Center for Interdisciplinary Cardiovascular Sciences

Greco E, Vinciguerra M, Sampaio R, Aikawa E

Editorial: New insights in heart valve disease 2022.

Front Cardiovasc Med. 2023;10:1226113 - PMID: 37416925 - PMCID: PMC10321655 - DOI: 10.3389/fcvm.2023.1226113

Blaser MC, Buffolo F, Halu A, Turner ME, Schlotter F, Higashi H, Pantano L, Clift CL, Saddic LA, Atkins SK, Rogers MA, Pham T, Vromman A, Shvartz E, Sukhova GK, Monticone S, Camussi G, Robson SC, Body SC, Muehlschlegel JD, Singh SA, Aikawa M, Aikawa E

Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis.

Circulation. 2023;148(8):661-678 - PMID: 37427430 - PMCID: PMC10527599 - DOI: 10.1161/CIRCULATIONAHA.122.063402

Bartoli-Leonard F, Chelvanambi S, Pham T, Turner ME, Blaser MC, Caputo M, Aikawa M, Pang A, Muehlschlegel J, Aikawa E

Single-cell T cell receptor sequencing of paired tissue and blood samples reveals clonal expansion of CD8+ effector T cells in patients with calcific aortic valve disease.

bioRxiv. 2023;:ePub - PMID: 37461603 - PMCID: PMC10350049 - DOI: 10.1101/2023.07.08.548203

Santinelli-Pestana DV, Aikawa E, Singh SA, Aikawa M

PARPs and ADP-Ribosylation in Chronic Inflammation: A Focus on Macrophages.

Pathogens. 2023;12(7):ePub - PMID: 37513811 - PMCID: PMC10386340 - DOI: 10.3390/pathogens12070964

Perez KA, Deppe DW, Filas A, Singh SA, Aikawa E

Multimodal analytical tools to enhance mechanistic understanding of aortic valve calcification.

Am J Pathol. 2023;194(4):539-550 - PMID: 37517686 - PMCID: PMC10988764 - DOI: 10.1016/j.ajpath.2023.06.017

Ho YC, Geng X, O'Donnell A, Ibarrola J, Fernandez-Celis A, Varshney R, Subramani K, Azartash-Namin ZJ, Kim J, Silasi R, Wylie-Sears J, Alvandi Z, Chen L, Cha B, Chen H, Xia L, Zhou B, Lupu F, Burkhart HM, Aikawa E, Olson LE, Ahamed J, López-Andrés N, Bischoff J, Yutzey KE, Srinivasan RS

PROX1 Inhibits PDGF-B Expression to Prevent Myxomatous Degeneration of Heart Valves.

Circ Res. 2023;133(6):463-480 - PMID: 37555328 - PMCID: PMC10487359 - DOI: 10.1161/CIRCRESAHA.123.323027

Kasai T, Kuraoka S, Higashi H, Delanghe B, Aikawa M, Singh SA

A Combined Gas-Phase Separation Strategy for ADP-ribosylated Peptides.

J Am Soc Mass Spectrom. 2023;34(10):2136-2145 - PMID: 37589412 - PMCID: PMC10557377 - DOI: 10.1021/jasms.3c00129

Rouhollahi A, Willi JN, Haltmeier S, Mehrtash A, Straughan R, Javadikasgari H, Brown J, Itoh A, de la Cruz KI, Aikawa E, Edelman ER, Nezami FR

CardioVision: A fully automated deep learning package for medical image segmentation and reconstruction generating digital twins for patients with aortic stenosis.

Comput Med Imaging Graph. 2023;109:102289 - PMID: 37633032 - PMCID: PMC10599298 - DOI: 10.1016/j.compmedimag.2023.102289

Machaidze Z, D'Amore A, Freitas RCC, Joyce AJ, Bayoumi A, Rich K, Brown DW, Aikawa E, Wagner WR, Sacks MS, Mayer JE

Tissue formation and host remodeling of an elastomeric biodegradable scaffold in an ovine pulmonary leaflet replacement model.

J Biomed Mater Res A. 2023;112(2):276-287 - PMID: 37772456 - PMCID: PMC11034854 - DOI: 10.1002/jbm.a.37622

Velissari R, Ilieva M, Dao J, Miller HE, Madsen JH, Gorodkin J, Aikawa M, Ishii H, Uchida S

Systematic analysis and characterization of long non-coding RNA genes in inflammatory bowel disease.

Brief Funct Genomics. 2023;:ePub - PMID: 37791426 - DOI: 10.1093/bfgp/elad044

Yacoub MH, Tseng YT, Kluin J, Vis A, Stock U, Smail H, Sarathchandra P, Aikawa E, El-Nashar H, Chester AH, Shehata N, Nagy M, El-Sawy A, Li W, Burriesci G, Salmonsmith J, Romeih S, Latif N

Valvulogenesis of a living, innervated pulmonary root induced by an acellular scaffold.

Commun Biol. 2023;6(1):1017 - PMID: 37805576 - PMCID: PMC10560219 - DOI: 10.1038/s42003-023-05383-z

Decano JL, Maiorino E, Matamalas JT, Chelvanambi S, Tiemeijer BM, Yanagihara Y, Mukai S, Jha PK, Pestana DVS, D'Souza E, Whelan M, Ge R, Asano T, Sharma A, Libby P, Singh SA, Aikawa E, Aikawa M

Cellular Heterogeneity of Activated Primary Human Macrophages and Associated Drug-Gene Networks: From Biology to Precision Therapeutics.

Circulation. 2023;148(19):1459-78 - PMID: 37850387 - PMCID: PMC10624416 - DOI: 10.1161/CIRCULATIONAHA.123.064794

Turner ME, Aikawa E

Updating the paradigm: inflammation as a targetable modulator of medial vascular calcification.

Cardiovasc Res. 2023;119(13):2259-2261 - PMID: 37875065 - PMCID: PMC10597605 - DOI: 10.1093/cvr/cvad139

Yurdagul A, Aikawa E

Discovering a Rare Smooth Muscle Cell Population Specific to Males in Ascending Aortic Aneurysm Using Spatial Transcriptomics.

Arterioscler Thromb Vasc Biol. 2023;43(12):2298-2300 - PMID: 37916413 - PMCID: PMC10842258 - DOI: 10.1161/ATVBAHA.123.320235

Rogers MA, Bartoli-Leonard F, Zheng KH, Small AM, Chen HY, Clift CL, Asano T, Kuraoka S, Blaser MC, Perez KA, Natarajan P, Yeang C, Stroes ESG, Tsimikas S, Engert JC, Thanassoulis G, O'Donnell CJ, Aikawa M, Singh SA, Aikawa E

Major Facilitator Superfamily Domain Containing 5 Inhibition Reduces Lipoprotein(a) Uptake and Calcification in Valvular Heart Disease.

Circulation. 2023;149(5):391-401 - PMID: 37937463 - PMCID: PMC10842618 - DOI: 10.1161/CIRCULATIONAHA.123.066822

Tzani A, Haemmig S, Cheng HS, Perez-Cremades D, Heuschkel MA, Jamaiyar A, Singh S, Aikawa M, Yu P, Wang T, Ye S, Feinberg MW, Plutzky J

FAM222A, Part of the BET-Regulated Basal Endothelial Transcriptome, Is a Novel Determinant of Endothelial Biology and Angiogenesis.

Arterioscler Thromb Vasc Biol. 2023;44(1):143-155 - PMID: 37942611 - PMCID: PMC10840377 - DOI: 10.1161/ATVBAHA.123.319909

Kip P, Sluiter TJ, MacArthur MR, Tao M, Jung J, Mitchell SJ, Kooijman S, Kruit N, Gorham J, Seidman JG, Quax PHA, Aikawa M, Ozaki CK, Mitchell JR, de Vries MR

Short-term Pre-operative Methionine Restriction Induces Browning of Perivascular Adipose Tissue and Improves Vein Graft Remodeling in Mice.

bioRxiv. 2023;:ePub - PMID: 37961405 - PMCID: PMC10635070 - DOI: 10.1101/2023.11.02.565269

Andraski AB, Sacks FM, Aikawa M, Singh SA

Understanding HDL Metabolism and Biology Through In Vivo Tracer Kinetics.

Arterioscler Thromb Vasc Biol. 2023;44(1):76-88 - PMID: 38031838 - PMCID: PMC10842918 - DOI: 10.1161/ATVBAHA.123.319742

Hashmi S, Shah PW, Aherrahrou Z, Aikawa E, Aherrahrou R

Beyond the Basics: Unraveling the Complexity of Coronary Artery Calcification.

Cells. 2023;12(24):ePub - PMID: 38132141 - PMCID: PMC10742130 - DOI: 10.3390/cells12242822

Raju S, Botts SR, Blaser MC, Abdul-Samad M, Prajapati K, Khosraviani N, Ho TWW, Breda LCD, Ching C, Galant NJ, Fiddes L, Wu R, Clift CL, Pham T, Lee WL, Singh SA, Aikawa E, Fish JE, Howe KL

Directional Endothelial Communication by Polarized Extracellular Vesicle Release.

Circ Res. 2024;134(3):269-289 - PMID: 38174557 - PMCID: PMC10826926 - DOI: 10.1161/CIRCRESAHA.123.322993

Turner ME, Beck L, Hill Gallant KM, Chen Y, Moe OW, Kuro-O M, Moe S, Aikawa E

Phosphate in Cardiovascular Disease: From New Insights Into Molecular Mechanisms to Clinical Implications.

Arterioscler Thromb Vasc Biol. 2024;44(3):584-602 - PMID: 38205639 - PMCID: PMC10922848 - DOI: 10.1161/ATVBAHA.123.319198

Kumar Jha P, Aikawa M, Aikawa E

Macrophage Heterogeneity and Efferocytosis: Beyond the M1/M2 Dichotomy.

Circ Res. 2024;134(2):186-188 - PMID: 38236949 - PMCID: PMC10798221 - DOI: 10.1161/CIRCRESAHA.123.324011

Shelbaya K, Arthur V, Yang Y, Dorbala P, Buckley L, Claggett B, Skali H, Dufresne L, Yang TY, Engert JC, Thanassoulis G, Floyd J, Austin TR, Bortnick A, Kizer J, Freitas RCC, Singh SA, Aikawa E, Hoogeveen RC, Ballantyne C, Yu B, Coresh J, Blaha MJ, Matsushita K, Shah AM

Large-Scale Proteomics Identifies Novel Biomarkers and Circulating Risk Factors for Aortic Stenosis.

J Am Coll Cardiol. 2024;83(5):577-591 - PMID: 38296402 - DOI: 10.1016/j.jacc.2023.11.021

Jansen I, Cahalane R, Hengst R, Akyildiz A, Farrell E, Gijsen F, Aikawa E, van der Heiden K, Wissing T

The interplay of collagen, macrophages, and microcalcification in atherosclerotic plaque cap rupture mechanics.

Basic Res Cardiol. 2024;119(2):193-213 - PMID: 38329498 - PMCID: PMC11008085 - DOI: 10.1007/s00395-024-01033-5

Lupieri A, S A Passos L, Levine RA, Nizet V, Aikawa E

Lymphangiogenesis in Rheumatic Heart Valve Disease: A New Factor in the Pathogenic Conundrum.

Arterioscler Thromb Vasc Biol. 2024;44(4):822-825 - PMID: 38357818 - PMCID: PMC10978236 - DOI: 10.1161/ATVBAHA.124.320708

Clift CL, Blaser MC, Gerrits W, Turner ME, Sonawane A, Pham T, Andresen JL, Fenton OS, Grolman JM, Campedelli A, Buffolo F, Schoen FJ, Hjortnaes J, Muehlschlegel JD, Mooney DJ, Aikawa M, Singh SA, Langer R, Aikawa E

Intracellular proteomics and extracellular vesiculomics as a metric of disease recapitulation in 3D-bioprinted aortic valve arrays.

Sci Adv. 2024;10(9):eadj9793 - PMID: 38416823 - PMCID: PMC10901368 - DOI: 10.1126/sciadv.adj9793

Cahalane RME, Turner ME, Clift CL, Blaser MC, Bogut G, Levy S, Kasai T, Driedonks TAP, Nolte-'t Hoen ENM, Aikawa M, Singh SA, Aikawa E

Polycarbonate Ultracentrifuge Tube Re-use in Proteomic Analyses of Extracellular Vesicles.

J Vis Exp. 2024;(205):ePub - PMID: 38526125 - DOI: 10.3791/66126

Aikawa E, Blaser MC, Singh SA, Levine RA, Yacoub MH

Challenges and Opportunities in Valvular Heart Disease: From Molecular Mechanisms to the Community.

Arterioscler Thromb Vasc Biol. 2024;44(4):763-767 - PMID: 38536897 - PMCID: PMC10977651 - DOI: 10.1161/ATVBAHA.123.319563