcvm.2022.1077124

Corti A, De Paolis A, Grossman P, Dinh PA, Aikawa E, Weinbaum S, Cardoso L

The effect of plaque morphology, material composition and microcalcifications on the risk of cap rupture: A structural analysis of vulnerable atherosclerotic plaques.
Front Cardiovasc Med. 2022;9:1019917 - PMID: 36277774 - PMCID: PMC9583261 - DOI: 10.3389/fcvm.2022.1019917

Kuo A, Checa A, Niaudet C, Jung B, Fu Z, Wheelock CE, Singh SA, Aikawa M, Smith LEH, Proia RL, Hla T

Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasi.
Elife. 2022;11:ePub - PMID: 36197001 - PMCID: PMC9578713 - DOI: 10.7554/eLife.78861

Morgan S, Lee LH, Halu A, Nicolau JS, Higashi H, Ha AH, Wen JR, Daugherty A, Libby P, Cameron SJ, Mix D, Aikawa E, Owens AP, Singh SA, Aikawa M

Identifying novel mechanisms of abdominal aortic aneurysm via unbiased proteomics and systems biology.
Front Cardiovasc Med. 2022;9:889994 - PMID: 35990960 - PMCID: PMC9382335 - DOI: 10.3389/fcvm.2022.889994

Atkins SK, Sonawane AR, Brouwhuis R, Barrientos J, Ha A, Rogers M, Tanaka T, Okui T, Kuraoka S, Singh SA, Aikawa M, Aikawa E

Induced pluripotent stem cell-derived smooth muscle cells to study cardiovascular calcification.
Front Cardiovasc Med. 2022;9:925777 - PMID: 35958427 - PMCID: PMC9357895 - DOI: 10.3389/fcvm.2022.925777

Uchida S, Yu J, Goldman M, Asmis R, Yang X, Aikawa E, Bourantas C, Aikawa M, Tevaearai Stahel H

Editorial: Research reproducibility and preventing fraud.
Front Cardiovasc Med. 2022;9:979467 - PMID: 35979020 - PMCID: PMC9376614 - DOI: 10.3389/fcvm.2022.979467

Marsit O, Clavel MA, Paquin A, Deschênes V, Hadjadj S, Sénéchal-Dumais I, Couet J, Arsenault M, Handschumacher MD, Levine RA, Aikawa E, Pibarot P, Beaudoin J

Effects of Cyproheptadine on Mitral Valve Remodeling and Regurgitation After Myocardial Infarction.
J Am Coll Cardiol. 2022;80(5):500-510 - PMID: 35902173 - DOI: 10.1016/j.jacc.2022.05.025

Wang L, Xu GE, Pan L, Aikawa E, Aikawa M, Xiao J, Huang NF

Editorial: Frontiers in Cardiovascular Medicine: Rising Stars 2021.
Front Cardiovasc Med. 2022;9:928981 - PMID: 35757336 - PMCID: PMC9218798 - DOI: 10.3389/fcvm.2022.928981

Asano T, Chelvanambi S, Decano JL, Whelan MC, Aikawa E, Aikawa M

In silico Drug Screening Approach Using L1000-Based Connectivity Map and Its Application to COVID-19.
Front Cardiovasc Med. 2022;9:842641 - PMID: 35402570 - PMCID: PMC8989014 - DOI: 10.3389/fcvm.2022.842641

Decano JL, Iwamoto Y, Goto S, Lee JY, Matamalas JT, Halu A, Blaser M, Lee LH, Pieper B, Chelvanambi S, Silva-Nicolau J, Bartoli-Leonard F, Higashi H, Shibata H, Vyas P, Wang J, Gostjeva E, Body SC, Singh SA, Aikawa M, Aikawa E

A disease-driver population within interstitial cells of human calcific aortic valves identified via single-cell and proteomic profiling.
Cell Rep. 2022;39(2):110685 - PMID: 35417712 - DOI: 10.1016/j.celrep.2022.110685

Paquin A, Marsit O, Deschênes V, Rouabhia D, Hadjadj S, Clisson M, Robitaille C, Aikawa E, Levine RA, Pibarot P, Clavel MA, Beaudoin J

Progression of aortic stenosis after an acute myocardial infarction.
Open Heart. 2022;9(1):ePub - PMID: 35728891 - PMCID: PMC9214429 - DOI: 10.1136/openhrt-2022-002046

Bartoli-Leonard F, Turner ME, Zimmer J, Chapurlat R, Pham T, Aikawa M, Pradhan AD, Szulc P, Aikawa E

Elevated lipoprotein(a) as a predictor for coronary events in older men.
J Lipid Res. 2022;63(8):100242 - PMID: 35724702 - PMCID: PMC9304778 - DOI: 10.1016/j.jlr.2022.100242

Sonawane AR, Aikawa E, Aikawa M

Connections for Matters of the Heart: Network Medicine in Cardiovascular Diseases.
Front Cardiovasc Med. 2022;9:873582 - PMID: 35665246 - PMCID: PMC9160390 - DOI: 10.3389/fcvm.2022.873582

Dacano JL, Aikawa M, Singh SA

Promise of a Novel Bedside-to-Bench Paradigm: Can Percutaneous Coronary Intervention Proteomics Balloon Into Clinical Practice?
Arterioscler Thromb Vasc Biol. 2022;42(7):865-867 - PMID: 35616034 - DOI: 10.1161/ATVBAHA.122.317802

Garelnabi M, Cowdin M, Fang Y, Shrestha B, Ushio-Fukai M, Aikawa E, Graham G, Molema G, Yanagisawa H, Aikawa M

Embracing Diversity, Equity, and Inclusion in the Scientific Community-Viewpoints of the Diversity, Equity, and Inclusion Committee of the North American Vascular Biology Organization.
Front Cardiovasc Med. 2022;9:863256 - PMID: 35463765 - PMCID: PMC9021758 - DOI: 10.3389/fcvm.2022.863256

Passos LSA, Nunes MCP, Aikawa E

Rheumatic Heart Valve Disease Pathophysiology and Underlying Mechanisms.
Front Cardiovasc Med. 2021;7:612716 - PMID: 33537348 - PMCID: PMC7848031 - DOI: 10.3389/fcvm.2020.612716

Silva VR, Neves EGA, Passos LSA, Cristina de Melo F, Teixeira-Carvalho A, Nassif MCL, Junqueira LL, Aikawa E, Dutra WO, Nunes MCP

Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis.
Front Cardiovasc Med. 2021;7:604826 - PMID: 33614739 - PMCID: PMC7888299 - DOI: 10.3389/fcvm.2020.604826

Majumdar U, Manivannan S, Basu M, Ueyama Y, Blaser MC, Cameron E, McDermott MR, Lincoln J, Cole SE, Wood S, Aikawa E, Lilly B, Garg V

Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling.
Sci Adv. 2021;7(6):ePub - PMID: 33547080 - PMCID: PMC7864581 - DOI: 10.1126/sciadv.abe3706

Kraler S, Wenzl FA, Akhmedov A, Blaser MC, Aikawa E, Lüscher TF

ApoA-I mimetics improve aortic stenosis-associated left-ventricular diastolic dysfunction but fail to benefit rabbit models with normal aortic valves.
Int J Cardiol. 2021;332:159-161 - PMID: 33626387 - DOI: 10.1016/j.ijcard.2021.02.044

Rogers MA, Hutcheson JD, Okui T, Goettsch C, Singh SA, Halu A, Schlotter F, Higashi H, Wang L, Whelan MC, Mlynarchik AK, Daugherty A, Nomura M, Aikawa M, Aikawa E

Dynamin-related protein 1 inhibition reduces hepatic PCSK9 secretion.
Cardiovasc Res. 2021;117(11):2340-2353 - PMID: 33523181 - PMCID: PMC8479802 - DOI: 10.1093/cvr/cvab034

Passos LSA, Nunes MCP, Zilla P, Yacoub MH, Aikawa E

Raising awareness for rheumatic mitral valve disease.
Glob Cardiol Sci Pract. 2020;2020(2):e202026 - PMID: 33426043 - PMCID: PMC7768627 - DOI: 10.21542/gcsp.2020.26
350
© Center for Interdisciplinary Cardiovascular Sciences 2026