Center for Interdisciplinary Cardiovascular Sciences

Dr. Keishi Nihira received his Ph.D. in Science from Tokyo Medical and Dental University Japan in 2011. During graduate school, he studied the post-translational modification of proteins, such as phosphorylation, related to intracellular signaling of proliferation, apoptosis and cell cycle in cancer cells. After graduation, he entered Kowa Company, Ltd. Here Dr. Nihira arranged a method for high throughput screening and performed this system to find compounds for therapeutics.
Dr. Nihira joined the Center for Interdisciplinary Cardiovascular Sciences in April 2014. He is researching macrophage biology to identify therapeutic targets.

Kagami Y, Nihira K, Wada S, Ono M, Honda M, Yoshida K

Mps1 phosphorylation of condensin II controls chromosome condensation at the onset of mitosis.

J Cell Biol. 2014;205(6):781-90 - PMID: 24934155 - PMCID: PMC4068140 - DOI: 10.1083/jcb.201308172

Nihira K, Ando Y, Yamaguchi T, Kagami Y, Miki Y, Yoshida K

Pim-1 controls NF-kappaB signalling by stabilizing RelA/p65.

Cell Death Differ. 2009;17(4):689-98 - PMID: 19911008 - DOI: 10.1038/cdd.2009.174

Nihira K, Taira N, Miki Y, Yoshida K

TTK/Mps1 controls nuclear targeting of c-Abl by 14-3-3-coupled phosphorylation in response to oxidative stress.

Oncogene. 2008;27(58):7285-95 - PMID: 18794806 - DOI: 10.1038/onc.2008.334

Taira N, Nihira K, Yamaguchi T, Miki Y, Yoshida K

DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage.

Mol Cell. 2007;25(5):725-38 - PMID: 17349958 - DOI: 10.1016/j.molcel.2007.02.007

Nihira, Keishi

Publications