Nakamura, Yuto
Dr. Yuto Nakamura worked at Tokyo New Drug Research Laboratories, Kowa Company, Ltd. since he graduated from the University of Toyama, Japan in 2015. At University of Toyama, he studied metabolic diseases, especially non-alcoholic steatohepatitis (NASH), and he completed his Master’s course in Pharmaceutical Science under the guidance of Dr. Toshiyasu Sasaoka. Since joining Kowa, he has been engaged in drug development research regarding ophthalmology. Then, he moved on to the laboratory of the graduate school of medicine, department of metabolic medicine at Osaka University, Japan as a Kowa researcher. He obtained his doctorate in 2021 under the supervision of Dr. Iichiro Shimomura and Dr. Shunbun Kita. He investigated the relationship between adiponectin and therapeutic efficacy of Mesenchymal stem cells (MSCs), and uncovered that the circulating adiponectin concentration is closely related to the effect of MSCs for heart failure in mice.
He is engaged in research in the field of metabolic disease at CICS since Dec 2021 as a research fellow in Dr. Yusuke Sasaki’s group. He will be focusing on searching for new druggable targets in metabolic disease.
Publications
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Turner ME, Nakamura Y, Tanaka T, Blaser MC, Kasai T, Lupieri A, Itoh S, Ge R, Perez KA, Itagawa R, Weiss L, Okui T, Sasaki Y, Pradhan AD, Libby P, Ridker PM, Singh SA, Aikawa M, Aikawa E
Selective PPAR-α activation with pemafibrate attenuates macrophage-mediated progression of calcific aortic valve disease.
Jha PK, Chelvanambi S, Nakamura Y, Itto LYU, Vijay A, Lupieri A, Barbeiro MC, Le TD, Nascimento CB, Kasai T, Whelan MC, Hosokawa D, Becker-Greene D, Singh SA, Aikawa E, Uchida S, Aikawa M
A systems approach to target discovery identifies the role of lncRNA-SPANXA2-OT1 in macrophage chemotaxis.
Santinelli-Pestana DV, Delwarde C, Kasai T, Kuraoka S, Nakamura Y, Okada T, Decano JL, Chelvanambi S, Ge R, Mlynarchik AK, Perez K, Campedelli A, Sonawane AR, Aikawa E, Singh SA, Aikawa M
ADP-Ribosylation in Experimental Atherosclerosis: A Potential Link Between Dyslipidemia and Inflammation in Cardiovascular Disease.
Kasai T, Nakamura Y, Aikawa M, Singh SA
In-Source Collision-Induced Dissociation (CID) Improves Higher-Energy Collisional Dissociation (HCD)-Dependent Fragmentation of ADP-Ribosyl Peptides.
Iwata A, Chelvanambi S, Asano T, Whelan M, Nakamura Y, Aikawa E, Sasaki Y, Aikawa M
Gene expression profiles of precursor cells identify compounds that reduce NRP1 surface expression in macrophages: Implication for drug repositioning for COVID-19.
