Hutcheson, Joshua D.
Dr. Joshua (Josh) Hutcheson joined CICS in September 2012 after completing his Ph.D. in the Department of Biomedical Engineering at Vanderbilt University. His dissertation research in the Merryman Mechanobiology Laboratory focused on understanding the mechanisms of aortic valve disease progression and the identification of potential therapeutic targets. Prior to his Ph.D. work, Dr. Hutcheson received his B.S. in Chemical and Biomolecular engineering and M.S. in Chemical Engineering at the Georgia Institute of Technology, where he trained in the drug delivery laboratory of Dr. Mark Prausnitz.
Dr. Hutcheson is continuing to do translational research at CICS in Dr. Elena Aikawa’s group, where he is working to better understand the role of matrix vesicles in arterial calcification. Specifically, Dr. Hutcheson’s research is attempting to identify the mechanisms associated with matrix vesicle formation of microcalcifications and elucidate the resultant biomechanical changes that may lead to plaque vulnerability and thrombosis.
Dr. Hutcheson’s research has been presented at more than 20 conferences and research symposia and is the basis for two patent applications.
Publications
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Phillippi JA, Aikawa E, Hutcheson J
Editorial: Exploring the Frontiers of Regenerative Cardiovascular Medicine.
Hutcheson JD, Goergen CJ, Schoen FJ, Aikawa M, Zilla P, Aikawa E, Gaudette GR
After 50 Years of Heart Transplants: What Does the Next 50 Years Hold for Cardiovascular Medicine? A Perspective From the International Society for Applied Cardiovascular Biology.
Creager MD, Hohl T, Hutcheson JD, Moss AJ, Schlotter F, Blaser MC, Park MA, Lee LH, Singh SA, Alcaide-Corral CJ, Tavares AAS, Newby DE, Kijewski MF, Aikawa M, Di Carli M, Dweck MR, Aikawa E
18F-Fluoride Signal Amplification Identifies Microcalcifications Associated With Atherosclerotic Plaque Instability in Positron Emission Tomography/Computed Tomography Images.
Schlotter F, Halu A, Goto S, Blaser MC, Body SC, Lee LH, Higashi H, DeLaughter DM, Hutcheson JD, Vyas P, Pham T, Rogers MA, Sharma A, Seidman CE, Loscalzo J, Seidman JG, Aikawa M, Singh SA, Aikawa E
Spatiotemporal Multi-omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving Disease.
Hutcheson JD, Aikawa E
Extracellular vesicles in cardiovascular homeostasis and disease.
Bakhshian Nik A, Hutcheson JD, Aikawa E
Extracellular Vesicles As Mediators of Cardiovascular Calcification.
Rogers M, Maldonado-Martinez N, Hutcheson JD, Goettsch C, Goto S, Yamada I, Faits T, Sesaki H, Aikawa M, Aikawa E
Dynamin-Related Protein 1 Inhibition Attenuates Cardiovascular Calcification in the Presence of Oxidative Stress.
Goettsch C, Iwata H, Hutcheson JD, O'Donnell CJ, Chapurlat R, Cook NR, Aikawa M, Szulc P, Aikawa E
Serum Sortilin Associates With Aortic Calcification and Cardiovascular Risk in Men.
Hutcheson JD, Blaser MC, Aikawa E
Giving Calcification Its Due: Recognition of a Diverse Disease: A First Attempt to Standardize the Field.
Yabusaki K, Hutcheson JD, Vyas P, Bertazzo S, Body SC, Aikawa M, Aikawa E
Quantification of Calcified Particles in Human Valve Tissue Reveals Asymmetry of Calcific Aortic Valve Disease Development.
Kramann R, Goettsch C, Wongboonsin J, Iwata H, Schneider RK, Kuppe C, Kaesler N, Chang-Panesso M, Machado FG, Gratwohl S, Madhurima K, Hutcheson JD, Jain S, Aikawa E, Humphreys BD
Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease.
Goettsch C, Hutcheson JD, Hagita S, Rogers MA, Creager MD, Pham T, Choi J, Mlynarchik AK, Pieper B, Kjolby M, Aikawa M, Aikawa E
A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification.
O'Rourke C, Shelton G, Hutcheson JD, Burke MF, Martyn T, Thayer TE, Shakartzi HR, Buswell MD, Tainsh RE, Yu B, Bagchi A, Rhee DK, Wu C, Derwall M, Buys ES, Yu PB, Bloch KD, Aikawa E, Bloch DB, Malhotra R
Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation.
Ruiz JL, Weinbaum S, Aikawa E, Hutcheson JD
Zooming in on the genesis of atherosclerotic plaque microcalcifications.
Hjortnaes J, Goettsch C, Hutcheson JD, Camci-Unal G, Lax L, Scherer K, Body S, Schoen FJ, Kluin J, Khademhosseini A, Aikawa E
Simulation of early calcific aortic valve disease in a 3D platform: A role for myofibroblast differentiation.
Goettsch C, Hutcheson JD, Aikawa M, Iwata H, Pham T, Nykjaer A, Kjolby M, Rogers M, Michel T, Shibasaki M, Hagita S, Kramann R, Rader DJ, Libby P, Singh SA, Aikawa E
Sortilin mediates vascular calcification via its recruitment into extracellular vesicles.
Krohn JB, Hutcheson JD, Martínez-Martínez E, Aikawa E
Extracellular vesicles in cardiovascular calcification: Expanding current paradigms.
Krohn JB, Hutcheson JD, Martínez-Martínez E, Irvin WS, Bouten CV, Bertazzo S, Bendeck MP, Aikawa E
Discoidin Domain Receptor-1 Regulates Calcific Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response via Transforming Growth Factor-β Signaling.
Hutcheson JD, Goettsch C, Bertazzo S, Maldonado N, Ruiz JL, Goh W, Yabusaki K, Faits T, Bouten C, Franck G, Quillard T, Libby P, Aikawa M, Weinbaum S, Aikawa E
Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques.
Hutcheson JD, Goettsch C, Rogers MA, Aikawa E
Revisiting Cardiovascular Calcification: A Multifaceted Disease Requiring a Multidisciplinary Approach.
Hjortnaes J, Shapero K, Goettsch C, Hutcheson JD, Keegan J, Kluin J, Mayer JE, Bischoff J, Aikawa E
Valvular interstitial cells suppress calcification of valvular endothelial cells.
Ruiz JL, Hutcheson JD, Aikawa E
Cardiovascular calcification: current controversies and novel concepts.
Hutcheson JD, Goettsch C, Pham T, Iwashita M, Aikawa M, Singh SA, Aikawa E
Enrichment of calcifying extracellular vesicles using density-based ultracentrifugation protocol.
Hutcheson JD, Maldonado N, Aikawa E
Small entities with large impact: microcalcifications and atherosclerotic plaque vulnerability.
Hjortnaes J, Camci-Unal G, Hutcheson JD, Jung SM, Schoen FJ, Kluin J, Aikawa E, Khademhosseini A
Directing Valvular Interstitial Cell Myofibroblast-Like Differentiation in a Hybrid Hydrogel Platform.
Hutcheson JD, Aikawa E, Merryman WD
Potential drug targets for calcific aortic valve disease.
Goettsch C, Hutcheson JD, Aikawa E
MicroRNA in Cardiovascular Calcification: Focus on Targets and Extracellular Vesicle Delivery Mechanisms.
Hutcheson JD, Chen J, Sewell-Loftin MK, Ryzhova LM, Fisher CI, Su YR, Merryman WD
Cadherin-11 regulates cell-cell tension necessary for calcific nodule formation by valvular myofibroblasts.
Hutcheson JD, Ryzhova LM, Setola V, Merryman WD
5-HT(2B) antagonism arrests non-canonical TGF-β1-induced valvular myofibroblast differentiation.
Hutcheson JD, Venkataraman R, Baudenbacher FJ, Merryman WD
Intracellular Ca(2+) accumulation is strain-dependent and correlates with apoptosis in aortic valve fibroblasts.
Hutcheson JD, Setola V, Roth BL, Merryman WD
Serotonin receptors and heart valve disease--it was meant 2B.
Hutcheson JD, Schlicher RK, Hicks HK, Prausnitz MR
Saving cells from ultrasound-induced apoptosis: quantification of cell death and uptake following sonication and effects of targeted calcium chelation.
Choi SO, Kim YC, Park JH, Hutcheson J, Gill HS, Yoon YK, Prausnitz MR, Allen MG
An electrically active microneedle array for electroporation.
Schlicher RK, Hutcheson JD, Radhakrishna H, Apkarian RP, Prausnitz MR
Changes in cell morphology due to plasma membrane wounding by acoustic cavitation.
Kamaev PP, Hutcheson JD, Wilson ML, Prausnitz MR
Quantification of optison bubble size and lifetime during sonication dominant role of secondary cavitation bubbles causing acoustic bioeffects.