Dr. Shinsuke Ito studied molecular biology, biochemistry and cell biology as well as researched the regulation of cytoskeletal dynamics and functions of cell adhesion molecules at the Laboratory of Molecular Biology and Biochemistry with Professor Yoshimi Takai at the Graduate School of Medicine, Osaka University. After graduation, he began working on drug discovery at Tokyo New Drug Research Laboratories, Kowa Company, Ltd. He examined hypertriglyceridemia and renal disease. After which, he was assigned as a researcher under the guidance of Professor Takashi Kadowaki at a laboratory in the Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo. Here he explored the functions of insulin receptor substrate 1 and 2 in hepatic insulin signaling at the state of fasting and feeding, which was investigated using wild type and liver-specific insulin receptor substrate 1, 2, and 1/2 double knockout mice. Following, he returned to Tokyo New Drug Research Laboratories, Kowa Company, Ltd. as Chief Laboratory Researcher and worked on multiple tasks investigating Type 2 diabetes, metabolic disease and cardiovascular diseases. He has been researching cardiovascular calcification at the Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women’s Hospital since April 2014.