Decano, Julius L.
Dr. Julius L. Decano received his Doctorate in Medicine degree at the St. Luke’s College of Medicine and the St. Luke’s Medical Center in the Philippines and finished his pre-med bachelor’s degree in Molecular Biology and Biotechnology at the University of the Philippines, Diliman. Dr. Decano has held a post-doctoral position at the Whitaker Cardiovascular Institute of the Boston University Medical Campus (BUMC) and a managerial position at the BUMC Ultrasound Imaging Core Facility. At BUMC, Dr. Decano worked on various research projects that include: characterization of a timed spontaneous non-surgical stroke model, using juvenile protective factors like cell therapy for delaying stroke and prolonging survival among stroke-prones, and collaborated with proteomics experts to discover biochemical pathway targets in brain microvessels and blood-brain-barrier of the stroke model. These metabolic and structural targets can potentially be exploited (1) to uncover detailed mechanistic paradigms of microhemorrhages and low flow ischemia in stroke, and (2) to develop novel drugs for therapy. Dr. Decano has also done innovative work with high resolution sonographic molecular imaging of carotid vasa vasorum neovascularization in hypertensive hyperlipidemic models, as well as assessing arterial stiffness through pulsed wave imaging. While working on projects under the BU Clinical Translational Science Institute (CTSI), he did leading edge work on developing a system for delivering DNA/siRNA payload as well as inhibitory antibody therapy in a site specific manner to in vivo tissues in the live animals non-invasively. He managed to fuse ultrasound technology, molecular imaging and use of customized nanoparticles for targeted immunotherapy on spontaneous breast cancer rodent models as well as foreign gene introduction into specific tissue regions.
Dr. Decano joined CICS and Dr. Masanori Aikawa’s group in March of 2014 to continue his work on searching and testing for new translational targets for stroke and MI and to further investigate the role of macrophages in these diseases and their co-morbidities.
Publications
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Katsuki S, Kumar Jha P, Lupieri A, Nakano T, Passos LSA, Rogers MA, Becker-Greene D, Le TD, Decano JL, Ho Lee L, Guimaraes GC, Abdelhamid I, Halu A, Muscoloni A, Vittorio Cannistraci C, Higashi H, Zhang H, Vromman A, Libby P, Keith Ozaki C, Sharma A, Singh SA, Aikawa E, Aikawa M
Proprotein Convertase Subtilisin/Kexin 9 Promotes Macrophage Activation via LDL Receptor-Independent Mechanisms.
Decano JL, Iwamoto Y, Goto S, Lee JY, Matamalas JT, Halu A, Blaser M, Lee LH, Pieper B, Chelvanambi S, Silva-Nicolau J, Bartoli-Leonard F, Higashi H, Shibata H, Vyas P, Wang J, Gostjeva E, Body SC, Singh SA, Aikawa M, Aikawa E
A disease-driver population within interstitial cells of human calcific aortic valves identified via single-cell and proteomic profiling.
Asano T, Chelvanambi S, Decano JL, Whelan MC, Aikawa E, Aikawa M
In silico Drug Screening Approach Using L1000-Based Connectivity Map and Its Application to COVID-19.
Decano JL, Singh SA, Bueno CG, Lee LH, Halu A, Chelvanambi S, Matamalas JT, Zhang H, Mlynarchik AK, Qiao J, Sharma A, Mukai S, Wang J, Anderson DG, Ozaki CK, Libby P, Aikawa E, Aikawa M
Systems Approach to Discovery of Therapeutic Targets for Vein Graft Disease PPARα Pivotally Regulates Metabolism, Activation, and Heterogeneity of Macrophages and Lesion Development.
Decano JL, Aikawa M
Dynamic Macrophages: Understanding Mechanisms of Activation as Guide to Therapy for Atherosclerotic Vascular Disease.
Sharma A, Halu A, Decano JL, Padi M, Liu YY, Prasad RB, Fadista J, Santolini M, Menche J, Weiss ST, Vidal M, Silverman EK, Aikawa M, Barabási AL, Groop L, Loscalzo J
Controllability in an islet specific regulatory network identifies the transcriptional factor NFATC4, which regulates Type 2 Diabetes associated genes.
Decano JL, Mattson PC, Aikawa M
Macrophages in Vascular Inflammation: Origins and Functions.
Koga JI, Nakano T, Dahlman JE, Figueiredo JL, Zhang H, Decano J, Khan OF, Niida T, Iwata H, Aster JC, Yagita H, Anderson DG, Ozaki CK, Aikawa M
Macrophage Notch Ligand Delta-Like 4 Promotes Vein Graft Lesion Development: Implications for the Treatment of Vein Graft Failure.
Herrera VL, Decano JL, Tan GA, Moran AM, Pasion KA, Matsubara Y, Ruiz-Opazo N
DEspR Roles in Tumor Vasculo-Angiogenesis, Invasiveness, CSC-Survival and Anoikis Resistance: A 'Common Receptor Coordinator' Paradigm.
Decano JL, Moran AM, Giordano N, Ruiz-Opazo N, Herrera VL
Analysis of CD45- [CD34+/KDR+] endothelial progenitor cells as juvenile protective factors in a rat model of ischemic-hemorrhagic stroke.
Decano JL, Moran AM, Ruiz-Opazo N, Herrera VL
Molecular imaging of vasa vasorum neovascularization via DEspR-targeted contrast-enhanced ultrasound micro-imaging in transgenic atherosclerosis rat model.
Bergerat A, Decano J, Wu CJ, Choi H, Nesvizhskii AI, Moran AM, Ruiz-Opazo N, Steffen M, Herrera VL
Prestroke proteomic changes in cerebral microvessels in stroke-prone, transgenic[hCETP]-Hyperlipidemic, Dahl salt-sensitive hypertensive rats.
Herrera VL, Bagamasbad P, Decano JL, Ruiz-Opazo N
AVR/NAVR deficiency lowers blood pressure and differentially affects urinary concentrating ability, cognition, and anxiety-like behavior in male and female mice.
Decano JL, Viereck JC, McKee AC, Hamilton JA, Ruiz-Opazo N, Herrera VL
Early-life sodium exposure unmasks susceptibility to stroke in hyperlipidemic, hypertensive heterozygous Tg25 rats transgenic for human cholesteryl ester transfer protein.
Herrera VL, Decano JL, Steffen M, Ruiz-Opazo N
Autophagy: insights from DEspR-deficiency and haploinsufficiency.
Herrera VL, Decano JL, Bagamasbad P, Kufahl T, Steffen M, Ruiz-Opazo N
Sex-specific hippocampus-dependent cognitive deficits and increased neuronal autophagy in DEspR haploinsufficiency in mice.
Herrera VL, Bagamasbad P, Didishvili T, Decano JL, Ruiz-Opazo N
Overlapping genes in Nalp6/PYPAF5 locus encode two V2-type vasopressin isoreceptors: angiotensin-vasopressin receptor (AVR) and non-AVR.
Glorioso N, Herrera VL, Bagamasbad P, Filigheddu F, Troffa C, Argiolas G, Bulla E, Decano JL, Ruiz-Opazo N
Association of ATP1A1 and dear single-nucleotide polymorphism haplotypes with essential hypertension: sex-specific and haplotype-specific effects.
