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Iqbal F, Lupieri A, Aikawa M, Aikawa E
Harnessing Single-Cell RNA Sequencing to Better Understand How Diseased Cells Behave the Way They Do in Cardiovascular Disease.
Arterioscler Thromb Vasc Biol. 2020;41(2):585-600 - PMID: 33327741 - PMCID: PMC8105278 - DOI: 10.1161/ATVBAHA.120.314776
Alvandi Z, Nagata Y, Passos LSA, Hashemi Gheinani A, Guerrero JL, Wylie-Sears J, Romero DC, Morris BA, Sullivan SM, Yaghoubian KM, Alvandi A, Adam RM, Aikawa E, Levine RA, Bischoff J
Wnt Site Signaling Inhibitor Secreted Frizzled-Related Protein 3 Protects Mitral Valve Endothelium From Myocardial Infarction-Induced Endothelial-to-Mesenchymal Transition.
J Am Heart Assoc. 2022;11(7):e023695 - PMID: 35348006 - PMCID: PMC9075477 - DOI: 10.1161/JAHA.121.023695
Davidson SM, Boulanger CM, Aikawa E, Badimon L, Barile L, Binder CJ, Brisson A, Buzas E, Emanueli C, Jansen F, Katsur M, Lacroix R, Lim SK, Mackman N, Mayr M, Menasché P, Nieuwland R, Sahoo S, Takov K, Thum T, Vader P, Wauben MHM, Witwer K, Sluijter JPG
Methods for the identification and characterization of extracellular vesicles in cardiovascular studies - from exosomes to microvesicles.
Cardiovasc Res. 2022;119(1):45-63 - PMID: 35325061 - PMCID: PMC10233250 - DOI: 10.1093/cvr/cvac031
Passos LSA, Jha PK, Becker-Greene D, Blaser MC, Romero D, Lupieri A, Sukhova GK, Libby P, Singh SA, Dutra WO, Aikawa M, Levine RA, Nunes MCP, Aikawa E
Prothymosin Alpha: A Novel Contributor to Estradiol Receptor Alpha-Mediated CD8+ T-Cell Pathogenic Responses and Recognition of Type 1 Collagen in Rheumatic Heart Valve Disease.
Circulation. 2022;145(7):531-548 - PMID: 35157519 - PMCID: PMC8869797 - DOI: 10.1161/CIRCULATIONAHA.121.057301
Rogers MA, Atkins SK, Zheng KH, Singh SA, Chelvanambi S, Pham TH, Kuraoka S, Stroes ESG, Aikawa M, Aikawa E
Lipoprotein(a) Induces Vesicular Cardiovascular Calcification Revealed With Single-Extracellular Vesicle Analysis.
Front Cardiovasc Med. 2022;9:778919 - PMID: 35155626 - PMCID: PMC8831739 - DOI: 10.3389/fcvm.2022.778919
Sawada H, Katsumata Y, Higashi H, Zhang C, Li Y, Morgan S, Lee LH, Singh SA, Chen JZ, Franklin MK, Moorleghen JJ, Howatt DA, Rateri DL, Shen YH, LeMaire SA, Aikawa M, Majesky MW, Lu HS, Daugherty A
Second Heart Field-derived Cells Contribute to Angiotensin II-mediated Ascending Aortopathies.
Circulation. 2022;145(13):987-1001 - PMID: 35143327 - PMCID: PMC9008740 - DOI: 10.1161/CIRCULATIONAHA.121.058173
Buffolo F, Monticone S, Camussi G, Aikawa E
Role of Extracellular Vesicles in the Pathogenesis of Vascular Damage.
Hypertension. 2022;79(5):863-873 - PMID: 35144490 - PMCID: PMC9010370 - DOI: 10.1161/HYPERTENSIONAHA.121.17957
Tanaka T, Asano T, Okui T, Kuraoka S, Singh SA, Aikawa M, Aikawa E
Computational Screening Strategy for Drug Repurposing Identified Niclosamide as Inhibitor of Vascular Calcification.
Front Cardiovasc Med. 2022;8:826529 - PMID: 35127876 - PMCID: PMC8811128 - DOI: 10.3389/fcvm.2021.826529
Human P, Bezuidenhout D, Aikawa E, Zilla P
Residual Bioprosthetic Valve Immunogenicity: Forgotten, Not Lost.
Front Cardiovasc Med. 2022;8:760635 - PMID: 35059444 - PMCID: PMC8764456 - DOI: 10.3389/fcvm.2021.760635
Kraler S, Blaser MC, Aikawa E, Camici GG, Luscher TF
Calcific aortic valve disease: from molecular and cellular mechanisms to medical therapy.
Eur Heart J. 2021;43(7):683-697 - PMID: 34849696 - PMCID: PMC8843796 - DOI: 10.1093/eurheartj/ehab757
van der Ven CFT, Tibbitt MW, Conde J, van Mil A, Hjortnaes J, Doevendans PA, Sluijter JPG, Aikawa E, Langer RS
Controlled delivery of gold nanoparticle-coupled miRNA therapeutics via an injectable self-healing hydrogel.
Nanoscale. 2021;13(48):20451-20461 - PMID: 34817483 - PMCID: PMC8675028 - DOI: 10.1039/d1nr04973a
Iwata H, Osborn EA, Ughi GJ, Murakami K, Goettsch C, Hutcheson JD, Mauskapf A, Mattson PC, Libby P, Singh SA, Matamalas J, Aikawa E, Tearney GJ, Aikawa M, Jaffer FA
Highly Selective PPARα (Peroxisome Proliferator-Activated Receptor α) Agonist Pemafibrate Inhibits Stent Inflammation and Restenosis Assessed by Multimodality Molecular-Microstructural Imaging.
J Am Heart Assoc. 2021;10(20):e020834 - PMID: 34632804 - PMCID: PMC8751880 - DOI: 10.1161/JAHA.121.020834
Kuraoka S, Higashi H, Yanagihara Y, Sonawane AR, Mukai S, Mlynarchik AK, Whelan MC, Hottiger MO, Nasir W, Delanghe B, Aikawa M, Singh SA
A Novel Spectral Annotation Strategy Streamlines Reporting of mono-ADP-ribosylated Peptides Derived from Mouse Liver and Spleen in Response to IFN-γ.
Mol Cell Proteomics. 2021;21(4):100153 - PMID: 34592425 - PMCID: PMC9014395 - DOI: 10.1016/j.mcpro.2021.100153
Zhang H, Chen ZB, Fredman G, Gomez D, Grumbach IM, Huang NF, Nguyen P, Ouimet M, Sutton NR, Aikawa E
What Makes a Great Mentor: Interviews With Recipients of the ATVB Mentor of Women Award.
Arterioscler Thromb Vasc Biol. 2021;41(11):2641-2647 - PMID: 34547925 - PMCID: PMC8551033 - DOI: 10.1161/ATVBAHA.121.316558
Meerman M, Driessen R, van Engeland NCA, Bergsma I, Steenhuijsen JLG, Kozono D, Aikawa E, Hjortnaes J, Bouten CVC
Radiation Induces Valvular Interstitial Cell Calcific Response in an in vitro Model of Calcific Aortic Valve Disease.
Front Cardiovasc Med. 2021;8:687885 - PMID: 34527708 - PMCID: PMC8435633 - DOI: 10.3389/fcvm.2021.687885
Bartoli-Leonard F, Zimmer J, Aikawa E
Innate and adaptative immunity: The understudied driving force of heart valve disease.
Cardiovasc Res. 2021;117(13):2506-2524 - PMID: 34432007 - PMCID: PMC8783388 - DOI: 10.1093/cvr/cvab273
Lupieri A, Nagata Y, Passos LSA, Beker-Greene D, Kirkwood KA, Wylie-Sears J, Alvandi Z, Higashi H, Hung JW, Singh SA, Bischoff J, Levine RA, Aikawa E
Integration of Functional Imaging, Cytometry, and Unbiased Proteomics Reveals New Features of Endothelial-to-Mesenchymal Transition in Ischemic Mitral Valve Regurgitation in Human Patients.
Front Cardiovasc Med. 2021;8:688396 - PMID: 34458332 - PMCID: PMC8387660 - DOI: 10.3389/fcvm.2021.688396
Bartoli-Leonard F, Aikawa E
Recapitulating the Complex Pathology of Atherosclerosis: Which Model to Use?
Circ Res. 2021;129(4):491-493 - PMID: 34351800 - PMCID: PMC8352010 - DOI: 10.1161/CIRCRESAHA.121.319721
Hutcheson JD, Schlotter F, Creager MD, Li X, Pham T, Vyas P, Higashi H, Body SC, Aikawa M, Singh SA, Kos L, Aikawa E
Elastogenesis Correlates With Pigment Production in Murine Aortic Valve Leaflets.
Front Cardiovasc Med. 2021;8:678401 - PMID: 34239903 - PMCID: PMC8257952 - DOI: 10.3389/fcvm.2021.678401
Rogers MA, Aikawa E
Unbiased omics identifies mechanistic regulators of calcific aortic valve disease.
Eur Heart J. 2021;42(30):2948-2950 - PMID: 34179985 - PMCID: PMC8347449 - DOI: 10.1093/eurheartj/ehab381
Bartoli-Leonard F, Aikawa E
Old Drugs for an Old Pathology? Drug Repurposing for Calcific Aortic Valve Disease.
Circ Res. 2021;128(9):1317-1319 - PMID: 33914606 - PMCID: PMC8095786 - DOI: 10.1161/CIRCRESAHA.121.319149
Blaser MC, Kraler S, Lüscher TF, Aikawa E
Multi-Omics Approaches to Define Calcific Aortic Valve Disease Pathogenesis.
Circ Res. 2021;128(9):1371-1397 - PMID: 33914608 - PMCID: PMC8095729 - DOI: 10.1161/CIRCRESAHA.120.317979
Jha PK, Vijay A, Halu A, Uchida S, Aikawa M
Gene Expression Profiling Reveals the Shared and Distinct Transcriptional Signatures in Human Lung Epithelial Cells Infected With SARS-CoV-2, MERS-CoV, or SARS-CoV: Potential Implications in Cardiovascular Complications of COVID-19.
Front Cardiovasc Med. 2021;7:623012 - PMID: 33521069 - PMCID: PMC7844200 - DOI: 10.3389/fcvm.2020.623012
Ruiz JL, Hutcheson JD, Cardoso L, Bakhshian Nik A, Condado de Abreu A, Pham T, Buffolo F, Busatto S, Federici S, Ridolfi A, Aikawa M, Bertazzo S, Bergese P, Weinbaum S, Aikawa E
Nanoanalytical analysis of bisphosphonate-driven alterations of microcalcifications using a 3D hydrogel system and in vivo mouse model.
Proc Natl Acad Sci U S A. 2021;118(14):ePub - PMID: 33795519 - PMCID: PMC8040669 - DOI: 10.1073/pnas.1811725118
de Freitas RCC, Hirata RDC, Hirata MH, Aikawa E
Circulating Extracellular Vesicles As Biomarkers and Drug Delivery Vehicles in Cardiovascular Diseases.
Biomolecules. 2021;11(3):ePub - PMID: 33808038 - PMCID: PMC8001426 - DOI: 10.3390/biom11030388
Decano JL, Singh SA, Bueno CG, Lee LH, Halu A, Chelvanambi S, Matamalas JT, Zhang H, Mlynarchik AK, Qiao J, Sharma A, Mukai S, Wang J, Anderson DG, Ozaki CK, Libby P, Aikawa E, Aikawa M
Systems Approach to Discovery of Therapeutic Targets for Vein Graft Disease PPARα Pivotally Regulates Metabolism, Activation, and Heterogeneity of Macrophages and Lesion Development.
Circulation. 2021;143(25):2454-2470 - PMID: 33821665 - PMCID: PMC8212880 - DOI: 10.1161/CIRCULATIONAHA.119.043724
Kraler S, Wenzl FA, Akhmedov A, Blaser MC, Aikawa E, Lüscher TF
ApoA-I mimetics improve aortic stenosis-associated left-ventricular diastolic dysfunction but fail to benefit rabbit models with normal aortic valves.
Int J Cardiol. 2021;332:159-161 - PMID: 33626387 - DOI: 10.1016/j.ijcard.2021.02.044
Silva VR, Neves EGA, Passos LSA, Cristina de Melo F, Teixeira-Carvalho A, Nassif MCL, Junqueira LL, Aikawa E, Dutra WO, Nunes MCP
Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis.
Front Cardiovasc Med. 2021;7:604826 - PMID: 33614739 - PMCID: PMC7888299 - DOI: 10.3389/fcvm.2020.604826
Majumdar U, Manivannan S, Basu M, Ueyama Y, Blaser MC, Cameron E, McDermott MR, Lincoln J, Cole SE, Wood S, Aikawa E, Lilly B, Garg V
Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling.
Sci Adv. 2021;7(6):ePub - PMID: 33547080 - PMCID: PMC7864581 - DOI: 10.1126/sciadv.abe3706
Passos LSA, Nunes MCP, Aikawa E
Rheumatic Heart Valve Disease Pathophysiology and Underlying Mechanisms.
Front Cardiovasc Med. 2021;7:612716 - PMID: 33537348 - PMCID: PMC7848031 - DOI: 10.3389/fcvm.2020.612716
Rogers MA, Hutcheson JD, Okui T, Goettsch C, Singh SA, Halu A, Schlotter F, Higashi H, Wang L, Whelan MC, Mlynarchik AK, Daugherty A, Nomura M, Aikawa M, Aikawa E
Dynamin-related protein 1 inhibition reduces hepatic PCSK9 secretion.
Cardiovasc Res. 2021;117(11):2340-2353 - PMID: 33523181 - PMCID: PMC8479802 - DOI: 10.1093/cvr/cvab034
Passos LSA, Nunes MCP, Zilla P, Yacoub MH, Aikawa E
Raising awareness for rheumatic mitral valve disease.
Glob Cardiol Sci Pract. 2020;2020(2):e202026 - PMID: 33426043 - PMCID: PMC7768627 - DOI: 10.21542/gcsp.2020.26
Uiterwijk M, Smits AIPM, van Geemen D, van Klarenbosch B, Dekker S, Cramer MJ, van Rijswijk JW, Lurier EB, Di Luca A, Brugmans MCP, Mes T, Bosman AW, Aikawa E, Gründeman PF, Bouten CVC, Kluin J
In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Elastomeric Tissue-Engineered Heart Valves.
JACC Basic Transl Sci. 2020;5(12):1187-1206 - PMID: 33426376 - PMCID: PMC7775962 - DOI: 10.1016/j.jacbts.2020.09.011
Atkins SK, Singh SA, Aikawa E
Calcific Aortic Valve Disease "Omics"; Is Timely, But Are We Looking Too Late?
JACC Basic Transl Sci. 2020;5(12):1178-1180 - PMID: 33427821 - PMCID: PMC7775952 - DOI: 10.1016/j.jacbts.2020.11.001
Okui T, Iwashita M, Rogers MA, Halu A, Atkins SK, Kuraoka S, Abdelhamid I, Higashi H, Ramsaroop A, Aikawa M, Singh SA, Aikawa E
CROT (Carnitine O-Octanoyltransferase) Is a Novel Contributing Factor in Vascular Calcification via Promoting Fatty Acid Metabolism and Mitochondrial Dysfunction.
Arterioscler Thromb Vasc Biol. 2020;41(2):755-768 - PMID: 33356393 - PMCID: PMC8105275 - DOI: 10.1161/ATVBAHA.120.315007
Singh SA, Andraski AB, Higashi H, Lee LH, Ramsaroop A, Sacks FM, Aikawa M
Metabolism of PLTP, CETP, and LCAT on multiple HDL sizes using the Orbitrap Fusion Lumos.
JCI Insight. 2020;6(3):ePub - PMID: 33351780 - PMCID: PMC7934878 - DOI: 10.1172/jci.insight.143526
Schlotter F, de Freitas RCC, Rogers MA, Blaser MC, Wu PJ, Higashi H, Halu A, Iqbal F, Andraski AB, Rodia CN, Kuraoka S, Wen JR, Creager M, Pham T, Hutcheson JD, Body SC, Kohan AB, Sacks FM, Aikawa M, Singh SA, Aikawa E
ApoC-III is a novel inducer of calcification in human aortic valves.
J Biol Chem. 2020;296:100193 - PMID: 33334888 - PMCID: PMC7948477 - DOI: 10.1074/jbc.RA120.015700
Grunewald ME, Chen Y, Kuny C, Maejima T, Lease R, Ferraris D, Aikawa M, Sullivan CS, Perlman S, Fehr AR
The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression.
PLoS Pathog. 2019;15(5):e1007756 - PMID: 31095648 - PMCID: PMC6521996 - DOI: 10.1371/journal.ppat.1007756
Nakato R, Wada Y, Nakaki R, Nagae G, Katou Y, Tsutsumi S, Nakajima N, Fukuhara H, Iguchi A, Kohro T, Kanki Y, Saito Y, Kobayashi M, Izumi-Taguchi A, Osato N, Tatsuno K, Kamio A, Hayashi-Takanaka Y, Wada H, Ohta S, Aikawa M, Nakajima H, Nakamura M, McGee RC, Heppner KW, Kawakatsu T, Genno M, Yanase H, Kume H, Senbonmatsu T, Homma Y, Nishimura S, Mitsuyama T, Aburatani H, Kimura H, Shirahige K
Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells.
Epigenetics Chromatin. 2019;12(1):77 - PMID: 31856914 - PMCID: PMC6921469 - DOI: 10.1186/s13072-019-0319-0
Rogers MA, Chen J, Nallamshetty S, Pham T, Goto S, Muehlschlegel JD, Libby P, Aikawa M, Aikawa E, Plutzky J
Retinoids Repress Human Cardiovascular Cell Calcification With Evidence for Distinct Selective Retinoid Modulator Effects.
Arterioscler Thromb Vasc Biol. 2019;40(3):656-669 - PMID: 31852220 - PMCID: PMC7047603 - DOI: 10.1161/ATVBAHA.119.313366
Rogers MA, Aikawa E
MicroRNA Extracellular Vesicle Stowaways in Cell-Cell Communication and Organ Crosstalk.
Arterioscler Thromb Vasc Biol. 2019;39(12):2448-2450 - PMID: 31770027 - PMCID: PMC6980729 - DOI: 10.1161/ATVBAHA.119.313533
Arima N, Sasaki Y, Lee LH, Zhang H, Figueiredo JL, Mlynarchik AK, Qiao J, Yamada I, Higashi H, Ha AH, Halu A, Mizuno K, Singh SA, Yamazaki Y, Aikawa M
Multi-organ systems study reveals Igfbp7 as a suppressor of gluconeogenesis after gastric bypass surgery.
J Proteome Res. 2019;19(1):129-143 - PMID: 31661273 - DOI: 10.1021/acs.jproteome.9b00441
Andraski AB, Singh SA, Lee LH, Higashi H, Smith N, Zhang B, Aikawa M, Sacks FM
Effects of Replacing Dietary Monounsaturated Fat With Carbohydrate on HDL (High-Density Lipoprotein) Protein Metabolism and Proteome Composition in Humans.
Arterioscler Thromb Vasc Biol. 2019;39(11):2411-2430 - PMID: 31554421 - PMCID: PMC6874109 - DOI: 10.1161/ATVBAHA.119.312889
Aikawa M, Manabe I, Marx N
Editorial: New Trends in Vascular Inflammation Research: From Biology to Therapy.
Front Cardiovasc Med. 2019;6:102 - PMID: 31555666 - PMCID: PMC6722177 - DOI: 10.3389/fcvm.2019.00102
Atkins SK, Aikawa E
Valve under the microscope: shining a light on emerging technologies elucidating disease mechanisms.
Heart. 2019;105(21):1610-1611 - PMID: 31296591 - PMCID: PMC6855786 - DOI: 10.1136/heartjnl-2019-315236
Fruchart JC, Santos RD, Aguilar-Salinas C, Aikawa M, Al Rasadi K, Amarenco P, Barter PJ, Ceska R, Corsini A, Després JP, Duriez P, Eckel RH, Ezhov MV, Farnier M, Ginsberg HN, Hermans MP, Ishibashi S, Karpe F, Kodama T, Koenig W, Krempf M, Lim S, Lorenzatti AJ, McPherson R, Nuñez-Cortes JM, Nordestgaard BG, Ogawa H, Packard CJ, Plutzky J, Ponte-Negretti CI, Pradhan A, Ray KK, Reiner Ž, Ridker PM, Ruscica M, Sadikot S, Shimano H, Sritara P, Stock JK, Su TC, Susekov AV, Tartar A, Taskinen MR, Tenenbaum A, Tokgözoğlu LS, Tomlinson B, Tybjærg-Hansen A, Valensi P, Vrablík M, Wahli W, Watts GF, Yamashita S, Yokote K, Zambon A, Libby P
The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: conceptual framework and therapeutic potential : A consensus statement from the International Atherosclerosis Society (IAS) and the Residual Risk Reduction Initiative (R3i) Foundation.
Cardiovasc Diabetol. 2019;18(1):71 - PMID: 31164165 - PMCID: PMC6549355 - DOI: 10.1186/s12933-019-0864-7
Kovacic JC, Dimmeler S, Harvey RP, Finkel T, Aikawa E, Krenning G, Baker AH
Endothelial to Mesenchymal Transition in Cardiovascular Disease: JACC State-of-the-Art Review.
J Am Coll Cardiol. 2019;73(2):190-209 - PMID: 30654892 - PMCID: PMC6865825 - DOI: 10.1016/j.jacc.2018.09.089
Hutcheson JD, Goergen CJ, Schoen FJ, Aikawa M, Zilla P, Aikawa E, Gaudette GR
After 50 Years of Heart Transplants: What Does the Next 50 Years Hold for Cardiovascular Medicine? A Perspective From the International Society for Applied Cardiovascular Biology.
Front Cardiovasc Med. 2019;6:8 - PMID: 30838213 - PMCID: PMC6382669 - DOI: 10.3389/fcvm.2019.00008
Blaser MC, Aikawa E
Differential miRNA Loading Underpins Dual Harmful and Protective Roles for Extracellular Vesicles in Atherogenesis.
Circ Res. 2019;124(4):467-469 - PMID: 30763209 - PMCID: PMC6383776 - DOI: 10.1161/CIRCRESAHA.119.314596
Phillippi JA, Aikawa E, Hutcheson J
Editorial: Exploring the Frontiers of Regenerative Cardiovascular Medicine.
Front Cardiovasc Med. 2019;6:13 - PMID: 30873414 - PMCID: PMC6401650 - DOI: 10.3389/fcvm.2019.00013
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