Kasai, Taku
Dr. Taku Kasai earned his Ph.D. (Pharmaceutical Sciences) in 2014 from Kanazawa University, Japan in the laboratory of Professor Ikumi Tamai. He investigated the expression of prostaglandin transporter (OATP2A1/SLCO2A1) in human colorectal cancer-derived cell lines; and clarified the role of the transporter in regulating prostaglandin E2 (PGE2) in response to inflammatory and oxidative stress. OATP2A1 is expressed at plasma membranes, but also in the cytoplasmic domains of human colorectal cancer-derived cells. OATP2A1 is involved in the secretion of PGE2 in an exocytotic manner, a new finding that may contribute to controlling tumor progression induced by angiogenic signaling. After obtaining his Ph.D., Dr. Kasai joined Tokyo New Drug Research Lab., Kowa Company Ltd. His primary role was to evaluate the pharmacokinetic properties of new drug candidates for safety and efficacy, to predict their behaviors in humans. Dr. Kasai is, therefore, experienced in using a variety of in vitro methods to evaluate drug permeability, drug metabolism, drug-drug interactions, and drug-protein interactions. In addition, he is very experienced in pharmacokinetic profiling in animals. He has also developed mass spectrometry methods for hundreds of compounds. In January 2022, Dr. Kasai joined CICS, representing Kowa as a research fellow in the Proteomics Group led by Dr. Sasha Singh. He is focusing on mass spectrometry-based protein research, with the aim to develop novel technologies and help his colleagues in their research goals.
Publications
1. Shirasaka Y, Shichiri M, Kasai T, Ohno Y, Nakanishi T, Hayashi K, Nishiura A, Tamai I. A role of prostaglandin transporter in regulating PGE2 release from human bronchial epithelial BEAS-2B cells in response to LPS., J Endocrinol, 2013; 217(3):265-74.
2. Kasai T, Nakanishi T, Ohno Y, Shimada H, Nakamura Y, Arakawa H, Tamai I. Role of OATP2A1 in PGE2secretion from human colorectal cancer cells via exocytosis in response to oxidative stress., Exp Cell Res, 2016; 341(2):123-31.
3. Isobe T, Kasai T, Kawai H. Ocular Penetration and Pharmacokinetics of Ripasudil Following Topical Administration to Rabbits., J Ocul Pharmacol Ther, 2016; 32(7):405-14.
Publications
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Jung B, Yagi H, Kuo A, Dorweiler TF, Aikawa M, Kasai T, Singh SA, Dannenberg AJ, Fu Z, Niaudet C, Smith LEH, Hla T
ApoM-bound S1P acts via endothelial S1PR1 to suppress choroidal neovascularization and vascular leakage.
Yagi H, Qiu C, Zeng Y, Boeck M, Nian S, Chen CT, Harman JC, Kasai T, Lee J, Hirst V, Neilsen K, Wang C, Bora K, Maurya M, Rodrick T, Grumbine M, Yang Y, Hua Z, Sweet IR, Singh SA, Aikawa M, Chen J, Fu Z
Serine supplementation suppresses hypoxia-induced pathological retinal angiogenesis.
Boeck M, Yagi H, Chen CT, Zeng Y, Lee D, Nian S, Kasai T, Lee J, Hirst V, Wang C, Neilsen K, Rodrick TC, McCutcheon A, Yu M, Lodhi IJ, Singh SA, Aikawa M, Bazinet RP, Fu Z
Nutrient supplementation mitigates retinal dysfunction in Acox1 knockout mice with impaired peroxisomal fatty acid oxidation.
Kasai T, Nakamura Y, Aikawa M, Singh SA
In-Source Collision-Induced Dissociation (CID) Improves Higher-Energy Collisional Dissociation (HCD)-Dependent Fragmentation of ADP-Ribosyl Peptides.
Yagi H, Boeck M, Nian S, Neilsen K, Wang C, Lee J, Zeng Y, Grumbine M, Sweet IR, Kasai T, Negishi K, Singh SA, Aikawa M, Hellström A, Smith LEH, Fu Z
Correction: Mitochondrial control of hypoxia-induced pathological retinal angiogenesis.
Yagi H, Boeck M, Petrishka-Lozenska M, Lundgren P, Kasai T, Cagnone G, Neilsen K, Wang C, Lee J, Tomita Y, Singh SA, Joyal JS, Aikawa M, Negishi K, Fu Z, Hellström A, Smith LEH
Timed topical dexamethasone eye drops improve mitochondrial function to prevent severe retinopathy of prematurity.
Yagi H, Boeck M, Nian S, Neilsen K, Wang C, Lee J, Zeng Y, Grumbine M, Sweet IR, Kasai T, Negishi K, Singh SA, Aikawa M, Hellström A, Smith LEH, Fu Z
Mitochondrial control of hypoxia-induced pathological retinal angiogenesis.
Okui T, Kuraoka S, Iwashita M, Itagawa R, Kasai T, Aikawa M, Singh SA, Aikawa E
Carnitine O-octanoyltransferase (CROT) deficiency in mice leads to an increase of omega-3 fatty acids.
Yagi H, Boeck M, Petrishka-Lozenska M, Lundgren P, Kasai T, Cagnone G, gael.cagnone.1@gmail.com, Wang C, Lee J, Tomita Y, Singh SA, Joyal JS, Aikawa M, Negishi K, Fu Z, Hellström A, Smith LEH
Timed topical dexamethasone eye drops improve mitochondrial function to prevent severe retinopathy of prematurity.
Cahalane RME, Turner ME, Clift CL, Blaser MC, Bogut G, Levy S, Kasai T, Driedonks TAP, Nolte-'t Hoen ENM, Aikawa M, Singh SA, Aikawa E
Polycarbonate Ultracentrifuge Tube Re-use in Proteomic Analyses of Extracellular Vesicles.
Kasai T, Kuraoka S, Higashi H, Delanghe B, Aikawa M, Singh SA
A Combined Gas-Phase Separation Strategy for ADP-ribosylated Peptides.
