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Decano JL, Iwamoto Y, Goto S, Lee JY, Matamalas JT, Halu A, Blaser M, Lee LH, Pieper B, Chelvanambi S, Silva-Nicolau J, Bartoli-Leonard F, Higashi H, Shibata H, Vyas P, Wang J, Gostjeva E, Body SC, Singh SA, Aikawa M, Aikawa E

A disease-driver population within interstitial cells of human calcific aortic valves identified via single-cell and proteomic profiling.
Cell Rep. 2022;39(2):110685 - PMID: 35417712 - DOI: 10.1016/j.celrep.2022.110685

Asano T, Chelvanambi S, Decano JL, Whelan MC, Aikawa E, Aikawa M

In silico Drug Screening Approach Using L1000-Based Connectivity Map and Its Application to COVID-19.
Front Cardiovasc Med. 2022;9:842641 - PMID: 35402570 - PMCID: PMC8989014 - DOI: 10.3389/fcvm.2022.842641

Wang L, Xu GE, Pan L, Aikawa E, Aikawa M, Xiao J, Huang NF

Editorial: Frontiers in Cardiovascular Medicine: Rising Stars 2021.
Front Cardiovasc Med. 2022;9:928981 - PMID: 35757336 - PMCID: PMC9218798 - DOI: 10.3389/fcvm.2022.928981

Marsit O, Clavel MA, Paquin A, Deschênes V, Hadjadj S, Sénéchal-Dumais I, Couet J, Arsenault M, Handschumacher MD, Levine RA, Aikawa E, Pibarot P, Beaudoin J

Effects of Cyproheptadine on Mitral Valve Remodeling and Regurgitation After Myocardial Infarction.
J Am Coll Cardiol. 2022;80(5):500-510 - PMID: 35902173 - DOI: 10.1016/j.jacc.2022.05.025

Uchida S, Yu J, Goldman M, Asmis R, Yang X, Aikawa E, Bourantas C, Aikawa M, Tevaearai Stahel H

Editorial: Research reproducibility and preventing fraud.
Front Cardiovasc Med. 2022;9:979467 - PMID: 35979020 - PMCID: PMC9376614 - DOI: 10.3389/fcvm.2022.979467

Atkins SK, Sonawane AR, Brouwhuis R, Barrientos J, Ha A, Rogers M, Tanaka T, Okui T, Kuraoka S, Singh SA, Aikawa M, Aikawa E

Induced pluripotent stem cell-derived smooth muscle cells to study cardiovascular calcification.
Front Cardiovasc Med. 2022;9:925777 - PMID: 35958427 - PMCID: PMC9357895 - DOI: 10.3389/fcvm.2022.925777

Morgan S, Lee LH, Halu A, Nicolau JS, Higashi H, Ha AH, Wen JR, Daugherty A, Libby P, Cameron SJ, Mix D, Aikawa E, Owens AP, Singh SA, Aikawa M

Identifying novel mechanisms of abdominal aortic aneurysm via unbiased proteomics and systems biology.
Front Cardiovasc Med. 2022;9:889994 - PMID: 35990960 - PMCID: PMC9382335 - DOI: 10.3389/fcvm.2022.889994

Kuo A, Checa A, Niaudet C, Jung B, Fu Z, Wheelock CE, Singh SA, Aikawa M, Smith LEH, Proia RL, Hla T

Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasi.
Elife. 2022;11:ePub - PMID: 36197001 - PMCID: PMC9578713 - DOI: 10.7554/eLife.78861

Corti A, De Paolis A, Grossman P, Dinh PA, Aikawa E, Weinbaum S, Cardoso L

The effect of plaque morphology, material composition and microcalcifications on the risk of cap rupture: A structural analysis of vulnerable atherosclerotic plaques.
Front Cardiovasc Med. 2022;9:1019917 - PMID: 36277774 - PMCID: PMC9583261 - DOI: 10.3389/fcvm.2022.1019917

Krohn JB, Aikawa E, Aikawa M, Hutcheson JD, Sahoo S, Fish JE

Editorial: Extracellular vesicles in cardiovascular inflammation and calcification.
Front Cardiovasc Med. 2022;9:1077124 - PMID: 36426218 - PMCID: PMC9680153 - DOI: 10.3389/fcvm.2022.1077124

Sutton NR, Malhotra R, Hilaire CS, Aikawa E, Blumenthal RS, Gackenbach G, Goyal P, Johnson A, Nigwekar SU, Shanahan CM, Towler DA, Wolford BN, Chen Y

Molecular Mechanisms of Vascular Health: Insights From Vascular Aging and Calcification.
Arterioscler Thromb Vasc Biol. 2022;43(1):15-29 - PMID: 36412195 - PMCID: PMC9793888 - DOI: 10.1161/ATVBAHA.122.317332

Kum AST, De Moura DTH, Proença IM, Aikawa M, Sánchez-Luna SA, Ribeiro IB, Sasso JGRJ, Bestetti AM, Bernardo WM, Hourneaux de Moura EG

Gastroesophageal Reflux Waning Over Time in Endoscopic Versus Surgical Myotomy for the Treatment of Achalasia: A Systematic Review and Meta-Analysis.
Cureus. 2022;14(11):e31756 - PMID: 36569663 - PMCID: PMC9771598 - DOI: 10.7759/cureus.31756

Sud K, Narula N, Aikawa E, Arbustini E, Pibarot P, Merlini G, Rosenson RS, Seshan SV, Argulian E, Ahmadi A, Zhou F, Moreira AL, Côté N, Tsimikas S, Fuster V, Gandy S, Bonow RO, Gursky O, Narula J

The contribution of amyloid deposition in the aortic valve to calcification and aortic stenosis.
Nat Rev Cardiol. 2023;20(6):418-428 - PMID: 36624274 - PMCID: PMC10199673 - DOI: 10.1038/s41569-022-00818-2

Iqbal F, Schlotter F, Becker-Greene D, Lupieri A, Goettsch C, Hutcheson JD, Rogers MA, Itoh S, Halu A, Lee LH, Blaser MC, Mlynarchik AK, Hagita S, Kuraoka S, Chen HY, Engert JC, Passos LSA, Jha PK, Osborn EA, Jaffer FA, Body SC, Robson SC, Thanassoulis G, Aikawa M, Singh SA, Sonawane AR, Aikawa E

Sortilin enhances fibrosis and calcification in aortic valve disease by inducing interstitial cell heterogeneity.
Eur Heart J. 2023;44(10):885-898 - PMID: 36660854 - PMCID: PMC9991042 - DOI: 10.1093/eurheartj/ehac818

Blaser MC, Kraler S, Lüscher TF, Aikawa E

Network-Guided Multiomic Mapping of Aortic Valve Calcification.
Arterioscler Thromb Vasc Biol. 2023;43(3):417-426 - PMID: 36727519 - PMCID: PMC9975082 - DOI: 10.1161/ATVBAHA.122.318334

Wang Z, Tang M, Luan X, Tevaearai Stahel H, Aikawa M, Xie M, Ge S, Zhang S

Editorial: What do we know about COVID-19 implications for cardiovascular disease?
Front Cardiovasc Med. 2023;10:1125655 - PMID: 36733303 - PMCID: PMC9887308 - DOI: 10.3389/fcvm.2023.1125655

Natarajan R, Moore K, Sahoo D, Nana-Sinkam P, Fowler AAB, Sime P, Sorci-Thomas M, Aikawa E, ATVB Council, friends, and colleagues

Shobha Ghosh (1958-2021).
Arterioscler Thromb Vasc Biol. 2022;42(3):239-240 - PMID: 36808997 - DOI: 10.1161/ATVBAHA.122.317419

Sud K, Narula N, Aikawa E, Arbustini E, Pibarot P, Merlini G, Rosenson RS, Seshan SV, Argulian E, Ahmadi A, Zhou F, Moreira AL, Côté N, Tsimikas S, Fuster V, Gandy S, Bonow RO, Gursky O, Narula J

Author Correction: The contribution of amyloid deposition in the aortic valve to calcification and aortic stenosis.
Nat Rev Cardiol. 2023;20(6):429 - PMID: 36807395 - DOI: 10.1038/s41569-023-00848-4

Bartoli-Leonard F, Zimmer J, Sonawane AR, Perez K, Turner ME, Kuraoka S, Pham T, Li F, Aikawa M, Singh S, Brewster L, Aikawa E

NLRP3 Inflammasome Activation in Peripheral Arterial Disease.
J Am Heart Assoc. 2023;12(6):e026945 - PMID: 36892058 - PMCID: PMC10111545 - DOI: 10.1161/JAHA.122.026945

Cable J, Witwer KW, Coffey RJ, Milosavljevic A, von Lersner AK, Jimenez L, Pucci F, Barr MM, Dekker N, Barman B, Humphrys D, Williams J, de Palma M, Guo W, Bastos N, Hill AF, Levy E, Hantak MP, Crewe C, Aikawa E, Adamczyk AM, Zanotto TM, Ostrowski M, Arab T, Rabe DC, Sheikh A, da Silva DR, Jones JC, Okeoma C, Gaborski T, Zhang Q, Gololobova O

Exosomes, microvesicles, and other extracellular vesicles-a Keystone Symposia report.
Ann N Y Acad Sci. 2023;1523(1):24-37 - PMID: 36961472 - PMCID: PMC10715677 - DOI: 10.1111/nyas.14974

Veulemans V, Billaud M, Nunes MCP, Goettsch C, Aikawa E

Editorial: Women in heart valve disease.
Front Cardiovasc Med. 2023;10:1150169 - PMID: 36994000 - PMCID: PMC10041336 - DOI: 10.3389/fcvm.2023.1150169

Andraski AB, Singh SA, Higashi H, Lee LH, Aikawa M, Sacks FM

The distinct metabolism between large and small HDL indicates unique origins of human apolipoprotein A4.
JCI Insight. 2023;8(8):ePub - PMID: 37092549 - PMCID: PMC10243815 - DOI: 10.1172/jci.insight.162481

Raju S, Botts SR, Blaser M, Prajapati K, Ho TWW, Ching C, Galant NJ, Fiddes L, Wu R, Clift CL, Pham T, Lee WL, Singh SA, Aikawa E, Fish JE, Howe KL

Endothelial cells secrete small extracellular vesicles bidirectionally containing distinct cargo to uniquely reprogram vascular cells in the circulation and vessel wall.
bioRxiv. 2023;:ePub - PMID: 37162986 - PMCID: PMC10168399 - DOI: 10.1101/2023.04.28.538787

Distefano R, Ilieva M, Madsen JH, Ishii H, Aikawa M, Rennie S, Uchida S

T2DB: A Web Database for Long Non-Coding RNA Genes in Type II Diabetes.
Noncoding RNA. 2023;9(3):ePub - PMID: 37218990 - PMCID: PMC10204529 - DOI: 10.3390/ncrna9030030

Nehl D, Goody PR, Maus K, Pfeifer A, Aikawa E, Bakthiary F, Zimmer S, Nickenig G, Jansen F, Hosen MR

Human and porcine aortic valve endothelial and interstitial cell isolation and characterization.
Front Cardiovasc Med. 2023;10:1151028 - PMID: 37408661 - PMCID: PMC10318150 - DOI: 10.3389/fcvm.2023.1151028

Greco E, Vinciguerra M, Sampaio R, Aikawa E

Editorial: New insights in heart valve disease 2022.
Front Cardiovasc Med. 2023;10:1226113 - PMID: 37416925 - PMCID: PMC10321655 - DOI: 10.3389/fcvm.2023.1226113

Blaser MC, Buffolo F, Halu A, Turner ME, Schlotter F, Higashi H, Pantano L, Clift CL, Saddic LA, Atkins SK, Rogers MA, Pham T, Vromman A, Shvartz E, Sukhova GK, Monticone S, Camussi G, Robson SC, Body SC, Muehlschlegel JD, Singh SA, Aikawa M, Aikawa E

Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis.
Circulation. 2023;148(8):661-678 - PMID: 37427430 - PMCID: PMC10527599 - DOI: 10.1161/CIRCULATIONAHA.122.063402

Bartoli-Leonard F, Chelvanambi S, Pham T, Turner ME, Blaser MC, Caputo M, Aikawa M, Pang A, Muehlschlegel J, Aikawa E

Single-cell T cell receptor sequencing of paired tissue and blood samples reveals clonal expansion of CD8+ effector T cells in patients with calcific aortic valve disease.
bioRxiv. 2023;:ePub - PMID: 37461603 - PMCID: PMC10350049 - DOI: 10.1101/2023.07.08.548203

Santinelli-Pestana DV, Aikawa E, Singh SA, Aikawa M

PARPs and ADP-Ribosylation in Chronic Inflammation: A Focus on Macrophages.
Pathogens. 2023;12(7):ePub - PMID: 37513811 - PMCID: PMC10386340 - DOI: 10.3390/pathogens12070964

Perez KA, Deppe DW, Filas A, Singh SA, Aikawa E

Multimodal analytical tools to enhance mechanistic understanding of aortic valve calcification.
Am J Pathol. 2023;194(4):539-550 - PMID: 37517686 - PMCID: PMC10988764 - DOI: 10.1016/j.ajpath.2023.06.017

Ho YC, Geng X, O'Donnell A, Ibarrola J, Fernandez-Celis A, Varshney R, Subramani K, Azartash-Namin ZJ, Kim J, Silasi R, Wylie-Sears J, Alvandi Z, Chen L, Cha B, Chen H, Xia L, Zhou B, Lupu F, Burkhart HM, Aikawa E, Olson LE, Ahamed J, López-Andrés N, Bischoff J, Yutzey KE, Srinivasan RS

PROX1 Inhibits PDGF-B Expression to Prevent Myxomatous Degeneration of Heart Valves.
Circ Res. 2023;133(6):463-480 - PMID: 37555328 - PMCID: PMC10487359 - DOI: 10.1161/CIRCRESAHA.123.323027

Kasai T, Kuraoka S, Higashi H, Delanghe B, Aikawa M, Singh SA

A Combined Gas-Phase Separation Strategy for ADP-ribosylated Peptides.
J Am Soc Mass Spectrom. 2023;34(10):2136-2145 - PMID: 37589412 - PMCID: PMC10557377 - DOI: 10.1021/jasms.3c00129

Rouhollahi A, Willi JN, Haltmeier S, Mehrtash A, Straughan R, Javadikasgari H, Brown J, Itoh A, de la Cruz KI, Aikawa E, Edelman ER, Nezami FR

CardioVision: A fully automated deep learning package for medical image segmentation and reconstruction generating digital twins for patients with aortic stenosis.
Comput Med Imaging Graph. 2023;109:102289 - PMID: 37633032 - PMCID: PMC10599298 - DOI: 10.1016/j.compmedimag.2023.102289

Machaidze Z, D'Amore A, Freitas RCC, Joyce AJ, Bayoumi A, Rich K, Brown DW, Aikawa E, Wagner WR, Sacks MS, Mayer JE

Tissue formation and host remodeling of an elastomeric biodegradable scaffold in an ovine pulmonary leaflet replacement model.
J Biomed Mater Res A. 2023;112(2):276-287 - PMID: 37772456 - PMCID: PMC11034854 - DOI: 10.1002/jbm.a.37622

Velissari R, Ilieva M, Dao J, Miller HE, Madsen JH, Gorodkin J, Aikawa M, Ishii H, Uchida S

Systematic analysis and characterization of long non-coding RNA genes in inflammatory bowel disease.
Brief Funct Genomics. 2023;23(4):395-405 - PMID: 37791426 - PMCID: PMC11260263 - DOI: 10.1093/bfgp/elad044

Yacoub MH, Tseng YT, Kluin J, Vis A, Stock U, Smail H, Sarathchandra P, Aikawa E, El-Nashar H, Chester AH, Shehata N, Nagy M, El-Sawy A, Li W, Burriesci G, Salmonsmith J, Romeih S, Latif N

Valvulogenesis of a living, innervated pulmonary root induced by an acellular scaffold.
Commun Biol. 2023;6(1):1017 - PMID: 37805576 - PMCID: PMC10560219 - DOI: 10.1038/s42003-023-05383-z

Decano JL, Maiorino E, Matamalas JT, Chelvanambi S, Tiemeijer BM, Yanagihara Y, Mukai S, Jha PK, Pestana DVS, D'Souza E, Whelan M, Ge R, Asano T, Sharma A, Libby P, Singh SA, Aikawa E, Aikawa M

Cellular Heterogeneity of Activated Primary Human Macrophages and Associated Drug-Gene Networks: From Biology to Precision Therapeutics.
Circulation. 2023;148(19):1459-78 - PMID: 37850387 - PMCID: PMC10624416 - DOI: 10.1161/CIRCULATIONAHA.123.064794

Turner ME, Aikawa E

Updating the paradigm: inflammation as a targetable modulator of medial vascular calcification.
Cardiovasc Res. 2023;119(13):2259-2261 - PMID: 37875065 - PMCID: PMC10597605 - DOI: 10.1093/cvr/cvad139

Lupieri A, Aikawa E

Decoding calcific aortic valve disease: is liver X receptor the key to lipid metabolism?
Cardiovasc Res. 2025;121(6):844-846 - PMID: 40389228 - DOI: 10.1093/cvr/cvaf080

Jha PK, Aikawa M, Aikawa E

Indoxyl sulfate: fuelling cardiovascular inflammation and calcification.
Cardiovasc Res. 2025;121(11):1642-1644 - PMID: 40795292 - PMCID: PMC12477674 - DOI: 10.1093/cvr/cvaf134

Clift CL, Goudot G, Bogut G, Kasai T, van Kampen A, Negrao Pantaleao A, Messas E, Aikawa M, Singh SA, Levine RA, Pernot M, Aikawa E

Short- and Long-Term Effects of Pulsed Ultrasound Cavitation Therapy of Calcified Valvular Interstitial Cells in Culture.
Ultrasound Med Biol. 2025;51(11):1936-1944 - PMID: 40796501 - DOI: 10.1016/j.ultrasmedbio.2025.06.026

Chelvanambi S, Chen H, De Vries MR, Fang Y, Fredman G, Gomez D, Iwata H, Uchida S, Yanagisawa H, Aikawa M

Editorial: New trends in vascular biology 2024.
Front Cardiovasc Med. 2025;12:1649558 - PMID: 40777568 - PMCID: PMC12328353 - DOI: 10.3389/fcvm.2025.1649558

Delwarde C, Matamalas JT, Chelvanambi S, Kasai T, Shlayen G, Santinelli-Pestana DV, Zamani M, Aikawa E, Aikawa M, Singh SA

Nanoparticle-enabled plasma proteomics of a mouse atherosclerosis model.
bioRxiv. 2025;:ePub - PMID: 40766711 - PMCID: PMC12324543 - DOI: 10.1101/2025.08.01.667173

Boeck M, Yagi H, Lundgren P, Pivodic A, Nilsson AK, Zeng Y, Chen CT, Kasai T, Lee D, Nian S, Hirst V, Neilsen K, Wang C, Lee J, Yu M, McCutcheon A, Singh SA, Aikawa M, Bazinet RP, Fu Z, Hellström A, Smith LE

Combined dietary omega-3 and omega-6 fatty acids protect against hyperglycemia-associated retinopathy in neonatal mice.
Pharmacol Res. 2025;219:107877 - PMID: 40706777 - PMCID: PMC12445345 - DOI: 10.1016/j.phrs.2025.107877

Cahalane RME, Meuris B, Matamalas JT, Blaser MC, Billaud M, Kasai T, Hendrickx A, Goeminne LJE, Muehlschlegel J, Rega F, Aikawa M, McNamara L, Singh SA, Clift CL, Aikawa E

Cross-species proteomics quantification pipeline distinguishes donor versus host extracellular matrix in explanted biomaterials.
bioRxiv. 2025;:ePub - PMID: 40667106 - PMCID: PMC12262681 - DOI: 10.1101/2025.06.24.661315

Weiss L, Aikawa E

Glycolysis hijacked: a novel pathogenic role of lipoprotein(a) in valve disease.
Eur Heart J Open. 2025;5(4):oeaf069 - PMID: 40654528 - PMCID: PMC12246370 - DOI: 10.1093/ehjopen/oeaf069

Lupieri A, Becker-Greene D, Le TD, Roschel MM, Jha PK, Sonawane AR, Mullick A, Tsimikas S, Kuraoka S, Singh SA, Aikawa M, Aikawa E

Antisense Oligonucleotide Targeting Sortilin Reduces Vascular Calcification in Mice in a Sex-Dependent Manner.
Arterioscler Thromb Vasc Biol. 2025;45(8):1398-1415 - PMID: 40501380 - PMCID: PMC12503371 - DOI: 10.1161/ATVBAHA.124.321999

Higuita ML, Ajenu EO, Bolger-Chen M, Olverson G, Akbari Ghavimi SA, Lee SY, Kasai T, Michaud W, Chijioke C, Ruidas B, Pitti A, Minie N, Catricala J, Vincent D, Li S, D'Alessandro D, Aikawa E, Singh SA, Billaud M, Osho AA, Tessier SN, Rabi SA

Alternative preservation strategies of DCD hearts: Effect of cold ischemia time before normothermic machine perfusion.
medRxiv. 2025;:ePub - PMID: 40502597 - PMCID: PMC12154999 - DOI: 10.1101/2025.06.04.25329001

Raju S, Turner ME, Cao C, Abdul-Samad M, Punwasi N, Blaser MC, Cahalane RME, Botts SR, Prajapati K, Patel S, Wu R, Gustafson D, Galant NJ, Fiddes L, Chemaly M, Hedin U, Matic L, Seidman MA, Subasri V, Singh SA, Aikawa E, Fish JE, Howe KL

Multiomic Landscape of Extracellular Vesicles in Human Carotid Atherosclerotic Plaque Reveals Endothelial Communication Networks.
Arterioscler Thromb Vasc Biol. 2025;45(7):1277-1305 - PMID: 40438929 - PMCID: PMC12188822 - DOI: 10.1161/ATVBAHA.124.322324

Boeck M, Yagi H, Chen CT, Zeng Y, Lee D, Nian S, Kasai T, Lee J, Hirst V, Wang C, Neilsen K, Rodrick TC, McCutcheon A, Yu M, Lodhi IJ, Singh SA, Aikawa M, Bazinet RP, Fu Z

Nutrient supplementation mitigates retinal dysfunction in Acox1 knockout mice with impaired peroxisomal fatty acid oxidation.
J Adv Res. 2025;78:667-680 - PMID: 40049514 - PMCID: PMC12684955 - DOI: 10.1016/j.jare.2025.03.004
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