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Lansac E, Veen KM, Joseph A, Jaber PB, Sossi F, Das-Gupta Z, Aktaa S, Sádaba JR, Thourani VH, Dahle G, Szeto WY, Bakaeen F, Aikawa E, Schoen FJ, Girdauskas E, Almeida A, Zuckermann A, Meuris B, Stott J, Kluin J, Meel R, Woan W, Colgan D, Jneid H, Balkhy H, Szerlip M, Preventza O, Shah P, Rigolin VH, Medica S, Holmes P, Sitges M, Pibarot P, Donal E, Hahn RT, Takkenberg JJM
The first International Consortium for Health Outcomes Measurement (ICHOM) standard dataset for reporting outcomes in heart valve disease: moving from device- to patient- centered outcomes.
Eur Heart J Qual Care Clin Outcomes. 2025;:ePub - PMID: 39957667 - DOI: 10.1093/ehjqcco/qcae051
Lansac E, Veen KM, Joseph A, Jaber PB, Sossi F, Das-Gupta Z, Aktaa S, Rafael Sádaba J, Thourani VH, Dahle G, Szeto WY, Bakaeen F, Aikawa E, Schoen FJ, Girdauskas E, Almeida A, Zuckermann A, Meuris B, Stott J, Kluin J, Meel R, Woan W, Colgan D, Jneid H, Balkhy H, Szerlip M, Preventza O, Shah P, Rigolin VH, Medica S, Holmes P, Sitges M, Pibarot P, Donal E, Hahn RT, Takkenberg JJM
The First International Consortium for Health Outcomes Measurement (ICHOM) Standard Dataset for Reporting Outcomes in Heart Valve Disease: Moving From Device- to Patient-Centered Outcomes.
Eur J Cardiothorac Surg. 2025;67(2):ePub - PMID: 39957685 - PMCID: PMC11842054 - DOI: 10.1093/ejcts/ezae254
Boucher DM, Robichaud S, Lorant V, Leon JS, Suliman I, Rasheed A, Susser LI, Emerton C, Geoffrion M, De Jong E, Bowdish DME, Aikawa M, Aikawa E, Singh SA, Rayner KJ, Ouimet M
Age-Related Impairments in Immune Cell Efferocytosis and Autophagy Hinder Atherosclerosis Regression.
Arterioscler Thromb Vasc Biol. 2025;45(4):481-495 - PMID: 39945065 - PMCID: PMC11936474 - DOI: 10.1161/ATVBAHA.124.321662
Bhattacharjee S, Gao J, Lu YW, Eisa-Beygi S, Wu H, Li K, Birsner AE, Wong S, Song Y, Shyy JY, Cowan DB, Huang W, Wei W, Aikawa M, Shi J, Chen H
Endothelial FOXM1 and Dab2 promote diabetic wound healing.
JCI Insight. 2025;10(2):ePub - PMID: 39846251 - PMCID: PMC11790024 - DOI: 10.1172/jci.insight.186504
Halu A, Chelvanambi S, Decano JL, Matamalas JT, Whelan M, Asano T, Kalicharran N, Singh SA, Loscalzo J, Aikawa M
Integrating pharmacogenomics and cheminformatics with diverse disease phenotypes for cell type-guided drug discovery.
Genome Med. 2025;17(1):7 - PMID: 39833831 - PMCID: PMC11744892 - DOI: 10.1186/s13073-025-01431-x
Villa-Roel N, Park C, Andueza A, Baek KI, Su A, Blaser MC, Leshnower BG, Yoganathan A, Aikawa E, Jo H
Side- and Disease-Dependent Changes in Human Aortic Valve Cell Population and Transcriptomic Heterogeneity Determined by Single-Cell RNA Sequencing.
Genes (Basel). 2024;15(12):ePub - PMID: 39766890 - PMCID: PMC11675841 - DOI: 10.3390/genes15121623
Costa de Freitas RC, Bortolin RH, Kuraoka S, Rogers MA, Blaser MC, Chelvanambi S, Borges JB, de Oliveira VF, Dagli-Hernandez C, Bastos GM, da Silva Rodrigues Marçal E, Malaquias VB, Gonçalves RM, Faludi AA, Silbiger VN, Luchessi AD, Aikawa M, Crespo Hirata RD, Singh SA, Aikawa E, Hirata MH
Integrative analysis of miRNAs and proteins in plasma extracellular vesicles of patients with familial hypercholesterolemia.
Clin Chim Acta. 2025;568:120123 - PMID: 39778611 - DOI: 10.1016/j.cca.2025.120123
Kasai T, Nakamura Y, Aikawa M, Singh SA
In-Source Collision-Induced Dissociation (CID) Improves Higher-Energy Collisional Dissociation (HCD)-Dependent Fragmentation of ADP-Ribosyl Peptides.
Rapid Commun Mass Spectrom. 2025;39(4):e9961 - PMID: 39632390 - PMCID: PMC11617611 - DOI: 10.1002/rcm.9961
Kip P, Sluiter TJ, MacArthur MR, Tao M, Kruit N, Mitchell SJ, Jung J, Kooijman S, Gorham J, Seidman JG, Quax PHA, Decano JL, Aikawa M, Ozaki CK, Mitchell JR, de Vries MR
Preoperative methionine restriction induces perivascular adipose tissue browning and improves vein graft remodeling in male mice.
Nat Commun. 2024;15(1):9652 - PMID: 39511181 - PMCID: PMC11544300 - DOI: 10.1038/s41467-024-53844-8
Iwata A, Chelvanambi S, Asano T, Whelan M, Nakamura Y, Aikawa E, Sasaki Y, Aikawa M
Gene expression profiles of precursor cells identify compounds that reduce NRP1 surface expression in macrophages: Implication for drug repositioning for COVID-19.
Front Cardiovasc Med. 2024;11:1438396 - PMID: 39512370 - PMCID: PMC11541348 - DOI: 10.3389/fcvm.2024.1438396
Garelnabi M, Ntsekhe M, Doubell A, Aikawa M
Editorial: Global Excellence in Cardiovascular Medicine in Africa: challenges and opportunities.
Front Cardiovasc Med. 2024;11:1479281 - PMID: 39502195 - PMCID: PMC11534761 - DOI: 10.3389/fcvm.2024.1479281
Peng Q, Arulsamy K, Lu YW, Wu H, Zhu B, Singh B, Cui K, Wylie-Sears J, Li KS, Wong S, Cowan DB, Aikawa M, Wang DZ, Bischoff J, Chen K, Chen H
Novel Role of Endothelial CD45 in Regulating Endothelial-to-Mesenchymal Transition in Atherosclerosis.
bioRxiv. 2024;:ePub - PMID: 39282400 - PMCID: PMC11398423 - DOI: 10.1101/2024.09.03.610974
Yagi H, Boeck M, Petrishka-Lozenska M, Lundgren P, Kasai T, Cagnone G, Neilsen K, Wang C, Lee J, Tomita Y, Singh SA, Joyal JS, Aikawa M, Negishi K, Fu Z, Hellström A, Smith LEH
Timed topical dexamethasone eye drops improve mitochondrial function to prevent severe retinopathy of prematurity.
Angiogenesis. 2024;27(4):903-917 - PMID: 39287727 - PMCID: PMC11564262 - DOI: 10.1007/s10456-024-09948-2
Bhattacharjee S, Gao J, Lu YW, Eisa-Beygi S, Wu H, Li K, Birsner AE, Wong S, Song Y, Shyy JY, Cowan DB, Wei W, Aikawa M, Shi J, Chen H
Interplay Between FoxM1 and Dab2 Promotes Endothelial Cell Responses in Diabetic Wound Healing.
bioRxiv. 2024;:ePub - PMID: 39253510 - PMCID: PMC11383039 - DOI: 10.1101/2024.02.07.579019
Matamalas JT, Chelvanambi S, Decano JL, França RF, Halu A, Santinelli-Pestana DV, Aikawa E, Malhotra R, Aikawa M
Obesity and age are transmission risk factors for SARS-CoV-2 infection among exposed individuals.
PNAS Nexus. 2024;3(8):pgae294 - PMID: 39192848 - PMCID: PMC11348562 - DOI: 10.1093/pnasnexus/pgae294
Delwarde C, Aikawa M
Novel Mouse Model of Late-Stage Coronary Atherosclerosis With Features of Plaque Rupture and Stroke.
Circulation. 2024;150(9):706-709 - PMID: 39186532 - PMCID: PMC11540410 - DOI: 10.1161/CIRCULATIONAHA.124.070464
Katsuki S, Jha PK, Aikawa E, Aikawa M
The role of proprotein convertase subtilisin/kexin 9 (PCSK9) in macrophage activation: a focus on its LDL receptor-independent mechanisms.
Front Cardiovasc Med. 2024;11:1431398 - PMID: 39149582 - PMCID: PMC11324467 - DOI: 10.3389/fcvm.2024.1431398
Yagi H, Boeck M, Nian S, Neilsen K, Wang C, Lee J, Zeng Y, Grumbine M, Sweet IR, Kasai T, Negishi K, Singh SA, Aikawa M, Hellström A, Smith LEH, Fu Z
Mitochondrial control of hypoxia-induced pathological retinal angiogenesis.
Angiogenesis. 2024;27(4):691-699 - PMID: 39096357 - PMCID: PMC11564381 - DOI: 10.1007/s10456-024-09940-w
Okui T, Kuraoka S, Iwashita M, Itagawa R, Kasai T, Aikawa M, Singh SA, Aikawa E
Carnitine O-octanoyltransferase (CROT) deficiency in mice leads to an increase of omega-3 fatty acids.
Front Mol Biosci. 2024;11:1374316 - PMID: 39076376 - PMCID: PMC11284101 - DOI: 10.3389/fmolb.2024.1374316
Yagi H, Boeck M, Petrishka-Lozenska M, Lundgren P, Kasai T, Cagnone G, gael.cagnone.1@gmail.com, Wang C, Lee J, Tomita Y, Singh SA, Joyal JS, Aikawa M, Negishi K, Fu Z, Hellström A, Smith LEH
Timed topical dexamethasone eye drops improve mitochondrial function to prevent severe retinopathy of prematurity.
Res Sq. 2024;:ePub - PMID: 38978601 - PMCID: PMC11230485 - DOI: 10.21203/rs.3.rs-4619093/v1
Raju S, Turner ME, Cao C, Abdul-Samad M, Punwasi N, Blaser MC, Cahalane RM, Botts SR, Prajapati K, Patel S, Wu R, Gustafson D, Galant NJ, Fiddes L, Chemaly M, Hedin U, Matic L, Seidman M, Subasri V, Singh SA, Aikawa E, Fish JE, Howe KL
Multi-omic Landscape of Extracellular Vesicles in Human Carotid Atherosclerotic Plaque Reveals Endothelial Communication Networks.
bioRxiv. 2024;:ePub - PMID: 38979218 - PMCID: PMC11230219 - DOI: 10.1101/2024.06.21.599781
Chen ZB, Aikawa E, Alfaidi M, Ali K, Clift CL, Erbay E, Fredman G, Gomez D, Huang NF, Lu HS, Nguyen PK, Darc Oliveira S, Rodriguez-Miguelez P, SenthilKumar G, Zhang H, by the ATVB WLC
Institutional Support for the Career Advancement of Women Faculty in Science and Academic Medicine: Successes, Challenges, and Future Directions.
Arterioscler Thromb Vasc Biol. 2024;44(9):1916-1924 - PMID: 38957985 - PMCID: PMC11338710 - DOI: 10.1161/ATVBAHA.124.320910
Turner ME, Aikawa E
Updating the paradigm: inflammation as a targetable modulator of medial vascular calcification.
Cardiovasc Res. 2023;119(13):2259-2261 - PMID: 37875065 - PMCID: PMC10597605 - DOI: 10.1093/cvr/cvad139
Bartoli-Leonard F, Zimmer J, Sonawane AR, Perez K, Turner ME, Kuraoka S, Pham T, Li F, Aikawa M, Singh S, Brewster L, Aikawa E
NLRP3 Inflammasome Activation in Peripheral Arterial Disease.
J Am Heart Assoc. 2023;12(6):e026945 - PMID: 36892058 - PMCID: PMC10111545 - DOI: 10.1161/JAHA.122.026945
Cable J, Witwer KW, Coffey RJ, Milosavljevic A, von Lersner AK, Jimenez L, Pucci F, Barr MM, Dekker N, Barman B, Humphrys D, Williams J, de Palma M, Guo W, Bastos N, Hill AF, Levy E, Hantak MP, Crewe C, Aikawa E, Adamczyk AM, Zanotto TM, Ostrowski M, Arab T, Rabe DC, Sheikh A, da Silva DR, Jones JC, Okeoma C, Gaborski T, Zhang Q, Gololobova O
Exosomes, microvesicles, and other extracellular vesicles-a Keystone Symposia report.
Ann N Y Acad Sci. 2023;1523(1):24-37 - PMID: 36961472 - PMCID: PMC10715677 - DOI: 10.1111/nyas.14974
Veulemans V, Billaud M, Nunes MCP, Goettsch C, Aikawa E
Editorial: Women in heart valve disease.
Front Cardiovasc Med. 2023;10:1150169 - PMID: 36994000 - PMCID: PMC10041336 - DOI: 10.3389/fcvm.2023.1150169
Andraski AB, Singh SA, Higashi H, Lee LH, Aikawa M, Sacks FM
The distinct metabolism between large and small HDL indicates unique origins of human apolipoprotein A4.
JCI Insight. 2023;8(8):ePub - PMID: 37092549 - PMCID: PMC10243815 - DOI: 10.1172/jci.insight.162481
Raju S, Botts SR, Blaser M, Prajapati K, Ho TWW, Ching C, Galant NJ, Fiddes L, Wu R, Clift CL, Pham T, Lee WL, Singh SA, Aikawa E, Fish JE, Howe KL
Endothelial cells secrete small extracellular vesicles bidirectionally containing distinct cargo to uniquely reprogram vascular cells in the circulation and vessel wall.
bioRxiv. 2023;:ePub - PMID: 37162986 - PMCID: PMC10168399 - DOI: 10.1101/2023.04.28.538787
Distefano R, Ilieva M, Madsen JH, Ishii H, Aikawa M, Rennie S, Uchida S
T2DB: A Web Database for Long Non-Coding RNA Genes in Type II Diabetes.
Noncoding RNA. 2023;9(3):ePub - PMID: 37218990 - PMCID: PMC10204529 - DOI: 10.3390/ncrna9030030
Nehl D, Goody PR, Maus K, Pfeifer A, Aikawa E, Bakthiary F, Zimmer S, Nickenig G, Jansen F, Hosen MR
Human and porcine aortic valve endothelial and interstitial cell isolation and characterization.
Front Cardiovasc Med. 2023;10:1151028 - PMID: 37408661 - PMCID: PMC10318150 - DOI: 10.3389/fcvm.2023.1151028
Greco E, Vinciguerra M, Sampaio R, Aikawa E
Editorial: New insights in heart valve disease 2022.
Front Cardiovasc Med. 2023;10:1226113 - PMID: 37416925 - PMCID: PMC10321655 - DOI: 10.3389/fcvm.2023.1226113
Blaser MC, Buffolo F, Halu A, Turner ME, Schlotter F, Higashi H, Pantano L, Clift CL, Saddic LA, Atkins SK, Rogers MA, Pham T, Vromman A, Shvartz E, Sukhova GK, Monticone S, Camussi G, Robson SC, Body SC, Muehlschlegel JD, Singh SA, Aikawa M, Aikawa E
Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis.
Circulation. 2023;148(8):661-678 - PMID: 37427430 - PMCID: PMC10527599 - DOI: 10.1161/CIRCULATIONAHA.122.063402
Bartoli-Leonard F, Chelvanambi S, Pham T, Turner ME, Blaser MC, Caputo M, Aikawa M, Pang A, Muehlschlegel J, Aikawa E
Single-cell T cell receptor sequencing of paired tissue and blood samples reveals clonal expansion of CD8+ effector T cells in patients with calcific aortic valve disease.
bioRxiv. 2023;:ePub - PMID: 37461603 - PMCID: PMC10350049 - DOI: 10.1101/2023.07.08.548203
Santinelli-Pestana DV, Aikawa E, Singh SA, Aikawa M
PARPs and ADP-Ribosylation in Chronic Inflammation: A Focus on Macrophages.
Pathogens. 2023;12(7):ePub - PMID: 37513811 - PMCID: PMC10386340 - DOI: 10.3390/pathogens12070964
Perez KA, Deppe DW, Filas A, Singh SA, Aikawa E
Multimodal analytical tools to enhance mechanistic understanding of aortic valve calcification.
Am J Pathol. 2023;194(4):539-550 - PMID: 37517686 - PMCID: PMC10988764 - DOI: 10.1016/j.ajpath.2023.06.017
Ho YC, Geng X, O'Donnell A, Ibarrola J, Fernandez-Celis A, Varshney R, Subramani K, Azartash-Namin ZJ, Kim J, Silasi R, Wylie-Sears J, Alvandi Z, Chen L, Cha B, Chen H, Xia L, Zhou B, Lupu F, Burkhart HM, Aikawa E, Olson LE, Ahamed J, López-Andrés N, Bischoff J, Yutzey KE, Srinivasan RS
PROX1 Inhibits PDGF-B Expression to Prevent Myxomatous Degeneration of Heart Valves.
Circ Res. 2023;133(6):463-480 - PMID: 37555328 - PMCID: PMC10487359 - DOI: 10.1161/CIRCRESAHA.123.323027
Kasai T, Kuraoka S, Higashi H, Delanghe B, Aikawa M, Singh SA
A Combined Gas-Phase Separation Strategy for ADP-ribosylated Peptides.
J Am Soc Mass Spectrom. 2023;34(10):2136-2145 - PMID: 37589412 - PMCID: PMC10557377 - DOI: 10.1021/jasms.3c00129
Rouhollahi A, Willi JN, Haltmeier S, Mehrtash A, Straughan R, Javadikasgari H, Brown J, Itoh A, de la Cruz KI, Aikawa E, Edelman ER, Nezami FR
CardioVision: A fully automated deep learning package for medical image segmentation and reconstruction generating digital twins for patients with aortic stenosis.
Comput Med Imaging Graph. 2023;109:102289 - PMID: 37633032 - PMCID: PMC10599298 - DOI: 10.1016/j.compmedimag.2023.102289
Machaidze Z, D'Amore A, Freitas RCC, Joyce AJ, Bayoumi A, Rich K, Brown DW, Aikawa E, Wagner WR, Sacks MS, Mayer JE
Tissue formation and host remodeling of an elastomeric biodegradable scaffold in an ovine pulmonary leaflet replacement model.
J Biomed Mater Res A. 2023;112(2):276-287 - PMID: 37772456 - PMCID: PMC11034854 - DOI: 10.1002/jbm.a.37622
Velissari R, Ilieva M, Dao J, Miller HE, Madsen JH, Gorodkin J, Aikawa M, Ishii H, Uchida S
Systematic analysis and characterization of long non-coding RNA genes in inflammatory bowel disease.
Brief Funct Genomics. 2023;23(4):395-405 - PMID: 37791426 - PMCID: PMC11260263 - DOI: 10.1093/bfgp/elad044
Yacoub MH, Tseng YT, Kluin J, Vis A, Stock U, Smail H, Sarathchandra P, Aikawa E, El-Nashar H, Chester AH, Shehata N, Nagy M, El-Sawy A, Li W, Burriesci G, Salmonsmith J, Romeih S, Latif N
Valvulogenesis of a living, innervated pulmonary root induced by an acellular scaffold.
Commun Biol. 2023;6(1):1017 - PMID: 37805576 - PMCID: PMC10560219 - DOI: 10.1038/s42003-023-05383-z
Decano JL, Maiorino E, Matamalas JT, Chelvanambi S, Tiemeijer BM, Yanagihara Y, Mukai S, Jha PK, Pestana DVS, D'Souza E, Whelan M, Ge R, Asano T, Sharma A, Libby P, Singh SA, Aikawa E, Aikawa M
Cellular Heterogeneity of Activated Primary Human Macrophages and Associated Drug-Gene Networks: From Biology to Precision Therapeutics.
Circulation. 2023;148(19):1459-78 - PMID: 37850387 - PMCID: PMC10624416 - DOI: 10.1161/CIRCULATIONAHA.123.064794
Aikawa E, Blaser MC, Singh SA, Levine RA, Yacoub MH
Challenges and Opportunities in Valvular Heart Disease: From Molecular Mechanisms to the Community.
Arterioscler Thromb Vasc Biol. 2024;44(4):763-767 - PMID: 38536897 - PMCID: PMC10977651 - DOI: 10.1161/ATVBAHA.123.319563
Jansen I, Cahalane R, Hengst R, Akyildiz A, Farrell E, Gijsen F, Aikawa E, van der Heiden K, Wissing T
The interplay of collagen, macrophages, and microcalcification in atherosclerotic plaque cap rupture mechanics.
Basic Res Cardiol. 2024;119(2):193-213 - PMID: 38329498 - PMCID: PMC11008085 - DOI: 10.1007/s00395-024-01033-5
Lupieri A, S A Passos L, Levine RA, Nizet V, Aikawa E
Lymphangiogenesis in Rheumatic Heart Valve Disease: A New Factor in the Pathogenic Conundrum.
Arterioscler Thromb Vasc Biol. 2024;44(4):822-825 - PMID: 38357818 - PMCID: PMC10978236 - DOI: 10.1161/ATVBAHA.124.320708
Clift CL, Blaser MC, Gerrits W, Turner ME, Sonawane A, Pham T, Andresen JL, Fenton OS, Grolman JM, Campedelli A, Buffolo F, Schoen FJ, Hjortnaes J, Muehlschlegel JD, Mooney DJ, Aikawa M, Singh SA, Langer R, Aikawa E
Intracellular proteomics and extracellular vesiculomics as a metric of disease recapitulation in 3D-bioprinted aortic valve arrays.
Sci Adv. 2024;10(9):eadj9793 - PMID: 38416823 - PMCID: PMC10901368 - DOI: 10.1126/sciadv.adj9793
Cahalane RME, Turner ME, Clift CL, Blaser MC, Bogut G, Levy S, Kasai T, Driedonks TAP, Nolte-'t Hoen ENM, Aikawa M, Singh SA, Aikawa E
Polycarbonate Ultracentrifuge Tube Re-use in Proteomic Analyses of Extracellular Vesicles.
J Vis Exp. 2024;(205):ePub - PMID: 38526125 - DOI: 10.3791/66126
Parthasarathy S, Saenjamsai P, Hao H, Ferkul A, Pfannenstiel JJ, Suder EL, Bejan DS, Chen Y, Schwarting N, Aikawa M, Muhlberger E, Orozco RC, Sullivan CS, Cohen MS, Davido DJ, Hume AJ, Fehr AR
PARP14 is pro- and anti-viral host factor that promotes IFN production and affects the replication of multiple viruses.
bioRxiv. 2024;:ePub - PMID: 38712082 - PMCID: PMC11071520 - DOI: 10.1101/2024.04.26.591186
Small AM, Yutzey KE, Binstadt BA, Voigts Key K, Bouatia-Naji N, Milan D, Aikawa E, Otto CM, St Hilaire C, American Heart Association Council on Genomic and Precision Medicine Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation and Council on Cardiovascular and Stroke Nursing
Unraveling the Mechanisms of Valvular Heart Disease to Identify Medical Therapy Targets: A Scientific Statement From the American Heart Association.
Circulation. 2024;150(6):e109-e128 - PMID: 38881493 - PMCID: PMC11542557 - DOI: 10.1161/CIR.0000000000001254
Gordon LB, Basso S, Maestranzi J, Aikawa E, Clift CL, Cammardella AG, Danesi TH, Del Nido PJ, Edelman ER, Hamdy A, Hegde SM, Kleinman ME, Maschietto N, Mehra MR, Mukundan S, Musumeci F, Russo M, Rybicki FJ, Shah PB, Suarez WA, Tuminelli K, Zaleski K, Prakash A, Gerhard-Herman M
Intervention for critical aortic stenosis in Hutchinson-Gilford progeria syndrome.
Front Cardiovasc Med. 2024;11:1356010 - PMID: 38725831 - PMCID: PMC11079313 - DOI: 10.3389/fcvm.2024.1356010
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