Wang, Jianguo

Dr. Wang obtained his Ph.D. at Shanghai Institute of Biochemistry and Cell Biology in 2003. In the past 9 years, his research has been focusing on the biology of Tissue Factor(TF) and roles of Microparticles(MPs) in thrombosis and inflammation.
Dr. Wang competed his first postdoc training in Professor Arne Slungaard’s laboratory in Department of medicine at University of Minnesota (2003-2007). He found that HOSCN is a potent inducer of endothelial cell TF and several important cell adhesion molecules expression through the activation of NF-κB and Erk-Egr-1 signaling pathways. He also discovered that histone deacetylase-3(HDAC3) plays a critical role in regulating TFgene expression in cultured endothelial cells and monocytes.
Dr. Wang joined Dr. Nigel Mackman’s research group at University of North Carolina-Chapel Hill in 2007. He developed and validated a novel method to measure the levels of microparticle(MP) TF activity in plasma from human and mouse. He found that plasma level of TF-positive MPs correlates with the activation of coagulation in endotoxemic mice and may be a potential biomarker associated with the risk of venous thromboembolism in patients with pancreatic cancer. In an orthotopicmouse model of pancreatic cancer, he found that tumor-derived TF drives the coagulation activation and tumors are the major source of TF-positive MP in the plasma from tumor-bearing mice. In addition, He found that monocytic MPs activate endothelial cells by an IL-1β-dependent mechanism. Dr. Wang received Pier M. Mannucci Young Investigator Award from the International Society of Thrombosis and Haemostasis in 2010.
Dr. Wang joined the Center for Interdisciplinary Cardiovascular Sciences in August 2012. He is investigating the roles of long noncoding RNAs(lncRNAs) in macrophage differentiation and polarization. His major scientific goal is to identify novel lncRNAs as the potential therapeutic targets in cardiovascular diseases.