Maejima, Takashi
I transferred from the Drug Discovery Research Group in KOWA’s Tokyo laboratory to CICS this May 2015. At CICS, I‘ll be part of the macrophage Group, focusing on inflammation due to atherosclerosis. In the Tokyo lab, I mainly focused on signal transduction analysis using one of HMG-CoA reductase inhibitors, statins, pitavastatin. From 2005-2008 and 2010-2012, I collaborated with Professor Tatsuhiko Kodama and we showed pitavastatin regulated gene expression via changing chromatin conformation. I obtained my PhD in 2008 from the University of Tokyo.
Publications
ShowGrunewald ME, Chen Y, Kuny C, Maejima T, Lease R, Ferraris D, Aikawa M, Sullivan CS, Perlman S, Fehr AR
The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression.
PLoS Pathog. 2019;15(5):e1007756 - PMID: 31095648 - PMCID: PMC6521996 - DOI: 10.1371/journal.ppat.1007756
Higashi H, Maejima T, Lee LH, Yamazaki Y, Hottiger MO, Singh SA, Aikawa M
A study into the ADP-ribosylome of IFN-γ-stimulated THP-1 human macrophage-like cells identifies ARTD8/PARP14 and ARTD9/PARP9 ADP-ribosylation.
J Proteome Res. 2019;18(4):1607-1622 - PMID: 30848916 - PMCID: PMC6456868 - DOI: 10.1021/acs.jproteome.8b00895
Higashi H, Maejima T, Lee LH, Yamazaki Y, Hottiger MO, Singh SA, Aikawa M
A study into the ADP-ribosylome of IFN-γ-stimulated THP-1 human macrophage-like cells identifies ARTD8/PARP14 and ARTD9/PARP9 ADP-ribosylation.
J Proteome Res. 2019;18(4):1607-1622 - PMID: 30848916 - PMCID: PMC6456868 - DOI: 10.1021/acs.jproteome.8b00895
Maejima T, Inoue T, Kanki Y, Kohro T, Li G, Ohta Y, Kimura H, Kobayashi M, Taguchi A, Tsutsumi S, Iwanari H, Yamamoto S, Aruga H, Dong S, Stevens JF, Poh HM, Yamamoto K, Kawamura T, Mimura I, Suehiro J, Sugiyama A, Kaneki K, Shibata H, Yoshinaka Y, Doi T, Asanuma A, Tanabe S, Tanaka T, Minami T, Hamakubo T, Sakai J, Nozaki N, Aburatani H, Nangaku M, Ruan X, Tanabe H, Ruan Y, Ihara S, Endo A, Kodama T, Wada Y
Direct evidence for pitavastatin induced chromatin structure change in the KLF4 gene in endothelial cells.
Inoue T, Kohro T, Tanaka T, Kanki Y, Li G, Poh HM, Mimura I, Kobayashi M, Taguchi A, Maejima T, Suehiro J, Sugiyama A, Kaneki K, Aruga H, Dong S, Stevens JF, Yamamoto S, Tsutsumi S, Fujita T, Ruan X, Aburatani H, Nangaku M, Ruan Y, Kodama T, Wada Y
Cross-enhancement of ANGPTL4 transcription by HIF1 alpha and PPAR beta/delta is the result of the conformational proximity of two response elements.
Maejima T, Sugano T, Yamazaki H, Yoshinaka Y, Doi T, Tanabe S, Nishimaki-Mogami T
Pitavastatin increases ABCA1 expression by dual mechanisms: SREBP2-driven transcriptional activation and PPARα-dependent protein stabilization but without activating LXR in rat hepatoma McARH7777 cells.
J Pharmacol Sci. 2011;116(1):107-15 - PMID: 21521932 - DOI: 10.1254/jphs.10241fp
Sumi K, Tanaka T, Uchida A, Magoori K, Urashima Y, Ohashi R, Ohguchi H, Okamura M, Kudo H, Daigo K, Maejima T, Kojima N, Sakakibara I, Jiang S, Hasegawa G, Kim I, Osborne TF, Naito M, Gonzalez FJ, Hamakubo T, Kodama T, Sakai J
Cooperative interaction between hepatocyte nuclear factor 4 alpha and GATA transcription factors regulates ATP-binding cassette sterol transporters ABCG5 and ABCG8.
Sakamoto A, Kawasaki T, Kazawa T, Ohashi R, Jiang S, Maejima T, Tanaka T, Iwanari H, Hamakubo T, Sakai J, Kodama T, Naito M
Expression of liver X receptor alpha in rat fetal tissues at different developmental stages.
J Histochem Cytochem. 2007;55(6):641-9 - PMID: 17341476 - DOI: 10.1369/jhc.6A7120.2007
Yamazaki H, Suzuki M, Aoki T, Morikawa S, Maejima T, Sato F, Sawanobori K, Kitahara M, Kodama T, Saito Y
Influence of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on ubiquinone levels in rat skeletal muscle and heart: relationship to cytotoxicity and inhibitory activity for cholesterol synthesis in human skeletal muscle cells.
J Atheroscler Thromb. 2006;13(6):295-307 - PMID: 17192694 - DOI: 10.5551/jat.13.295
Iguchi H, Ikeda Y, Okamura M, Tanaka T, Urashima Y, Ohguchi H, Takayasu S, Kojima N, Iwasaki S, Ohashi R, Jiang S, Hasegawa G, Ioka RX, Magoori K, Sumi K, Maejima T, Uchida A, Naito M, Osborne TF, Yanagisawa M, Yamamoto TT, Kodama T, Sakai J
SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice.
J Biol Chem. 2005;280(45):37669-80 - PMID: 16148004 - DOI: 10.1074/jbc.M505392200
Maejima T, Yamazaki H, Aoki T, Tamaki T, Sato F, Kitahara M, Saito Y
Effect of pitavastatin on apolipoprotein A-I production in HepG2 cell.
Biochem Biophys Res Commun. 2004;324(2):835-9 - PMID: 15474503 - DOI: 10.1016/j.bbrc.2004.09.122
Aoki T, Yamazaki H, Maejima T, Sato F, Kitahara M, Saito Y
Effect of pitavastatin on sterol and bile acid excretion in guinea pigs.
Arzneimittelforschung. 2003;53(5):351-6 - PMID: 12854362