Hagita, Sumihiko
Dr. Sumihiko Hagita received his Ph.D. in medicine at Tokyo Medical and Dental University in 2011. After graduation, he began working for Kowa Company, Limited in 2011 and was assigned to the diabetes research group in the Pharmacology Department at Tokyo New Drug Research Laboratories. He performed research studies to evaluate new drugs or compounds for type 2 diabetes mellitus.
He has been working on elucidation of the mechanisms underlying arterial calcification to find new therapeutic target preventing cardiovascular calcification.
Publications
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Hagita S, Rogers MA, Pham T, Wen JR, Mlynarchik AK, Aikawa M, Aikawa E
Transcriptional control of intestinal cholesterol absorption, adipose energy expenditure and lipid handling by Sortilin.
Goettsch C, Hutcheson JD, Hagita S, Rogers MA, Creager MD, Pham T, Choi J, Mlynarchik AK, Pieper B, Kjolby M, Aikawa M, Aikawa E
A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification.
Goettsch C, Hutcheson JD, Aikawa M, Iwata H, Pham T, Nykjaer A, Kjolby M, Rogers M, Michel T, Shibasaki M, Hagita S, Kramann R, Rader DJ, Libby P, Singh SA, Aikawa E
Sortilin mediates vascular calcification via its recruitment into extracellular vesicles.
Osaka M, Hagita S, Yoshida M
In vivo imaging of leukocyte recruitment to the atheroprone femoral artery reveals anti-inflammatory effects of rosuvastatin.
Hagita S, Osaka M, Shimokado K, Yoshida M
Adipose inflammation initiates recruitment of leukocytes to mouse femoral artery: role of adipo-vascular axis in chronic inflammation.
Hagita S, Osaka M, Shimokado K, Yoshida M
Combination of amlodipine and atorvastatin synergistically reduces leukocyte recruitment to mechanically injured mouse femoral artery.
Hagita S, Osaka M, Shimokado K, Yoshida M
Oxidative stress in mononuclear cells plays a dominant role in their adhesion to mouse femoral artery after injury.
Osaka M, Hagita S, Haraguchi M, Kajimura M, Suematsu M, Yoshida M
Real-time imaging of mechanically injured femoral artery in mice reveals a biphasic pattern of leukocyte accumulation.
